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Protein

Conotoxin Rg11a

Gene
N/A
Organism
Conus regius (Crown cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neurotoxin. Elicits hypersensibility when injected intracranially in mice. May act via potassium channel currents.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Rg11a
OrganismiConus regius (Crown cone)
Taxonomic identifieri101314 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1508. RgXIA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868761 – 44Conotoxin Rg11aAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 15By similarity
Disulfide bondi8 ↔ 22By similarity
Disulfide bondi14 ↔ 30By similarity
Disulfide bondi21 ↔ 36By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiP84197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I1 superfamily.Curated

Sequencei

Sequence statusi: Complete.

P84197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
CQAYGESCSA VVRCCDPNAV CCQYPEDAVC VTRGYCRPPA TVLT
Length:44
Mass (Da):4,703
Last modified:February 1, 2005 - v1
Checksum:i3B2D0D25718D234B
GO

Mass spectrometryi

Molecular mass is 4695.61 Da from positions 1 - 44. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiCI1BA_CONRE
AccessioniPrimary (citable) accession number: P84197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 22, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families