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Protein

Neuron-specific calcium-binding protein hippocalcin

Gene

Hpca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. inner ear development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific calcium-binding protein hippocalcin
Gene namesi
Name:Hpca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1336200. Hpca.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 193192Neuron-specific calcium-binding protein hippocalcinPRO_0000073769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Post-translational modificationi

Myristoylation facilitates interaction with membranes.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP84075.
PaxDbiP84075.
PRIDEiP84075.

PTM databases

PhosphoSiteiP84075.

Expressioni

Gene expression databases

BgeeiP84075.
CleanExiMM_HPCA.
ExpressionAtlasiP84075. baseline and differential.
GenevestigatoriP84075.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084603EBI-2128343,EBI-1633915

Protein-protein interaction databases

IntActiP84075. 2 interactions.
MINTiMINT-4097878.

Structurei

3D structure databases

ProteinModelPortaliP84075.
SMRiP84075. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP84075.
OMAiFREFIVA.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP84075.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK
110 120 130 140 150
LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,427
Last modified:January 23, 2007 - v2
Checksum:i3DBEA176AC945DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015200 Genomic DNA. Translation: BAA74455.1.
AF326551 mRNA. Translation: AAL37397.1.
AF326552 mRNA. Translation: AAL37398.1.
AK002992 mRNA. Translation: BAB22502.1.
AL606977 Genomic DNA. Translation: CAM19712.1.
BC049607 mRNA. Translation: AAH49607.1.
BC058588 mRNA. Translation: AAH58588.1.
CCDSiCCDS18682.1.
RefSeqiNP_001123891.1. NM_001130419.2.
NP_001273010.1. NM_001286081.1.
NP_001273012.1. NM_001286083.1.
NP_034601.1. NM_010471.4.
XP_006502838.1. XM_006502775.1.
XP_006502839.1. XM_006502776.1.
XP_006502840.1. XM_006502777.1.
XP_006537013.1. XM_006536950.1.
XP_006537014.1. XM_006536951.1.
UniGeneiMm.384452.

Genome annotation databases

EnsembliENSMUST00000030572; ENSMUSP00000030572; ENSMUSG00000028785.
ENSMUST00000095807; ENSMUSP00000093486; ENSMUSG00000028785.
ENSMUST00000116442; ENSMUSP00000112143; ENSMUSG00000028785.
ENSMUST00000116444; ENSMUSP00000112145; ENSMUSG00000028785.
ENSMUST00000139450; ENSMUSP00000119178; ENSMUSG00000028785.
ENSMUST00000164649; ENSMUSP00000129548; ENSMUSG00000028785.
GeneIDi15444.
KEGGimmu:15444.
UCSCiuc008uwb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015200 Genomic DNA. Translation: BAA74455.1.
AF326551 mRNA. Translation: AAL37397.1.
AF326552 mRNA. Translation: AAL37398.1.
AK002992 mRNA. Translation: BAB22502.1.
AL606977 Genomic DNA. Translation: CAM19712.1.
BC049607 mRNA. Translation: AAH49607.1.
BC058588 mRNA. Translation: AAH58588.1.
CCDSiCCDS18682.1.
RefSeqiNP_001123891.1. NM_001130419.2.
NP_001273010.1. NM_001286081.1.
NP_001273012.1. NM_001286083.1.
NP_034601.1. NM_010471.4.
XP_006502838.1. XM_006502775.1.
XP_006502839.1. XM_006502776.1.
XP_006502840.1. XM_006502777.1.
XP_006537013.1. XM_006536950.1.
XP_006537014.1. XM_006536951.1.
UniGeneiMm.384452.

3D structure databases

ProteinModelPortaliP84075.
SMRiP84075. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP84075. 2 interactions.
MINTiMINT-4097878.

PTM databases

PhosphoSiteiP84075.

Proteomic databases

MaxQBiP84075.
PaxDbiP84075.
PRIDEiP84075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030572; ENSMUSP00000030572; ENSMUSG00000028785.
ENSMUST00000095807; ENSMUSP00000093486; ENSMUSG00000028785.
ENSMUST00000116442; ENSMUSP00000112143; ENSMUSG00000028785.
ENSMUST00000116444; ENSMUSP00000112145; ENSMUSG00000028785.
ENSMUST00000139450; ENSMUSP00000119178; ENSMUSG00000028785.
ENSMUST00000164649; ENSMUSP00000129548; ENSMUSG00000028785.
GeneIDi15444.
KEGGimmu:15444.
UCSCiuc008uwb.2. mouse.

Organism-specific databases

CTDi3208.
MGIiMGI:1336200. Hpca.

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP84075.
OMAiFREFIVA.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP84075.
TreeFamiTF300009.

Miscellaneous databases

NextBioi288236.
PROiP84075.
SOURCEiSearch...

Gene expression databases

BgeeiP84075.
CleanExiMM_HPCA.
ExpressionAtlasiP84075. baseline and differential.
GenevestigatoriP84075.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
    Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
    Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
    Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
    J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Retina.

Entry informationi

Entry nameiHPCA_MOUSE
AccessioniPrimary (citable) accession number: P84075
Secondary accession number(s): A2A7R4
, P32076, P41211, P70510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.