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Protein

Complexin-2

Gene

CPLX2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Mast cell degranulation, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-2
Alternative name(s):
Complexin II
Short name:
CPX II
Synaphin-11 Publication
Gene namesi
Name:CPLX2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448741 – 134Complexin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP84088.
PRIDEiP84088.

PTM databases

iPTMnetiP84088.

Expressioni

Tissue specificityi

Nervous system. Also present in adrenal chromaffin cells (at protein level).1 Publication

Gene expression databases

BgeeiENSBTAG00000013741.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP84088.
STRINGi9913.ENSBTAP00000018256.

Structurei

3D structure databases

ProteinModelPortaliP84088.
SMRiP84088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 97Interaction with the SNARE complexBy similarityAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 84Sequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS. Eukaryota.
ENOG4111MX0. LUCA.
GeneTreeiENSGT00490000043416.
HOGENOMiHOG000017716.
HOVERGENiHBG062792.
InParanoidiP84088.
KOiK15294.
OMAiAMEQPCE.
TreeFamiTF315172.

Family and domain databases

InterProiView protein in InterPro
IPR008849. Synaphin.
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiView protein in Pfam
PF05835. Synaphin. 1 hit.

Sequencei

Sequence statusi: Complete.

P84088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA
60 70 80 90 100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA
110 120 130
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
Length:134
Mass (Da):15,394
Last modified:August 16, 2004 - v1
Checksum:i7791812FD4194AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50807 mRNA. Translation: BAA09434.1.
RefSeqiNP_776708.1. NM_174283.2.
XP_005211237.1. XM_005211180.3.
XP_005211238.1. XM_005211181.3.
UniGeneiBt.87768.

Genome annotation databases

EnsembliENSBTAT00000018256; ENSBTAP00000018256; ENSBTAG00000013741.
GeneIDi281711.
KEGGibta:281711.

Similar proteinsi

Entry informationi

Entry nameiCPLX2_BOVIN
AccessioniPrimary (citable) accession number: P84088
Secondary accession number(s): O09056
, Q13329, Q28184, Q64386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 27, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families