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Protein

Oxygen-dependent coproporphyrinogen-III oxidase

Gene

LMAJ006828

Organism
Leishmania major
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).By similarity

Catalytic activityi

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O.Curated

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoporphyrinogen-IX from coproporphyrinogen-III (O2 route).
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent coproporphyrinogen-III oxidase (LMAJ006828)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoporphyrinogen-IX from coproporphyrinogen-III (O2 route), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93Substrate1
Active sitei107Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00322.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent coproporphyrinogen-III oxidase (EC:1.3.3.3)
Short name:
Coprogen oxidase
Short name:
Coproporphyrinogenase
Gene namesi
ORF Names:LMAJ006828, LmjF06.1270, LmjF_06_1270
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001098761 – 301Oxygen-dependent coproporphyrinogen-III oxidaseAdd BLAST301

Interactioni

Subunit structurei

Homodimer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5664.LmjF.06.1270.

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 27Combined sources26
Beta strandi33 – 39Combined sources7
Turni40 – 42Combined sources3
Beta strandi43 – 52Combined sources10
Beta strandi54 – 69Combined sources16
Helixi73 – 76Combined sources4
Turni81 – 84Combined sources4
Beta strandi86 – 100Combined sources15
Beta strandi105 – 117Combined sources13
Beta strandi120 – 133Combined sources14
Helixi139 – 153Combined sources15
Helixi154 – 156Combined sources3
Helixi160 – 171Combined sources12
Beta strandi172 – 174Combined sources3
Helixi175 – 177Combined sources3
Beta strandi179 – 191Combined sources13
Helixi196 – 221Combined sources26
Helixi228 – 247Combined sources20
Helixi250 – 257Combined sources8
Helixi262 – 265Combined sources4
Helixi266 – 268Combined sources3
Beta strandi271 – 274Combined sources4
Helixi286 – 292Combined sources7
Helixi294 – 297Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VJUX-ray1.40A/B1-301[»]
2QT8X-ray1.75A/B1-301[»]
3DWRX-ray1.66A/B1-301[»]
3DWSX-ray2.50A/B1-301[»]
ProteinModelPortaliP84155.
SMRiP84155.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84155.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 58Important for dimerizationBy similarity10
Regioni109 – 111Substrate binding3
Regioni241 – 276Important for dimerizationBy similarityAdd BLAST36
Regioni259 – 261Substrate binding3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1518. Eukaryota.
COG0408. LUCA.
HOGENOMiHOG000262768.
InParanoidiP84155.
KOiK00228.
OMAiGKEPVWW.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
HAMAPiMF_00333. Coprogen_oxidas. 1 hit.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFiPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAVEAVKD FLLKLQDDIC EALEAEDGQA TFVEDKWTRE GGGGGRTRVM
60 70 80 90 100
VDGAVIEKGG VNFSHVYGKG LPMSSTERHP DIAGCNFEAM GVSLVIHPKN
110 120 130 140 150
PHVPTSHANV RLFVAEREGK EPVWWFGGGF DLTPYYAVEE DCRDFHQVAQ
160 170 180 190 200
DLCKPFGADV YARFKGWCDE YFFIPYRNEA RGIGGLFFDD LNEWPFEKCF
210 220 230 240 250
EFVQAVGKGY MDAYIPIVNR RKNTPYTEQQ VEFQEFRRGR YAEFNLVIDR
260 270 280 290 300
GTKFGLQSGG RTESILISLP PRARWGYNWQ PEPGTPEARL TEYFLTKRQW

V
Length:301
Mass (Da):34,370
Last modified:September 13, 2004 - v1
Checksum:iA5D8CFE90BA90435
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796402 Genomic DNA. Translation: CAJ02175.1.
RefSeqiXP_001680900.1. XM_001680848.1.

Genome annotation databases

GeneIDi5649152.
KEGGilma:LMJF_06_1270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796402 Genomic DNA. Translation: CAJ02175.1.
RefSeqiXP_001680900.1. XM_001680848.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VJUX-ray1.40A/B1-301[»]
2QT8X-ray1.75A/B1-301[»]
3DWRX-ray1.66A/B1-301[»]
3DWSX-ray2.50A/B1-301[»]
ProteinModelPortaliP84155.
SMRiP84155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.06.1270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5649152.
KEGGilma:LMJF_06_1270.

Phylogenomic databases

eggNOGiKOG1518. Eukaryota.
COG0408. LUCA.
HOGENOMiHOG000262768.
InParanoidiP84155.
KOiK00228.
OMAiGKEPVWW.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00322.

Miscellaneous databases

EvolutionaryTraceiP84155.

Family and domain databases

Gene3Di3.40.1500.10. 1 hit.
HAMAPiMF_00333. Coprogen_oxidas. 1 hit.
InterProiIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
PANTHERiPTHR10755. PTHR10755. 1 hit.
PfamiPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFiPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSiPR00073. COPRGNOXDASE.
SUPFAMiSSF102886. SSF102886. 1 hit.
PROSITEiPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEM6_LEIMA
AccessioniPrimary (citable) accession number: P84155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.