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P84149 (MEX67_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
mRNA export factor MEX67
Gene names
Name:MEX67
ORF Names:CaO19.488, CaO19.8118
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the export of mRNA from the nucleus to the cytoplasm By similarity. UniProtKB Q99257

Subunit structure

Interacts with nucleoporin complex protein MTR2.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm By similarity.

Domain

The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats. UniProtKB Q99257 Ref.2

The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

Sequence similarities

Belongs to the NXF family.

Contains 3 LRR (leucine-rich) repeats.

Contains 1 NTF2 domain.

Contains 1 TAP-C domain.

Ontologies

Keywords
   Biological processTransport
mRNA transport
   Cellular componentCytoplasm
Nucleus
   DomainLeucine-rich repeat
Repeat
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA export from nucleus

Inferred from sequence or structural similarity Ref.2. Source: CGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear pore

Inferred from sequence or structural similarity Ref.2. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617mRNA export factor MEX67
PRO_0000220540

Regions

Repeat185 – 20622LRR 1
Repeat211 – 23222LRR 2
Repeat237 – 25822LRR 3
Domain309 – 499191NTF2
Domain565 – 61753TAP-C

Secondary structure

1 ............................... 617
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P84149 [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: F014C89D5F56AC2D

FASTA61768,257
        10         20         30         40         50         60 
MSYRGRGGGY NNNRGQFSSG PHQHQQNVDS FVAANQYPIE IMGWNGASSG ECINFISRKC 

        70         80         90        100        110        120 
KVIVSNYSVD SNSGVLKGYV KNESQANTLL NWSGVKFAGQ SLRFSKGVSN ISNQMGGGAS 

       130        140        150        160        170        180 
TGSQSTIETI SQFLKARYQP EIKMLNLSNV KQDPTLTAQG FFGSLSVSSK FFPALMKVAS 

       190        200        210        220        230        240 
DLKLDVDSID LSNNELQDLQ TLTSMAQTFP KLQNLSLQNN NFTKIKVFET WRHKLNFLRE 

       250        260        270        280        290        300 
LILFNNPIVQ TNDPAEIQTI KLELMKSFPR LVVLSGEILR NEQVLIANLS FPFESPETMF 

       310        320        330        340        350        360 
FQDEDSRNLA TNFIANYLKL WDANRSELMI LYQNESQFSM QVDSSHPHLI ESGNSGYSGS 

       370        380        390        400        410        420 
TDFGYYLNNS RNLTRVSSIK ARMAKLSIGQ EQIYKSFQQL PKTRHDIIAT PELFSMEVYK 

       430        440        450        460        470        480 
FPTLNGIMIT LHGSFDEVAQ PEVDGSASSA PSGPRGGSRY HSGPKHKRIP LSKKSFDRTF 

       490        500        510        520        530        540 
VVIPGPNGSM IVASDTLLIR PYTSDFPWKV QKLPSNPTAA TPGVSATSTP SPLPPTTITT 

       550        560        570        580        590        600 
PQLAPPGTGP TTADLPADIK ARLNQIQQEL LVKILLETKL NINYGIMLCE QSNWDYQQAS 

       610 
VNFKNSAASL PSDAFVQ

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export."
Senay C., Ferrari P., Rocher C., Rieger K.J., Winter J., Platel D., Bourne Y.
J. Biol. Chem. 278:48395-48403(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 295-512 IN COMPLEX WITH MTR2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AACQ01000055 Genomic DNA. Translation: EAK98382.1.
AACQ01000054 Genomic DNA. Translation: EAK98474.1.
RefSeqXP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q40X-ray1.95B/D295-512[»]
ProteinModelPortalP84149.
SMRP84149. Positions 306-510, 562-617.
ModBaseSearch...

Protein-protein interaction databases

STRING5476.CAL0005845.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3640921.
3641020.
KEGGcal:CaO19.488.
cal:CaO19.8118.

Organism-specific databases

CGDCAL0005845. MEX67.

Phylogenomic databases

eggNOGNOG324438.
KOK14284.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR018222. Nuclear_transport_factor_2_euk.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PfamPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMSSF46934. UBA_like. 1 hit.
PROSITEPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP84149.

Entry information

Entry nameMEX67_CANAL
AccessionPrimary (citable) accession number: P84149
Secondary accession number(s): Q5A6R6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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