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Protein

Rho-related GTP-binding protein RhoG

Gene

Rhog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-416572. Sema4D induced cell migration and growth-cone collapse.
R-MMU-5625970. RHO GTPases activate KTN1.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoG
Alternative name(s):
Sid 10750
Gene namesi
Name:Rhog
Synonyms:Arhg, Sid10750
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928370. Rhog.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420301 – 188Rho-related GTP-binding protein RhoGAdd BLAST188
PropeptideiPRO_0000042031189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphothreonineBy similarity1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP84096.
PaxDbiP84096.
PeptideAtlasiP84096.
PRIDEiP84096.

PTM databases

iPTMnetiP84096.
PhosphoSitePlusiP84096.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073982.
CleanExiMM_RHOG.
ExpressionAtlasiP84096. baseline and differential.
GenevisibleiP84096. MM.

Interactioni

Subunit structurei

Interacts with ARHGEF26. Interacts with ARHGEF16 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207846. 1 interactor.
IntActiP84096. 2 interactors.
MINTiMINT-4132387.
STRINGi10090.ENSMUSP00000095832.

Structurei

3D structure databases

ProteinModelPortaliP84096.
SMRiP84096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP84096.
KOiK07863.
OMAiRQIRAVK.
OrthoDBiEOG091G0KCM.
PhylomeDBiP84096.
TreeFamiTF101109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT
60 70 80 90 100
VNLNLWDTAG QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE
110 120 130 140 150
VCHHCPDVPI LLVGTKKDLR AQPDTLRRLK EQGQAPITPQ QGQALAKQIH
160 170 180 190
AVRYLECSAL QQDGVKEVFA EAVRAVLNPT PIKRGRSCIL L
Length:191
Mass (Da):21,309
Last modified:August 16, 2004 - v1
Checksum:i0C4FE9C54140F499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025943 mRNA. Translation: BAA84696.1.
BC059775 mRNA. Translation: AAH59775.1.
CCDSiCCDS21529.1.
RefSeqiNP_062512.1. NM_019566.3.
UniGeneiMm.259795.

Genome annotation databases

EnsembliENSMUST00000098230; ENSMUSP00000095832; ENSMUSG00000073982.
ENSMUST00000106923; ENSMUSP00000102536; ENSMUSG00000073982.
GeneIDi56212.
KEGGimmu:56212.
UCSCiuc009irk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025943 mRNA. Translation: BAA84696.1.
BC059775 mRNA. Translation: AAH59775.1.
CCDSiCCDS21529.1.
RefSeqiNP_062512.1. NM_019566.3.
UniGeneiMm.259795.

3D structure databases

ProteinModelPortaliP84096.
SMRiP84096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207846. 1 interactor.
IntActiP84096. 2 interactors.
MINTiMINT-4132387.
STRINGi10090.ENSMUSP00000095832.

PTM databases

iPTMnetiP84096.
PhosphoSitePlusiP84096.

Proteomic databases

EPDiP84096.
PaxDbiP84096.
PeptideAtlasiP84096.
PRIDEiP84096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098230; ENSMUSP00000095832; ENSMUSG00000073982.
ENSMUST00000106923; ENSMUSP00000102536; ENSMUSG00000073982.
GeneIDi56212.
KEGGimmu:56212.
UCSCiuc009irk.1. mouse.

Organism-specific databases

CTDi391.
MGIiMGI:1928370. Rhog.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP84096.
KOiK07863.
OMAiRQIRAVK.
OrthoDBiEOG091G0KCM.
PhylomeDBiP84096.
TreeFamiTF101109.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-416572. Sema4D induced cell migration and growth-cone collapse.
R-MMU-5625970. RHO GTPases activate KTN1.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP84096.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073982.
CleanExiMM_RHOG.
ExpressionAtlasiP84096. baseline and differential.
GenevisibleiP84096. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHOG_MOUSE
AccessioniPrimary (citable) accession number: P84096
Secondary accession number(s): P35238, Q8NI04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.