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Protein

Prohibitin

Gene

PHB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA synthesis

Enzyme and pathway databases

ReactomeiR-GGA-5673000. RAF activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin
Gene namesi
Name:PHBBy similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272ProhibitinCuratedPRO_0000223490Add
BLAST

Proteomic databases

PaxDbiP84173.
PRIDEiP84173.

Interactioni

Subunit structurei

Interacts with PHB2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1636878,EBI-1635766

Protein-protein interaction databases

IntActiP84173. 1 interaction.
STRINGi9031.ENSGALP00000001750.

Structurei

3D structure databases

ProteinModelPortaliP84173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili177 – 21135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the prohibitin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3083. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074770.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiP84173.
OMAiYLNIGLD.
PhylomeDBiP84173.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

P84173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKVFESIG KFGLGLAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDTVV
60 70 80 90 100
GEGTHFLIPW VQKPIIFDCR SRPRNIPVIT GSKDLQNVNI TLRILFRPVT
110 120 130 140 150
AQLPRIFTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV
160 170 180 190 200
SEDLTERAAT FGLILDDVSL THLTFGKEFT EAVEMKQVAQ QEAERARFIV
210 220 230 240 250
EKAEQQKKAA VISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ
260 270
LSRSRNITYL PSGQSVLLQL PQ
Length:272
Mass (Da):29,896
Last modified:February 21, 2006 - v1
Checksum:i3FCD502A96EC3633
GO

Mass spectrometryi

Molecular mass is 29804±2 Da from positions 1 - 272. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR387706 mRNA. No translation available.
UniGeneiGga.5534.

Genome annotation databases

EnsembliENSGALT00000001752; ENSGALP00000001750; ENSGALG00000001162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR387706 mRNA. No translation available.
UniGeneiGga.5534.

3D structure databases

ProteinModelPortaliP84173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP84173. 1 interaction.
STRINGi9031.ENSGALP00000001750.

Proteomic databases

PaxDbiP84173.
PRIDEiP84173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000001752; ENSGALP00000001750; ENSGALG00000001162.

Phylogenomic databases

eggNOGiKOG3083. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074770.
HOGENOMiHOG000205692.
HOVERGENiHBG004457.
InParanoidiP84173.
OMAiYLNIGLD.
PhylomeDBiP84173.

Enzyme and pathway databases

ReactomeiR-GGA-5673000. RAF activation.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: White Leghorn Hisex.
    Tissue: Trunk.
  2. "Proteomic analysis of the Gallus gallus embryo at stage-29 of development."
    Agudo D., Gomez-Esquer F., Diaz-Gil G., Martinez-Arribas F., Delcan J., Schneider J., Palomar M.A., Linares R.
    Proteomics 5:4946-4957(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, MASS SPECTROMETRY.
    Tissue: Embryo1 Publication.

Entry informationi

Entry nameiPHB_CHICK
AccessioniPrimary (citable) accession number: P84173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.