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Protein
Submitted name:

Indole-3-glycerol phosphate synthase

Gene

tthHB8IM

Organism
Thermus thermophilus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.SAAS annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.SAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC), Indole-3-glycerol phosphate synthase (tthHB8IM)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseSAAS annotation, Lyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisSAAS annotation

Enzyme and pathway databases

BRENDAi4.1.1.48. 2305.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Submitted name:
Indole-3-glycerol phosphate synthaseImported (EC:4.1.1.48Imported)
Gene namesi
Name:tthHB8IMImported
OrganismiThermus thermophilusImported
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VC4X-ray1.80A/B1-254[»]
ProteinModelPortaliP84126.
SMRiP84126.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 252IGPSInterPro annotationAdd BLAST222

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00218. IGPS. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P84126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDLSRVPG VLGEIARKRA SEVAPYPLPE PPSVPSFKEA LLRPGLSVIA
60 70 80 90 100
EVKRQSPSEG LIREVDPVEA ALAYARGGAR AVSVLTEPHR FGGSLLDLKR
110 120 130 140 150
VREAVDLPLL RKDFVVDPFM LEEARAFGAS AALLIVALLG ELTGAYLEEA
160 170 180 190 200
RRLGLEALVE VHTERELEIA LEAGAEVLGI NNRDLATLHI NLETAPRLGR
210 220 230 240 250
LARKRGFGGV LVAESGYSRK EELKALEGLF DAVLIGTSLM RAPDLEAALR

ELVG
Length:254
Mass (Da):27,419
Last modified:September 13, 2004 - v1
Checksum:iCFED2E4DFFC8E95B
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiP84126_THETH
AccessioniPrimary (citable) accession number: P84126
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 5, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sourcesImported