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Protein

mRNA export factor MEX67

Gene

MEX67

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.PROSITE-ProRule annotationBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor MEX67
Gene namesi
Name:MEX67By similarity
ORF Names:CaO19.488, CaO19.8118
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000181331. MEX67.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Cytoplasm PROSITE-ProRule annotation

  • Note: Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm.PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205401 – 617mRNA export factor MEX67Add BLAST617

Proteomic databases

PRIDEiP84149.

Interactioni

Subunit structurei

Interacts with nucleoporin complex protein MTR2.1 Publication

Structurei

Secondary structure

1617
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi307 – 322Combined sources16
Helixi325 – 331Combined sources7
Beta strandi337 – 342Combined sources6
Turni364 – 369Combined sources6
Turni373 – 375Combined sources3
Helixi379 – 384Combined sources6
Helixi389 – 398Combined sources10
Beta strandi402 – 404Combined sources3
Turni407 – 409Combined sources3
Helixi411 – 413Combined sources3
Beta strandi415 – 420Combined sources6
Beta strandi427 – 439Combined sources13
Beta strandi460 – 464Combined sources5
Beta strandi474 – 483Combined sources10
Beta strandi491 – 501Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q40X-ray1.95B/D295-512[»]
ProteinModelPortaliP84149.
SMRiP84149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 206LRR 1Add BLAST22
Repeati211 – 232LRR 2Add BLAST22
Repeati237 – 258LRR 3Add BLAST22
Domaini309 – 499NTF2PROSITE-ProRule annotationAdd BLAST191
Domaini565 – 617TAP-CPROSITE-ProRule annotationAdd BLAST53

Domaini

The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.By similarity1 Publication
The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

Sequence similaritiesi

Belongs to the NXF family.Sequence analysis
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 NTF2 domain.PROSITE-ProRule annotation
Contains 1 TAP-C domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

InParanoidiP84149.
KOiK14284.
OrthoDBiEOG092C3PB8.

Family and domain databases

CDDicd14342. UBA_TAP-C. 1 hit.
Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 2 hits.
PfamiPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRGRGGGY NNNRGQFSSG PHQHQQNVDS FVAANQYPIE IMGWNGASSG
60 70 80 90 100
ECINFISRKC KVIVSNYSVD SNSGVLKGYV KNESQANTLL NWSGVKFAGQ
110 120 130 140 150
SLRFSKGVSN ISNQMGGGAS TGSQSTIETI SQFLKARYQP EIKMLNLSNV
160 170 180 190 200
KQDPTLTAQG FFGSLSVSSK FFPALMKVAS DLKLDVDSID LSNNELQDLQ
210 220 230 240 250
TLTSMAQTFP KLQNLSLQNN NFTKIKVFET WRHKLNFLRE LILFNNPIVQ
260 270 280 290 300
TNDPAEIQTI KLELMKSFPR LVVLSGEILR NEQVLIANLS FPFESPETMF
310 320 330 340 350
FQDEDSRNLA TNFIANYLKL WDANRSELMI LYQNESQFSM QVDSSHPHLI
360 370 380 390 400
ESGNSGYSGS TDFGYYLNNS RNLTRVSSIK ARMAKLSIGQ EQIYKSFQQL
410 420 430 440 450
PKTRHDIIAT PELFSMEVYK FPTLNGIMIT LHGSFDEVAQ PEVDGSASSA
460 470 480 490 500
PSGPRGGSRY HSGPKHKRIP LSKKSFDRTF VVIPGPNGSM IVASDTLLIR
510 520 530 540 550
PYTSDFPWKV QKLPSNPTAA TPGVSATSTP SPLPPTTITT PQLAPPGTGP
560 570 580 590 600
TTADLPADIK ARLNQIQQEL LVKILLETKL NINYGIMLCE QSNWDYQQAS
610
VNFKNSAASL PSDAFVQ
Length:617
Mass (Da):68,257
Last modified:May 10, 2005 - v2
Checksum:iF014C89D5F56AC2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98382.1.
AACQ01000054 Genomic DNA. Translation: EAK98474.1.
RefSeqiXP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

Genome annotation databases

EnsemblFungiiEAK98382; EAK98382; CaO19.488.
EAK98474; EAK98474; CaO19.8118.
GeneIDi3640921.
3641020.
KEGGical:CaO19.488.
cal:CaO19.8118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98382.1.
AACQ01000054 Genomic DNA. Translation: EAK98474.1.
RefSeqiXP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q40X-ray1.95B/D295-512[»]
ProteinModelPortaliP84149.
SMRiP84149.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP84149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK98382; EAK98382; CaO19.488.
EAK98474; EAK98474; CaO19.8118.
GeneIDi3640921.
3641020.
KEGGical:CaO19.488.
cal:CaO19.8118.

Organism-specific databases

CGDiCAL0000181331. MEX67.

Phylogenomic databases

InParanoidiP84149.
KOiK14284.
OrthoDBiEOG092C3PB8.

Miscellaneous databases

EvolutionaryTraceiP84149.

Family and domain databases

CDDicd14342. UBA_TAP-C. 1 hit.
Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 2 hits.
PfamiPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEX67_CANAL
AccessioniPrimary (citable) accession number: P84149
Secondary accession number(s): Q5A6R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.