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Protein

Complexin-2

Gene

Cplx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244). Also involved in mast cell exocytosis (PubMed:11163241). Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444).4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-2
Alternative name(s):
921-L
Complexin II
Short name:
CPX II
Synaphin-1
Gene namesi
Name:Cplx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:104726 Cplx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mice show no obvious phenotypic changes and no significant motor deficiencies. However, they show abnormalities in a number of complex behaviors including exploration, socialization, motor coordination, learning and reversal learning.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448761 – 134Complexin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP84086
PaxDbiP84086
PeptideAtlasiP84086
PRIDEiP84086

PTM databases

iPTMnetiP84086
PhosphoSitePlusiP84086

Expressioni

Tissue specificityi

Nervous system. Expressed predominantly in brain, where it is present in many regions, including hippocampus and cerebellum. In the retina, present at conventional amacrine cell synapses (at protein level).2 Publications

Developmental stagei

In the brain, expression starts at P6 and increases to reach a plateau at P20.1 Publication

Gene expression databases

BgeeiENSMUSG00000025867
CleanExiMM_CPLX2
GenevisibleiP84086 MM

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP84086
IntActiP84086, 1 interactor
MINTiP84086
STRINGi10090.ENSMUSP00000026985

Structurei

3D structure databases

ProteinModelPortaliP84086
SMRiP84086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 97Interaction with the SNARE complexBy similarityAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 84Sequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS Eukaryota
ENOG4111MX0 LUCA
GeneTreeiENSGT00490000043416
HOGENOMiHOG000017716
HOVERGENiHBG062792
InParanoidiP84086
KOiK15294
OMAiAMEQPCE
PhylomeDBiP84086
TreeFamiTF315172

Family and domain databases

InterProiView protein in InterPro
IPR008849 Synaphin
PANTHERiPTHR16705 PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835 Synaphin, 1 hit

Sequencei

Sequence statusi: Complete.

P84086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA
60 70 80 90 100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA
110 120 130
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
Length:134
Mass (Da):15,394
Last modified:August 16, 2004 - v1
Checksum:i7791812FD4194AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35101 Genomic DNA Translation: AAC52272.1
D38613 mRNA Translation: BAA07604.1
BN000501 mRNA Translation: CAG26661.1
BN000502 mRNA Translation: CAG26662.1
CCDSiCCDS36667.1
PIRiS66293 D57233
RefSeqiNP_034076.1, NM_009946.3
XP_017170864.1, XM_017315375.1
XP_017170865.1, XM_017315376.1
UniGeneiMm.268902

Genome annotation databases

EnsembliENSMUST00000026985; ENSMUSP00000026985; ENSMUSG00000025867
GeneIDi12890
KEGGimmu:12890
UCSCiuc029sbi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCPLX2_MOUSE
AccessioniPrimary (citable) accession number: P84086
Secondary accession number(s): O09056
, Q13329, Q28184, Q32KK4, Q64386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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