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P84149

- MEX67_CANAL

UniProt

P84149 - MEX67_CANAL

Protein

mRNA export factor MEX67

Gene

MEX67

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    Involved in the export of mRNA from the nucleus to the cytoplasm.By similarityPROSITE-ProRule annotation

    GO - Biological processi

    1. mRNA export from nucleus Source: CGD

    Keywords - Biological processi

    mRNA transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    mRNA export factor MEX67
    Gene namesi
    Name:MEX67By similarity
    ORF Names:CaO19.488, CaO19.8118
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005845. MEX67.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Cytoplasm PROSITE-ProRule annotation
    Note: Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm.PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear pore Source: CGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617mRNA export factor MEX67PRO_0000220540Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with nucleoporin complex protein MTR2.1 Publication

    Protein-protein interaction databases

    STRINGi5476.CAL0005845.

    Structurei

    Secondary structure

    1
    617
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi307 – 32216
    Helixi325 – 3317
    Beta strandi337 – 3426
    Turni364 – 3696
    Turni373 – 3753
    Helixi379 – 3846
    Helixi389 – 39810
    Beta strandi402 – 4043
    Turni407 – 4093
    Helixi411 – 4133
    Beta strandi415 – 4206
    Beta strandi427 – 43913
    Beta strandi460 – 4645
    Beta strandi474 – 48310
    Beta strandi491 – 50111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Q40X-ray1.95B/D295-512[»]
    ProteinModelPortaliP84149.
    SMRiP84149. Positions 306-510, 562-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP84149.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati185 – 20622LRR 1Add
    BLAST
    Repeati211 – 23222LRR 2Add
    BLAST
    Repeati237 – 25822LRR 3Add
    BLAST
    Domaini309 – 499191NTF2PROSITE-ProRule annotationAdd
    BLAST
    Domaini565 – 61753TAP-CPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.By similarity1 Publication
    The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

    Sequence similaritiesi

    Belongs to the NXF family.Sequence Analysis
    Contains 3 LRR (leucine-rich) repeats.Curated
    Contains 1 NTF2 domain.PROSITE-ProRule annotation
    Contains 1 TAP-C domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG324438.
    KOiK14284.
    OrthoDBiEOG7G7M0Q.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR018222. Nuclear_transport_factor_2_euk.
    IPR005637. TAP_C_dom.
    IPR009060. UBA-like.
    [Graphical view]
    PfamiPF03943. TAP_C. 1 hit.
    [Graphical view]
    SMARTiSM00804. TAP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    PROSITEiPS51450. LRR. 3 hits.
    PS50177. NTF2_DOMAIN. 1 hit.
    PS51281. TAP_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P84149-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYRGRGGGY NNNRGQFSSG PHQHQQNVDS FVAANQYPIE IMGWNGASSG    50
    ECINFISRKC KVIVSNYSVD SNSGVLKGYV KNESQANTLL NWSGVKFAGQ 100
    SLRFSKGVSN ISNQMGGGAS TGSQSTIETI SQFLKARYQP EIKMLNLSNV 150
    KQDPTLTAQG FFGSLSVSSK FFPALMKVAS DLKLDVDSID LSNNELQDLQ 200
    TLTSMAQTFP KLQNLSLQNN NFTKIKVFET WRHKLNFLRE LILFNNPIVQ 250
    TNDPAEIQTI KLELMKSFPR LVVLSGEILR NEQVLIANLS FPFESPETMF 300
    FQDEDSRNLA TNFIANYLKL WDANRSELMI LYQNESQFSM QVDSSHPHLI 350
    ESGNSGYSGS TDFGYYLNNS RNLTRVSSIK ARMAKLSIGQ EQIYKSFQQL 400
    PKTRHDIIAT PELFSMEVYK FPTLNGIMIT LHGSFDEVAQ PEVDGSASSA 450
    PSGPRGGSRY HSGPKHKRIP LSKKSFDRTF VVIPGPNGSM IVASDTLLIR 500
    PYTSDFPWKV QKLPSNPTAA TPGVSATSTP SPLPPTTITT PQLAPPGTGP 550
    TTADLPADIK ARLNQIQQEL LVKILLETKL NINYGIMLCE QSNWDYQQAS 600
    VNFKNSAASL PSDAFVQ 617
    Length:617
    Mass (Da):68,257
    Last modified:May 10, 2005 - v2
    Checksum:iF014C89D5F56AC2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000055 Genomic DNA. Translation: EAK98382.1.
    AACQ01000054 Genomic DNA. Translation: EAK98474.1.
    RefSeqiXP_717351.1. XM_712258.1.
    XP_717440.1. XM_712347.1.

    Genome annotation databases

    GeneIDi3640921.
    3641020.
    KEGGical:CaO19.488.
    cal:CaO19.8118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000055 Genomic DNA. Translation: EAK98382.1 .
    AACQ01000054 Genomic DNA. Translation: EAK98474.1 .
    RefSeqi XP_717351.1. XM_712258.1.
    XP_717440.1. XM_712347.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Q40 X-ray 1.95 B/D 295-512 [» ]
    ProteinModelPortali P84149.
    SMRi P84149. Positions 306-510, 562-617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005845.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3640921.
    3641020.
    KEGGi cal:CaO19.488.
    cal:CaO19.8118.

    Organism-specific databases

    CGDi CAL0005845. MEX67.

    Phylogenomic databases

    eggNOGi NOG324438.
    KOi K14284.
    OrthoDBi EOG7G7M0Q.

    Miscellaneous databases

    EvolutionaryTracei P84149.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR018222. Nuclear_transport_factor_2_euk.
    IPR005637. TAP_C_dom.
    IPR009060. UBA-like.
    [Graphical view ]
    Pfami PF03943. TAP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00804. TAP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    PROSITEi PS51450. LRR. 3 hits.
    PS50177. NTF2_DOMAIN. 1 hit.
    PS51281. TAP_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export."
      Senay C., Ferrari P., Rocher C., Rieger K.J., Winter J., Platel D., Bourne Y.
      J. Biol. Chem. 278:48395-48403(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 295-512 IN COMPLEX WITH MTR2.

    Entry informationi

    Entry nameiMEX67_CANAL
    AccessioniPrimary (citable) accession number: P84149
    Secondary accession number(s): Q5A6R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3