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P84099

- RL19_MOUSE

UniProt

P84099 - RL19_MOUSE

Protein

60S ribosomal protein L19

Gene

Rpl19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: MGI

    GO - Biological processi

    1. translation Source: MGI

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L19
    Gene namesi
    Name:Rpl19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98020. Rpl19.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19619660S ribosomal protein L19PRO_0000131171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei5 – 51Citrulline1 Publication
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei16 – 161Citrulline1 Publication
    Modified residuei38 – 381Citrulline1 Publication
    Modified residuei187 – 1871PhosphothreonineBy similarity

    Post-translational modificationi

    Citrullinated by PADI4.1 Publication

    Keywords - PTMi

    Citrullination, Phosphoprotein

    Proteomic databases

    MaxQBiP84099.
    PaxDbiP84099.
    PRIDEiP84099.

    PTM databases

    PhosphoSiteiP84099.

    Expressioni

    Gene expression databases

    BgeeiP84099.
    CleanExiMM_RPL19.
    GenevestigatoriP84099.

    Interactioni

    Protein-protein interaction databases

    BioGridi202969. 9 interactions.
    IntActiP84099. 6 interactions.
    MINTiMINT-1864295.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K8DX-ray2.30P137-145[»]
    ProteinModelPortaliP84099.
    SMRiP84099. Positions 1-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP84099.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L19e family.Curated

    Phylogenomic databases

    eggNOGiCOG2147.
    HOGENOMiHOG000231277.
    HOVERGENiHBG056059.
    InParanoidiP84099.
    KOiK02885.
    OMAiYRDAGKI.
    PhylomeDBiP84099.
    TreeFamiTF313598.

    Family and domain databases

    Gene3Di1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    HAMAPiMF_01475. Ribosomal_L19e.
    InterProiIPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view]
    PfamiPF01280. Ribosomal_L19e. 1 hit.
    [Graphical view]
    SUPFAMiSSF48140. SSF48140. 1 hit.
    PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P84099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI    50
    IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR 100
    ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA 150
    RKKLLADQAE ARRSKTKEAR KRREERLQAK KEEIIKTLSK EEETKK 196
    Length:196
    Mass (Da):23,466
    Last modified:August 16, 2004 - v1
    Checksum:i4AF506393E526216
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791A → S in AAB48630. (PubMed:1702292)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62952 mRNA. Translation: AAB48630.1.
    AK010440 mRNA. Translation: BAB26941.1.
    BC010710 mRNA. Translation: AAH10710.1.
    BC083131 mRNA. Translation: AAH83131.1.
    CCDSiCCDS25337.1.
    PIRiA36554.
    RefSeqiNP_033104.2. NM_009078.2.
    UniGeneiMm.10247.

    Genome annotation databases

    EnsembliENSMUST00000017548; ENSMUSP00000017548; ENSMUSG00000017404.
    GeneIDi19921.
    KEGGimmu:19921.
    UCSCiuc007lfj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62952 mRNA. Translation: AAB48630.1 .
    AK010440 mRNA. Translation: BAB26941.1 .
    BC010710 mRNA. Translation: AAH10710.1 .
    BC083131 mRNA. Translation: AAH83131.1 .
    CCDSi CCDS25337.1.
    PIRi A36554.
    RefSeqi NP_033104.2. NM_009078.2.
    UniGenei Mm.10247.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K8D X-ray 2.30 P 137-145 [» ]
    ProteinModelPortali P84099.
    SMRi P84099. Positions 1-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202969. 9 interactions.
    IntActi P84099. 6 interactions.
    MINTi MINT-1864295.

    PTM databases

    PhosphoSitei P84099.

    Proteomic databases

    MaxQBi P84099.
    PaxDbi P84099.
    PRIDEi P84099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017548 ; ENSMUSP00000017548 ; ENSMUSG00000017404 .
    GeneIDi 19921.
    KEGGi mmu:19921.
    UCSCi uc007lfj.2. mouse.

    Organism-specific databases

    CTDi 6143.
    MGIi MGI:98020. Rpl19.

    Phylogenomic databases

    eggNOGi COG2147.
    HOGENOMi HOG000231277.
    HOVERGENi HBG056059.
    InParanoidi P84099.
    KOi K02885.
    OMAi YRDAGKI.
    PhylomeDBi P84099.
    TreeFami TF313598.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    ChiTaRSi RPL19. mouse.
    EvolutionaryTracei P84099.
    NextBioi 23865.
    PROi P84099.
    SOURCEi Search...

    Gene expression databases

    Bgeei P84099.
    CleanExi MM_RPL19.
    Genevestigatori P84099.

    Family and domain databases

    Gene3Di 1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    HAMAPi MF_01475. Ribosomal_L19e.
    InterProi IPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view ]
    Pfami PF01280. Ribosomal_L19e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48140. SSF48140. 1 hit.
    PROSITEi PS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of mouse L19 ribosomal protein cDNA isolated in screening with tre oncogene probes."
      Nakamura T., Onno M., Mariage-Samson R., Hillova J., Hill M.
      DNA Cell Biol. 9:697-703(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 187-195, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. Cited for: CITRULLINATION AT ARG-5; ARG-16 AND ARG-38.
    6. "Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation."
      He X., Tabaczewski P., Ho J., Stroynowski I., Garcia K.C.
      Structure 9:1213-1224(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 137-145 IN COMPLEX WITH MHC.

    Entry informationi

    Entry nameiRL19_MOUSE
    AccessioniPrimary (citable) accession number: P84099
    Secondary accession number(s): P14118, P22908
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3