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P84098

- RL19_HUMAN

UniProt

P84098 - RL19_HUMAN

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Protein

60S ribosomal protein L19

Gene
RPL19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: UniProtKB
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. RNA metabolic process Source: Reactome
  6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  7. translation Source: UniProtKB
  8. translational elongation Source: Reactome
  9. translational initiation Source: Reactome
  10. translational termination Source: Reactome
  11. viral life cycle Source: Reactome
  12. viral process Source: Reactome
  13. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19
Gene namesi
Name:RPL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10312. RPL19.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic large ribosomal subunit Source: UniProtKB
  4. nucleolus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19619660S ribosomal protein L19UniRule annotationPRO_0000131169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Citrulline By similarity
Modified residuei13 – 131Phosphoserine1 Publication
Modified residuei16 – 161Citrulline By similarity
Modified residuei38 – 381Citrulline By similarity
Modified residuei187 – 1871Phosphothreonine1 Publication

Post-translational modificationi

Citrullinated by PADI4 By similarity.UniRule annotation

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

MaxQBiP84098.
PaxDbiP84098.
PRIDEiP84098.

PTM databases

PhosphoSiteiP84098.

Expressioni

Gene expression databases

BgeeiP84098.
CleanExiHS_RPL19.
GenevestigatoriP84098.

Organism-specific databases

HPAiHPA043014.
HPA051987.

Interactioni

Protein-protein interaction databases

BioGridi112063. 124 interactions.
IntActiP84098. 19 interactions.
MINTiMINT-1815479.
STRINGi9606.ENSP00000225430.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00R1-196[»]
ProteinModelPortaliP84098.
SMRiP84098. Positions 1-189.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2147.
HOGENOMiHOG000231277.
HOVERGENiHBG056059.
InParanoidiP84098.
KOiK02885.
OMAiYRDAGKI.
OrthoDBiEOG75B86V.
PhylomeDBiP84098.
TreeFamiTF313598.

Family and domain databases

Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e.
InterProiIPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84098-1 [UniParc]FASTAAdd to Basket

« Hide

MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI    50
IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR 100
ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA 150
RKKLLADQAE ARRSKTKEAR KRREERLQAK KEEIIKTLSK EEETKK 196
Length:196
Mass (Da):23,466
Last modified:August 16, 2004 - v1
Checksum:i4AF506393E526216
GO

Sequence cautioni

The sequence CAD97677.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63527 mRNA. Translation: CAA45090.1.
S56985 mRNA. Translation: AAB25672.1.
AK311858 mRNA. Translation: BAG34799.1.
BX537435 mRNA. Translation: CAD97677.1. Different initiation.
BC000530 mRNA. Translation: AAH00530.1.
BC013016 mRNA. Translation: AAH13016.1.
BC062709 mRNA. Translation: AAH62709.1.
BC066315 mRNA. Translation: AAH66315.1.
BC095445 mRNA. Translation: AAH95445.1.
CCDSiCCDS42312.1.
PIRiA48992.
RefSeqiNP_000972.1. NM_000981.3.
UniGeneiHs.381061.

Genome annotation databases

EnsembliENST00000225430; ENSP00000225430; ENSG00000108298.
GeneIDi6143.
KEGGihsa:6143.
UCSCiuc002hrq.1. human.

Polymorphism databases

DMDMi51338661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63527 mRNA. Translation: CAA45090.1 .
S56985 mRNA. Translation: AAB25672.1 .
AK311858 mRNA. Translation: BAG34799.1 .
BX537435 mRNA. Translation: CAD97677.1 . Different initiation.
BC000530 mRNA. Translation: AAH00530.1 .
BC013016 mRNA. Translation: AAH13016.1 .
BC062709 mRNA. Translation: AAH62709.1 .
BC066315 mRNA. Translation: AAH66315.1 .
BC095445 mRNA. Translation: AAH95445.1 .
CCDSi CCDS42312.1.
PIRi A48992.
RefSeqi NP_000972.1. NM_000981.3.
UniGenei Hs.381061.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 R 1-196 [» ]
ProteinModelPortali P84098.
SMRi P84098. Positions 1-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112063. 124 interactions.
IntActi P84098. 19 interactions.
MINTi MINT-1815479.
STRINGi 9606.ENSP00000225430.

PTM databases

PhosphoSitei P84098.

Polymorphism databases

DMDMi 51338661.

Proteomic databases

MaxQBi P84098.
PaxDbi P84098.
PRIDEi P84098.

Protocols and materials databases

DNASUi 6143.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225430 ; ENSP00000225430 ; ENSG00000108298 .
GeneIDi 6143.
KEGGi hsa:6143.
UCSCi uc002hrq.1. human.

Organism-specific databases

CTDi 6143.
GeneCardsi GC17P037356.
HGNCi HGNC:10312. RPL19.
HPAi HPA043014.
HPA051987.
MIMi 180466. gene.
neXtProti NX_P84098.
PharmGKBi PA34681.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2147.
HOGENOMi HOG000231277.
HOVERGENi HBG056059.
InParanoidi P84098.
KOi K02885.
OMAi YRDAGKI.
OrthoDBi EOG75B86V.
PhylomeDBi P84098.
TreeFami TF313598.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

GeneWikii RPL19.
GenomeRNAii 6143.
NextBioi 23865.
PROi P84098.
SOURCEi Search...

Gene expression databases

Bgeei P84098.
CleanExi HS_RPL19.
Genevestigatori P84098.

Family and domain databases

Gene3Di 1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPi MF_01475. Ribosomal_L19e.
InterProi IPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view ]
Pfami PF01280. Ribosomal_L19e. 1 hit.
[Graphical view ]
SUPFAMi SSF48140. SSF48140. 1 hit.
PROSITEi PS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19."
    Kumabe T., Schma Y., Yamamoto T.
    Nucleic Acids Res. 20:2598-2598(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2."
    Henry J.L., Coggin D.L., King C.R.
    Cancer Res. 53:1403-1408(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Hypothalamus and Muscle.
  6. Bienvenut W.V., Vousden K.H., Lukashchuk N.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 10-16; 22-38 AND 154-162, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND THR-187, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRL19_HUMAN
AccessioniPrimary (citable) accession number: P84098
Secondary accession number(s): B2R4K2
, P14118, P22908, Q502Y6, Q7Z6E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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