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Protein

Bombesin

Gene
N/A
Organism
Bombina variegata (Yellow-bellied toad)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates smooth muscle contraction. Role in induction of hypothermia, stimulation of DNA replication and release of many gastrointestinal hormones. Possesses insulin-releasing activity.1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

  • defense response Source: UniProtKB
  • neuropeptide signaling pathway Source: InterPro
  • positive regulation of smooth muscle contraction Source: UniProtKB
  • regulation of insulin secretion Source: UniProtKB

Keywordsi

Molecular functionAmphibian defense peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin
OrganismiBombina variegata (Yellow-bellied toad)
Taxonomic identifieri8348 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000000300827 – 41Add BLAST15
PeptideiPRO_000000300942 – 55BombesinAdd BLAST14
PropeptideiPRO_000000301056 – 107Add BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Pyrrolidone carboxylic acid1 Publication1
Modified residuei55Methionine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the skin glands.3 Publications

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004867.

Family and domain databases

InterProiView protein in InterPro
IPR000874. Bombesin.
PfamiView protein in Pfam
PF02044. Bombesin. 1 hit.
PROSITEiView protein in PROSITE
PS00257. BOMBESIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIPLNRIL PLGFLLIFSF ISLSSCMEFV EDPNNQGGLN LQQRLGNQWA
60 70 80 90 100
VGHLMGKKSL QDTDFEEMES FAKRNVENMK AESERELRHA QLVVRNILEQ

YLKNMQN
Length:107
Mass (Da):12,341
Last modified:November 9, 2004 - v1
Checksum:i9692B50600FAF618
GO

Mass spectrometryi

Molecular mass is 1619.8 Da from positions 42 - 55. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52447 mRNA. Translation: CAA36686.1.
PIRiS09095. BSTDY.

Similar proteinsi

Entry informationi

Entry nameiBOMB_BOMVA
AccessioniPrimary (citable) accession number: P84213
Secondary accession number(s): P01296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 9, 2004
Last modified: April 12, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families