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Protein

Small EDRK-rich factor 2

Gene

SERF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small EDRK-rich factor 2
Alternative name(s):
Gastric cancer-related protein VRG107
Protein 4F5-related
Short name:
4F5rel
Short name:
h4F5rel
Gene namesi
Name:SERF2
Synonyms:FAM2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:10757. SERF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140264.
PharmGKBiPA35677.

Polymorphism and mutation databases

BioMutaiSERF2.
DMDMi51338670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507121 – 59Small EDRK-rich factor 2Add BLAST59

Proteomic databases

EPDiP84101.
MaxQBiP84101.
PaxDbiP84101.
PeptideAtlasiP84101.
PRIDEiP84101.
TopDownProteomicsiP84101-1. [P84101-1]

PTM databases

iPTMnetiP84101.
PhosphoSitePlusiP84101.

Expressioni

Gene expression databases

BgeeiENSG00000140264.
CleanExiHS_SERF2.
ExpressionAtlasiP84101. baseline and differential.
GenevisibleiP84101. HS.

Organism-specific databases

HPAiHPA056613.

Interactioni

Protein-protein interaction databases

BioGridi115471. 15 interactors.
IntActiP84101. 9 interactors.
MINTiMINT-4584440.
STRINGi9606.ENSP00000387187.

Structurei

3D structure databases

ProteinModelPortaliP84101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SERF family.Curated

Phylogenomic databases

eggNOGiKOG4488. Eukaryota.
ENOG410XWDZ. LUCA.
GeneTreeiENSGT00600000084564.
HOGENOMiHOG000231843.
HOVERGENiHBG054789.
InParanoidiP84101.
OMAiCPIHFHL.
OrthoDBiEOG091G0L6E.
PhylomeDBiP84101.

Family and domain databases

InterProiIPR007513. Uncharacterised_SERF.
[Graphical view]
PfamiPF04419. 4F5. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P84101-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRGNQRELA RQKNMKKQSD SVKGKRRDDG LSAAARKQRD SEIMQQKQKK

ANEKKEEPK
Length:59
Mass (Da):6,900
Last modified:August 16, 2004 - v1
Checksum:i24FB33BF94FFFAE4
GO
Isoform 2 (identifier: P84101-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-59: DSEIMQQKQKKANEKKEEPK → VGVQQPNAEL...ASLPLGHSRG

Note: Gene prediction based on EST data.
Show »
Length:170
Mass (Da):18,315
Checksum:i6EDA45B82A43FFBD
GO
Isoform 3 (identifier: P84101-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-59: RDSEIMQQKQKKANEKKEEPK → SAPSSLPPGT...ASLPLGHSRG

Note: Gene prediction based on EST data.
Show »
Length:133
Mass (Da):14,334
Checksum:i5DFC4E1DBAD3BC03
GO
Isoform 4 (identifier: P84101-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Note: Gene prediction based on EST data.
Show »
Length:45
Mass (Da):5,216
Checksum:i7A1957786A56EA18
GO

Sequence cautioni

The sequence AAK07636 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05193740D → Y.Corresponds to variant rs11269dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467301 – 14Missing in isoform 4. CuratedAdd BLAST14
Alternative sequenceiVSP_04673139 – 59RDSEI…KEEPK → SAPSSLPPGTRRSCSRSRKR QTRRRRNPSSFVASCPTLLP FACVPGASPTTLAFPPVVLT GPSTDGIPFALSLQRVPFVL PSPQVASLPLGHSRG in isoform 3. CuratedAdd BLAST21
Alternative sequenceiVSP_04673240 – 59DSEIM…KEEPK → VGVQQPNAELSPIHFHLILC ALHPPASCPFCPLVPPSAPS SLPPGTRRSCSRSRKRQTRR RRNPSSFVASCPTLLPFACV PGASPTTLAFPPVVLTGPST DGIPFALSLQRVPFVLPSPQ VASLPLGHSRG in isoform 2. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073298 mRNA. Translation: AAC63516.1.
AF320073 mRNA. Translation: AAK07636.1. Sequence problems.
AC018512 Genomic DNA. No translation available.
BC009869 mRNA. No translation available.
BC015491 mRNA. Translation: AAH15491.2.
CCDSiCCDS32218.1. [P84101-1]
CCDS55963.1. [P84101-2]
CCDS55964.1. [P84101-3]
CCDS55965.1. [P84101-4]
RefSeqiNP_001018118.1. NM_001018108.3. [P84101-1]
NP_001186804.1. NM_001199875.1. [P84101-2]
NP_001186805.1. NM_001199876.1. [P84101-3]
NP_001186806.1. NM_001199877.1. [P84101-1]
NP_001186807.1. NM_001199878.1. [P84101-4]
UniGeneiHs.424126.
Hs.604985.
Hs.732549.

Genome annotation databases

EnsembliENST00000249786; ENSP00000249786; ENSG00000140264. [P84101-1]
ENST00000339624; ENSP00000339647; ENSG00000140264. [P84101-3]
ENST00000381359; ENSP00000370764; ENSG00000140264. [P84101-1]
ENST00000402131; ENSP00000386044; ENSG00000140264. [P84101-4]
ENST00000403425; ENSP00000384300; ENSG00000140264. [P84101-4]
ENST00000409614; ENSP00000386783; ENSG00000140264. [P84101-4]
ENST00000409960; ENSP00000387187; ENSG00000140264. [P84101-2]
ENST00000445816; ENSP00000400178; ENSG00000140264. [P84101-1]
GeneIDi10169.
KEGGihsa:10169.
UCSCiuc001zsz.5. human. [P84101-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073298 mRNA. Translation: AAC63516.1.
AF320073 mRNA. Translation: AAK07636.1. Sequence problems.
AC018512 Genomic DNA. No translation available.
BC009869 mRNA. No translation available.
BC015491 mRNA. Translation: AAH15491.2.
CCDSiCCDS32218.1. [P84101-1]
CCDS55963.1. [P84101-2]
CCDS55964.1. [P84101-3]
CCDS55965.1. [P84101-4]
RefSeqiNP_001018118.1. NM_001018108.3. [P84101-1]
NP_001186804.1. NM_001199875.1. [P84101-2]
NP_001186805.1. NM_001199876.1. [P84101-3]
NP_001186806.1. NM_001199877.1. [P84101-1]
NP_001186807.1. NM_001199878.1. [P84101-4]
UniGeneiHs.424126.
Hs.604985.
Hs.732549.

3D structure databases

ProteinModelPortaliP84101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115471. 15 interactors.
IntActiP84101. 9 interactors.
MINTiMINT-4584440.
STRINGi9606.ENSP00000387187.

PTM databases

iPTMnetiP84101.
PhosphoSitePlusiP84101.

Polymorphism and mutation databases

BioMutaiSERF2.
DMDMi51338670.

Proteomic databases

EPDiP84101.
MaxQBiP84101.
PaxDbiP84101.
PeptideAtlasiP84101.
PRIDEiP84101.
TopDownProteomicsiP84101-1. [P84101-1]

Protocols and materials databases

DNASUi10169.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249786; ENSP00000249786; ENSG00000140264. [P84101-1]
ENST00000339624; ENSP00000339647; ENSG00000140264. [P84101-3]
ENST00000381359; ENSP00000370764; ENSG00000140264. [P84101-1]
ENST00000402131; ENSP00000386044; ENSG00000140264. [P84101-4]
ENST00000403425; ENSP00000384300; ENSG00000140264. [P84101-4]
ENST00000409614; ENSP00000386783; ENSG00000140264. [P84101-4]
ENST00000409960; ENSP00000387187; ENSG00000140264. [P84101-2]
ENST00000445816; ENSP00000400178; ENSG00000140264. [P84101-1]
GeneIDi10169.
KEGGihsa:10169.
UCSCiuc001zsz.5. human. [P84101-1]

Organism-specific databases

CTDi10169.
GeneCardsiSERF2.
HGNCiHGNC:10757. SERF2.
HPAiHPA056613.
MIMi605054. gene.
neXtProtiNX_P84101.
OpenTargetsiENSG00000140264.
PharmGKBiPA35677.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4488. Eukaryota.
ENOG410XWDZ. LUCA.
GeneTreeiENSGT00600000084564.
HOGENOMiHOG000231843.
HOVERGENiHBG054789.
InParanoidiP84101.
OMAiCPIHFHL.
OrthoDBiEOG091G0L6E.
PhylomeDBiP84101.

Miscellaneous databases

GeneWikiiSERF2.
GenomeRNAii10169.
PROiP84101.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140264.
CleanExiHS_SERF2.
ExpressionAtlasiP84101. baseline and differential.
GenevisibleiP84101. HS.

Family and domain databases

InterProiIPR007513. Uncharacterised_SERF.
[Graphical view]
PfamiPF04419. 4F5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERF2_HUMAN
AccessioniPrimary (citable) accession number: P84101
Secondary accession number(s): A6NL45
, B5MCG1, B9A026, O75918, O88891, Q9BZH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.