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Protein
Submitted name:

Indole-3-glycerol phosphate synthase

Gene

tthHB8IM

Organism
Thermus thermophilus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.SAAS annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.SAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (tthHB8IM)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseSAAS annotation, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisSAAS annotation

Enzyme and pathway databases

BRENDAi4.1.1.48. 2305.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Submitted name:
Indole-3-glycerol phosphate synthaseImported (EC:4.1.1.48Imported)
Gene namesi
Name:tthHB8IMImported
OrganismiThermus thermophilusImported
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1164.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VC4X-ray1.80A/B1-254[»]
ProteinModelPortaliP84126.
SMRiP84126. Positions 1-254.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84126.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 252222IGPSInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P84126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDLSRVPG VLGEIARKRA SEVAPYPLPE PPSVPSFKEA LLRPGLSVIA
60 70 80 90 100
EVKRQSPSEG LIREVDPVEA ALAYARGGAR AVSVLTEPHR FGGSLLDLKR
110 120 130 140 150
VREAVDLPLL RKDFVVDPFM LEEARAFGAS AALLIVALLG ELTGAYLEEA
160 170 180 190 200
RRLGLEALVE VHTERELEIA LEAGAEVLGI NNRDLATLHI NLETAPRLGR
210 220 230 240 250
LARKRGFGGV LVAESGYSRK EELKALEGLF DAVLIGTSLM RAPDLEAALR

ELVG
Length:254
Mass (Da):27,419
Last modified:September 13, 2004 - v1
Checksum:iCFED2E4DFFC8E95B
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VC4X-ray1.80A/B1-254[»]
ProteinModelPortaliP84126.
SMRiP84126. Positions 1-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00043.
BRENDAi4.1.1.48. 2305.

Miscellaneous databases

EvolutionaryTraceiP84126.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Crystal Structure of Indole-3-Glycerol Phosphate Synthase (TrpC) from Thermus Thermophilus."
    Bagautdinov B., Tahirov T.H.
    Submitted (MAR-2004) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
  2. "Structure of indole-3-glycerol phosphate synthase from Thermus thermophilus HB8: implications for thermal stability."
    Bagautdinov B., Yutani K.
    Acta Crystallogr. D 67:1054-1064(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).

Entry informationi

Entry nameiP84126_THETH
AccessioniPrimary (citable) accession number: P84126
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sourcesImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.