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P84177

- PROF1_CITSI

UniProt

P84177 - PROF1_CITSI

Protein

Profilin

Gene
N/A
Organism
Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin1 Publication
    Alternative name(s):
    Allergen: Cit s 21 Publication
    OrganismiCitrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
    Taxonomic identifieri2711 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE. Induces histamine release from basophils of profilin-allergic patients.2 Publications

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei1173. Cit s 2.
    3200. Cit s 2.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 131130Profilin1 PublicationPRO_0000199626Add
    BLAST

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP84177.
    SMRiP84177. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84177-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDDH LMCDIDGNRL TAAAILGQDG SVWSQSATFP AFRLEEIAAI    50
    LKDFDQPGTL APTGLFLGGT KYMVIQGEAG AVIRGKKGSG GIIVKKTNQA 100
    LIIGIYDEPL TPGQCNMIVE RLGDYLIEQG L 131
    Length:131
    Mass (Da):14,060
    Last modified:October 13, 2009 - v2
    Checksum:i163FC690C9444866
    GO

    Mass spectrometryi

    Molecular mass is 14137 Da from positions 2 - 131. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601L → F.1 Publication
    Natural varianti93 – 931I → T.1 Publication
    Natural varianti114 – 1141Q → R.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ865015 mRNA. Translation: CAI23765.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ865015 mRNA. Translation: CAI23765.1 .

    3D structure databases

    ProteinModelPortali P84177.
    SMRi P84177. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1173. Cit s 2.
    3200. Cit s 2.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, cloning and allergenic reactivity of natural profilin Cit s 2, a major orange allergen."
      Lopez-Torrejon G., Ibanez M.D., Ahrazem O., Sanchez-Monge R., Sastre J., Lombardero M., Barber D., Salcedo G.
      Allergy 60:1424-1429(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-11, MASS SPECTROMETRY, ALLERGEN, VARIANTS PHE-60; THR-93 AND ARG-114.
      Strain: cv. Navel late1 Publication.
      Tissue: Fruit flesh1 Publication and Peelings1 Publication.
    2. "Germin-like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits."
      Crespo J.F., Retzek M., Foetisch K., Sierra-Maestro E., Cid-Sanchez A.B., Pascual C.Y., Conti A., Feliu A., Rodriguez J., Vieths S., Scheurer S.
      Mol. Nutr. Food Res. 50:282-290(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLERGEN.

    Entry informationi

    Entry nameiPROF1_CITSI
    AccessioniPrimary (citable) accession number: P84177
    Secondary accession number(s): Q5TIM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3