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Protein

26S proteasome non-ATPase regulatory subunit 13

Gene

PSMD13

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-1169091. Activation of NF-kappaB in B cells.
R-GGA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-GGA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-GGA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-GGA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-GGA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-GGA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-GGA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-GGA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-GGA-195253. Degradation of beta-catenin by the destruction complex.
R-GGA-202424. Downstream TCR signaling.
R-GGA-2467813. Separation of Sister Chromatids.
R-GGA-2871837. FCERI mediated NF-kB activation.
R-GGA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-GGA-350562. Regulation of ornithine decarboxylase (ODC).
R-GGA-382556. ABC-family proteins mediated transport.
R-GGA-446652. Interleukin-1 signaling.
R-GGA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-GGA-4608870. Asymmetric localization of PCP proteins.
R-GGA-4641257. Degradation of AXIN.
R-GGA-4641258. Degradation of DVL.
R-GGA-5358346. Hedgehog ligand biogenesis.
R-GGA-5607764. CLEC7A (Dectin-1) signaling.
R-GGA-5610780. Degradation of GLI1 by the proteasome.
R-GGA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-GGA-5632684. Hedgehog 'on' state.
R-GGA-5658442. Regulation of RAS by GAPs.
R-GGA-5668541. TNFR2 non-canonical NF-kB pathway.
R-GGA-5687128. MAPK6/MAPK4 signaling.
R-GGA-5689603. UCH proteinases.
R-GGA-5689880. Ub-specific processing proteases.
R-GGA-6798695. Neutrophil degranulation.
R-GGA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-GGA-68949. Orc1 removal from chromatin.
R-GGA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-GGA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-GGA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-GGA-8941858. Regulation of RUNX3 expression and activity.
R-GGA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 13
Alternative name(s):
26S proteasome regulatory subunit RPN9
26S proteasome regulatory subunit S11
26S proteasome regulatory subunit p40.5
Gene namesi
Name:PSMD13By similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002234821 – 37626S proteasome non-ATPase regulatory subunit 13CuratedAdd BLAST376

Proteomic databases

PRIDEiP84169.

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.By similarity

Structurei

3D structure databases

SMRiP84169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 335PCISequence analysisAdd BLAST97

Sequence similaritiesi

Belongs to the proteasome subunit S11 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001802.
HOVERGENiHBG053740.
InParanoidiP84169.
KOiK03039.
PhylomeDBiP84169.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P84169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVPGFLQQ SQSAGPGQAA VWHRLEELYN KKLWHQLTLQ VLDFVQDPCF
60 70 80 90 100
AQGDGLIKLY ENFISEFEHR VNPLSLVEII LHVVRQMTDP TVALTFLEKT
110 120 130 140 150
REKVKSSDEA VILCKTAIGA LKLNIGDLQV TKETIEEVEE MLNNLPGVTS
160 170 180 190 200
VHSRFYDLSS KYYQTIGNHA SYYKDALRFL GCIDVKDLPV SEQQERAFTL
210 220 230 240 250
GLAGLLGEGV YNFGELLMHP VLESLRSTDR QWLIDTLYAF NSGNVETFQA
260 270 280 290 300
LKSAWGQQPD LAANEALLLQ KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA
310 320 330 340 350
KVTVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK
360 370
DRLEFWCTDV RSMEMLVEHQ AHDILT
Length:376
Mass (Da):42,751
Last modified:February 21, 2006 - v1
Checksum:i9983A04807AD567F
GO

Mass spectrometryi

Molecular mass is 42810±2 Da from positions 1 - 376. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB017092 mRNA. No translation available.
CN218176 mRNA. No translation available.
BU427099 mRNA. No translation available.
RefSeqiXP_015141752.1. XM_015286266.1.
UniGeneiGga.53678.

Genome annotation databases

EnsembliENSGALT00000082342; ENSGALP00000054631; ENSGALG00000043684.
GeneIDi422990.
KEGGigga:422990.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPSD13_CHICK
AccessioniPrimary (citable) accession number: P84169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: June 7, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families