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P84075

- HPCA_MOUSE

UniProt

P84075 - HPCA_MOUSE

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Protein
Neuron-specific calcium-binding protein hippocalcin
Gene
Hpca
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121 Reviewed prediction
Add
BLAST
Calcium bindingi109 – 120122 Reviewed prediction
Add
BLAST
Calcium bindingi157 – 168123 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. inner ear development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific calcium-binding protein hippocalcin
Gene namesi
Name:Hpca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1336200. Hpca.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 193192Neuron-specific calcium-binding protein hippocalcin
PRO_0000073769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Post-translational modificationi

Myristoylation facilitates interaction with membranes By similarity.

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP84075.
PaxDbiP84075.
PRIDEiP84075.

PTM databases

PhosphoSiteiP84075.

Expressioni

Gene expression databases

BgeeiP84075.
CleanExiMM_HPCA.
GenevestigatoriP84075.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084603EBI-2128343,EBI-1633915

Protein-protein interaction databases

IntActiP84075. 2 interactions.
MINTiMINT-4097878.

Structurei

3D structure databases

ProteinModelPortaliP84075.
SMRiP84075. Positions 5-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5936EF-hand 1
Add
BLAST
Domaini60 – 9536EF-hand 2
Add
BLAST
Domaini96 – 13136EF-hand 3
Add
BLAST
Domaini144 – 17936EF-hand 4
Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00560000076803.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiA2A7R4.
OMAiQANYKMV.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP84075.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84075-1 [UniParc]FASTAAdd to Basket

« Hide

MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK    50
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK 100
LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE 150
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF 193
Length:193
Mass (Da):22,427
Last modified:January 23, 2007 - v2
Checksum:i3DBEA176AC945DB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015200 Genomic DNA. Translation: BAA74455.1.
AF326551 mRNA. Translation: AAL37397.1.
AF326552 mRNA. Translation: AAL37398.1.
AK002992 mRNA. Translation: BAB22502.1.
AL606977 Genomic DNA. Translation: CAM19712.1.
BC049607 mRNA. Translation: AAH49607.1.
BC058588 mRNA. Translation: AAH58588.1.
CCDSiCCDS18682.1.
RefSeqiNP_001123891.1. NM_001130419.2.
NP_001273010.1. NM_001286081.1.
NP_001273012.1. NM_001286083.1.
NP_034601.1. NM_010471.4.
XP_006502838.1. XM_006502775.1.
XP_006502839.1. XM_006502776.1.
XP_006502840.1. XM_006502777.1.
XP_006537013.1. XM_006536950.1.
XP_006537014.1. XM_006536951.1.
UniGeneiMm.384452.

Genome annotation databases

EnsembliENSMUST00000030572; ENSMUSP00000030572; ENSMUSG00000028785.
ENSMUST00000095807; ENSMUSP00000093486; ENSMUSG00000028785.
ENSMUST00000116442; ENSMUSP00000112143; ENSMUSG00000028785.
ENSMUST00000116444; ENSMUSP00000112145; ENSMUSG00000028785.
ENSMUST00000139450; ENSMUSP00000119178; ENSMUSG00000028785.
ENSMUST00000164649; ENSMUSP00000129548; ENSMUSG00000028785.
GeneIDi15444.
KEGGimmu:15444.
UCSCiuc008uwb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015200 Genomic DNA. Translation: BAA74455.1 .
AF326551 mRNA. Translation: AAL37397.1 .
AF326552 mRNA. Translation: AAL37398.1 .
AK002992 mRNA. Translation: BAB22502.1 .
AL606977 Genomic DNA. Translation: CAM19712.1 .
BC049607 mRNA. Translation: AAH49607.1 .
BC058588 mRNA. Translation: AAH58588.1 .
CCDSi CCDS18682.1.
RefSeqi NP_001123891.1. NM_001130419.2.
NP_001273010.1. NM_001286081.1.
NP_001273012.1. NM_001286083.1.
NP_034601.1. NM_010471.4.
XP_006502838.1. XM_006502775.1.
XP_006502839.1. XM_006502776.1.
XP_006502840.1. XM_006502777.1.
XP_006537013.1. XM_006536950.1.
XP_006537014.1. XM_006536951.1.
UniGenei Mm.384452.

3D structure databases

ProteinModelPortali P84075.
SMRi P84075. Positions 5-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P84075. 2 interactions.
MINTi MINT-4097878.

PTM databases

PhosphoSitei P84075.

Proteomic databases

MaxQBi P84075.
PaxDbi P84075.
PRIDEi P84075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030572 ; ENSMUSP00000030572 ; ENSMUSG00000028785 .
ENSMUST00000095807 ; ENSMUSP00000093486 ; ENSMUSG00000028785 .
ENSMUST00000116442 ; ENSMUSP00000112143 ; ENSMUSG00000028785 .
ENSMUST00000116444 ; ENSMUSP00000112145 ; ENSMUSG00000028785 .
ENSMUST00000139450 ; ENSMUSP00000119178 ; ENSMUSG00000028785 .
ENSMUST00000164649 ; ENSMUSP00000129548 ; ENSMUSG00000028785 .
GeneIDi 15444.
KEGGi mmu:15444.
UCSCi uc008uwb.2. mouse.

Organism-specific databases

CTDi 3208.
MGIi MGI:1336200. Hpca.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00560000076803.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
InParanoidi A2A7R4.
OMAi QANYKMV.
OrthoDBi EOG7GJ6F3.
PhylomeDBi P84075.
TreeFami TF300009.

Miscellaneous databases

NextBioi 288236.
PROi P84075.
SOURCEi Search...

Gene expression databases

Bgeei P84075.
CleanExi MM_HPCA.
Genevestigatori P84075.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
Pfami PF00036. EF-hand_1. 3 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
    Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
    Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
    Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
    J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Retina.

Entry informationi

Entry nameiHPCA_MOUSE
AccessioniPrimary (citable) accession number: P84075
Secondary accession number(s): A2A7R4
, P32076, P41211, P70510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi