P84098 (RL19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L19

Gene names

Name:

RPL19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the ribosomal protein L19e family.
Sequence caution	The sequence CAD97677.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB
Molecular_function	RNA binding Traceable author statement PubMed 1577483. Source: UniProtKB structural constituent of ribosome Non-traceable author statement PubMed 12962325. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	60S ribosomal protein L19		PRO_0000131169
Amino acid modifications
	Modified residue	13	1	Phosphoserine Ref.8
	Modified residue	187	1	Phosphothreonine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P84098 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 4AF506393E526216	FASTA	196	23,466
	10 20 30 40 50 60 MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR 70 80 90 100 110 120 ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY 130 140 150 160 170 180 HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE ARRSKTKEAR KRREERLQAK 190 KEEIIKTLSK EEETKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19." Kumabe T., Schma Y., Yamamoto T. Nucleic Acids Res. 20:2598-2598(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2." Henry J.L., Coggin D.L., King C.R. Cancer Res. 53:1403-1408(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Hypothalamus and Muscle.
[6]	Bienvenut W.V., Vousden K.H., Lukashchuk N. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 10-16; 22-38 AND 154-162, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND THR-187, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63527 mRNA. Translation: CAA45090.1. S56985 mRNA. Translation: AAB25672.1. AK311858 mRNA. Translation: BAG34799.1. BX537435 mRNA. Translation: CAD97677.1. Different initiation. BC000530 mRNA. Translation: AAH00530.1. BC013016 mRNA. Translation: AAH13016.1. BC062709 mRNA. Translation: AAH62709.1. BC066315 mRNA. Translation: AAH66315.1. BC095445 mRNA. Translation: AAH95445.1.
IPI	IPI00025329.
PIR	A48992.
RefSeq	NP_000972.1. NM_000981.3.
UniGene	Hs.381061.
3D structure databases
ProteinModelPortal	P84098.
ModBase	Search...
Protein-protein interaction databases
IntAct	P84098. 13 interactions.
MINT	MINT-1815479.
STRING	9606.ENSP00000225430.
PTM databases
PhosphoSite	P84098.
Polymorphism databases
DMDM	51338661.
Proteomic databases
PaxDb	P84098.
PRIDE	P84098.
Protocols and materials databases
DNASU	6143.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225430; ENSP00000225430; ENSG00000108298.
GeneID	6143.
KEGG	hsa:6143.
UCSC	uc002hrq.1. human.
Organism-specific databases
CTD	6143.
GeneCards	GC17P037356.
HGNC	HGNC:10312. RPL19.
HPA	HPA043014.
MIM	180466. gene.
neXtProt	NX_P84098.
PharmGKB	PA34681.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2147.
HOGENOM	HOG000231277.
HOVERGEN	HBG056059.
InParanoid	P84098.
KO	K02885.
OMA	AGKIDKH.
OrthoDB	EOG4K9BDK.
PhylomeDB	P84098.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P84098.
Bgee	P84098.
CleanEx	HS_RPL19.
Genevestigator	P84098.
GermOnline	ENSG00000108298. Homo sapiens.
Family and domain databases
Gene3D	1.10.1200.60. 1 hit. 1.10.1650.10. 1 hit.
InterPro	IPR000196. Ribosomal_L19/L19e. IPR023638. Ribosomal_L19/L19e_CS. IPR015972. Ribosomal_L19/L19e_dom1. IPR015974. Ribosomal_L19/L19e_dom3. [Graphical view]
Pfam	PF01280. Ribosomal_L19e. 1 hit. [Graphical view]
SUPFAM	SSF48140. Ribosomal_L19/L19e. 1 hit.
PROSITE	PS00526. RIBOSOMAL_L19E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6143.
NextBio	23865.
SOURCE	Search...

Entry information

Entry name

RL19_HUMAN

Accession

Primary (citable) accession number: P84098
Secondary accession number(s): B2R4K2 , P14118, P22908, Q502Y6, Q7Z6E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.