Reviewed, UniProtKB/Swiss-Prot P84310 (CTR1_LUMTE)

Names and origin

Protein names	Recommended name:     Chymotrypsin LT_CH 1     EC=3.4.21.1
Organism	Lumbricus terrestris (Common earthworm)
Taxonomic identifier	6398 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Annelida › Clitellata › Oligochaeta › Haplotaxida › Lumbricina › Lumbricidae › Lumbricus

Protein attributes

Sequence length	19 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa. Ref.1
Enzyme regulation	Inhibited by the chymotrypsin inhibitor LTCI. Ref.1
Subunit structure	Monomer. Ref.1
Subcellular location	Secreted › extracellular space By similarity.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.
Mass spectrometry	Molecular mass is 23126 Da from positions 1 - ?. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hydrolase Protease Serine protease
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›19	›19	Chymotrypsin LT_CH 1		PRO_0000088688
Regions
	Domain	1 – ›19	›19	Peptidase S1
Experimental info
	Non-terminal residue	19	1

Sequences

	Sequence		Length	Mass (Da)
	P84310-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: A2F0179A5281E5F3	FASTA	19	2,042
	10 VIGGSDTTIG QYPHQLSLR

References

[1]	Wojtaszek J., Wilusz T. Submitted (NOV-2004) to UniProtKB Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBUNIT, MASS SPECTROMETRY. Tissue: Intestine.
[2]	"LTCI, a novel chymotrypsin inhibitor of the potato I family from the earthworm Lumbricus terrestris. Purification, cDNA cloning, and expression." Wojtaszek J., Kolaczkowska A., Kowalska J., Nowak K., Wilusz T. Comp. Biochem. Physiol. 143B:465-472(2006) [PubMed: 16469515] [Abstract] Cited for: ENZYME REGULATION.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.4.21.1. 96703.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTR1_LUMTE

Accession

Primary (citable) accession number: P84310

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)