Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P84149

- MEX67_CANAL

UniProt

P84149 - MEX67_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

mRNA export factor MEX67

Gene

MEX67

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.By similarityPROSITE-ProRule annotation

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor MEX67
Gene namesi
Name:MEX67By similarity
ORF Names:CaO19.488, CaO19.8118
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005845. MEX67.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Cytoplasm PROSITE-ProRule annotation
Note: Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm.PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617mRNA export factor MEX67PRO_0000220540Add
BLAST

Interactioni

Subunit structurei

Interacts with nucleoporin complex protein MTR2.1 Publication

Protein-protein interaction databases

STRINGi5476.CAL0005845.

Structurei

Secondary structure

1
617
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi307 – 32216
Helixi325 – 3317
Beta strandi337 – 3426
Turni364 – 3696
Turni373 – 3753
Helixi379 – 3846
Helixi389 – 39810
Beta strandi402 – 4043
Turni407 – 4093
Helixi411 – 4133
Beta strandi415 – 4206
Beta strandi427 – 43913
Beta strandi460 – 4645
Beta strandi474 – 48310
Beta strandi491 – 50111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q40X-ray1.95B/D295-512[»]
ProteinModelPortaliP84149.
SMRiP84149. Positions 306-510, 562-617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati185 – 20622LRR 1Add
BLAST
Repeati211 – 23222LRR 2Add
BLAST
Repeati237 – 25822LRR 3Add
BLAST
Domaini309 – 499191NTF2PROSITE-ProRule annotationAdd
BLAST
Domaini565 – 61753TAP-CPROSITE-ProRule annotationAdd
BLAST

Domaini

The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.By similarity1 Publication
The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

Sequence similaritiesi

Belongs to the NXF family.Sequence Analysis
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 NTF2 domain.PROSITE-ProRule annotation
Contains 1 TAP-C domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG324438.
InParanoidiP84149.
KOiK14284.
OrthoDBiEOG7G7M0Q.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR018222. Nuclear_transport_factor_2_euk.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PfamiPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84149 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYRGRGGGY NNNRGQFSSG PHQHQQNVDS FVAANQYPIE IMGWNGASSG
60 70 80 90 100
ECINFISRKC KVIVSNYSVD SNSGVLKGYV KNESQANTLL NWSGVKFAGQ
110 120 130 140 150
SLRFSKGVSN ISNQMGGGAS TGSQSTIETI SQFLKARYQP EIKMLNLSNV
160 170 180 190 200
KQDPTLTAQG FFGSLSVSSK FFPALMKVAS DLKLDVDSID LSNNELQDLQ
210 220 230 240 250
TLTSMAQTFP KLQNLSLQNN NFTKIKVFET WRHKLNFLRE LILFNNPIVQ
260 270 280 290 300
TNDPAEIQTI KLELMKSFPR LVVLSGEILR NEQVLIANLS FPFESPETMF
310 320 330 340 350
FQDEDSRNLA TNFIANYLKL WDANRSELMI LYQNESQFSM QVDSSHPHLI
360 370 380 390 400
ESGNSGYSGS TDFGYYLNNS RNLTRVSSIK ARMAKLSIGQ EQIYKSFQQL
410 420 430 440 450
PKTRHDIIAT PELFSMEVYK FPTLNGIMIT LHGSFDEVAQ PEVDGSASSA
460 470 480 490 500
PSGPRGGSRY HSGPKHKRIP LSKKSFDRTF VVIPGPNGSM IVASDTLLIR
510 520 530 540 550
PYTSDFPWKV QKLPSNPTAA TPGVSATSTP SPLPPTTITT PQLAPPGTGP
560 570 580 590 600
TTADLPADIK ARLNQIQQEL LVKILLETKL NINYGIMLCE QSNWDYQQAS
610
VNFKNSAASL PSDAFVQ
Length:617
Mass (Da):68,257
Last modified:May 10, 2005 - v2
Checksum:iF014C89D5F56AC2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98382.1.
AACQ01000054 Genomic DNA. Translation: EAK98474.1.
RefSeqiXP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

Genome annotation databases

GeneIDi3640921.
3641020.
KEGGical:CaO19.488.
cal:CaO19.8118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98382.1 .
AACQ01000054 Genomic DNA. Translation: EAK98474.1 .
RefSeqi XP_717351.1. XM_712258.1.
XP_717440.1. XM_712347.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q40 X-ray 1.95 B/D 295-512 [» ]
ProteinModelPortali P84149.
SMRi P84149. Positions 306-510, 562-617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3640921.
3641020.
KEGGi cal:CaO19.488.
cal:CaO19.8118.

Organism-specific databases

CGDi CAL0005845. MEX67.

Phylogenomic databases

eggNOGi NOG324438.
InParanoidi P84149.
KOi K14284.
OrthoDBi EOG7G7M0Q.

Miscellaneous databases

EvolutionaryTracei P84149.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR018222. Nuclear_transport_factor_2_euk.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view ]
Pfami PF03943. TAP_C. 1 hit.
[Graphical view ]
SMARTi SM00804. TAP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
PROSITEi PS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export."
    Senay C., Ferrari P., Rocher C., Rieger K.J., Winter J., Platel D., Bourne Y.
    J. Biol. Chem. 278:48395-48403(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 295-512 IN COMPLEX WITH MTR2.

Entry informationi

Entry nameiMEX67_CANAL
AccessioniPrimary (citable) accession number: P84149
Secondary accession number(s): Q5A6R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3