Reviewed, UniProtKB/Swiss-Prot P84155 (HEM6_LEIMA)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen III oxidase
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3

Gene names

ORF Names:

LMAJ006828, LmjF06.1270

Organism

Leishmania major

Taxonomic identifier

5664 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subunit structure	Monomer.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 301

301

Coproporphyrinogen III oxidase

PRO_0000109876

Secondary structure

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301

Helix Strand Turn

Details...

Helix

2 – 27

26

Beta strand

33 – 39

7

Turn

40 – 42

3

Beta strand

43 – 52

10

Beta strand

54 – 69

16

Beta strand

86 – 100

15

Beta strand

105 – 117

13

Beta strand

120 – 133

14

Helix

139 – 153

15

Helix

154 – 156

3

Helix

160 – 171

12

Beta strand

172 – 174

3

Helix

175 – 177

3

Beta strand

179 – 191

13

Helix

196 – 221

26

Helix

228 – 247

20

Helix

250 – 257

8

Helix

262 – 265

4

Helix

266 – 268

3

Helix

286 – 292

7

Helix

294 – 297

4

Sequences

	Sequence		Length	Mass (Da)
	P84155-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: A5D8CFE90BA90435	FASTA	301	34,370
	10 20 30 40 50 60 MSLAVEAVKD FLLKLQDDIC EALEAEDGQA TFVEDKWTRE GGGGGRTRVM VDGAVIEKGG 70 80 90 100 110 120 VNFSHVYGKG LPMSSTERHP DIAGCNFEAM GVSLVIHPKN PHVPTSHANV RLFVAEREGK 130 140 150 160 170 180 EPVWWFGGGF DLTPYYAVEE DCRDFHQVAQ DLCKPFGADV YARFKGWCDE YFFIPYRNEA 190 200 210 220 230 240 RGIGGLFFDD LNEWPFEKCF EFVQAVGKGY MDAYIPIVNR RKNTPYTEQQ VEFQEFRRGR 250 260 270 280 290 300 YAEFNLVIDR GTKFGLQSGG RTESILISLP PRARWGYNWQ PEPGTPEARL TEYFLTKRQW V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the kinetoplastid parasite, Leishmania major." Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G. , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J. Science 309:436-442(2005) [PubMed: 16020728] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MHOM/IL/81/Friedlin.
[2]	Structural genomics of pathogenic protozoa consortium (SGPP) Submitted (MAR-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).

Cross-references

Sequence databases

EMBLGenBankDDBJ

CT005245 Genomic DNA. Translation: CAJ02175.1.

RefSeq

XP_001680900.1.

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VJU	X-ray	1.40	A/B	1-301	[»]
2QT8	X-ray	1.75	A/B	1-301	[»]
3DWR	X-ray	1.66	A/B	1-301	[»]
3DWS	X-ray	2.50	A/B	1-301	[»]

ModBase

Search...

Genome annotation databases

GeneID

5649152.

KEGG

lma:LmjF06.1270.

Phylogenomic databases

HOGENOM

P84155.

Family and domain databases

InterPro

IPR001260. Coprogen_oxidas.
[Graphical view]

Gene3D

G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.

PANTHER

PTHR10755. Coprogen_oxidas. 1 hit.

Pfam

PF01218. Coprogen_oxidas. 1 hit.
[Graphical view]

PIRSF

PIRSF000166. Coproporphyri_ox. 1 hit.

PRINTS

PR00073. COPRGNOXDASE.

PROSITE

PS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HEM6_LEIMA

Accession

Primary (citable) accession number: P84155

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2004
Last modified:	November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)