Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor 5

Gene

Arf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: MGI

GO - Biological processi

  • protein transport Source: MGI
  • retrograde vesicle-mediated transport, Golgi to ER Source: MGI

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 5
Gene namesi
Name:Arf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:99434 Arf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002073972 – 180ADP-ribosylation factor 5Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP84084
MaxQBiP84084
PaxDbiP84084
PeptideAtlasiP84084
PRIDEiP84084
TopDownProteomicsiP84084

PTM databases

iPTMnetiP84084
PhosphoSitePlusiP84084
SwissPalmiP84084

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000020440
CleanExiMM_ARF5
GenevisibleiP84084 MM

Interactioni

Subunit structurei

Binds ASAP2 (By similarity). Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Cadps2Q8BYR55EBI-7569461,EBI-7569313

Protein-protein interaction databases

BioGridi198188, 5 interactors
IntActiP84084, 6 interactors
MINTiP84084
STRINGi10090.ENSMUSP00000020717

Structurei

3D structure databases

ProteinModelPortaliP84084
SMRiP84084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP84084
KOiK07940
OMAiMVQEDEL
OrthoDBiEOG091G0S7S
PhylomeDBiP84084
TreeFamiTF300808

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
QESADELQKM LQEDELRDAV LLVFANKQDM PNAMPVSELT DKLGLQHLRS
160 170 180
RTWYVQATCA TQGTGLYDGL DWLSHELSKR
Length:180
Mass (Da):20,530
Last modified:January 23, 2007 - v2
Checksum:i25EF3D4895408147
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87902 mRNA Translation: BAA13494.1
BC132452 mRNA Translation: AAI32453.1
BC138756 mRNA Translation: AAI38757.1
CCDSiCCDS19952.1
PIRiJC4949
RefSeqiNP_031506.1, NM_007480.1
UniGeneiMm.389075

Genome annotation databases

EnsembliENSMUST00000020717; ENSMUSP00000020717; ENSMUSG00000020440
ENSMUST00000169841; ENSMUSP00000127281; ENSMUSG00000020440
GeneIDi11844
KEGGimmu:11844
UCSCiuc009bcq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARF5_MOUSE
AccessioniPrimary (citable) accession number: P84084
Secondary accession number(s): A2RTC5, P26437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health