P84157 (MXRA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Matrix-remodeling-associated protein 7

Alternative name(s):
Transmembrane anchor protein 1

Gene names

Name:	MXRA7
Synonyms:	TMAP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence caution	The sequence AW888225 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P84157-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: P84157-2)

The sequence of this isoform differs from the canonical sequence as follows:
     168-170: VQK → TEE
     171-204: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P84157-3)

The sequence of this isoform differs from the canonical sequence as follows:
     168-204: VQKEQLAAIFKLMKDNKETFGEMSDGDVQEQLRLYDM → IELTSDLTSL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Matrix-remodeling-associated protein 7		PRO_0000072586
Regions
	Transmembrane	7 – 27	21	Helical; Potential
Amino acid modifications
	Modified residue	128	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	168 – 204	37	VQKEQ…RLYDM → IELTSDLTSL in isoform 3.		VSP_024252
	Alternative sequence	168 – 170	3	VQK → TEE in isoform 2.		VSP_022589
	Alternative sequence	171 – 204	34	Missing in isoform 2.		VSP_022590
Experimental info
	Sequence conflict	80	1	L → V Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 3298195FCAC7AECF	FASTA	204	21,466
	10 20 30 40 50 60 MEAPAELLAA LPALATALAL LLAWLLVRRG AAASPEPARA PPEPAPPAEA TGAPAPSRPC 70 80 90 100 110 120 APEPAASPAG PEEPGEPAGL GELGEPAGPG EPEGPGDPAA APAEAEEQAV EARQEEEQDL 130 140 150 160 170 180 DGEKGPSSEG PEEEDGEGFS FKYSPGKLRG NQYKKMMTKE ELEEEQRVQK EQLAAIFKLM 190 200 KDNKETFGEM SDGDVQEQLR LYDM
	Isoform 2 [UniParc]. Checksum: D3A7979306B63163	FASTA	170	17,493
	10 20 30 40 50 60 MEAPAELLAA LPALATALAL LLAWLLVRRG AAASPEPARA PPEPAPPAEA TGAPAPSRPC 70 80 90 100 110 120 APEPAASPAG PEEPGEPAGL GELGEPAGPG EPEGPGDPAA APAEAEEQAV EARQEEEQDL 130 140 150 160 170 DGEKGPSSEG PEEEDGEGFS FKYSPGKLRG NQYKKMMTKE ELEEEQRTEE
	Isoform 3 [UniParc]. Checksum: A0F859727A3949CF	FASTA	177	18,207
	10 20 30 40 50 60 MEAPAELLAA LPALATALAL LLAWLLVRRG AAASPEPARA PPEPAPPAEA TGAPAPSRPC 70 80 90 100 110 120 APEPAASPAG PEEPGEPAGL GELGEPAGPG EPEGPGDPAA APAEAEEQAV EARQEEEQDL 130 140 150 160 170 DGEKGPSSEG PEEEDGEGFS FKYSPGKLRG NQYKKMMTKE ELEEEQRIEL TSDLTSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[3]	"Matrix-remodeling associated genes identified by co-expression." Walker M.G., Volkmuth W. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-204 (ISOFORM 3).
[4]	"Characterising unknown proteins by location proteomics." Southan C., Hearath A., Rohlff C. Submitted (AUG-2004) to UniProtKB Cited for: IDENTIFICATION.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, MASS SPECTROMETRY. Tissue: Embryonic kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005837 Genomic DNA. No translation available. BC053983 mRNA. Translation: AAH53983.1. AW888225 mRNA. No translation available.
IPI	IPI00397645. IPI00465377. IPI00514725.
RefSeq	NP_001008528.1. NM_001008528.1. NP_001008529.1. NM_001008529.1. NP_940932.2. NM_198530.2.
UniGene	Hs.250723. Hs.597019. Hs.707692.
3D structure databases
ProteinModelPortal	P84157.
ModBase	Search...
Protein-protein interaction databases
STRING	P84157.
PTM databases
PhosphoSite	P84157.
Polymorphism databases
DMDM	52783434.
Proteomic databases
PRIDE	P84157.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355797; ENSP00000348050; ENSG00000182534.
GeneID	439921.
KEGG	hsa:439921.
UCSC	uc002jsk.1. human. uc002jsl.1. human. uc002jsm.1. human.
Organism-specific databases
CTD	439921.
GeneCards	GC17M074671.
HGNC	HGNC:7541. MXRA7.
HPA	HPA044819.
neXtProt	NX_P84157.
PharmGKB	PA31342.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21436.
GeneTree	ENSGT00530000064433.
OMA	CAPEPAG.
OrthoDB	EOG4M0F3G.
Gene expression databases
ArrayExpress	P84157.
Bgee	P84157.
CleanEx	HS_MXRA7.
Genevestigator	P84157.
GermOnline	ENSG00000182534. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	108734.

Entry information

Entry name

MXRA7_HUMAN

Accession

Primary (citable) accession number: P84157
Secondary accession number(s): Q0P5W3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.