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P84095 (RHOG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related GTP-binding protein RhoG
Gene names
Name:RHOG
Synonyms:ARHG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. Ref.4 Ref.5 Ref.6 Ref.7

Subunit structure

Interacts with ARHGEF26. Interacts with ARHGEF16. Ref.4 Ref.7

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   LigandGTP-binding
Nucleotide-binding
   PTMADP-ribosylation
Lipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from direct assay PubMed 12376551. Source: GOC

Rac protein signal transduction

Inferred from direct assay PubMed 12376551. Source: MGI

Rho protein signal transduction

Inferred from direct assay PubMed 12376551. Source: MGI

actin cytoskeleton organization

Inferred from direct assay PubMed 12545154. Source: MGI

activation of Rac GTPase activity

Inferred from mutant phenotype Ref.7. Source: UniProtKB

axon guidance

Traceable author statement. Source: Reactome

blood coagulation

Traceable author statement. Source: Reactome

cell chemotaxis

Inferred from mutant phenotype Ref.7. Source: UniProtKB

platelet activation

Traceable author statement. Source: Reactome

positive regulation of cell proliferation

Traceable author statement Ref.1. Source: ProtInc

positive regulation of establishment of protein localization to plasma membrane

Inferred from mutant phenotype Ref.7. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12545154. Source: MGI

regulation of small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 20458337PubMed 23376485. Source: UniProt

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from direct assay PubMed 12376551. Source: MGI

protein binding

Inferred from physical interaction Ref.7. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ELMO1Q925563EBI-446579,EBI-346417

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Rho-related GTP-binding protein RhoG
PRO_0000042028
Propeptide189 – 1913Removed in mature form By similarity
PRO_0000042029

Regions

Nucleotide binding10 – 178GTP By similarity
Nucleotide binding57 – 615GTP By similarity
Nucleotide binding115 – 1184GTP By similarity
Motif32 – 409Effector region Potential

Amino acid modifications

Modified residue391ADP-ribosylasparagine; by botulinum toxin By similarity
Modified residue1881Cysteine methyl ester By similarity
Lipidation1881S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict1331G → S in CAA43784. Ref.1
Sequence conflict1691F → L in AAM21121. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P84095 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 0C4FE9C54140F499

FASTA19121,309
        10         20         30         40         50         60 
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT VNLNLWDTAG 

        70         80         90        100        110        120 
QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE VCHHCPDVPI LLVGTKKDLR 

       130        140        150        160        170        180 
AQPDTLRRLK EQGQAPITPQ QGQALAKQIH AVRYLECSAL QQDGVKEVFA EAVRAVLNPT 

       190 
PIKRGRSCIL L 

« Hide

References

« Hide 'large scale' references
[1]"Growth-regulated expression of rhoG, a new member of the ras homolog gene family."
Vincent S., Jeanteur P., Fort P.
Mol. Cell. Biol. 12:3138-3148(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Oncogene ect2 is related to regulators of small GTP-binding proteins."
Miki T., Smith C.L., Long J.E., Eva A., Fleming T.P.
Nature 362:462-465(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis."
Ellerbroek S.M., Wennerberg K., Arthur W.T., Dunty J.M., Bowman D.R., DeMali K.A., Der C., Burridge K.
Mol. Biol. Cell 15:3309-3319(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARHGEF26, FUNCTION.
[5]"Differential activation and function of Rho GTPases during Salmonella-host cell interactions."
Patel J.C., Galan J.E.
J. Cell Biol. 175:453-463(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
van Buul J.D., Allingham M.J., Samson T., Meller J., Boulter E., Garcia-Mata R., Burridge K.
J. Cell Biol. 178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism."
Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H.
J. Cell Biol. 190:461-477(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ARHGEF16.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11317 mRNA. Translation: AAA60268.1.
X61587 mRNA. Translation: CAA43784.1.
AF498974 mRNA. Translation: AAM21121.1.
AY563952 mRNA. Translation: AAS75333.1.
CCDSCCDS7748.1.
PIRTVHURG. S25722.
RefSeqNP_001656.2. NM_001665.3.
XP_005252973.1. XM_005252916.1.
UniGeneHs.501728.

3D structure databases

ProteinModelPortalP84095.
SMRP84095. Positions 1-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106884. 10 interactions.
IntActP84095. 2 interactions.
MINTMINT-4132365.
STRING9606.ENSP00000339467.

PTM databases

PhosphoSiteP84095.

Polymorphism databases

DMDM51338611.

Proteomic databases

MaxQBP84095.
PaxDbP84095.
PeptideAtlasP84095.
PRIDEP84095.

Protocols and materials databases

DNASU391.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000351018; ENSP00000339467; ENSG00000177105.
ENST00000396978; ENSP00000380175; ENSG00000177105.
ENST00000396979; ENSP00000380176; ENSG00000177105.
ENST00000533217; ENSP00000436932; ENSG00000177105.
GeneID391.
KEGGhsa:391.
UCSCuc001lyu.2. human.

Organism-specific databases

CTD391.
GeneCardsGC11M003848.
HGNCHGNC:672. RHOG.
HPAHPA039871.
MIM179505. gene.
neXtProtNX_P84095.
PharmGKBPA24955.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233974.
HOVERGENHBG009351.
InParanoidP84095.
KOK07863.
OMAKRGRSCF.
OrthoDBEOG764747.
PhylomeDBP84095.
TreeFamTF101109.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressP84095.
BgeeP84095.
CleanExHS_RHOG.
GenevestigatorP84095.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRHOG. human.
GeneWikiRhoG.
GenomeRNAi391.
NextBio1631.
PROP84095.
SOURCESearch...

Entry information

Entry nameRHOG_HUMAN
AccessionPrimary (citable) accession number: P84095
Secondary accession number(s): P35238, Q8NI04
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM