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P84149

- MEX67_CANAL

UniProt

P84149 - MEX67_CANAL

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Protein

mRNA export factor MEX67

Gene
MEX67, CaO19.488, CaO19.8118
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm By similarity.By similarity

GO - Biological processi

  1. mRNA export from nucleus Source: CGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor MEX67
Gene namesi
Name:MEX67
ORF Names:CaO19.488, CaO19.8118
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005845. MEX67.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear pore Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617mRNA export factor MEX67PRO_0000220540Add
BLAST

Interactioni

Subunit structurei

Interacts with nucleoporin complex protein MTR2.

Protein-protein interaction databases

STRINGi5476.CAL0005845.

Structurei

Secondary structure

1
617
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi307 – 32216
Helixi325 – 3317
Beta strandi337 – 3426
Turni364 – 3696
Turni373 – 3753
Helixi379 – 3846
Helixi389 – 39810
Beta strandi402 – 4043
Turni407 – 4093
Helixi411 – 4133
Beta strandi415 – 4206
Beta strandi427 – 43913
Beta strandi460 – 4645
Beta strandi474 – 48310
Beta strandi491 – 50111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q40X-ray1.95B/D295-512[»]
ProteinModelPortaliP84149.
SMRiP84149. Positions 306-510, 562-617.

Miscellaneous databases

EvolutionaryTraceiP84149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati185 – 20622LRR 1Add
BLAST
Repeati211 – 23222LRR 2Add
BLAST
Repeati237 – 25822LRR 3Add
BLAST
Domaini309 – 499191NTF2Add
BLAST
Domaini565 – 61753TAP-CAdd
BLAST

Domaini

The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.By similarity1 Publication
The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

Sequence similaritiesi

Belongs to the NXF family.
Contains 1 NTF2 domain.
Contains 1 TAP-C domain.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG324438.
KOiK14284.
OrthoDBiEOG7G7M0Q.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR018222. Nuclear_transport_factor_2_euk.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PfamiPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84149-1 [UniParc]FASTAAdd to Basket

« Hide

MSYRGRGGGY NNNRGQFSSG PHQHQQNVDS FVAANQYPIE IMGWNGASSG    50
ECINFISRKC KVIVSNYSVD SNSGVLKGYV KNESQANTLL NWSGVKFAGQ 100
SLRFSKGVSN ISNQMGGGAS TGSQSTIETI SQFLKARYQP EIKMLNLSNV 150
KQDPTLTAQG FFGSLSVSSK FFPALMKVAS DLKLDVDSID LSNNELQDLQ 200
TLTSMAQTFP KLQNLSLQNN NFTKIKVFET WRHKLNFLRE LILFNNPIVQ 250
TNDPAEIQTI KLELMKSFPR LVVLSGEILR NEQVLIANLS FPFESPETMF 300
FQDEDSRNLA TNFIANYLKL WDANRSELMI LYQNESQFSM QVDSSHPHLI 350
ESGNSGYSGS TDFGYYLNNS RNLTRVSSIK ARMAKLSIGQ EQIYKSFQQL 400
PKTRHDIIAT PELFSMEVYK FPTLNGIMIT LHGSFDEVAQ PEVDGSASSA 450
PSGPRGGSRY HSGPKHKRIP LSKKSFDRTF VVIPGPNGSM IVASDTLLIR 500
PYTSDFPWKV QKLPSNPTAA TPGVSATSTP SPLPPTTITT PQLAPPGTGP 550
TTADLPADIK ARLNQIQQEL LVKILLETKL NINYGIMLCE QSNWDYQQAS 600
VNFKNSAASL PSDAFVQ 617
Length:617
Mass (Da):68,257
Last modified:May 10, 2005 - v2
Checksum:iF014C89D5F56AC2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98382.1.
AACQ01000054 Genomic DNA. Translation: EAK98474.1.
RefSeqiXP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

Genome annotation databases

GeneIDi3640921.
3641020.
KEGGical:CaO19.488.
cal:CaO19.8118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98382.1 .
AACQ01000054 Genomic DNA. Translation: EAK98474.1 .
RefSeqi XP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q40 X-ray 1.95 B/D 295-512 [» ]
ProteinModelPortali P84149.
SMRi P84149. Positions 306-510, 562-617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3640921.
3641020.
KEGGi cal:CaO19.488.
cal:CaO19.8118.

Organism-specific databases

CGDi CAL0005845. MEX67.

Phylogenomic databases

eggNOGi NOG324438.
KOi K14284.
OrthoDBi EOG7G7M0Q.

Miscellaneous databases

EvolutionaryTracei P84149.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR018222. Nuclear_transport_factor_2_euk.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view ]
Pfami PF03943. TAP_C. 1 hit.
[Graphical view ]
SMARTi SM00804. TAP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
PROSITEi PS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export."
    Senay C., Ferrari P., Rocher C., Rieger K.J., Winter J., Platel D., Bourne Y.
    J. Biol. Chem. 278:48395-48403(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 295-512 IN COMPLEX WITH MTR2.

Entry informationi

Entry nameiMEX67_CANAL
AccessioniPrimary (citable) accession number: P84149
Secondary accession number(s): Q5A6R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 13, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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