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Protein

Prohibitin

Gene

PHB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA synthesis

Enzyme and pathway databases

ReactomeiR-GGA-5673000 RAF activation
R-GGA-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin
Gene namesi
Name:PHBBy similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002234901 – 272ProhibitinCuratedAdd BLAST272

Proteomic databases

PaxDbiP84173
PRIDEiP84173

Expressioni

Gene expression databases

BgeeiENSGALG00000001162

Interactioni

Subunit structurei

Interacts with PHB2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1636878,EBI-1635766

GO - Molecular functioni

Protein-protein interaction databases

IntActiP84173, 1 interactor
STRINGi9031.ENSGALP00000001750

Structurei

3D structure databases

ProteinModelPortaliP84173
SMRiP84173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili177 – 211Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the prohibitin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3083 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074770
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiP84173
OMAiVINEGTH
OrthoDBiEOG091G0IHW
PhylomeDBiP84173

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequencei

Sequence statusi: Complete.

P84173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLGLAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDTVV
60 70 80 90 100
GEGTHFLIPW VQKPIIFDCR SRPRNIPVIT GSKDLQNVNI TLRILFRPVT
110 120 130 140 150
AQLPRIFTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV
160 170 180 190 200
SEDLTERAAT FGLILDDVSL THLTFGKEFT EAVEMKQVAQ QEAERARFIV
210 220 230 240 250
EKAEQQKKAA VISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ
260 270
LSRSRNITYL PSGQSVLLQL PQ
Length:272
Mass (Da):29,896
Last modified:February 21, 2006 - v1
Checksum:i3FCD502A96EC3633
GO

Mass spectrometryi

Molecular mass is 29804±2 Da from positions 1 - 272. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR387706 mRNA No translation available.
UniGeneiGga.5534

Genome annotation databases

EnsembliENSGALT00000047234; ENSGALP00000048291; ENSGALG00000038604
ENSGALT00000049859; ENSGALP00000050951; ENSGALG00000038604
ENSGALT00000078755; ENSGALP00000047091; ENSGALG00000038604
ENSGALT00000088527; ENSGALP00000061263; ENSGALG00000038604

Similar proteinsi

Entry informationi

Entry nameiPHB_CHICK
AccessioniPrimary (citable) accession number: P84173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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