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P84288 (COX2_CHOFU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana)
Taxonomic identifier7141 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaTortricoideaTortricidaeTortricinaeChoristoneura

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Cytochrome c oxidase subunit 2
PRO_0000183550

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 5125Helical; Potential
Topological domain52 – 6211Mitochondrial matrix Potential
Transmembrane63 – 8119Helical; Potential
Topological domain82 – 227146Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P84288 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 22364BBD4BC17663

FASTA22726,434
        10         20         30         40         50         60 
MATWSNFNLQ NSASPLMEQI IFFHDHTLVI LIMITILVGY LMISLFFNSY INRFLLEGQM 

        70         80         90        100        110        120 
IELIWTILPA ITLIFIALPS LRLLYLLDEL NNPLITLKSI GHQWYWSYEY SDFQNIQFDS 

       130        140        150        160        170        180 
YMIPINEMKN NNFRLLDVDN RIVLPMNNQI RILVTATDVI HSWTIPSLGV KVDANPGRLN 

       190        200        210        220 
QTNFFINRPG IFYGQCSEIC GANHSFMPIV IESISIKNFI NWINNYS 

« Hide

References

[1]"Mitochondrial DNA sequence variation in the spruce budworm species complex (Choristoneura: Lepidoptera)."
Sperling F.A.H., Hickey D.A.
Mol. Biol. Evol. 11:656-665(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 37.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19098 Genomic DNA. Translation: AAA53641.1.

3D structure databases

ProteinModelPortalP84288.
SMRP84288. Positions 1-225.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CHOFU
AccessionPrimary (citable) accession number: P84288
Secondary accession number(s): P98026
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families