Reviewed, UniProtKB/Swiss-Prot P84090 (ERH_HUMAN)

Names and origin

Protein names

Recommended name:
    Enhancer of rudimentary homolog

Gene names

Name:

ERH

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May have a role in the cell cycle.
Subunit structure	Homodimer By similarity.
Tissue specificity	Expressed in all tissues examined. Ref.1
Sequence similarities	Belongs to the E(R) family.

Ontologies

Keywords
Biological process	Cell cycle
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW pyrimidine nucleoside metabolic process Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNBP	P62633	1	EBI-711389,EBI-1047529
EIF1B	O60739	1	EBI-711389,EBI-1043343
ILK	Q13418	1	EBI-711389,EBI-747644

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.6

Chain

2 – 104

103

Enhancer of rudimentary homolog

PRO_0000219351

Amino acid modifications

Modified residue

2

1

N-acetylserine Ref.6

Secondary structure

1

.

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.

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104

Helix Strand Turn

Details...

Beta strand

4 – 9

6

Helix

14 – 16

3

Beta strand

18 – 24

7

Helix

25 – 43

19

Helix

54 – 63

10

Beta strand

64 – 73

10

Turn

74 – 77

4

Beta strand

78 – 82

5

Helix

84 – 101

18

Sequences

	Sequence		Length	Mass (Da)
	P84090-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: C609AFF7F63E5279	FASTA	104	12,259
	10 20 30 40 50 60 MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF 70 80 90 100 IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene." Isomura M., Okui K., Fujiwara T., Shin S., Nakamura Y. Genomics 32:125-127(1996) [PubMed: 8786099] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals." Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I. Gene 186:189-195(1997) [PubMed: 9074495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	Bienvenut W.V., Matallanas D., Cooper W.N., Lilla S., von Kriegsheim A., Lempens A., Kolch W. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-12 AND 74-88, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Tissue: Mammary carcinoma and Ovarian carcinoma.
[7]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 18-34; 74-84 AND 91-96, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]	"Structure of the conserved transcriptional repressor enhancer of rudimentary homolog." Wan C., Tempel W., Liu Z.J., Wang B.C., Rose R.B. Biochemistry 44:5017-5023(2005) [PubMed: 15794639] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

D85758 mRNA. Translation: BAA12865.1.
U66871 mRNA. Translation: AAC51172.1.
BT006877 mRNA. Translation: AAP35523.1.
BC014301 mRNA. Translation: AAH14301.1.
BC071709 mRNA. Translation: AAH71709.1.
CR450298 mRNA. Translation: CAG29294.1.
CR542178 mRNA. Translation: CAG46975.1.

IPI

IPI00029631.

RefSeq

NP_004441.1.

UniGene

Hs.509791

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1W9G	X-ray	2.00	A/B	1-104	[»]
2NML	X-ray	1.55	A	1-104	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P84090. 21 interactions.

PTM databases

PhosphoSite

P84090.

Proteomic databases

PeptideAtlas

P84090.

PRIDE

P84090.

Genome annotation databases

Ensembl

ENSG00000100632. Homo sapiens. [Contig view]

GeneID

2079.

KEGG

hsa:2079.

UCSC

uc001xlc.1. human.

Organism-specific databases

GeneCards

GC14M068916.

HGNC

HGNC:3447. ERH.

HPA

HPA002567.

MIM

601191. gene.

PharmGKB

PA27859.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P84090.

HOVERGEN

P84090.

OMA

P84090. MEGVCKI.

Gene expression databases

ArrayExpress

P84090.

Bgee

P84090.

CleanEx

HS_ERH.

GermOnline

ENSG00000100632. Homo sapiens.

Family and domain databases

InterPro

IPR000781. Enh_rudimentary.
[Graphical view]

PANTHER

PTHR12373. Enh_rudimentary. 1 hit.

Pfam

PF01133. ER. 1 hit.
[Graphical view]

PIRSF

PIRSF016393. Enh_rudimentary. 1 hit.

ProDom

PD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS01290. ER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

8453.

SOURCE

Search...

Entry information

Entry name

ERH_HUMAN

Accession

Primary (citable) accession number: P84090
Secondary accession number(s): P70659, Q14259

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	July 7, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)