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Protein

60S ribosomal protein L19

Gene

RPL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 5.8S rRNA binding Source: Ensembl
  • large ribosomal subunit rRNA binding Source: Ensembl
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108298-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19
Gene namesi
Name:RPL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10312. RPL19.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6143.
OpenTargetsiENSG00000108298.
PharmGKBiPA34681.

Polymorphism and mutation databases

BioMutaiRPL19.
DMDMi51338661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001311691 – 19660S ribosomal protein L19Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5CitrullineBy similarity1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16CitrullineBy similarity1
Modified residuei38CitrullineBy similarity1
Modified residuei164PhosphoserineCombined sources1
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei187PhosphothreonineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP84098.
MaxQBiP84098.
PaxDbiP84098.
PeptideAtlasiP84098.
PRIDEiP84098.
TopDownProteomicsiP84098.

PTM databases

iPTMnetiP84098.
PhosphoSitePlusiP84098.
SwissPalmiP84098.

Expressioni

Gene expression databases

BgeeiENSG00000108298.
CleanExiHS_RPL19.
ExpressionAtlasiP84098. baseline and differential.
GenevisibleiP84098. HS.

Organism-specific databases

HPAiHPA043014.
HPA051987.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-916524,EBI-710997

Protein-protein interaction databases

BioGridi112063. 155 interactors.
IntActiP84098. 23 interactors.
MINTiMINT-1815479.
STRINGi9606.ENSP00000225430.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LR1-196[»]
4V6Xelectron microscopy5.00CR1-196[»]
5A2Qelectron microscopy3.90r162-174[»]
5AJ0electron microscopy3.50AR1-196[»]
ProteinModelPortaliP84098.
SMRiP84098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L19e family.Curated

Phylogenomic databases

eggNOGiKOG1696. Eukaryota.
COG2147. LUCA.
GeneTreeiENSGT00390000012628.
HOGENOMiHOG000231277.
HOVERGENiHBG056059.
InParanoidiP84098.
KOiK02885.
OMAiARTPQKD.
OrthoDBiEOG091G0MKY.
PhylomeDBiP84098.
TreeFamiTF313598.

Family and domain databases

CDDicd01417. Ribosomal_L19e_E. 1 hit.
Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e. 1 hit.
InterProiIPR000196. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
IPR033935. Ribosomal_L19_euka.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI
60 70 80 90 100
IRKPVTVHSR ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR
110 120 130 140 150
ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA
160 170 180 190
RKKLLADQAE ARRSKTKEAR KRREERLQAK KEEIIKTLSK EEETKK
Length:196
Mass (Da):23,466
Last modified:August 16, 2004 - v1
Checksum:i4AF506393E526216
GO

Sequence cautioni

The sequence CAD97677 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63527 mRNA. Translation: CAA45090.1.
S56985 mRNA. Translation: AAB25672.1.
AK311858 mRNA. Translation: BAG34799.1.
BX537435 mRNA. Translation: CAD97677.1. Different initiation.
BC000530 mRNA. Translation: AAH00530.1.
BC013016 mRNA. Translation: AAH13016.1.
BC062709 mRNA. Translation: AAH62709.1.
BC066315 mRNA. Translation: AAH66315.1.
BC095445 mRNA. Translation: AAH95445.1.
CCDSiCCDS42312.1.
PIRiA48992.
RefSeqiNP_000972.1. NM_000981.3.
UniGeneiHs.381061.
Hs.655411.

Genome annotation databases

EnsembliENST00000225430; ENSP00000225430; ENSG00000108298.
GeneIDi6143.
KEGGihsa:6143.
UCSCiuc002hrq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63527 mRNA. Translation: CAA45090.1.
S56985 mRNA. Translation: AAB25672.1.
AK311858 mRNA. Translation: BAG34799.1.
BX537435 mRNA. Translation: CAD97677.1. Different initiation.
BC000530 mRNA. Translation: AAH00530.1.
BC013016 mRNA. Translation: AAH13016.1.
BC062709 mRNA. Translation: AAH62709.1.
BC066315 mRNA. Translation: AAH66315.1.
BC095445 mRNA. Translation: AAH95445.1.
CCDSiCCDS42312.1.
PIRiA48992.
RefSeqiNP_000972.1. NM_000981.3.
UniGeneiHs.381061.
Hs.655411.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LR1-196[»]
4V6Xelectron microscopy5.00CR1-196[»]
5A2Qelectron microscopy3.90r162-174[»]
5AJ0electron microscopy3.50AR1-196[»]
ProteinModelPortaliP84098.
SMRiP84098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112063. 155 interactors.
IntActiP84098. 23 interactors.
MINTiMINT-1815479.
STRINGi9606.ENSP00000225430.

PTM databases

iPTMnetiP84098.
PhosphoSitePlusiP84098.
SwissPalmiP84098.

Polymorphism and mutation databases

BioMutaiRPL19.
DMDMi51338661.

Proteomic databases

EPDiP84098.
MaxQBiP84098.
PaxDbiP84098.
PeptideAtlasiP84098.
PRIDEiP84098.
TopDownProteomicsiP84098.

Protocols and materials databases

DNASUi6143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225430; ENSP00000225430; ENSG00000108298.
GeneIDi6143.
KEGGihsa:6143.
UCSCiuc002hrq.1. human.

Organism-specific databases

CTDi6143.
DisGeNETi6143.
GeneCardsiRPL19.
HGNCiHGNC:10312. RPL19.
HPAiHPA043014.
HPA051987.
MIMi180466. gene.
neXtProtiNX_P84098.
OpenTargetsiENSG00000108298.
PharmGKBiPA34681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1696. Eukaryota.
COG2147. LUCA.
GeneTreeiENSGT00390000012628.
HOGENOMiHOG000231277.
HOVERGENiHBG056059.
InParanoidiP84098.
KOiK02885.
OMAiARTPQKD.
OrthoDBiEOG091G0MKY.
PhylomeDBiP84098.
TreeFamiTF313598.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108298-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL19. human.
GeneWikiiRPL19.
GenomeRNAii6143.
PROiP84098.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108298.
CleanExiHS_RPL19.
ExpressionAtlasiP84098. baseline and differential.
GenevisibleiP84098. HS.

Family and domain databases

CDDicd01417. Ribosomal_L19e_E. 1 hit.
Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e. 1 hit.
InterProiIPR000196. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
IPR033935. Ribosomal_L19_euka.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL19_HUMAN
AccessioniPrimary (citable) accession number: P84098
Secondary accession number(s): B2R4K2
, P14118, P22908, Q502Y6, Q7Z6E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.