P84090 (ERH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enhancer of rudimentary homolog

Gene names

Name:

ERH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a role in the cell cycle.
Subunit structure	Homodimer By similarity. Interacts with POLDIP3. Ref.10
Tissue specificity	Expressed in all tissues examined. Ref.1
Sequence similarities	Belongs to the E(R) family.

Ontologies

Keywords
Biological process	Cell cycle
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW pyrimidine nucleoside metabolic process Traceable author statement. Source: ProtInc
Cellular component	midbody Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.8

Chain

2 – 104

103

Enhancer of rudimentary homolog

PRO_0000219351

Amino acid modifications

Modified residue

2

1

N-acetylserine Ref.8

Modified residue

12

1

N6-acetyllysine Ref.11

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

104

Helix Strand Turn

Details...

Beta strand

4 – 9

6

Helix

14 – 16

3

Beta strand

18 – 24

7

Helix

25 – 43

19

Helix

54 – 63

10

Beta strand

64 – 73

10

Turn

74 – 77

4

Beta strand

78 – 82

5

Helix

84 – 101

18

Sequences

	Sequence		Length	Mass (Da)
	P84090 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: C609AFF7F63E5279	FASTA	104	12,259
	10 20 30 40 50 60 MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF 70 80 90 100 IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene." Isomura M., Okui K., Fujiwara T., Shin S., Nakamura Y. Genomics 32:125-127(1996) [PubMed: 8786099] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals." Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I. Gene 186:189-195(1997) [PubMed: 9074495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[8]	Bienvenut W.V., Matallanas D., Cooper W.N., Lilla S., von Kriegsheim A., Lempens A., Kolch W. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-12 AND 74-88, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Tissue: Mammary carcinoma and Ovarian carcinoma.
[9]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 18-34; 74-84 AND 91-96, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[10]	"Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth." Smyk A., Szuminska M., Uniewicz K.A., Graves L.M., Kozlowski P. FEBS J. 273:4728-4741(2006) [PubMed: 16984396] [Abstract] Cited for: INTERACTION WITH POLDIP3.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-12, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Structure of the conserved transcriptional repressor enhancer of rudimentary homolog." Wan C., Tempel W., Liu Z.J., Wang B.C., Rose R.B. Biochemistry 44:5017-5023(2005) [PubMed: 15794639] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D85758 mRNA. Translation: BAA12865.1.
U66871 mRNA. Translation: AAC51172.1.
BT006877 mRNA. Translation: AAP35523.1.
AK312186 mRNA. Translation: BAG35119.1.
CH471061 Genomic DNA. Translation: EAW80989.1.
BC014301 mRNA. Translation: AAH14301.1.
BC071709 mRNA. Translation: AAH71709.1.
CR450298 mRNA. Translation: CAG29294.1.
CR542178 mRNA. Translation: CAG46975.1.

IPI

IPI00029631.

RefSeq

NP_004441.1. NM_004450.2.

UniGene

Hs.509791.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1W9G	X-ray	2.00	A/B	1-104	[»]
2NML	X-ray	1.55	A	1-104	[»]

ProteinModelPortal

P84090.

SMR

P84090. Positions 1-102.

ModBase

Search...

Protein-protein interaction databases

IntAct

P84090. 15 interactions.

MINT

MINT-1217007.

STRING

P84090.

PTM databases

PhosphoSite

P84090.

Polymorphism databases

DMDM

51317296.

Proteomic databases

PeptideAtlas

P84090.

PRIDE

P84090.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000216520; ENSP00000216520; ENSG00000100632.

GeneID

2079.

KEGG

hsa:2079.

UCSC

uc001xlc.1. human.

Organism-specific databases

CTD

2079.

GeneCards

GC14M069846.

H-InvDB

HIX0011766.

HGNC

HGNC:3447. ERH.

HPA

HPA002567.

MIM

601191. gene.

neXtProt

NX_P84090.

PharmGKB

PA27859.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG20713.

GeneTree

ENSGT00390000003316.

HOGENOM

HBG630438.

HOVERGEN

HBG000348.

InParanoid

P84090.

OMA

NIESRSW.

OrthoDB

EOG41G35M.

PhylomeDB

P84090.

Gene expression databases

ArrayExpress

P84090.

Bgee

P84090.

CleanEx

HS_ERH.

Genevestigator

P84090.

GermOnline

ENSG00000100632. Homo sapiens.

Family and domain databases

InterPro

IPR000781. Enh_rudimentary.
[Graphical view]

PANTHER

PTHR12373. Enh_rudimentary. 1 hit.

Pfam

PF01133. ER. 1 hit.
[Graphical view]

PIRSF

PIRSF016393. Enh_rudimentary. 1 hit.

ProDom

PD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS01290. ER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

8453.

SOURCE

Search...

Entry information

Entry name

ERH_HUMAN

Accession

Primary (citable) accession number: P84090
Secondary accession number(s): B2R5H2, P70659, Q14259

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.