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Protein

ADP-ribosylation factor 5

Gene

ARF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTP8
Nucleotide bindingi67 – 71GTP5
Nucleotide bindingi126 – 129GTP4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: WormBase
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004059-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 5
Gene namesi
Name:ARF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:658. ARF5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000004059.
PharmGKBiPA24941.

Chemistry databases

ChEMBLiCHEMBL5986.

Polymorphism and mutation databases

BioMutaiARF5.
DMDMi51316990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002073962 – 180ADP-ribosylation factor 5Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP84085.
MaxQBiP84085.
PaxDbiP84085.
PeptideAtlasiP84085.
PRIDEiP84085.
TopDownProteomicsiP84085.

PTM databases

iPTMnetiP84085.
PhosphoSitePlusiP84085.
SwissPalmiP84085.

Expressioni

Gene expression databases

BgeeiENSG00000004059.
CleanExiHS_ARF5.
ExpressionAtlasiP84085. baseline and differential.
GenevisibleiP84085. HS.

Organism-specific databases

HPAiCAB009111.

Interactioni

Subunit structurei

Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4.4 Publications

Protein-protein interaction databases

BioGridi106876. 52 interactors.
DIPiDIP-61289N.
IntActiP84085. 6 interactors.
MINTiMINT-4825056.
STRINGi9606.ENSP00000000233.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 11Combined sources4
Turni12 – 15Combined sources4
Beta strandi18 – 25Combined sources8
Helixi30 – 37Combined sources8
Beta strandi43 – 48Combined sources6
Beta strandi51 – 58Combined sources8
Beta strandi61 – 67Combined sources7
Helixi78 – 83Combined sources6
Beta strandi87 – 93Combined sources7
Helixi97 – 99Combined sources3
Helixi100 – 111Combined sources12
Helixi114 – 116Combined sources3
Beta strandi120 – 126Combined sources7
Helixi136 – 142Combined sources7
Helixi145 – 147Combined sources3
Beta strandi153 – 157Combined sources5
Turni160 – 163Combined sources4
Helixi166 – 176Combined sources11
Turni177 – 179Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6HX-ray1.76A8-180[»]
ProteinModelPortaliP84085.
SMRiP84085.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84085.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP84085.
KOiK07940.
OMAiMVQEDEL.
OrthoDBiEOG091G0S7S.
PhylomeDBiP84085.
TreeFamiTF300808.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
QESADELQKM LQEDELRDAV LLVFANKQDM PNAMPVSELT DKLGLQHLRS
160 170 180
RTWYVQATCA TQGTGLYDGL DWLSHELSKR
Length:180
Mass (Da):20,530
Last modified:January 23, 2007 - v2
Checksum:i25EF3D4895408147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57567 mRNA. Translation: AAA90927.1.
U73002 Genomic DNA. Translation: AAC51299.1.
AF493884 mRNA. Translation: AAM12598.1.
BT007087 mRNA. Translation: AAP35750.1.
BC003043 mRNA. Translation: AAH03043.1.
BC033104 mRNA. Translation: AAH33104.1.
CCDSiCCDS34745.1.
PIRiA23741.
RefSeqiNP_001653.1. NM_001662.3.
UniGeneiHs.653202.

Genome annotation databases

EnsembliENST00000000233; ENSP00000000233; ENSG00000004059.
GeneIDi381.
KEGGihsa:381.
UCSCiuc003vmb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57567 mRNA. Translation: AAA90927.1.
U73002 Genomic DNA. Translation: AAC51299.1.
AF493884 mRNA. Translation: AAM12598.1.
BT007087 mRNA. Translation: AAP35750.1.
BC003043 mRNA. Translation: AAH03043.1.
BC033104 mRNA. Translation: AAH33104.1.
CCDSiCCDS34745.1.
PIRiA23741.
RefSeqiNP_001653.1. NM_001662.3.
UniGeneiHs.653202.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6HX-ray1.76A8-180[»]
ProteinModelPortaliP84085.
SMRiP84085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106876. 52 interactors.
DIPiDIP-61289N.
IntActiP84085. 6 interactors.
MINTiMINT-4825056.
STRINGi9606.ENSP00000000233.

Chemistry databases

ChEMBLiCHEMBL5986.

PTM databases

iPTMnetiP84085.
PhosphoSitePlusiP84085.
SwissPalmiP84085.

Polymorphism and mutation databases

BioMutaiARF5.
DMDMi51316990.

Proteomic databases

EPDiP84085.
MaxQBiP84085.
PaxDbiP84085.
PeptideAtlasiP84085.
PRIDEiP84085.
TopDownProteomicsiP84085.

Protocols and materials databases

DNASUi381.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000000233; ENSP00000000233; ENSG00000004059.
GeneIDi381.
KEGGihsa:381.
UCSCiuc003vmb.3. human.

Organism-specific databases

CTDi381.
GeneCardsiARF5.
HGNCiHGNC:658. ARF5.
HPAiCAB009111.
MIMi103188. gene.
neXtProtiNX_P84085.
OpenTargetsiENSG00000004059.
PharmGKBiPA24941.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP84085.
KOiK07940.
OMAiMVQEDEL.
OrthoDBiEOG091G0S7S.
PhylomeDBiP84085.
TreeFamiTF300808.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004059-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiARF5. human.
EvolutionaryTraceiP84085.
GeneWikiiARF5.
GenomeRNAii381.
PROiP84085.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004059.
CleanExiHS_ARF5.
ExpressionAtlasiP84085. baseline and differential.
GenevisibleiP84085. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARF5_HUMAN
AccessioniPrimary (citable) accession number: P84085
Secondary accession number(s): P26437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.