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Protein

Serine/arginine-rich splicing factor 3

Gene

SRSF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export such as of histone H2A (PubMed:11336712, PubMed:18364396). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). RNA-binding is semi-sequence specific (PubMed:17036044).4 Publications

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • sequence-specific mRNA binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
SIGNORiP84103.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 3
Alternative name(s):
Pre-mRNA-splicing factor SRP20
Splicing factor, arginine/serine-rich 3
Gene namesi
Name:SRSF3
Synonyms:SFRS3, SRP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10785. SRSF3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi86 – 861R → E: Abolishes interaction with NXF1. 1 Publication
Mutagenesisi88 – 881R → E: Abolishes interaction with NXF1. 1 Publication
Mutagenesisi90 – 901R → E: Abolishes interaction with NXF1. 1 Publication

Organism-specific databases

PharmGKBiPA35701.

Polymorphism and mutation databases

BioMutaiSRSF3.
DMDMi51338672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Serine/arginine-rich splicing factor 3PRO_0000081923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei5 – 51PhosphoserineCombined sources
Modified residuei23 – 231N6-acetyllysineCombined sources

Post-translational modificationi

Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP84103.
MaxQBiP84103.
PaxDbiP84103.
PRIDEiP84103.
TopDownProteomicsiP84103-1. [P84103-1]

PTM databases

iPTMnetiP84103.
PhosphoSiteiP84103.
SwissPalmiP84103.

Expressioni

Gene expression databases

BgeeiP84103.
CleanExiHS_SFRS3.
ExpressionAtlasiP84103. baseline and differential.
GenevisibleiP84103. HS.

Organism-specific databases

HPAiCAB012986.
HPA056981.

Interactioni

Subunit structurei

Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NXF1Q9UBU94EBI-372557,EBI-398874
PCBP2Q153663EBI-372557,EBI-945799
Srek1Q9JKL73EBI-372557,EBI-6452221From a different organism.

Protein-protein interaction databases

BioGridi112326. 125 interactions.
IntActiP84103. 39 interactions.
MINTiMINT-5002707.
STRINGi9606.ENSP00000362820.

Structurei

Secondary structure

1
164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1514Combined sources
Turni18 – 203Combined sources
Helixi23 – 319Combined sources
Beta strandi37 – 459Combined sources
Beta strandi48 – 525Combined sources
Helixi56 – 6510Combined sources
Beta strandi67 – 693Combined sources
Beta strandi77 – 804Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I2YNMR-A1-86[»]
2I38NMR-A1-86[»]
ProteinModelPortaliP84103.
SMRiP84103. Positions 3-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84103.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8374RRMPROSITE-ProRule annotationAdd
BLAST
Repeati119 – 13315B-1Add
BLAST
Repeati149 – 16416B-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9090Sufficiernt for interaction with NXF1Add
BLAST
Regioni119 – 164462 X approximate repeats, basicAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi86 – 16479Arg/Ser-rich (RS domain)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0107. Eukaryota.
ENOG4111N8Y. LUCA.
GeneTreeiENSGT00700000104103.
HOGENOMiHOG000208722.
HOVERGENiHBG107480.
InParanoidiP84103.
KOiK12892.
OMAiDSIMHRD.
OrthoDBiEOG73NG5V.
PhylomeDBiP84103.
TreeFamiTF351858.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P84103-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF
60 70 80 90 100
VEFEDPRDAA DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP
110 120 130 140 150
RDDYRRRSPP PRRRSPRRRS FSRSRSRSLS RDRRRERSLS RERNHKPSRS
160
FSRSRSRSRS NERK
Length:164
Mass (Da):19,330
Last modified:August 16, 2004 - v1
Checksum:i02F0A5EE33FF28A0
GO
Isoform 2 (identifier: P84103-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-164: SPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK → VTIMSLLTTL

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):14,203
Checksum:i78979851C38232C1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei115 – 16450SPRRR…SNERK → VTIMSLLTTL in isoform 2. 1 PublicationVSP_056243Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10838 mRNA. Translation: AAA36648.1.
AF107405 mRNA. Translation: AAD44523.1.
AK304097 mRNA. Translation: BAG65003.1.
BT007017 mRNA. Translation: AAP35663.1.
Z85986 Genomic DNA. Translation: CAI19115.1.
CH471081 Genomic DNA. Translation: EAX03898.1.
BC000914 mRNA. Translation: AAH00914.1.
BC069018 mRNA. Translation: AAH69018.1.
CCDSiCCDS4823.1. [P84103-1]
PIRiI54089.
RefSeqiNP_003008.1. NM_003017.4. [P84103-1]
UniGeneiHs.405144.

Genome annotation databases

EnsembliENST00000373715; ENSP00000362820; ENSG00000112081. [P84103-1]
ENST00000477442; ENSP00000436036; ENSG00000112081. [P84103-2]
ENST00000620941; ENSP00000482833; ENSG00000112081. [P84103-1]
GeneIDi6428.
KEGGihsa:6428.
UCSCiuc003omj.4. human. [P84103-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10838 mRNA. Translation: AAA36648.1.
AF107405 mRNA. Translation: AAD44523.1.
AK304097 mRNA. Translation: BAG65003.1.
BT007017 mRNA. Translation: AAP35663.1.
Z85986 Genomic DNA. Translation: CAI19115.1.
CH471081 Genomic DNA. Translation: EAX03898.1.
BC000914 mRNA. Translation: AAH00914.1.
BC069018 mRNA. Translation: AAH69018.1.
CCDSiCCDS4823.1. [P84103-1]
PIRiI54089.
RefSeqiNP_003008.1. NM_003017.4. [P84103-1]
UniGeneiHs.405144.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I2YNMR-A1-86[»]
2I38NMR-A1-86[»]
ProteinModelPortaliP84103.
SMRiP84103. Positions 3-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112326. 125 interactions.
IntActiP84103. 39 interactions.
MINTiMINT-5002707.
STRINGi9606.ENSP00000362820.

PTM databases

iPTMnetiP84103.
PhosphoSiteiP84103.
SwissPalmiP84103.

Polymorphism and mutation databases

BioMutaiSRSF3.
DMDMi51338672.

Proteomic databases

EPDiP84103.
MaxQBiP84103.
PaxDbiP84103.
PRIDEiP84103.
TopDownProteomicsiP84103-1. [P84103-1]

Protocols and materials databases

DNASUi6428.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373715; ENSP00000362820; ENSG00000112081. [P84103-1]
ENST00000477442; ENSP00000436036; ENSG00000112081. [P84103-2]
ENST00000620941; ENSP00000482833; ENSG00000112081. [P84103-1]
GeneIDi6428.
KEGGihsa:6428.
UCSCiuc003omj.4. human. [P84103-1]

Organism-specific databases

CTDi6428.
GeneCardsiSRSF3.
HGNCiHGNC:10785. SRSF3.
HPAiCAB012986.
HPA056981.
MIMi603364. gene.
neXtProtiNX_P84103.
PharmGKBiPA35701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0107. Eukaryota.
ENOG4111N8Y. LUCA.
GeneTreeiENSGT00700000104103.
HOGENOMiHOG000208722.
HOVERGENiHBG107480.
InParanoidiP84103.
KOiK12892.
OMAiDSIMHRD.
OrthoDBiEOG73NG5V.
PhylomeDBiP84103.
TreeFamiTF351858.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
SIGNORiP84103.

Miscellaneous databases

ChiTaRSiSRSF3. human.
EvolutionaryTraceiP84103.
GeneWikiiSFRS3.
GenomeRNAii6428.
PROiP84103.
SOURCEiSearch...

Gene expression databases

BgeeiP84103.
CleanExiHS_SFRS3.
ExpressionAtlasiP84103. baseline and differential.
GenevisibleiP84103. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SR proteins: a conserved family of pre-mRNA splicing factors."
    Zahler A.M., Lane W.S., Stolk J.A., Roth M.B.
    Genes Dev. 6:837-847(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 29-37 AND 54-64.
  2. "Identification and characterization of novel full-length cDNAs differentially expressed in hematopoietic lineages."
    Liu W.L., Wang M., Tang D., Rodgers G.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Placenta.
  8. "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein."
    Barnard D.C., Patton J.G.
    Mol. Cell. Biol. 20:3049-3057(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SREK1.
  9. "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA."
    Huang Y., Steitz J.A.
    Mol. Cell 7:899-905(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MRNA EXPORT, SUBCELLULAR LOCATION.
  10. "SR splicing factors serve as adapter proteins for TAP-dependent mRNA export."
    Huang Y., Gattoni R., Stevenin J., Steitz J.A.
    Mol. Cell 11:837-843(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NXF1.
  11. "The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis."
    Elliott D.J.
    Int. J. Androl. 27:328-334(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RBMY1A1.
  12. "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization."
    Dettwiler S., Aringhieri C., Cardinale S., Keller W., Barabino S.M.
    J. Biol. Chem. 279:35788-35797(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CPSF6.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP."
    Hautbergue G.M., Hung M.L., Golovanov A.P., Lian L.Y., Wilson S.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:5154-5159(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MRNA EXPORT.
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8."
    Hargous Y., Hautbergue G.M., Tintaru A.M., Skrisovska L., Golovanov A.P., Stevenin J., Lian L.Y., Wilson S.A., Allain F.H.
    EMBO J. 25:5126-5137(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-86, RNA-BINDING, FUNCTION, INTERACTION WITH NXF1, MUTAGENESIS OF ARG-86; ARG-88 AND ARG-90.
  20. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH YTHDC1.

Entry informationi

Entry nameiSRSF3_HUMAN
AccessioniPrimary (citable) accession number: P84103
Secondary accession number(s): B4E241
, O08831, P23152, Q5R3K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.