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Protein

Rho-related GTP-binding protein RhoG

Gene

RHOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • activation of GTPase activity Source: UniProtKB
  • cell chemotaxis Source: UniProtKB
  • platelet activation Source: Reactome
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
  • Rac protein signal transduction Source: MGI
  • regulation of ruffle assembly Source: Ensembl
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177105-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625970. RHO GTPases activate KTN1.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoG
Gene namesi
Name:RHOG
Synonyms:ARHG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:672. RHOG.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi391.
OpenTargetsiENSG00000177105.
PharmGKBiPA24955.

Polymorphism and mutation databases

BioMutaiRHOG.
DMDMi51338611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420281 – 188Rho-related GTP-binding protein RhoGAdd BLAST188
PropeptideiPRO_0000042029189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39ADP-ribosylasparagine; by botulinum toxinBy similarity1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei180PhosphothreonineCombined sources1
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP84095.
PaxDbiP84095.
PeptideAtlasiP84095.
PRIDEiP84095.

PTM databases

iPTMnetiP84095.
PhosphoSitePlusiP84095.
SwissPalmiP84095.

Expressioni

Gene expression databases

BgeeiENSG00000177105.
CleanExiHS_RHOG.
ExpressionAtlasiP84095. baseline and differential.
GenevisibleiP84095. HS.

Organism-specific databases

HPAiHPA039871.

Interactioni

Subunit structurei

Interacts with ARHGEF26. Interacts with ARHGEF16.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ELMO1Q925563EBI-446579,EBI-346417

Protein-protein interaction databases

BioGridi106884. 14 interactors.
IntActiP84095. 5 interactors.
MINTiMINT-4132365.
STRINGi9606.ENSP00000339467.

Structurei

3D structure databases

ProteinModelPortaliP84095.
SMRiP84095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP84095.
KOiK07863.
OMAiRQIRAVK.
OrthoDBiEOG091G0KCM.
PhylomeDBiP84095.
TreeFamiTF101109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT
60 70 80 90 100
VNLNLWDTAG QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE
110 120 130 140 150
VCHHCPDVPI LLVGTKKDLR AQPDTLRRLK EQGQAPITPQ QGQALAKQIH
160 170 180 190
AVRYLECSAL QQDGVKEVFA EAVRAVLNPT PIKRGRSCIL L
Length:191
Mass (Da):21,309
Last modified:August 16, 2004 - v1
Checksum:i0C4FE9C54140F499
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133G → S in CAA43784 (PubMed:1620121).Curated1
Sequence conflicti169F → L in AAM21121 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11317 mRNA. Translation: AAA60268.1.
X61587 mRNA. Translation: CAA43784.1.
AF498974 mRNA. Translation: AAM21121.1.
AY563952 mRNA. Translation: AAS75333.1.
CCDSiCCDS7748.1.
PIRiS25722. TVHURG.
RefSeqiNP_001656.2. NM_001665.3.
XP_005252973.1. XM_005252916.2.
XP_016873208.1. XM_017017719.1.
UniGeneiHs.501728.

Genome annotation databases

EnsembliENST00000351018; ENSP00000339467; ENSG00000177105.
ENST00000396978; ENSP00000380175; ENSG00000177105.
ENST00000396979; ENSP00000380176; ENSG00000177105.
ENST00000533217; ENSP00000436932; ENSG00000177105.
GeneIDi391.
KEGGihsa:391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11317 mRNA. Translation: AAA60268.1.
X61587 mRNA. Translation: CAA43784.1.
AF498974 mRNA. Translation: AAM21121.1.
AY563952 mRNA. Translation: AAS75333.1.
CCDSiCCDS7748.1.
PIRiS25722. TVHURG.
RefSeqiNP_001656.2. NM_001665.3.
XP_005252973.1. XM_005252916.2.
XP_016873208.1. XM_017017719.1.
UniGeneiHs.501728.

3D structure databases

ProteinModelPortaliP84095.
SMRiP84095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106884. 14 interactors.
IntActiP84095. 5 interactors.
MINTiMINT-4132365.
STRINGi9606.ENSP00000339467.

PTM databases

iPTMnetiP84095.
PhosphoSitePlusiP84095.
SwissPalmiP84095.

Polymorphism and mutation databases

BioMutaiRHOG.
DMDMi51338611.

Proteomic databases

EPDiP84095.
PaxDbiP84095.
PeptideAtlasiP84095.
PRIDEiP84095.

Protocols and materials databases

DNASUi391.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351018; ENSP00000339467; ENSG00000177105.
ENST00000396978; ENSP00000380175; ENSG00000177105.
ENST00000396979; ENSP00000380176; ENSG00000177105.
ENST00000533217; ENSP00000436932; ENSG00000177105.
GeneIDi391.
KEGGihsa:391.

Organism-specific databases

CTDi391.
DisGeNETi391.
GeneCardsiRHOG.
HGNCiHGNC:672. RHOG.
HPAiHPA039871.
MIMi179505. gene.
neXtProtiNX_P84095.
OpenTargetsiENSG00000177105.
PharmGKBiPA24955.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP84095.
KOiK07863.
OMAiRQIRAVK.
OrthoDBiEOG091G0KCM.
PhylomeDBiP84095.
TreeFamiTF101109.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177105-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625970. RHO GTPases activate KTN1.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiRHOG. human.
GeneWikiiRhoG.
GenomeRNAii391.
PROiP84095.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177105.
CleanExiHS_RHOG.
ExpressionAtlasiP84095. baseline and differential.
GenevisibleiP84095. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHOG_HUMAN
AccessioniPrimary (citable) accession number: P84095
Secondary accession number(s): P35238, Q8NI04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.