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Reviewed, UniProtKB/Swiss-Prot P84095 (RHOG_HUMAN)

Last modified November 25, 2008. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Rho-related GTP-binding protein RhoG
Gene names
Name: RHOG
Synonyms: ARHG
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Subunit structure

Interacts with SGEF.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ELMO1Q925562EBI-446579,EBI-346417

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Rho-related GTP-binding protein RhoG
PRO_0000042028
Propeptide189 – 1913Removed in mature form By similarity
PRO_0000042029

Regions

Nucleotide binding10 – 178GTP By similarity
Nucleotide binding57 – 615GTP By similarity
Nucleotide binding115 – 1184GTP By similarity
Motif32 – 409Effector region Potential

Amino acid modifications

Modified residue391ADP-ribosylasparagine; by botulinum toxin By similarity
Modified residue1881Cysteine methyl ester By similarity
Lipidation1881S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict1331G → S in CAA43784. Ref.1
Sequence conflict1691F → L in AAM21121. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P84095-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 0C4FE9C54140F499

FASTA19121,309
        10         20         30         40         50         60 
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT VNLNLWDTAG 

        70         80         90        100        110        120 
QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE VCHHCPDVPI LLVGTKKDLR 

       130        140        150        160        170        180 
AQPDTLRRLK EQGQAPITPQ QGQALAKQIH AVRYLECSAL QQDGVKEVFA EAVRAVLNPT 

       190 
PIKRGRSCIL L 

« Hide

References

« Hide 'large scale' references
[1]"Growth-regulated expression of rhoG, a new member of the ras homolog gene family."
Vincent S., Jeanteur P., Fort P.
Mol. Cell. Biol. 12:3138-3148(1992) [PubMed: 1620121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Oncogene ect2 is related to regulators of small GTP-binding proteins."
Miki T., Smith C.L., Long J.E., Eva A., Fleming T.P.
Nature 362:462-465(1993) [PubMed: 8464478] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis."
Ellerbroek S.M., Wennerberg K., Arthur W.T., Dunty J.M., Bowman D.R., DeMali K.A., Der C., Burridge K.
Mol. Biol. Cell 15:3309-3319(2004) [PubMed: 15133129] [Abstract]
Cited for: INTERACTION WITH SGEF, FUNCTION.
[5]"Differential activation and function of Rho GTPases during Salmonella-host cell interactions."
Patel J.C., Galan J.E.
J. Cell Biol. 175:453-463(2006) [PubMed: 17074883] [Abstract]
Cited for: FUNCTION.
[6]"RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
van Buul J.D., Allingham M.J., Samson T., Meller J., Boulter E., Garcia-Mata R., Burridge K.
J. Cell Biol. 178:1279-1293(2007) [PubMed: 17875742] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

L11317 mRNA. Translation: AAA60268.1.
X61587 mRNA. Translation: CAA43784.1.
AF498974 mRNA. Translation: AAM21121.1.
AY563952 mRNA. Translation: AAS75333.1.
PIRTVHURG. S25722.
RefSeqNP_001656.2.
UniGeneHs.501728
Hs.705620

3D structure databases

HSSPHSSP built from PDB template 1AM4 based on UniProtKB P21181.
SMRP84095. Positions 1-177.
ModBaseSearch...

Protein-protein interaction databases

IntActP84095.

PTM databases

PhosphoSiteP84095.

Proteomic databases

PeptideAtlasP84095.

Genome annotation databases

EnsemblENSG00000177105. Homo sapiens. [Contig view]
GeneID391.
KEGGhsa:391.

Organism-specific databases

H-InvDBHIX0035905.
HGNCHGNC:672. RHOG.
MIM179505. gene.
PharmGKBPA24955.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP84095.
HOVERGENP84095.

Enzyme and pathway databases

ReactomeREACT_11044. Signaling by Rho GTPases.

Gene expression databases

CleanExHS_RHOG.
GermOnlineENSG00000177105. Homo sapiens.

Family and domain databases

InterProIPR003578. GTPase_Rho.
IPR013753. Ras.
IPR001806. Ras_trnsfrmng.
IPR005225. Small_GTP_bd.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Other Resources

LinkHubP84095.
NextBio1631.
SOURCESearch...

Entry information

Entry nameRHOG_HUMAN
AccessionPrimary (citable) accession number: P84095
Secondary accession number(s): P35238, Q8NI04
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents