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Protein

Complexin-2

Gene

Cplx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (PubMed:15870114).1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: RGD
  • SNARE binding Source: RGD
  • syntaxin-1 binding Source: MGI

GO - Biological processi

  • mast cell degranulation Source: UniProtKB-KW
  • positive regulation of synaptic plasticity Source: UniProtKB
  • synaptic vesicle exocytosis Source: RGD
  • vesicle docking involved in exocytosis Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Mast cell degranulation, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-2
Alternative name(s):
Complexin II
Short name:
CPX II
Synaphin-1
Gene namesi
Name:Cplx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi70945. Cplx2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytosol Source: UniProtKB-SubCell
  • dendrite Source: MGI
  • mast cell granule Source: GOC
  • neuronal cell body Source: MGI
  • nucleus Source: UniProtKB-SubCell
  • SNARE complex Source: RGD
  • synapse Source: MGI
  • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Complexin-2PRO_0000144877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931Phosphoserine1 Publication

Post-translational modificationi

Ser-93 is dephosphorylated by PP2A.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP84087.
PRIDEiP84087.

PTM databases

iPTMnetiP84087.
PhosphoSiteiP84087.

Expressioni

Tissue specificityi

Nervous system. Strongly expressed in brain, where it is predominant in neurons from cerebral cortex and hippocampus. Also present in mast cells (at protein level).6 Publications

Gene expression databases

BgeeiENSRNOG00000000105.
GenevisibleiP84087. RN.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.3 Publications

GO - Molecular functioni

  • calcium-dependent protein binding Source: RGD
  • SNARE binding Source: RGD
  • syntaxin-1 binding Source: MGI

Protein-protein interaction databases

BioGridi250542. 1 interaction.
DIPiDIP-48643N.
STRINGi10116.ENSRNOP00000000117.

Structurei

3D structure databases

ProteinModelPortaliP84087.
SMRiP84087. Positions 32-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 9757Interaction with the SNARE complexAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili28 – 8457Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS. Eukaryota.
ENOG4111MX0. LUCA.
GeneTreeiENSGT00490000043416.
HOGENOMiHOG000017716.
HOVERGENiHBG062792.
InParanoidiP84087.
KOiK15294.
OMAiAMEQPCE.
PhylomeDBiP84087.
TreeFamiTF315172.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA
60 70 80 90 100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA
110 120 130
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
Length:134
Mass (Da):15,394
Last modified:August 16, 2004 - v1
Checksum:i7791812FD4194AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35099 mRNA. Translation: AAC52271.1.
D70816 mRNA. Translation: BAA11096.1.
PIRiC57233.
JC4226.
RefSeqiNP_446330.1. NM_053878.1.
XP_006253658.1. XM_006253596.2.
XP_006253659.1. XM_006253597.2.
XP_008769704.1. XM_008771482.1.
XP_008769705.1. XM_008771483.1.
UniGeneiRn.10134.

Genome annotation databases

EnsembliENSRNOT00000000117; ENSRNOP00000000117; ENSRNOG00000000105.
ENSRNOT00000091046; ENSRNOP00000072664; ENSRNOG00000000105.
GeneIDi116657.
KEGGirno:116657.
UCSCiRGD:70945. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35099 mRNA. Translation: AAC52271.1.
D70816 mRNA. Translation: BAA11096.1.
PIRiC57233.
JC4226.
RefSeqiNP_446330.1. NM_053878.1.
XP_006253658.1. XM_006253596.2.
XP_006253659.1. XM_006253597.2.
XP_008769704.1. XM_008771482.1.
XP_008769705.1. XM_008771483.1.
UniGeneiRn.10134.

3D structure databases

ProteinModelPortaliP84087.
SMRiP84087. Positions 32-72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250542. 1 interaction.
DIPiDIP-48643N.
STRINGi10116.ENSRNOP00000000117.

PTM databases

iPTMnetiP84087.
PhosphoSiteiP84087.

Proteomic databases

PaxDbiP84087.
PRIDEiP84087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000117; ENSRNOP00000000117; ENSRNOG00000000105.
ENSRNOT00000091046; ENSRNOP00000072664; ENSRNOG00000000105.
GeneIDi116657.
KEGGirno:116657.
UCSCiRGD:70945. rat.

Organism-specific databases

CTDi10814.
RGDi70945. Cplx2.

Phylogenomic databases

eggNOGiENOG410IWGS. Eukaryota.
ENOG4111MX0. LUCA.
GeneTreeiENSGT00490000043416.
HOGENOMiHOG000017716.
HOVERGENiHBG062792.
InParanoidiP84087.
KOiK15294.
OMAiAMEQPCE.
PhylomeDBiP84087.
TreeFamiTF315172.

Miscellaneous databases

PROiP84087.

Gene expression databases

BgeeiENSRNOG00000000105.
GenevisibleiP84087. RN.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPLX2_RAT
AccessioniPrimary (citable) accession number: P84087
Secondary accession number(s): O09056
, Q13329, Q28184, Q64386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.