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Protein

Acylphosphatase

Gene

acyP

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Kineticsi

  1. KM=0.12 mM for benzoylphosphate at 25 degrees Celsius1 Publication

    pH dependencei

    Optimum pH is 5.3 at 25 degrees Celsius.1 Publication

    Temperature dependencei

    Optimum temperature is 98 degrees Celsius. Poorly active at 25 degrees Celsius. Thermostable up to 100 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei201 Publication1
    Active sitei381 Publication1

    GO - Molecular functioni

    Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BioCyciPHOR70601:G1G39-286-MONOMER
    BRENDAi3.6.1.7 5244
    SABIO-RKiP84142

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylphosphatase (EC:3.6.1.7)
    Alternative name(s):
    Acylphosphate phosphohydrolase
    Gene namesi
    Name:acyP
    Ordered Locus Names:PH0305.1
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    Proteomesi
    • UP000000752 Componenti: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001585601 – 91AcylphosphataseAdd BLAST91

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    STRINGi70601.PH0305a

    Structurei

    Secondary structure

    191
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi3 – 13Combined sources11
    Beta strandi15 – 18Combined sources4
    Helixi19 – 30Combined sources12
    Beta strandi33 – 38Combined sources6
    Beta strandi44 – 51Combined sources8
    Helixi52 – 61Combined sources10
    Turni62 – 64Combined sources3
    Beta strandi70 – 79Combined sources10
    Beta strandi86 – 89Combined sources4

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1V3ZX-ray1.72A/B1-91[»]
    1W2IX-ray1.50A/B1-91[»]
    2W4DX-ray2.40A/B/C/D/E/F2-91[»]
    3TNVX-ray1.60A1-91[»]
    ProteinModelPortaliP84142
    SMRiP84142
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP84142

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini5 – 91Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST87

    Sequence similaritiesi

    Belongs to the acylphosphatase family.Curated

    Phylogenomic databases

    eggNOGiarCOG01674 Archaea
    COG1254 LUCA
    OMAiRGWVRNR
    OrthoDBiPOG093Z04KU

    Family and domain databases

    InterProiView protein in InterPro
    IPR020456 Acylphosphatase
    IPR001792 Acylphosphatase-like_dom
    IPR036046 Acylphosphatase-like_dom_sf
    IPR017968 Acylphosphatase_CS
    PANTHERiPTHR10029 PTHR10029, 1 hit
    PfamiView protein in Pfam
    PF00708 Acylphosphatase, 1 hit
    PRINTSiPR00112 ACYLPHPHTASE
    SUPFAMiSSF54975 SSF54975, 1 hit
    PROSITEiView protein in PROSITE
    PS00150 ACYLPHOSPHATASE_1, 1 hit
    PS00151 ACYLPHOSPHATASE_2, 1 hit
    PS51160 ACYLPHOSPHATASE_3, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P84142-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAIVRAHLKI YGRVQGVGFR WSMQREARKL GVNGWVRNLP DGSVEAVLEG
    60 70 80 90
    DEERVEALIG WAHQGPPLAR VTRVEVKWEQ PKGEKGFRIV G
    Length:91
    Mass (Da):10,260
    Last modified:September 13, 2004 - v1
    Checksum:i6DDB6B69DBA17087
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BA000001 Genomic DNA No translation available.
    RefSeqiWP_010884399.1, NC_000961.1

    Genome annotation databases

    GeneIDi1444186

    Similar proteinsi

    Entry informationi

    Entry nameiACYP_PYRHO
    AccessioniPrimary (citable) accession number: P84142
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: September 13, 2004
    Last modified: April 25, 2018
    This is version 90 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

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