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P84075

- HPCA_MOUSE

UniProt

P84075 - HPCA_MOUSE

Protein

Neuron-specific calcium-binding protein hippocalcin

Gene

Hpca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. calcium ion binding Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. inner ear development Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuron-specific calcium-binding protein hippocalcin
    Gene namesi
    Name:Hpca
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1336200. Hpca.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 193192Neuron-specific calcium-binding protein hippocalcinPRO_0000073769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Post-translational modificationi

    Myristoylation facilitates interaction with membranes.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP84075.
    PaxDbiP84075.
    PRIDEiP84075.

    PTM databases

    PhosphoSiteiP84075.

    Expressioni

    Gene expression databases

    BgeeiP84075.
    CleanExiMM_HPCA.
    GenevestigatoriP84075.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kcnma1Q084603EBI-2128343,EBI-1633915

    Protein-protein interaction databases

    IntActiP84075. 2 interactions.
    MINTiMINT-4097878.

    Structurei

    3D structure databases

    ProteinModelPortaliP84075.
    SMRiP84075. Positions 5-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 5936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00560000076803.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    InParanoidiA2A7R4.
    OMAiQANYKMV.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiP84075.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PfamiPF00036. EF-hand_1. 3 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK    50
    IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK 100
    LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE 150
    KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF 193
    Length:193
    Mass (Da):22,427
    Last modified:January 23, 2007 - v2
    Checksum:i3DBEA176AC945DB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015200 Genomic DNA. Translation: BAA74455.1.
    AF326551 mRNA. Translation: AAL37397.1.
    AF326552 mRNA. Translation: AAL37398.1.
    AK002992 mRNA. Translation: BAB22502.1.
    AL606977 Genomic DNA. Translation: CAM19712.1.
    BC049607 mRNA. Translation: AAH49607.1.
    BC058588 mRNA. Translation: AAH58588.1.
    CCDSiCCDS18682.1.
    RefSeqiNP_001123891.1. NM_001130419.2.
    NP_001273010.1. NM_001286081.1.
    NP_001273012.1. NM_001286083.1.
    NP_034601.1. NM_010471.4.
    XP_006502838.1. XM_006502775.1.
    XP_006502839.1. XM_006502776.1.
    XP_006502840.1. XM_006502777.1.
    XP_006537013.1. XM_006536950.1.
    XP_006537014.1. XM_006536951.1.
    UniGeneiMm.384452.

    Genome annotation databases

    EnsembliENSMUST00000030572; ENSMUSP00000030572; ENSMUSG00000028785.
    ENSMUST00000095807; ENSMUSP00000093486; ENSMUSG00000028785.
    ENSMUST00000116442; ENSMUSP00000112143; ENSMUSG00000028785.
    ENSMUST00000116444; ENSMUSP00000112145; ENSMUSG00000028785.
    ENSMUST00000139450; ENSMUSP00000119178; ENSMUSG00000028785.
    ENSMUST00000164649; ENSMUSP00000129548; ENSMUSG00000028785.
    GeneIDi15444.
    KEGGimmu:15444.
    UCSCiuc008uwb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015200 Genomic DNA. Translation: BAA74455.1 .
    AF326551 mRNA. Translation: AAL37397.1 .
    AF326552 mRNA. Translation: AAL37398.1 .
    AK002992 mRNA. Translation: BAB22502.1 .
    AL606977 Genomic DNA. Translation: CAM19712.1 .
    BC049607 mRNA. Translation: AAH49607.1 .
    BC058588 mRNA. Translation: AAH58588.1 .
    CCDSi CCDS18682.1.
    RefSeqi NP_001123891.1. NM_001130419.2.
    NP_001273010.1. NM_001286081.1.
    NP_001273012.1. NM_001286083.1.
    NP_034601.1. NM_010471.4.
    XP_006502838.1. XM_006502775.1.
    XP_006502839.1. XM_006502776.1.
    XP_006502840.1. XM_006502777.1.
    XP_006537013.1. XM_006536950.1.
    XP_006537014.1. XM_006536951.1.
    UniGenei Mm.384452.

    3D structure databases

    ProteinModelPortali P84075.
    SMRi P84075. Positions 5-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P84075. 2 interactions.
    MINTi MINT-4097878.

    PTM databases

    PhosphoSitei P84075.

    Proteomic databases

    MaxQBi P84075.
    PaxDbi P84075.
    PRIDEi P84075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030572 ; ENSMUSP00000030572 ; ENSMUSG00000028785 .
    ENSMUST00000095807 ; ENSMUSP00000093486 ; ENSMUSG00000028785 .
    ENSMUST00000116442 ; ENSMUSP00000112143 ; ENSMUSG00000028785 .
    ENSMUST00000116444 ; ENSMUSP00000112145 ; ENSMUSG00000028785 .
    ENSMUST00000139450 ; ENSMUSP00000119178 ; ENSMUSG00000028785 .
    ENSMUST00000164649 ; ENSMUSP00000129548 ; ENSMUSG00000028785 .
    GeneIDi 15444.
    KEGGi mmu:15444.
    UCSCi uc008uwb.2. mouse.

    Organism-specific databases

    CTDi 3208.
    MGIi MGI:1336200. Hpca.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00560000076803.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    InParanoidi A2A7R4.
    OMAi QANYKMV.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi P84075.
    TreeFami TF300009.

    Miscellaneous databases

    NextBioi 288236.
    PROi P84075.
    SOURCEi Search...

    Gene expression databases

    Bgeei P84075.
    CleanExi MM_HPCA.
    Genevestigatori P84075.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    Pfami PF00036. EF-hand_1. 3 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
      Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
      Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    2. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
      Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
      J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J and DBA/2J.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Retina.

    Entry informationi

    Entry nameiHPCA_MOUSE
    AccessioniPrimary (citable) accession number: P84075
    Secondary accession number(s): A2A7R4
    , P32076, P41211, P70510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3