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Protein

Defensin ARD1

Gene
N/A
Organism
Archaeoprepona demophon (One-spotted leafwing butterfly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possesses potent anti-fungal activity.1 Publication

GO - Biological processi

  • antifungal humoral response Source: UniProtKB
  • defense response Source: UniProtKB
  • innate immune response Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Defensin, Fungicide

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin ARD1
OrganismiArchaeoprepona demophon (One-spotted leafwing butterfly)
Taxonomic identifieri191427 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaNymphalidaeCharaxinaePreponiniArchaeoprepona

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi19 – 191N → R: Improves antifungal activity. 1 Publication
Mutagenesisi36 – 361A → L: Improves antifungal activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4444Defensin ARD1PRO_0000074476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 32PROSITE-ProRule annotation1 Publication
Disulfide bondi18 ↔ 40PROSITE-ProRule annotation1 Publication
Disulfide bondi22 ↔ 42PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
44
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Beta strandi11 – 144Combined sources
Helixi18 – 258Combined sources
Beta strandi27 – 348Combined sources
Helixi35 – 373Combined sources
Beta strandi39 – 435Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OZZNMR-A1-44[»]
1P00NMR-A1-44[»]
1P0ANMR-A1-44[»]
ProteinModelPortaliP84156.
SMRiP84156. Positions 1-44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84156.

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 2 subfamily.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
DKLIGSCVWG AVNYTSNCNA ECKRRGYKGG HCGSFANVNC WCET
Length:44
Mass (Da):4,803
Last modified:September 13, 2004 - v1
Checksum:i367DC7B793DCFCD5
GO

Mass spectrometryi

Molecular mass is 4803.4 Da from positions 1 - 44. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OZZNMR-A1-44[»]
1P00NMR-A1-44[»]
1P0ANMR-A1-44[»]
ProteinModelPortaliP84156.
SMRiP84156. Positions 1-44.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP84156.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Lead optimization of antifungal peptides with 3D NMR structures analysis."
    Landon C., Barbault F., Legrain M., Menin L., Guenneugues M., Schott V., Vovelle F., Dimarcq J.-L.
    Protein Sci. 13:703-713(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, STRUCTURE BY NMR, FUNCTION, MASS SPECTROMETRY, MUTAGENESIS OF ASN-19 AND ALA-36.
    Tissue: Hemolymph1 Publication.

Entry informationi

Entry nameiDEFN_ARCDE
AccessioniPrimary (citable) accession number: P84156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2004
Last modified: October 14, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.