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Protein

Enhancer of rudimentary homolog

Gene

Erh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in the cell cycle.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of rudimentary homolog
Short name:
Mer
Gene namesi
Name:Erh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 12, Chromosome 8

Organism-specific databases

MGIiMGI:108089. Erh.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • methylosome Source: UniProtKB
  • midbody Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002193522 – 104Enhancer of rudimentary homologAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei11PhosphothreonineBy similarity1
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP84089.
PaxDbiP84089.
PeptideAtlasiP84089.
PRIDEiP84089.
TopDownProteomicsiP84089.

PTM databases

iPTMnetiP84089.
PhosphoSitePlusiP84089.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021131.
CleanExiMM_ERH.
ExpressionAtlasiP84089. baseline and differential.
GenevisibleiP84089. MM.

Interactioni

Subunit structurei

Homodimer (PubMed:15937287). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH. Interacts with CHTOP (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi199505. 27 interactors.
IntActiP84089. 30 interactors.
MINTiMINT-4430981.
STRINGi10090.ENSMUSP00000021559.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Beta strandi11 – 14Combined sources4
Beta strandi18 – 24Combined sources7
Helixi25 – 43Combined sources19
Helixi54 – 63Combined sources10
Beta strandi64 – 73Combined sources10
Turni74 – 77Combined sources4
Beta strandi78 – 82Combined sources5
Helixi84 – 96Combined sources13
Turni97 – 99Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWQNMR-A1-104[»]
1WZ7X-ray2.10A/B/C1-104[»]
ProteinModelPortaliP84089.
SMRiP84089.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84089.

Family & Domainsi

Sequence similaritiesi

Belongs to the E(R) family.Curated

Phylogenomic databases

eggNOGiKOG1766. Eukaryota.
ENOG4111Z48. LUCA.
GeneTreeiENSGT00390000003316.
HOGENOMiHOG000246458.
HOVERGENiHBG000348.
InParanoidiP84089.
PhylomeDBiP84089.
TreeFamiTF314568.

Family and domain databases

InterProiIPR000781. Enh_rudimentary.
[Graphical view]
PANTHERiPTHR12373. PTHR12373. 1 hit.
PfamiPF01133. ER. 1 hit.
[Graphical view]
PIRSFiPIRSF016393. Enh_rudimentary. 1 hit.
ProDomiPD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143875. SSF143875. 1 hit.
PROSITEiPS01290. ER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI
60 70 80 90 100
TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ

QAGK
Length:104
Mass (Da):12,259
Last modified:August 16, 2004 - v1
Checksum:iC609AFF7F63E5279
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66870 mRNA. Translation: AAC53105.1.
D73368 mRNA. Translation: BAA11118.1.
AK010451 mRNA. Translation: BAB26950.1.
AK080617 mRNA. Translation: BAC37960.1.
BC083141 mRNA. Translation: AAH83141.1.
CCDSiCCDS36483.1.
RefSeqiNP_031977.1. NM_007951.3.
UniGeneiMm.246551.
Mm.378913.

Genome annotation databases

EnsembliENSMUST00000021559; ENSMUSP00000021559; ENSMUSG00000021131.
ENSMUST00000080152; ENSMUSP00000147411; ENSMUSG00000063412.
GeneIDi13877.
KEGGimmu:13877.
UCSCiuc007oaz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66870 mRNA. Translation: AAC53105.1.
D73368 mRNA. Translation: BAA11118.1.
AK010451 mRNA. Translation: BAB26950.1.
AK080617 mRNA. Translation: BAC37960.1.
BC083141 mRNA. Translation: AAH83141.1.
CCDSiCCDS36483.1.
RefSeqiNP_031977.1. NM_007951.3.
UniGeneiMm.246551.
Mm.378913.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WWQNMR-A1-104[»]
1WZ7X-ray2.10A/B/C1-104[»]
ProteinModelPortaliP84089.
SMRiP84089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199505. 27 interactors.
IntActiP84089. 30 interactors.
MINTiMINT-4430981.
STRINGi10090.ENSMUSP00000021559.

PTM databases

iPTMnetiP84089.
PhosphoSitePlusiP84089.

Proteomic databases

EPDiP84089.
PaxDbiP84089.
PeptideAtlasiP84089.
PRIDEiP84089.
TopDownProteomicsiP84089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021559; ENSMUSP00000021559; ENSMUSG00000021131.
ENSMUST00000080152; ENSMUSP00000147411; ENSMUSG00000063412.
GeneIDi13877.
KEGGimmu:13877.
UCSCiuc007oaz.2. mouse.

Organism-specific databases

CTDi2079.
MGIiMGI:108089. Erh.

Phylogenomic databases

eggNOGiKOG1766. Eukaryota.
ENOG4111Z48. LUCA.
GeneTreeiENSGT00390000003316.
HOGENOMiHOG000246458.
HOVERGENiHBG000348.
InParanoidiP84089.
PhylomeDBiP84089.
TreeFamiTF314568.

Miscellaneous databases

EvolutionaryTraceiP84089.
PROiP84089.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021131.
CleanExiMM_ERH.
ExpressionAtlasiP84089. baseline and differential.
GenevisibleiP84089. MM.

Family and domain databases

InterProiIPR000781. Enh_rudimentary.
[Graphical view]
PANTHERiPTHR12373. PTHR12373. 1 hit.
PfamiPF01133. ER. 1 hit.
[Graphical view]
PIRSFiPIRSF016393. Enh_rudimentary. 1 hit.
ProDomiPD008105. Enh_rudimentary. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143875. SSF143875. 1 hit.
PROSITEiPS01290. ER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERH_MOUSE
AccessioniPrimary (citable) accession number: P84089
Secondary accession number(s): P70659, Q14259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.