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Protein

Rho-related GTP-binding protein RhoG

Gene

Rhog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-5625970 RHO GTPases activate KTN1
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoG
Alternative name(s):
Sid 10750
Gene namesi
Name:Rhog
Synonyms:Arhg, Sid10750
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928370 Rhog

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420301 – 188Rho-related GTP-binding protein RhoGAdd BLAST188
PropeptideiPRO_0000042031189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphothreonineBy similarity1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP84096
PaxDbiP84096
PeptideAtlasiP84096
PRIDEiP84096

PTM databases

iPTMnetiP84096
PhosphoSitePlusiP84096

Expressioni

Gene expression databases

BgeeiENSMUSG00000073982
CleanExiMM_RHOG
ExpressionAtlasiP84096 baseline and differential
GenevisibleiP84096 MM

Interactioni

Subunit structurei

Interacts with ARHGEF26. Interacts with ARHGEF16 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207846, 2 interactors
CORUMiP84096
IntActiP84096, 2 interactors
MINTiP84096
STRINGi10090.ENSMUSP00000095832

Structurei

3D structure databases

ProteinModelPortaliP84096
SMRiP84096
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP84096
KOiK07863
OMAiHCPDAPV
OrthoDBiEOG091G0KCM
PhylomeDBiP84096
TreeFamiTF101109

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT
60 70 80 90 100
VNLNLWDTAG QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE
110 120 130 140 150
VCHHCPDVPI LLVGTKKDLR AQPDTLRRLK EQGQAPITPQ QGQALAKQIH
160 170 180 190
AVRYLECSAL QQDGVKEVFA EAVRAVLNPT PIKRGRSCIL L
Length:191
Mass (Da):21,309
Last modified:August 16, 2004 - v1
Checksum:i0C4FE9C54140F499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025943 mRNA Translation: BAA84696.1
BC059775 mRNA Translation: AAH59775.1
CCDSiCCDS21529.1
RefSeqiNP_062512.1, NM_019566.3
UniGeneiMm.259795

Genome annotation databases

EnsembliENSMUST00000098230; ENSMUSP00000095832; ENSMUSG00000073982
ENSMUST00000106923; ENSMUSP00000102536; ENSMUSG00000073982
GeneIDi56212
KEGGimmu:56212
UCSCiuc009irk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRHOG_MOUSE
AccessioniPrimary (citable) accession number: P84096
Secondary accession number(s): P35238, Q8NI04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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