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P84090

- ERH_HUMAN

UniProt

P84090 - ERH_HUMAN

Protein

Enhancer of rudimentary homolog

Gene

ERH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May have a role in the cell cycle.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. nucleobase-containing compound metabolic process Source: ProtInc
    3. pyrimidine nucleoside metabolic process Source: ProtInc

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enhancer of rudimentary homolog
    Gene namesi
    Name:ERH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:3447. ERH.

    Subcellular locationi

    GO - Cellular componenti

    1. midbody Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27859.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 104103Enhancer of rudimentary homologPRO_0000219351Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP84090.
    PaxDbiP84090.
    PeptideAtlasiP84090.
    PRIDEiP84090.

    PTM databases

    PhosphoSiteiP84090.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined.1 Publication

    Gene expression databases

    ArrayExpressiP84090.
    BgeeiP84090.
    CleanExiHS_ERH.
    GenevestigatoriP84090.

    Organism-specific databases

    HPAiHPA002567.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with POLDIP3.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi108390. 43 interactions.
    DIPiDIP-42473N.
    IntActiP84090. 22 interactions.
    MINTiMINT-1217007.
    STRINGi9606.ENSP00000216520.

    Structurei

    Secondary structure

    1
    104
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 96
    Helixi14 – 163
    Beta strandi18 – 247
    Helixi25 – 4319
    Helixi54 – 6310
    Beta strandi64 – 7310
    Turni74 – 774
    Beta strandi78 – 825
    Helixi84 – 10017

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1W9GX-ray2.00A/B1-104[»]
    2NMLX-ray1.55A1-104[»]
    ProteinModelPortaliP84090.
    SMRiP84090. Positions 1-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP84090.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the E(R) family.Curated

    Phylogenomic databases

    eggNOGiNOG317332.
    HOGENOMiHOG000246458.
    HOVERGENiHBG000348.
    InParanoidiP84090.
    OMAiHTIILLQ.
    OrthoDBiEOG7H4DWR.
    PhylomeDBiP84090.
    TreeFamiTF314568.

    Family and domain databases

    InterProiIPR000781. Enh_rudimentary.
    [Graphical view]
    PANTHERiPTHR12373. PTHR12373. 1 hit.
    PfamiPF01133. ER. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016393. Enh_rudimentary. 1 hit.
    ProDomiPD008105. Enh_rudimentary. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS01290. ER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI    50
    TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ 100
    QAGK 104
    Length:104
    Mass (Da):12,259
    Last modified:August 16, 2004 - v1
    Checksum:iC609AFF7F63E5279
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85758 mRNA. Translation: BAA12865.1.
    U66871 mRNA. Translation: AAC51172.1.
    BT006877 mRNA. Translation: AAP35523.1.
    AK312186 mRNA. Translation: BAG35119.1.
    CH471061 Genomic DNA. Translation: EAW80989.1.
    BC014301 mRNA. Translation: AAH14301.1.
    BC071709 mRNA. Translation: AAH71709.1.
    CR450298 mRNA. Translation: CAG29294.1.
    CR542178 mRNA. Translation: CAG46975.1.
    CCDSiCCDS9794.1.
    RefSeqiNP_004441.1. NM_004450.2.
    UniGeneiHs.509791.

    Genome annotation databases

    EnsembliENST00000557016; ENSP00000451080; ENSG00000100632.
    GeneIDi2079.
    KEGGihsa:2079.
    UCSCiuc001xlc.2. human.

    Polymorphism databases

    DMDMi51317296.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85758 mRNA. Translation: BAA12865.1 .
    U66871 mRNA. Translation: AAC51172.1 .
    BT006877 mRNA. Translation: AAP35523.1 .
    AK312186 mRNA. Translation: BAG35119.1 .
    CH471061 Genomic DNA. Translation: EAW80989.1 .
    BC014301 mRNA. Translation: AAH14301.1 .
    BC071709 mRNA. Translation: AAH71709.1 .
    CR450298 mRNA. Translation: CAG29294.1 .
    CR542178 mRNA. Translation: CAG46975.1 .
    CCDSi CCDS9794.1.
    RefSeqi NP_004441.1. NM_004450.2.
    UniGenei Hs.509791.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1W9G X-ray 2.00 A/B 1-104 [» ]
    2NML X-ray 1.55 A 1-104 [» ]
    ProteinModelPortali P84090.
    SMRi P84090. Positions 1-102.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108390. 43 interactions.
    DIPi DIP-42473N.
    IntActi P84090. 22 interactions.
    MINTi MINT-1217007.
    STRINGi 9606.ENSP00000216520.

    PTM databases

    PhosphoSitei P84090.

    Polymorphism databases

    DMDMi 51317296.

    Proteomic databases

    MaxQBi P84090.
    PaxDbi P84090.
    PeptideAtlasi P84090.
    PRIDEi P84090.

    Protocols and materials databases

    DNASUi 2079.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000557016 ; ENSP00000451080 ; ENSG00000100632 .
    GeneIDi 2079.
    KEGGi hsa:2079.
    UCSCi uc001xlc.2. human.

    Organism-specific databases

    CTDi 2079.
    GeneCardsi GC14M069846.
    HGNCi HGNC:3447. ERH.
    HPAi HPA002567.
    MIMi 601191. gene.
    neXtProti NX_P84090.
    PharmGKBi PA27859.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317332.
    HOGENOMi HOG000246458.
    HOVERGENi HBG000348.
    InParanoidi P84090.
    OMAi HTIILLQ.
    OrthoDBi EOG7H4DWR.
    PhylomeDBi P84090.
    TreeFami TF314568.

    Miscellaneous databases

    ChiTaRSi ERH. human.
    EvolutionaryTracei P84090.
    GeneWikii ERH_(gene).
    GenomeRNAii 2079.
    NextBioi 8453.
    PROi P84090.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P84090.
    Bgeei P84090.
    CleanExi HS_ERH.
    Genevestigatori P84090.

    Family and domain databases

    InterProi IPR000781. Enh_rudimentary.
    [Graphical view ]
    PANTHERi PTHR12373. PTHR12373. 1 hit.
    Pfami PF01133. ER. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016393. Enh_rudimentary. 1 hit.
    ProDomi PD008105. Enh_rudimentary. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS01290. ER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene."
      Isomura M., Okui K., Fujiwara T., Shin S., Nakamura Y.
      Genomics 32:125-127(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals."
      Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I.
      Gene 186:189-195(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    8. Cited for: PROTEIN SEQUENCE OF 2-12 AND 74-88, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Mammary carcinoma and Ovarian carcinoma.
    9. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 18-34; 74-84 AND 91-96, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    10. "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth."
      Smyk A., Szuminska M., Uniewicz K.A., Graves L.M., Kozlowski P.
      FEBS J. 273:4728-4741(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH POLDIP3.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Structure of the conserved transcriptional repressor enhancer of rudimentary homolog."
      Wan C., Tempel W., Liu Z.J., Wang B.C., Rose R.B.
      Biochemistry 44:5017-5023(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiERH_HUMAN
    AccessioniPrimary (citable) accession number: P84090
    Secondary accession number(s): B2R5H2, P70659, Q14259
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3