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Protein

Enhancer of rudimentary homolog

Gene

Erh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in the cell cycle.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of rudimentary homolog
Short name:
Mer
Gene namesi
Name:Erh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 12, Chromosome 8

Organism-specific databases

MGIiMGI:108089 Erh

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002193522 – 104Enhancer of rudimentary homologAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei11PhosphothreonineBy similarity1
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP84089
PaxDbiP84089
PeptideAtlasiP84089
PRIDEiP84089
TopDownProteomicsiP84089

PTM databases

iPTMnetiP84089
PhosphoSitePlusiP84089
SwissPalmiP84089

Expressioni

Gene expression databases

BgeeiENSMUSG00000021131
CleanExiMM_ERH
ExpressionAtlasiP84089 baseline and differential
GenevisibleiP84089 MM

Interactioni

Subunit structurei

Homodimer (PubMed:15937287). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH. Interacts with CHTOP (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi199505, 29 interactors
IntActiP84089, 32 interactors
MINTiP84089
STRINGi10090.ENSMUSP00000021559

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Beta strandi11 – 14Combined sources4
Beta strandi18 – 24Combined sources7
Helixi25 – 43Combined sources19
Helixi54 – 63Combined sources10
Beta strandi64 – 73Combined sources10
Turni74 – 77Combined sources4
Beta strandi78 – 82Combined sources5
Helixi84 – 96Combined sources13
Turni97 – 99Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWQNMR-A1-104[»]
1WZ7X-ray2.10A/B/C1-104[»]
ProteinModelPortaliP84089
SMRiP84089
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84089

Family & Domainsi

Sequence similaritiesi

Belongs to the E(R) family.Curated

Phylogenomic databases

eggNOGiKOG1766 Eukaryota
ENOG4111Z48 LUCA
GeneTreeiENSGT00390000003316
HOGENOMiHOG000246458
HOVERGENiHBG000348
InParanoidiP84089
PhylomeDBiP84089
TreeFamiTF314568

Family and domain databases

Gene3Di3.30.2260.10, 1 hit
InterProiView protein in InterPro
IPR035912 EHR_sf
IPR000781 Enh_rudimentary
PANTHERiPTHR12373 PTHR12373, 1 hit
PfamiView protein in Pfam
PF01133 ER, 1 hit
PIRSFiPIRSF016393 Enh_rudimentary, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008105 Enh_rudimentary, 1 hit
SUPFAMiSSF143875 SSF143875, 1 hit
PROSITEiView protein in PROSITE
PS01290 ER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI
60 70 80 90 100
TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ

QAGK
Length:104
Mass (Da):12,259
Last modified:August 16, 2004 - v1
Checksum:iC609AFF7F63E5279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66870 mRNA Translation: AAC53105.1
D73368 mRNA Translation: BAA11118.1
AK010451 mRNA Translation: BAB26950.1
AK080617 mRNA Translation: BAC37960.1
BC083141 mRNA Translation: AAH83141.1
CCDSiCCDS36483.1
RefSeqiNP_031977.1, NM_007951.4
UniGeneiMm.246551
Mm.378913

Genome annotation databases

EnsembliENSMUST00000021559; ENSMUSP00000021559; ENSMUSG00000021131
ENSMUST00000080152; ENSMUSP00000147411; ENSMUSG00000063412
GeneIDi13877
KEGGimmu:13877
UCSCiuc007oaz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiERH_MOUSE
AccessioniPrimary (citable) accession number: P84089
Secondary accession number(s): P70659, Q14259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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