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Protein

Enhancer of rudimentary homolog

Gene

ERH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in the cell cycle.

GO - Molecular functioni

  • methyl-CpG binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • nucleobase-containing compound metabolic process Source: ProtInc
  • positive regulation of Notch signaling pathway Source: InterPro
  • pyrimidine nucleoside metabolic process Source: ProtInc
  • pyrimidine nucleotide biosynthetic process Source: InterPro

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of rudimentary homolog
Gene namesi
Name:ERH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100632.10
HGNCiHGNC:3447 ERH
MIMi601191 gene
neXtProtiNX_P84090

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi2079
OpenTargetsiENSG00000100632
PharmGKBiPA27859

Polymorphism and mutation databases

BioMutaiERH
DMDMi51317296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002193512 – 104Enhancer of rudimentary homologAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei11PhosphothreonineCombined sources1
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP84090
MaxQBiP84090
PaxDbiP84090
PeptideAtlasiP84090
PRIDEiP84090
TopDownProteomicsiP84090

PTM databases

iPTMnetiP84090
PhosphoSitePlusiP84090

Expressioni

Tissue specificityi

Expressed in all tissues examined.1 Publication

Gene expression databases

BgeeiENSG00000100632
CleanExiHS_ERH
ExpressionAtlasiP84090 baseline and differential
GenevisibleiP84090 HS

Organism-specific databases

HPAiHPA002567

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with POLDIP3. Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with CHTOP (PubMed:25284789).By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108390, 72 interactors
CORUMiP84090
DIPiDIP-42473N
IntActiP84090, 37 interactors
MINTiP84090
STRINGi9606.ENSP00000451080

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi14 – 16Combined sources3
Beta strandi18 – 24Combined sources7
Helixi25 – 43Combined sources19
Helixi54 – 63Combined sources10
Beta strandi64 – 73Combined sources10
Turni74 – 77Combined sources4
Beta strandi78 – 82Combined sources5
Helixi84 – 100Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W9GX-ray2.00A/B1-104[»]
2NMLX-ray1.55A1-104[»]
ProteinModelPortaliP84090
SMRiP84090
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84090

Family & Domainsi

Sequence similaritiesi

Belongs to the E(R) family.Curated

Phylogenomic databases

eggNOGiKOG1766 Eukaryota
ENOG4111Z48 LUCA
GeneTreeiENSGT00390000003316
HOGENOMiHOG000246458
HOVERGENiHBG000348
InParanoidiP84090
OMAiRTWSDYE
OrthoDBiEOG091G1CHJ
PhylomeDBiP84090
TreeFamiTF314568

Family and domain databases

Gene3Di3.30.2260.10, 1 hit
InterProiView protein in InterPro
IPR035912 EHR_sf
IPR000781 Enh_rudimentary
PANTHERiPTHR12373 PTHR12373, 1 hit
PfamiView protein in Pfam
PF01133 ER, 1 hit
PIRSFiPIRSF016393 Enh_rudimentary, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008105 Enh_rudimentary, 1 hit
SUPFAMiSSF143875 SSF143875, 1 hit
PROSITEiView protein in PROSITE
PS01290 ER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI
60 70 80 90 100
TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ

QAGK
Length:104
Mass (Da):12,259
Last modified:August 16, 2004 - v1
Checksum:iC609AFF7F63E5279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85758 mRNA Translation: BAA12865.1
U66871 mRNA Translation: AAC51172.1
BT006877 mRNA Translation: AAP35523.1
AK312186 mRNA Translation: BAG35119.1
CH471061 Genomic DNA Translation: EAW80989.1
BC014301 mRNA Translation: AAH14301.1
BC071709 mRNA Translation: AAH71709.1
CR450298 mRNA Translation: CAG29294.1
CR542178 mRNA Translation: CAG46975.1
CCDSiCCDS9794.1
RefSeqiNP_004441.1, NM_004450.2
UniGeneiHs.509791

Genome annotation databases

EnsembliENST00000557016; ENSP00000451080; ENSG00000100632
GeneIDi2079
KEGGihsa:2079
UCSCiuc001xlc.3 human

Similar proteinsi

Entry informationi

Entry nameiERH_HUMAN
AccessioniPrimary (citable) accession number: P84090
Secondary accession number(s): B2R5H2, P70659, Q14259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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