ID   HEM6_LEIMA              Reviewed;         301 AA.
AC   P84155;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   16-JUN-2009, entry version 36.
DE   RecName: Full=Coproporphyrinogen-III oxidase;
DE            Short=Coproporphyrinogenase;
DE            Short=Coprogen oxidase;
DE            EC=1.3.3.3;
GN   ORFNames=LMAJ006828, LmjF06.1270;
OS   Leishmania major.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M.,
RA   Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A.,
RA   Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A.,
RA   Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C.,
RA   Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D.,
RA   Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L.,
RA   Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S.,
RA   Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H.,
RA   Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B.,
RA   Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J.,
RA   Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D.,
RA   Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S.,
RA   Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C.,
RA   Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S.,
RA   Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G.,
RA   Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
RG   Structural genomics of pathogenic protozoa consortium (SGPP);
RL   Submitted (MAR-2004) to the PDB data bank.
CC   -!- CATALYTIC ACTIVITY: Coproporphyrinogen-III + O(2) + 2 H(+) =
CC       protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
CC   -!- PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis;
CC       protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step
CC       1/1.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aerobic coproporphyrinogen-III oxidase
CC       family.
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DR   EMBL; CT005245; CAJ02175.1; -; Genomic_DNA.
DR   RefSeq; XP_001680900.1; -.
DR   PDB; 1VJU; X-ray; 1.40 A; A/B=1-301.
DR   PDB; 2QT8; X-ray; 1.75 A; A/B=1-301.
DR   PDB; 3DWR; X-ray; 1.66 A; A/B=1-301.
DR   PDB; 3DWS; X-ray; 2.50 A; A/B=1-301.
DR   PDBsum; 1VJU; -.
DR   PDBsum; 2QT8; -.
DR   PDBsum; 3DWR; -.
DR   PDBsum; 3DWS; -.
DR   GeneID; 5649152; -.
DR   KEGG; lma:LmjF06.1270; -.
DR   HOGENOM; P84155; -.
DR   OMA; P84155; GKEPVWW.
DR   BRENDA; 1.3.3.3; 19061.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004109; F:coproporphyrinogen oxidase activity; IEA:EC.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001260; Coprogen_oxidas.
DR   InterPro; IPR018375; Coproporphyrinogen-3_ox_CS.
DR   Gene3D; G3DSA:3.40.1500.10; Coprogen_oxidas; 1.
DR   PANTHER; PTHR10755; Coprogen_oxidas; 1.
DR   Pfam; PF01218; Coprogen_oxidas; 1.
DR   PIRSF; PIRSF000166; Coproporphyri_ox; 1.
DR   PRINTS; PR00073; COPRGNOXDASE.
DR   PROSITE; PS01021; COPROGEN_OXIDASE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Heme biosynthesis; Oxidoreductase;
KW   Porphyrin biosynthesis.
FT   CHAIN         1    301       Coproporphyrinogen-III oxidase.
FT                                /FTId=PRO_0000109876.
FT   HELIX         2     27
FT   STRAND       33     39
FT   TURN         40     42
FT   STRAND       43     52
FT   STRAND       54     69
FT   STRAND       86    100
FT   STRAND      105    117
FT   STRAND      120    133
FT   HELIX       139    153
FT   HELIX       154    156
FT   HELIX       160    171
FT   STRAND      172    174
FT   HELIX       175    177
FT   STRAND      179    191
FT   HELIX       196    221
FT   HELIX       228    247
FT   HELIX       250    257
FT   HELIX       262    265
FT   HELIX       266    268
FT   HELIX       286    292
FT   HELIX       294    297
SQ   SEQUENCE   301 AA;  34370 MW;  A5D8CFE90BA90435 CRC64;
     MSLAVEAVKD FLLKLQDDIC EALEAEDGQA TFVEDKWTRE GGGGGRTRVM VDGAVIEKGG
     VNFSHVYGKG LPMSSTERHP DIAGCNFEAM GVSLVIHPKN PHVPTSHANV RLFVAEREGK
     EPVWWFGGGF DLTPYYAVEE DCRDFHQVAQ DLCKPFGADV YARFKGWCDE YFFIPYRNEA
     RGIGGLFFDD LNEWPFEKCF EFVQAVGKGY MDAYIPIVNR RKNTPYTEQQ VEFQEFRRGR
     YAEFNLVIDR GTKFGLQSGG RTESILISLP PRARWGYNWQ PEPGTPEARL TEYFLTKRQW
     V
//