Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuron-specific calcium-binding protein hippocalcin

Gene

Hpca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841By similarityAdd BLAST12
Calcium bindingi109 – 1202By similarityAdd BLAST12
Calcium bindingi157 – 1683By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific calcium-binding protein hippocalcinCurated
Gene namesi
Name:HpcaImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1336200. Hpca.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737692 – 193Neuron-specific calcium-binding protein hippocalcinAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Post-translational modificationi

Myristoylation facilitates association with membranes.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP84075.
PaxDbiP84075.
PeptideAtlasiP84075.
PRIDEiP84075.

PTM databases

iPTMnetiP84075.
PhosphoSitePlusiP84075.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028785.
CleanExiMM_HPCA.
ExpressionAtlasiP84075. baseline and differential.
GenevisibleiP84075. MM.

Interactioni

Subunit structurei

Oligomer; oligomerization is calcium-dependent. May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084603EBI-2128343,EBI-1633915

GO - Molecular functioni

Protein-protein interaction databases

IntActiP84075. 2 interactors.
MINTiMINT-4097878.
STRINGi10090.ENSMUSP00000030572.

Structurei

3D structure databases

ProteinModelPortaliP84075.
SMRiP84075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 59EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Domaini

Binds 3 calcium via EF-hand domains. The cryptic EF-hand 1 does not bind calcium.By similarity

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP84075.
OMAiRTFDTNN.
OrthoDBiEOG091G11T4.
PhylomeDBiP84075.
TreeFamiTF300009.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK
110 120 130 140 150
LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,427
Last modified:January 23, 2007 - v2
Checksum:i3DBEA176AC945DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015200 Genomic DNA. Translation: BAA74455.1.
AF326551 mRNA. Translation: AAL37397.1.
AF326552 mRNA. Translation: AAL37398.1.
AK002992 mRNA. Translation: BAB22502.1.
AL606977 Genomic DNA. Translation: CAM19712.1.
BC049607 mRNA. Translation: AAH49607.1.
BC058588 mRNA. Translation: AAH58588.1.
CCDSiCCDS18682.1.
RefSeqiNP_001123891.1. NM_001130419.2.
NP_001273010.1. NM_001286081.1.
NP_001273012.1. NM_001286083.1.
NP_034601.1. NM_010471.4.
XP_006502838.1. XM_006502775.3.
XP_006502839.1. XM_006502776.3.
XP_006502840.1. XM_006502777.1.
XP_011238748.1. XM_011240446.2.
UniGeneiMm.384452.

Genome annotation databases

EnsembliENSMUST00000030572; ENSMUSP00000030572; ENSMUSG00000028785.
ENSMUST00000095807; ENSMUSP00000093486; ENSMUSG00000028785.
ENSMUST00000116442; ENSMUSP00000112143; ENSMUSG00000028785.
ENSMUST00000116444; ENSMUSP00000112145; ENSMUSG00000028785.
ENSMUST00000139450; ENSMUSP00000119178; ENSMUSG00000028785.
ENSMUST00000164649; ENSMUSP00000129548; ENSMUSG00000028785.
GeneIDi15444.
KEGGimmu:15444.
UCSCiuc008uwb.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiHPCA_MOUSE
AccessioniPrimary (citable) accession number: P84075
Secondary accession number(s): A2A7R4
, P32076, P41211, P70510
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families