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P84075 (HPCA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuron-specific calcium-binding protein hippocalcin
Gene names
Name:Hpca
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Post-translational modification

Myristoylation facilitates interaction with membranes By similarity.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Kcnma1Q084603EBI-2128343,EBI-1633915

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 193192Neuron-specific calcium-binding protein hippocalcin
PRO_0000073769

Regions

Domain24 – 5936EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain144 – 17936EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding157 – 168123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
P84075 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3DBEA176AC945DB1

FASTA19322,427
        10         20         30         40         50         60 
MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD 

        70         80         90        100        110        120 
ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE 

       130        140        150        160        170        180 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 

       190 
RLLQCDPSSA SQF 

« Hide

References

« Hide 'large scale' references
[1]"Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]"Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J and DBA/2J.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015200 Genomic DNA. Translation: BAA74455.1.
AF326551 mRNA. Translation: AAL37397.1.
AF326552 mRNA. Translation: AAL37398.1.
AK002992 mRNA. Translation: BAB22502.1.
AL606977 Genomic DNA. Translation: CAM19712.1.
BC049607 mRNA. Translation: AAH49607.1.
BC058588 mRNA. Translation: AAH58588.1.
RefSeqNP_001123891.1. NM_001130419.2.
NP_001273010.1. NM_001286081.1.
NP_001273012.1. NM_001286083.1.
NP_034601.1. NM_010471.4.
XP_006502838.1. XM_006502775.1.
XP_006502839.1. XM_006502776.1.
XP_006502840.1. XM_006502777.1.
XP_006537013.1. XM_006536950.1.
XP_006537014.1. XM_006536951.1.
UniGeneMm.384452.

3D structure databases

ProteinModelPortalP84075.
SMRP84075. Positions 5-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP84075. 2 interactions.
MINTMINT-4097878.

PTM databases

PhosphoSiteP84075.

Proteomic databases

PaxDbP84075.
PRIDEP84075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030572; ENSMUSP00000030572; ENSMUSG00000028785.
ENSMUST00000095807; ENSMUSP00000093486; ENSMUSG00000028785.
ENSMUST00000116442; ENSMUSP00000112143; ENSMUSG00000028785.
ENSMUST00000116444; ENSMUSP00000112145; ENSMUSG00000028785.
ENSMUST00000139450; ENSMUSP00000119178; ENSMUSG00000028785.
ENSMUST00000164649; ENSMUSP00000129548; ENSMUSG00000028785.
GeneID15444.
KEGGmmu:15444.
UCSCuc008uwb.2. mouse.

Organism-specific databases

CTD3208.
MGIMGI:1336200. Hpca.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00560000076803.
HOGENOMHOG000233019.
HOVERGENHBG108179.
InParanoidA2A7R4.
OMAQKINWSF.
OrthoDBEOG7GJ6F3.
PhylomeDBP84075.
TreeFamTF300009.

Gene expression databases

BgeeP84075.
CleanExMM_HPCA.
GenevestigatorP84075.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF00036. EF-hand_1. 3 hits.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio288236.
PROP84075.
SOURCESearch...

Entry information

Entry nameHPCA_MOUSE
AccessionPrimary (citable) accession number: P84075
Secondary accession number(s): A2A7R4 expand/collapse secondary AC list , P32076, P41211, P70510
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot