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P84074

- HPCA_HUMAN

UniProt

P84074 - HPCA_HUMAN

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Protein

Neuron-specific calcium-binding protein hippocalcin

Gene
HPCA, BDR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121 Reviewed predictionAdd
BLAST
Calcium bindingi109 – 120122 Reviewed predictionAdd
BLAST
Calcium bindingi157 – 168123 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. calcium ion binding Source: UniProtKB

GO - Biological processi

  1. inner ear development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific calcium-binding protein hippocalcin
Alternative name(s):
Calcium-binding protein BDR-2
Gene namesi
Name:HPCA
Synonyms:BDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:5144. HPCA.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 193192Neuron-specific calcium-binding protein hippocalcinPRO_0000073768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Post-translational modificationi

Myristoylation facilitates interaction with membranes By similarity.

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP84074.
PaxDbiP84074.
PeptideAtlasiP84074.
PRIDEiP84074.

PTM databases

PhosphoSiteiP84074.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Gene expression databases

BgeeiP84074.
CleanExiHS_HPCA.
GenevestigatoriP84074.

Organism-specific databases

HPAiCAB012340.
HPA043245.

Interactioni

Protein-protein interaction databases

BioGridi109448. 3 interactions.
STRINGi9606.ENSP00000362566.

Structurei

3D structure databases

ProteinModelPortaliP84074.
SMRiP84074. Positions 5-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5936EF-hand 1Add
BLAST
Domaini60 – 9536EF-hand 2Add
BLAST
Domaini96 – 13136EF-hand 3Add
BLAST
Domaini144 – 17936EF-hand 4Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP84074.
OMAiQANYKMV.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP84074.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84074-1 [UniParc]FASTAAdd to Basket

« Hide

MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK    50
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK 100
LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE 150
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF 193
Length:193
Mass (Da):22,427
Last modified:January 23, 2007 - v2
Checksum:i3DBEA176AC945DB1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211E → D.
Corresponds to variant rs11554958 [ dbSNP | Ensembl ].
VAR_048662

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941R → P in BAA04019. 1 Publication
Sequence conflicti190 – 1901A → R in BAA04019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16593 mRNA. Translation: BAA04019.1.
AB015202 Genomic DNA. Translation: BAA74456.1.
AK313907 mRNA. Translation: BAG36630.1.
CH471059 Genomic DNA. Translation: EAX07495.1.
CH471059 Genomic DNA. Translation: EAX07496.1.
CH471059 Genomic DNA. Translation: EAX07498.1.
BC001777 mRNA. Translation: AAH01777.1.
CCDSiCCDS370.1.
PIRiJC2186.
RefSeqiNP_002134.2. NM_002143.2.
XP_005270849.1. XM_005270792.1.
UniGeneiHs.632391.

Genome annotation databases

EnsembliENST00000373467; ENSP00000362566; ENSG00000121905.
GeneIDi3208.
KEGGihsa:3208.
UCSCiuc001bwh.3. human.

Polymorphism databases

DMDMi51317406.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16593 mRNA. Translation: BAA04019.1 .
AB015202 Genomic DNA. Translation: BAA74456.1 .
AK313907 mRNA. Translation: BAG36630.1 .
CH471059 Genomic DNA. Translation: EAX07495.1 .
CH471059 Genomic DNA. Translation: EAX07496.1 .
CH471059 Genomic DNA. Translation: EAX07498.1 .
BC001777 mRNA. Translation: AAH01777.1 .
CCDSi CCDS370.1.
PIRi JC2186.
RefSeqi NP_002134.2. NM_002143.2.
XP_005270849.1. XM_005270792.1.
UniGenei Hs.632391.

3D structure databases

ProteinModelPortali P84074.
SMRi P84074. Positions 5-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109448. 3 interactions.
STRINGi 9606.ENSP00000362566.

PTM databases

PhosphoSitei P84074.

Polymorphism databases

DMDMi 51317406.

Proteomic databases

MaxQBi P84074.
PaxDbi P84074.
PeptideAtlasi P84074.
PRIDEi P84074.

Protocols and materials databases

DNASUi 3208.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373467 ; ENSP00000362566 ; ENSG00000121905 .
GeneIDi 3208.
KEGGi hsa:3208.
UCSCi uc001bwh.3. human.

Organism-specific databases

CTDi 3208.
GeneCardsi GC01P033351.
HGNCi HGNC:5144. HPCA.
HPAi CAB012340.
HPA043245.
MIMi 142622. gene.
neXtProti NX_P84074.
PharmGKBi PA29417.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
InParanoidi P84074.
OMAi QANYKMV.
OrthoDBi EOG7GJ6F3.
PhylomeDBi P84074.
TreeFami TF300009.

Miscellaneous databases

GeneWikii Hippocalcin.
GenomeRNAii 3208.
NextBioi 12766.
PROi P84074.
SOURCEi Search...

Gene expression databases

Bgeei P84074.
CleanExi HS_HPCA.
Genevestigatori P84074.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
Pfami PF00036. EF-hand_1. 3 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene."
    Takamatsu K., Kobayashi M., Saitoh S., Fujishiro M., Noguchi T.
    Biochem. Biophys. Res. Commun. 200:606-611(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hippocampus.
  2. "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
    Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
    Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiHPCA_HUMAN
AccessioniPrimary (citable) accession number: P84074
Secondary accession number(s): B2R9T3
, D3DPQ7, P32076, P41211, P70510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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