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P84074 (HPCA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuron-specific calcium-binding protein hippocalcin
Alternative name(s):
Calcium-binding protein BDR-2
Gene names
Name:HPCA
Synonyms:BDR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Tissue specificity

Brain specific. Ref.1

Post-translational modification

Myristoylation facilitates interaction with membranes By similarity.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMLipoprotein
Myristate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinner ear development

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionactin binding

Inferred from direct assay PubMed 11964161. Source: UniProtKB

calcium ion binding

Non-traceable author statement PubMed 8387172. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 193192Neuron-specific calcium-binding protein hippocalcin
PRO_0000073768

Regions

Domain24 – 5936EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain144 – 17936EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding157 – 168123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Natural variations

Natural variant211E → D.
Corresponds to variant rs11554958 [ dbSNP | Ensembl ].
VAR_048662

Experimental info

Sequence conflict941R → P in BAA04019. Ref.1
Sequence conflict1901A → R in BAA04019. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P84074 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3DBEA176AC945DB1

FASTA19322,427
        10         20         30         40         50         60 
MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD 

        70         80         90        100        110        120 
ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE 

       130        140        150        160        170        180 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 

       190 
RLLQCDPSSA SQF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene."
Takamatsu K., Kobayashi M., Saitoh S., Fujishiro M., Noguchi T.
Biochem. Biophys. Res. Commun. 200:606-611(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Hippocampus.
[2]"Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16593 mRNA. Translation: BAA04019.1.
AB015202 Genomic DNA. Translation: BAA74456.1.
AK313907 mRNA. Translation: BAG36630.1.
CH471059 Genomic DNA. Translation: EAX07495.1.
CH471059 Genomic DNA. Translation: EAX07496.1.
CH471059 Genomic DNA. Translation: EAX07498.1.
BC001777 mRNA. Translation: AAH01777.1.
PIRJC2186.
RefSeqNP_002134.2. NM_002143.2.
XP_005270849.1. XM_005270792.1.
UniGeneHs.632391.

3D structure databases

ProteinModelPortalP84074.
SMRP84074. Positions 5-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109448. 3 interactions.
STRING9606.ENSP00000362566.

PTM databases

PhosphoSiteP84074.

Polymorphism databases

DMDM51317406.

Proteomic databases

PaxDbP84074.
PeptideAtlasP84074.
PRIDEP84074.

Protocols and materials databases

DNASU3208.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373467; ENSP00000362566; ENSG00000121905.
GeneID3208.
KEGGhsa:3208.
UCSCuc001bwh.3. human.

Organism-specific databases

CTD3208.
GeneCardsGC01P033351.
HGNCHGNC:5144. HPCA.
HPACAB012340.
HPA043245.
MIM142622. gene.
neXtProtNX_P84074.
PharmGKBPA29417.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233019.
HOVERGENHBG108179.
InParanoidP84074.
OMADLYKQSR.
OrthoDBEOG7GJ6F3.
PhylomeDBP84074.
TreeFamTF300009.

Gene expression databases

BgeeP84074.
CleanExHS_HPCA.
GenevestigatorP84074.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF00036. EF-hand_1. 3 hits.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHippocalcin.
GenomeRNAi3208.
NextBio12766.
PROP84074.
SOURCESearch...

Entry information

Entry nameHPCA_HUMAN
AccessionPrimary (citable) accession number: P84074
Secondary accession number(s): B2R9T3 expand/collapse secondary AC list , D3DPQ7, P32076, P41211, P70510
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM