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Protein

60S ribosomal protein L19

Gene

Rpl19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 5.8S rRNA binding Source: RGD
  • large ribosomal subunit rRNA binding Source: RGD
  • poly(A) RNA binding Source: Ensembl
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

  • liver regeneration Source: RGD
  • translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19
Gene namesi
Name:Rpl19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621183. Rpl19.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • focal adhesion Source: Ensembl
  • membrane Source: Ensembl
  • nucleolus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19619660S ribosomal protein L19PRO_0000131172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51CitrullineBy similarity
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei16 – 161CitrullineBy similarity
Modified residuei38 – 381CitrullineBy similarity
Modified residuei187 – 1871PhosphothreonineBy similarity

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

PaxDbiP84100.
PRIDEiP84100.

PTM databases

iPTMnetiP84100.
PhosphoSiteiP84100.

Expressioni

Gene expression databases

GenevisibleiP84100. RN.

Interactioni

Protein-protein interaction databases

BioGridi249639. 2 interactions.
IntActiP84100. 1 interaction.
MINTiMINT-1864312.
STRINGi10116.ENSRNOP00000006359.

Structurei

3D structure databases

ProteinModelPortaliP84100.
SMRiP84100. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L19e family.Curated

Phylogenomic databases

eggNOGiKOG1696. Eukaryota.
COG2147. LUCA.
GeneTreeiENSGT00390000012628.
HOGENOMiHOG000231277.
HOVERGENiHBG056059.
InParanoidiP84100.
KOiK02885.
OMAiEHIIQAK.
OrthoDBiEOG75B86V.
PhylomeDBiP84100.
TreeFamiTF313598.

Family and domain databases

Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e.
InterProiIPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI
60 70 80 90 100
IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR
110 120 130 140 150
ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA
160 170 180 190
RKKLLADQAE ARRSKTKEAR KRREERLQAK KEEIIKTLSK EEETKK
Length:196
Mass (Da):23,466
Last modified:August 16, 2004 - v1
Checksum:i4AF506393E526216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02650 mRNA. Translation: AAA42071.1.
X82202 Genomic DNA. Translation: CAA57685.1.
BC058135 mRNA. Translation: AAH58135.1.
PIRiA26710. R5RT19.
RefSeqiNP_112365.1. NM_031103.1.
UniGeneiRn.3384.

Genome annotation databases

EnsembliENSRNOT00000006359; ENSRNOP00000006359; ENSRNOG00000004741.
GeneIDi81767.
KEGGirno:81767.
UCSCiRGD:621183. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02650 mRNA. Translation: AAA42071.1.
X82202 Genomic DNA. Translation: CAA57685.1.
BC058135 mRNA. Translation: AAH58135.1.
PIRiA26710. R5RT19.
RefSeqiNP_112365.1. NM_031103.1.
UniGeneiRn.3384.

3D structure databases

ProteinModelPortaliP84100.
SMRiP84100. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249639. 2 interactions.
IntActiP84100. 1 interaction.
MINTiMINT-1864312.
STRINGi10116.ENSRNOP00000006359.

PTM databases

iPTMnetiP84100.
PhosphoSiteiP84100.

Proteomic databases

PaxDbiP84100.
PRIDEiP84100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006359; ENSRNOP00000006359; ENSRNOG00000004741.
GeneIDi81767.
KEGGirno:81767.
UCSCiRGD:621183. rat.

Organism-specific databases

CTDi6143.
RGDi621183. Rpl19.

Phylogenomic databases

eggNOGiKOG1696. Eukaryota.
COG2147. LUCA.
GeneTreeiENSGT00390000012628.
HOGENOMiHOG000231277.
HOVERGENiHBG056059.
InParanoidiP84100.
KOiK02885.
OMAiEHIIQAK.
OrthoDBiEOG75B86V.
PhylomeDBiP84100.
TreeFamiTF313598.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP84100.

Gene expression databases

GenevisibleiP84100. RN.

Family and domain databases

Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e.
InterProiIPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein."
    Chan Y.-L., Lin A., McNally J., Peleg D., Meyuhas O., Wool I.G.
    J. Biol. Chem. 262:1111-1115(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region."
    Davies B., Fried M.
    Genomics 25:372-380(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Fischer.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary anterior lobe.

Entry informationi

Entry nameiRL19_RAT
AccessioniPrimary (citable) accession number: P84100
Secondary accession number(s): P14118, P22908
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.