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P84090 (ERH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enhancer of rudimentary homolog
Gene names
Name:ERH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in the cell cycle.

Subunit structure

Homodimer By similarity. Interacts with POLDIP3. Ref.10

Tissue specificity

Expressed in all tissues examined. Ref.1

Sequence similarities

Belongs to the E(R) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 104103Enhancer of rudimentary homolog
PRO_0000219351

Amino acid modifications

Modified residue21N-acetylserine Ref.8 Ref.11 Ref.13

Secondary structure

............... 104
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P84090 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: C609AFF7F63E5279

FASTA10412,259
        10         20         30         40         50         60 
MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF 

        70         80         90        100 
IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene."
Isomura M., Okui K., Fujiwara T., Shin S., Nakamura Y.
Genomics 32:125-127(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals."
Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I.
Gene 186:189-195(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[8]Bienvenut W.V., Matallanas D., Cooper W.N., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-12 AND 74-88, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Mammary carcinoma and Ovarian carcinoma.
[9]Lubec G., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-34; 74-84 AND 91-96, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Fetal brain cortex.
[10]"Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth."
Smyk A., Szuminska M., Uniewicz K.A., Graves L.M., Kozlowski P.
FEBS J. 273:4728-4741(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH POLDIP3.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Structure of the conserved transcriptional repressor enhancer of rudimentary homolog."
Wan C., Tempel W., Liu Z.J., Wang B.C., Rose R.B.
Biochemistry 44:5017-5023(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D85758 mRNA. Translation: BAA12865.1.
U66871 mRNA. Translation: AAC51172.1.
BT006877 mRNA. Translation: AAP35523.1.
AK312186 mRNA. Translation: BAG35119.1.
CH471061 Genomic DNA. Translation: EAW80989.1.
BC014301 mRNA. Translation: AAH14301.1.
BC071709 mRNA. Translation: AAH71709.1.
CR450298 mRNA. Translation: CAG29294.1.
CR542178 mRNA. Translation: CAG46975.1.
CCDSCCDS9794.1.
RefSeqNP_004441.1. NM_004450.2.
UniGeneHs.509791.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1W9GX-ray2.00A/B1-104[»]
2NMLX-ray1.55A1-104[»]
ProteinModelPortalP84090.
SMRP84090. Positions 1-102.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108390. 43 interactions.
DIPDIP-42473N.
IntActP84090. 22 interactions.
MINTMINT-1217007.
STRING9606.ENSP00000216520.

PTM databases

PhosphoSiteP84090.

Polymorphism databases

DMDM51317296.

Proteomic databases

MaxQBP84090.
PaxDbP84090.
PeptideAtlasP84090.
PRIDEP84090.

Protocols and materials databases

DNASU2079.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000557016; ENSP00000451080; ENSG00000100632.
GeneID2079.
KEGGhsa:2079.
UCSCuc001xlc.2. human.

Organism-specific databases

CTD2079.
GeneCardsGC14M069846.
HGNCHGNC:3447. ERH.
HPAHPA002567.
MIM601191. gene.
neXtProtNX_P84090.
PharmGKBPA27859.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317332.
HOGENOMHOG000246458.
HOVERGENHBG000348.
InParanoidP84090.
OMAHTIILLQ.
OrthoDBEOG7H4DWR.
PhylomeDBP84090.
TreeFamTF314568.

Gene expression databases

ArrayExpressP84090.
BgeeP84090.
CleanExHS_ERH.
GenevestigatorP84090.

Family and domain databases

InterProIPR000781. Enh_rudimentary.
[Graphical view]
PANTHERPTHR12373. PTHR12373. 1 hit.
PfamPF01133. ER. 1 hit.
[Graphical view]
PIRSFPIRSF016393. Enh_rudimentary. 1 hit.
ProDomPD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01290. ER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSERH. human.
EvolutionaryTraceP84090.
GeneWikiERH_(gene).
GenomeRNAi2079.
NextBio8453.
PROP84090.
SOURCESearch...

Entry information

Entry nameERH_HUMAN
AccessionPrimary (citable) accession number: P84090
Secondary accession number(s): B2R5H2, P70659, Q14259
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM