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P84098

- RL19_HUMAN

UniProt

P84098 - RL19_HUMAN

Protein

60S ribosomal protein L19

Gene

RPL19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: UniProtKB
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L19
    Gene namesi
    Name:RPL19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10312. RPL19.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleolus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34681.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19619660S ribosomal protein L19PRO_0000131169Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei5 – 51CitrullineBy similarity
    Modified residuei13 – 131Phosphoserine1 Publication
    Modified residuei16 – 161CitrullineBy similarity
    Modified residuei38 – 381CitrullineBy similarity
    Modified residuei187 – 1871Phosphothreonine1 Publication

    Post-translational modificationi

    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Citrullination, Phosphoprotein

    Proteomic databases

    MaxQBiP84098.
    PaxDbiP84098.
    PRIDEiP84098.

    PTM databases

    PhosphoSiteiP84098.

    Expressioni

    Gene expression databases

    BgeeiP84098.
    CleanExiHS_RPL19.
    GenevestigatoriP84098.

    Organism-specific databases

    HPAiHPA043014.
    HPA051987.

    Interactioni

    Protein-protein interaction databases

    BioGridi112063. 124 interactions.
    IntActiP84098. 19 interactions.
    MINTiMINT-1815479.
    STRINGi9606.ENSP00000225430.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00R1-196[»]
    ProteinModelPortaliP84098.
    SMRiP84098. Positions 1-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L19e family.Curated

    Phylogenomic databases

    eggNOGiCOG2147.
    HOGENOMiHOG000231277.
    HOVERGENiHBG056059.
    InParanoidiP84098.
    KOiK02885.
    OMAiYRDAGKI.
    OrthoDBiEOG75B86V.
    PhylomeDBiP84098.
    TreeFamiTF313598.

    Family and domain databases

    Gene3Di1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    HAMAPiMF_01475. Ribosomal_L19e.
    InterProiIPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view]
    PfamiPF01280. Ribosomal_L19e. 1 hit.
    [Graphical view]
    SUPFAMiSSF48140. SSF48140. 1 hit.
    PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P84098-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI    50
    IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR 100
    ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA 150
    RKKLLADQAE ARRSKTKEAR KRREERLQAK KEEIIKTLSK EEETKK 196
    Length:196
    Mass (Da):23,466
    Last modified:August 16, 2004 - v1
    Checksum:i4AF506393E526216
    GO

    Sequence cautioni

    The sequence CAD97677.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63527 mRNA. Translation: CAA45090.1.
    S56985 mRNA. Translation: AAB25672.1.
    AK311858 mRNA. Translation: BAG34799.1.
    BX537435 mRNA. Translation: CAD97677.1. Different initiation.
    BC000530 mRNA. Translation: AAH00530.1.
    BC013016 mRNA. Translation: AAH13016.1.
    BC062709 mRNA. Translation: AAH62709.1.
    BC066315 mRNA. Translation: AAH66315.1.
    BC095445 mRNA. Translation: AAH95445.1.
    CCDSiCCDS42312.1.
    PIRiA48992.
    RefSeqiNP_000972.1. NM_000981.3.
    UniGeneiHs.381061.

    Genome annotation databases

    EnsembliENST00000225430; ENSP00000225430; ENSG00000108298.
    GeneIDi6143.
    KEGGihsa:6143.
    UCSCiuc002hrq.1. human.

    Polymorphism databases

    DMDMi51338661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63527 mRNA. Translation: CAA45090.1 .
    S56985 mRNA. Translation: AAB25672.1 .
    AK311858 mRNA. Translation: BAG34799.1 .
    BX537435 mRNA. Translation: CAD97677.1 . Different initiation.
    BC000530 mRNA. Translation: AAH00530.1 .
    BC013016 mRNA. Translation: AAH13016.1 .
    BC062709 mRNA. Translation: AAH62709.1 .
    BC066315 mRNA. Translation: AAH66315.1 .
    BC095445 mRNA. Translation: AAH95445.1 .
    CCDSi CCDS42312.1.
    PIRi A48992.
    RefSeqi NP_000972.1. NM_000981.3.
    UniGenei Hs.381061.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 R 1-196 [» ]
    ProteinModelPortali P84098.
    SMRi P84098. Positions 1-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112063. 124 interactions.
    IntActi P84098. 19 interactions.
    MINTi MINT-1815479.
    STRINGi 9606.ENSP00000225430.

    PTM databases

    PhosphoSitei P84098.

    Polymorphism databases

    DMDMi 51338661.

    Proteomic databases

    MaxQBi P84098.
    PaxDbi P84098.
    PRIDEi P84098.

    Protocols and materials databases

    DNASUi 6143.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225430 ; ENSP00000225430 ; ENSG00000108298 .
    GeneIDi 6143.
    KEGGi hsa:6143.
    UCSCi uc002hrq.1. human.

    Organism-specific databases

    CTDi 6143.
    GeneCardsi GC17P037356.
    HGNCi HGNC:10312. RPL19.
    HPAi HPA043014.
    HPA051987.
    MIMi 180466. gene.
    neXtProti NX_P84098.
    PharmGKBi PA34681.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2147.
    HOGENOMi HOG000231277.
    HOVERGENi HBG056059.
    InParanoidi P84098.
    KOi K02885.
    OMAi YRDAGKI.
    OrthoDBi EOG75B86V.
    PhylomeDBi P84098.
    TreeFami TF313598.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPL19.
    GenomeRNAii 6143.
    NextBioi 23865.
    PROi P84098.
    SOURCEi Search...

    Gene expression databases

    Bgeei P84098.
    CleanExi HS_RPL19.
    Genevestigatori P84098.

    Family and domain databases

    Gene3Di 1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    HAMAPi MF_01475. Ribosomal_L19e.
    InterProi IPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view ]
    Pfami PF01280. Ribosomal_L19e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48140. SSF48140. 1 hit.
    PROSITEi PS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19."
      Kumabe T., Schma Y., Yamamoto T.
      Nucleic Acids Res. 20:2598-2598(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2."
      Henry J.L., Coggin D.L., King C.R.
      Cancer Res. 53:1403-1408(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Hypothalamus and Muscle.
    6. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 10-16; 22-38 AND 154-162, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND THR-187, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL19_HUMAN
    AccessioniPrimary (citable) accession number: P84098
    Secondary accession number(s): B2R4K2
    , P14118, P22908, Q502Y6, Q7Z6E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3