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Protein
Submitted name:

Chondroitinase (Chondroitin lyase)

Gene
N/A
Organism
Arthrobacter aurescens
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421N-acetyl-D-glucosamineCombined sources
Binding sitei296 – 2961N-acetyl-D-glucosamineCombined sources
Binding sitei300 – 3001N-acetyl-D-glucosamineCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiPL8. Polysaccharide Lyase Family 8.

Names & Taxonomyi

Protein namesi
Submitted name:
Chondroitinase (Chondroitin lyase)Imported
OrganismiArthrobacter aurescensImported
Taxonomic identifieri43663 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePaenarthrobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RW9X-ray1.35A1-757[»]
1RWAX-ray1.30A1-757[»]
1RWCX-ray1.90A1-757[»]
1RWFX-ray1.45A1-757[»]
1RWGX-ray1.50A1-757[»]
1RWHX-ray1.25A1-757[»]
ProteinModelPortaliP84141.
SMRiP84141. Positions 4-757.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84141.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 336321Lyase_8_NInterPro annotationAdd
BLAST
Domaini376 – 633258Lyase_8InterPro annotationAdd
BLAST
Domaini648 – 71063Lyase_8_CInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1263N-acetyl-D-glucosamine bindingCombined sources

Family and domain databases

Gene3Di1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProiIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
[Graphical view]
PfamiPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMiSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

P84141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EAEPGAAEFA ALRNRWVDQI TGRNVIQAGD PDFAKAITAL NNKAADSLAK
60 70 80 90 100
LDVKKGRTSV FTDLSLAKDA EMVTTYTRLS QLATAWATPT AAVFGDAAVL
110 120 130 140 150
AAIKAGLADA NTLCYNDRKE EVGNWWSWEI GVPRALADAM VLLHAELSAA
160 170 180 190 200
ERTAYCAAID HFVPDPWLQF PPKRGKITSV GANRVDLCQG IIIRSLAGED
210 220 230 240 250
PTKLNHAVAG LSQVWQYVTS GDGIFRDGSF IQHSTTPYTG SYGVVLLTGL
260 270 280 290 300
SKLFSLLGGT AFEVSDPTRS IFFDAVEGSF APVMINGAMA DAVRGRSISR
310 320 330 340 350
EANTGYDLGA SAIEAILLLA RAMDPATAAR WRGLCAGWIA RDTYRPILNS
360 370 380 390 400
ASVPRTALVK QLEATGVAPV AEATGHKLFP AMDRTMHRGP GWALSLALSS
410 420 430 440 450
NRIAWYECGN GENNRGYHTG SGMTYFYTSD LGQYDDAFWA TANYNRLPGI
460 470 480 490 500
TVDTTPLPDK VEGQWGAAVP ADEWSGATAL GEVAAVGQHL VGPGRTGLTA
510 520 530 540 550
RKSWFVSGDV TVCLGADIST ASGAKVETIV DHRNLHQGSN TLTTAAGTIA
560 570 580 590 600
GTAGTVEVLG DGRWVHLEGF GGYAMLDDSP LHVLRETRSG SWSGVNINGS
610 620 630 640 650
ATVQQRNFAT LYVNHGVGPV AGSYAYMVAP GASVDLTRKL LEGNKYSVIR
660 670 680 690 700
NDATAQSVEF KTAKTTAATF WKPGMAGDLG ASGPACVVFS RHGNELSLAV
710 720 730 740 750
SEPTQKAAGL TLTLPEGTWS SVLEGAGTLG TDADGRSTLT LDTTGLSGKT

KLIKLKR
Length:757
Mass (Da):79,928
Last modified:September 13, 2004 - v1
Checksum:iA461E54AF0F3D88A
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RW9X-ray1.35A1-757[»]
1RWAX-ray1.30A1-757[»]
1RWCX-ray1.90A1-757[»]
1RWFX-ray1.45A1-757[»]
1RWGX-ray1.50A1-757[»]
1RWHX-ray1.25A1-757[»]
ProteinModelPortaliP84141.
SMRiP84141. Positions 4-757.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiPL8. Polysaccharide Lyase Family 8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP84141.

Family and domain databases

Gene3Di1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProiIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
[Graphical view]
PfamiPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMiSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism."
    Lunin V.V., Li Y., Linhardt R.J., Miyazono H., Kyogashima M., Kaneko T., Bell A.W., Cygler M.
    J. Mol. Biol. 337:367-386(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE.

Entry informationi

Entry nameiP84141_ARTAU
AccessioniPrimary (citable) accession number: P84141
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.