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Protein

Enhancer of rudimentary homolog

Gene

ERH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in the cell cycle.

GO - Molecular functioni

  • methyl-CpG binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of rudimentary homolog
Gene namesi
Name:ERH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:3447. ERH.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: Ensembl
  • methylosome Source: UniProtKB
  • midbody Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi2079.
OpenTargetsiENSG00000100632.
PharmGKBiPA27859.

Polymorphism and mutation databases

BioMutaiERH.
DMDMi51317296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002193512 – 104Enhancer of rudimentary homologAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei11PhosphothreonineCombined sources1
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP84090.
MaxQBiP84090.
PaxDbiP84090.
PeptideAtlasiP84090.
PRIDEiP84090.
TopDownProteomicsiP84090.

PTM databases

iPTMnetiP84090.
PhosphoSitePlusiP84090.

Expressioni

Tissue specificityi

Expressed in all tissues examined.1 Publication

Gene expression databases

BgeeiENSG00000100632.
CleanExiHS_ERH.
ExpressionAtlasiP84090. baseline and differential.
GenevisibleiP84090. HS.

Organism-specific databases

HPAiHPA002567.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with POLDIP3. Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with CHTOP (PubMed:25284789).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CHTOPQ9Y3Y23EBI-711389,EBI-347794
FAM208BQ5VWN63EBI-711389,EBI-745958
FAM208BQ5VWN6-23EBI-711389,EBI-10172380

Protein-protein interaction databases

BioGridi108390. 47 interactors.
DIPiDIP-42473N.
IntActiP84090. 25 interactors.
MINTiMINT-1217007.
STRINGi9606.ENSP00000451080.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi14 – 16Combined sources3
Beta strandi18 – 24Combined sources7
Helixi25 – 43Combined sources19
Helixi54 – 63Combined sources10
Beta strandi64 – 73Combined sources10
Turni74 – 77Combined sources4
Beta strandi78 – 82Combined sources5
Helixi84 – 100Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W9GX-ray2.00A/B1-104[»]
2NMLX-ray1.55A1-104[»]
ProteinModelPortaliP84090.
SMRiP84090.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84090.

Family & Domainsi

Sequence similaritiesi

Belongs to the E(R) family.Curated

Phylogenomic databases

eggNOGiKOG1766. Eukaryota.
ENOG4111Z48. LUCA.
GeneTreeiENSGT00390000003316.
HOGENOMiHOG000246458.
HOVERGENiHBG000348.
InParanoidiP84090.
OMAiRTWSDYE.
OrthoDBiEOG091G1CHJ.
PhylomeDBiP84090.
TreeFamiTF314568.

Family and domain databases

InterProiIPR000781. Enh_rudimentary.
[Graphical view]
PANTHERiPTHR12373. PTHR12373. 1 hit.
PfamiPF01133. ER. 1 hit.
[Graphical view]
PIRSFiPIRSF016393. Enh_rudimentary. 1 hit.
ProDomiPD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143875. SSF143875. 1 hit.
PROSITEiPS01290. ER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI
60 70 80 90 100
TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ

QAGK
Length:104
Mass (Da):12,259
Last modified:August 16, 2004 - v1
Checksum:iC609AFF7F63E5279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85758 mRNA. Translation: BAA12865.1.
U66871 mRNA. Translation: AAC51172.1.
BT006877 mRNA. Translation: AAP35523.1.
AK312186 mRNA. Translation: BAG35119.1.
CH471061 Genomic DNA. Translation: EAW80989.1.
BC014301 mRNA. Translation: AAH14301.1.
BC071709 mRNA. Translation: AAH71709.1.
CR450298 mRNA. Translation: CAG29294.1.
CR542178 mRNA. Translation: CAG46975.1.
CCDSiCCDS9794.1.
RefSeqiNP_004441.1. NM_004450.2.
UniGeneiHs.509791.

Genome annotation databases

EnsembliENST00000557016; ENSP00000451080; ENSG00000100632.
GeneIDi2079.
KEGGihsa:2079.
UCSCiuc001xlc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85758 mRNA. Translation: BAA12865.1.
U66871 mRNA. Translation: AAC51172.1.
BT006877 mRNA. Translation: AAP35523.1.
AK312186 mRNA. Translation: BAG35119.1.
CH471061 Genomic DNA. Translation: EAW80989.1.
BC014301 mRNA. Translation: AAH14301.1.
BC071709 mRNA. Translation: AAH71709.1.
CR450298 mRNA. Translation: CAG29294.1.
CR542178 mRNA. Translation: CAG46975.1.
CCDSiCCDS9794.1.
RefSeqiNP_004441.1. NM_004450.2.
UniGeneiHs.509791.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W9GX-ray2.00A/B1-104[»]
2NMLX-ray1.55A1-104[»]
ProteinModelPortaliP84090.
SMRiP84090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108390. 47 interactors.
DIPiDIP-42473N.
IntActiP84090. 25 interactors.
MINTiMINT-1217007.
STRINGi9606.ENSP00000451080.

PTM databases

iPTMnetiP84090.
PhosphoSitePlusiP84090.

Polymorphism and mutation databases

BioMutaiERH.
DMDMi51317296.

Proteomic databases

EPDiP84090.
MaxQBiP84090.
PaxDbiP84090.
PeptideAtlasiP84090.
PRIDEiP84090.
TopDownProteomicsiP84090.

Protocols and materials databases

DNASUi2079.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000557016; ENSP00000451080; ENSG00000100632.
GeneIDi2079.
KEGGihsa:2079.
UCSCiuc001xlc.3. human.

Organism-specific databases

CTDi2079.
DisGeNETi2079.
GeneCardsiERH.
HGNCiHGNC:3447. ERH.
HPAiHPA002567.
MIMi601191. gene.
neXtProtiNX_P84090.
OpenTargetsiENSG00000100632.
PharmGKBiPA27859.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1766. Eukaryota.
ENOG4111Z48. LUCA.
GeneTreeiENSGT00390000003316.
HOGENOMiHOG000246458.
HOVERGENiHBG000348.
InParanoidiP84090.
OMAiRTWSDYE.
OrthoDBiEOG091G1CHJ.
PhylomeDBiP84090.
TreeFamiTF314568.

Miscellaneous databases

ChiTaRSiERH. human.
EvolutionaryTraceiP84090.
GeneWikiiERH_(gene).
GenomeRNAii2079.
PROiP84090.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100632.
CleanExiHS_ERH.
ExpressionAtlasiP84090. baseline and differential.
GenevisibleiP84090. HS.

Family and domain databases

InterProiIPR000781. Enh_rudimentary.
[Graphical view]
PANTHERiPTHR12373. PTHR12373. 1 hit.
PfamiPF01133. ER. 1 hit.
[Graphical view]
PIRSFiPIRSF016393. Enh_rudimentary. 1 hit.
ProDomiPD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143875. SSF143875. 1 hit.
PROSITEiPS01290. ER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERH_HUMAN
AccessioniPrimary (citable) accession number: P84090
Secondary accession number(s): B2R5H2, P70659, Q14259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.