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Protein

ADP-ribosylation factor 5

Gene

Arf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 5
Gene namesi
Name:Arf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99434. Arf5.

Subcellular locationi

  • Golgi apparatus
  • Cytoplasmperinuclear region By similarity
  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002073972 – 180ADP-ribosylation factor 5Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP84084.
MaxQBiP84084.
PaxDbiP84084.
PeptideAtlasiP84084.
PRIDEiP84084.
TopDownProteomicsiP84084.

PTM databases

iPTMnetiP84084.
PhosphoSitePlusiP84084.
SwissPalmiP84084.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000020440.
CleanExiMM_ARF5.
GenevisibleiP84084. MM.

Interactioni

Subunit structurei

Binds ASAP2 (By similarity). Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Cadps2Q8BYR55EBI-7569461,EBI-7569313

Protein-protein interaction databases

BioGridi198188. 1 interactor.
IntActiP84084. 3 interactors.
STRINGi10090.ENSMUSP00000020717.

Structurei

3D structure databases

ProteinModelPortaliP84084.
SMRiP84084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP84084.
KOiK07940.
OMAiMVQEDEL.
OrthoDBiEOG091G0S7S.
PhylomeDBiP84084.
TreeFamiTF300808.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
QESADELQKM LQEDELRDAV LLVFANKQDM PNAMPVSELT DKLGLQHLRS
160 170 180
RTWYVQATCA TQGTGLYDGL DWLSHELSKR
Length:180
Mass (Da):20,530
Last modified:January 23, 2007 - v2
Checksum:i25EF3D4895408147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87902 mRNA. Translation: BAA13494.1.
BC132452 mRNA. Translation: AAI32453.1.
BC138756 mRNA. Translation: AAI38757.1.
CCDSiCCDS19952.1.
PIRiJC4949.
RefSeqiNP_031506.1. NM_007480.1.
UniGeneiMm.389075.

Genome annotation databases

EnsembliENSMUST00000020717; ENSMUSP00000020717; ENSMUSG00000020440.
ENSMUST00000169841; ENSMUSP00000127281; ENSMUSG00000020440.
GeneIDi11844.
KEGGimmu:11844.
UCSCiuc009bcq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87902 mRNA. Translation: BAA13494.1.
BC132452 mRNA. Translation: AAI32453.1.
BC138756 mRNA. Translation: AAI38757.1.
CCDSiCCDS19952.1.
PIRiJC4949.
RefSeqiNP_031506.1. NM_007480.1.
UniGeneiMm.389075.

3D structure databases

ProteinModelPortaliP84084.
SMRiP84084.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198188. 1 interactor.
IntActiP84084. 3 interactors.
STRINGi10090.ENSMUSP00000020717.

PTM databases

iPTMnetiP84084.
PhosphoSitePlusiP84084.
SwissPalmiP84084.

Proteomic databases

EPDiP84084.
MaxQBiP84084.
PaxDbiP84084.
PeptideAtlasiP84084.
PRIDEiP84084.
TopDownProteomicsiP84084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020717; ENSMUSP00000020717; ENSMUSG00000020440.
ENSMUST00000169841; ENSMUSP00000127281; ENSMUSG00000020440.
GeneIDi11844.
KEGGimmu:11844.
UCSCiuc009bcq.1. mouse.

Organism-specific databases

CTDi381.
MGIiMGI:99434. Arf5.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP84084.
KOiK07940.
OMAiMVQEDEL.
OrthoDBiEOG091G0S7S.
PhylomeDBiP84084.
TreeFamiTF300808.

Miscellaneous databases

PROiP84084.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020440.
CleanExiMM_ARF5.
GenevisibleiP84084. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARF5_MOUSE
AccessioniPrimary (citable) accession number: P84084
Secondary accession number(s): A2RTC5, P26437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.