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P84309

- ADCY5_MOUSE

UniProt

P84309 - ADCY5_MOUSE

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Protein
Adenylate cyclase type 5
Gene
Adcy5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.By similarity

Enzyme regulationi

Inhibition by calcium in the submicromolar concentration range By similarity. Phosphorylation by RAF1 results in its activation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi475 – 4751Magnesium 1 By similarity
Metal bindingi475 – 4751Magnesium 2 By similarity
Metal bindingi476 – 4761Magnesium 2; via carbonyl oxygen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: MGI
  3. adenylate cyclase binding Source: BHF-UCL
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  1. adenosine receptor signaling pathway Source: MGI
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  4. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
  5. cAMP biosynthetic process Source: MGI
  6. intracellular signal transduction Source: InterPro
  7. locomotory behavior Source: MGI
  8. neuromuscular process controlling balance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 5 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 5
Adenylate cyclase type V
Adenylyl cyclase 5
Gene namesi
Name:Adcy5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:99673. Adcy5.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity. Cell projectioncilium 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 196196Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei243 – 26321Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei300 – 32021Helical; Reviewed prediction
Add
BLAST
Transmembranei326 – 34621Helical; Reviewed prediction
Add
BLAST
Transmembranei375 – 39521Helical; Reviewed prediction
Add
BLAST
Topological domaini396 – 763368Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei764 – 78421Helical; Reviewed prediction
Add
BLAST
Transmembranei790 – 81021Helical; Reviewed prediction
Add
BLAST
Transmembranei837 – 85721Helical; Reviewed prediction
Add
BLAST
Topological domaini858 – 91053Extracellular Reviewed prediction
Add
BLAST
Transmembranei911 – 93121Helical; Reviewed prediction
Add
BLAST
Transmembranei936 – 95621Helical; Reviewed prediction
Add
BLAST
Transmembranei985 – 100521Helical; Reviewed prediction
Add
BLAST
Topological domaini1006 – 1262257Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: BHF-UCL
  4. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12621262Adenylate cyclase type 5
PRO_0000195695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi834 – 8341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi871 – 8711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi888 – 8881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi973 – 9731N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated by RAF1 By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP84309.
PRIDEiP84309.

PTM databases

PhosphoSiteiP84309.

Expressioni

Gene expression databases

BgeeiP84309.
CleanExiMM_ADCY5.
GenevestigatoriP84309.

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2. Interacts with RAF1 By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP84309.
SMRiP84309. Positions 455-644, 1065-1256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini470 – 597128Guanylate cyclase 1
Add
BLAST
Domaini1072 – 1211140Guanylate cyclase 2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1019 – 104527 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 674Poly-Gln
Compositional biasi141 – 1477Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00680000099709.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08045.
OMAiVRSKMNS.
OrthoDBiEOG7B8S30.
PhylomeDBiP84309.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P84309-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGSKSVSPP GYAAQTAASP APRGGPEHRA AWGEADSRAN GYPHAPGGST     50
RGSTKRSGGA VTPQQQQRLA SRWRGGDDDE DPPLSGDDPL AGGFGFSFRS 100
KSAWQERGGD DGGRGSRRQR RGAAGGGSTR APPAGGSGSS AAAAAAAGGT 150
EVRPRSVELG LEERRGKGRA AEELEPGTGI VEDGDGSEDG GSSVASGSGT 200
GAVLSLGACC LALLQIFRSK KFPSDKLERL YQRYFFRLNQ SSLTMLMAVL 250
VLVCLVMLAF HAARPPLQIA YLAVLAAAVG VILIMAVLCN RAAFHQDHMG 300
LACYALIAVV LAVQVVGLLL PQPRSASEGI WWTVFFIYTI YTLLPVRMRA 350
AVLSGVLLSA LHLAISLHTN SQDQFLLKQL VSNVLIFSCT NIVGVCTHYP 400
AEVSQRQAFQ ETRECIQARL HSQRENQQQE RLLLSVLPRH VAMEMKADIN 450
AKQEDMMFHK IYIQKHDNVS ILFADIEGFT SLASQCTAQE LVMTLNELFA 500
RFDKLAAENH CLRIKILGDC YYCVSGLPEA RADHAHCCVE MGMDMIEAIS 550
LVREVTGVNV NMRVGIHSGR VHCGVLGLRK WQFDVWSNDV TLANHMEAGG 600
KAGRIHITKA TLNYLNGDYE VEPGCGGDRN AYLKEHSIET FLILSCTQKR 650
KEEKAMIAKM NRQRTNSIGH NPPHWGAERP FYNHLGGNQV SKEMKRMGFE 700
DPKDKNAQES ANPEDEVDEF LGRAIDARSI DRLRSEHVRK FLLTFREPDL 750
EKKYSKQVDD RFGAYVACAS LVFLFICFVQ ITIVPHSLFM LSFYLSCFLL 800
LALVVFVSVI YACVKLFPTP LQTLSRKIVR SKKNSTLVGV FTITLVFLSA 850
FVNMFMCNSK NLVGCLAEEH NITVNQVNAC HVMESAFNYS LGDEQGFCGS 900
PQPNCNFPEY FTYSVLLSLL ACSVFLQISC IGKLVLMLAI EFIYVLIVEV 950
PGVTLFDNAD LLVTANAIDF SNNGTSQCPE HATKVALKVV TPIIISVFVL 1000
ALYLHAQQVE STARLDFLWK LQATEEKEEM EELQAYNRRL LHNILPKDVA 1050
AHFLARERRN DELYYQSCEC VAVMFASIAN FSEFYVELEA NNEGVECLRL 1100
LNEIIADFDE IISEDRFRQL EKIKTIGSTY MAASGLNDST YDKAGKTHIK 1150
AIADFAMKLM DQMKYINEHS FNNFQMKIGL NIGPVVAGVI GARKPQYDIW 1200
GNTVNVASRM DSTGVPDRIQ VTTDMYQVLA ANTYQLECRG VVKVKGKGEM 1250
MTYFLNGGPP LS 1262
Length:1,262
Mass (Da):139,122
Last modified:January 9, 2007 - v2
Checksum:i342966E7CA67E28D
GO
Isoform 2 (identifier: P84309-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1262: PPLS → LGHDGVVGKL...GSEQKKIFIK

Note: No experimental confirmation available.

Show »
Length:1,348
Mass (Da):148,383
Checksum:iB4997E3A2BC14305
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1259 – 12624PPLS → LGHDGVVGKLKAGLGVSMEL KGLLFHCGEVTPPHNVWGTG TGRRVACAILSPHLHAQRQC PVRETGLLTREARGHQARSS GSEQKKIFIK in isoform 2.
VSP_022224

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → S in AAH90846. 1 Publication
Sequence conflicti686 – 6861G → D in BAE28048. 1 Publication
Sequence conflicti924 – 9241V → M in AAH90846. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK147649 mRNA. Translation: BAE28048.1.
AK160942 mRNA. Translation: BAE36104.1.
BC035550 mRNA. No translation available.
BC090846 mRNA. Translation: AAH90846.1.
CCDSiCCDS37322.1. [P84309-1]
RefSeqiNP_001012783.3. NM_001012765.4. [P84309-1]
UniGeneiMm.41137.

Genome annotation databases

EnsembliENSMUST00000114913; ENSMUSP00000110563; ENSMUSG00000022840. [P84309-1]
GeneIDi224129.
KEGGimmu:224129.
UCSCiuc007zbj.1. mouse. [P84309-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK147649 mRNA. Translation: BAE28048.1 .
AK160942 mRNA. Translation: BAE36104.1 .
BC035550 mRNA. No translation available.
BC090846 mRNA. Translation: AAH90846.1 .
CCDSi CCDS37322.1. [P84309-1 ]
RefSeqi NP_001012783.3. NM_001012765.4. [P84309-1 ]
UniGenei Mm.41137.

3D structure databases

ProteinModelPortali P84309.
SMRi P84309. Positions 455-644, 1065-1256.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P84309.

PTM databases

PhosphoSitei P84309.

Proteomic databases

PaxDbi P84309.
PRIDEi P84309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114913 ; ENSMUSP00000110563 ; ENSMUSG00000022840 . [P84309-1 ]
GeneIDi 224129.
KEGGi mmu:224129.
UCSCi uc007zbj.1. mouse. [P84309-1 ]

Organism-specific databases

CTDi 111.
MGIi MGI:99673. Adcy5.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00680000099709.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
KOi K08045.
OMAi VRSKMNS.
OrthoDBi EOG7B8S30.
PhylomeDBi P84309.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

NextBioi 377103.
PROi P84309.
SOURCEi Search...

Gene expression databases

Bgeei P84309.
CleanExi MM_ADCY5.
Genevestigatori P84309.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain and Retina.
  3. "Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
    Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
    Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP5; ADCY6; PDE4C AND PKD2.

Entry informationi

Entry nameiADCY5_MOUSE
AccessioniPrimary (citable) accession number: P84309
Secondary accession number(s): Q3TU67, Q3UH09, Q5BL06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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