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P84074

- HPCA_HUMAN

UniProt

P84074 - HPCA_HUMAN

Protein

Neuron-specific calcium-binding protein hippocalcin

Gene

HPCA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. calcium ion binding Source: UniProtKB

    GO - Biological processi

    1. inner ear development Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuron-specific calcium-binding protein hippocalcin
    Alternative name(s):
    Calcium-binding protein BDR-2
    Gene namesi
    Name:HPCA
    Synonyms:BDR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:5144. HPCA.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 193192Neuron-specific calcium-binding protein hippocalcinPRO_0000073768Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Post-translational modificationi

    Myristoylation facilitates interaction with membranes.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP84074.
    PaxDbiP84074.
    PeptideAtlasiP84074.
    PRIDEiP84074.

    PTM databases

    PhosphoSiteiP84074.

    Expressioni

    Tissue specificityi

    Brain specific.1 Publication

    Gene expression databases

    BgeeiP84074.
    CleanExiHS_HPCA.
    GenevestigatoriP84074.

    Organism-specific databases

    HPAiCAB012340.
    HPA043245.

    Interactioni

    Protein-protein interaction databases

    BioGridi109448. 3 interactions.
    STRINGi9606.ENSP00000362566.

    Structurei

    3D structure databases

    ProteinModelPortaliP84074.
    SMRiP84074. Positions 5-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 5936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    InParanoidiP84074.
    OMAiQANYKMV.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiP84074.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PfamiPF00036. EF-hand_1. 3 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK    50
    IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK 100
    LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE 150
    KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF 193
    Length:193
    Mass (Da):22,427
    Last modified:January 23, 2007 - v2
    Checksum:i3DBEA176AC945DB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941R → P in BAA04019. (PubMed:8166736)Curated
    Sequence conflicti190 – 1901A → R in BAA04019. (PubMed:8166736)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211E → D.
    Corresponds to variant rs11554958 [ dbSNP | Ensembl ].
    VAR_048662

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16593 mRNA. Translation: BAA04019.1.
    AB015202 Genomic DNA. Translation: BAA74456.1.
    AK313907 mRNA. Translation: BAG36630.1.
    CH471059 Genomic DNA. Translation: EAX07495.1.
    CH471059 Genomic DNA. Translation: EAX07496.1.
    CH471059 Genomic DNA. Translation: EAX07498.1.
    BC001777 mRNA. Translation: AAH01777.1.
    CCDSiCCDS370.1.
    PIRiJC2186.
    RefSeqiNP_002134.2. NM_002143.2.
    XP_005270849.1. XM_005270792.1.
    UniGeneiHs.632391.

    Genome annotation databases

    EnsembliENST00000373467; ENSP00000362566; ENSG00000121905.
    GeneIDi3208.
    KEGGihsa:3208.
    UCSCiuc001bwh.3. human.

    Polymorphism databases

    DMDMi51317406.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16593 mRNA. Translation: BAA04019.1 .
    AB015202 Genomic DNA. Translation: BAA74456.1 .
    AK313907 mRNA. Translation: BAG36630.1 .
    CH471059 Genomic DNA. Translation: EAX07495.1 .
    CH471059 Genomic DNA. Translation: EAX07496.1 .
    CH471059 Genomic DNA. Translation: EAX07498.1 .
    BC001777 mRNA. Translation: AAH01777.1 .
    CCDSi CCDS370.1.
    PIRi JC2186.
    RefSeqi NP_002134.2. NM_002143.2.
    XP_005270849.1. XM_005270792.1.
    UniGenei Hs.632391.

    3D structure databases

    ProteinModelPortali P84074.
    SMRi P84074. Positions 5-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109448. 3 interactions.
    STRINGi 9606.ENSP00000362566.

    PTM databases

    PhosphoSitei P84074.

    Polymorphism databases

    DMDMi 51317406.

    Proteomic databases

    MaxQBi P84074.
    PaxDbi P84074.
    PeptideAtlasi P84074.
    PRIDEi P84074.

    Protocols and materials databases

    DNASUi 3208.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373467 ; ENSP00000362566 ; ENSG00000121905 .
    GeneIDi 3208.
    KEGGi hsa:3208.
    UCSCi uc001bwh.3. human.

    Organism-specific databases

    CTDi 3208.
    GeneCardsi GC01P033351.
    HGNCi HGNC:5144. HPCA.
    HPAi CAB012340.
    HPA043245.
    MIMi 142622. gene.
    neXtProti NX_P84074.
    PharmGKBi PA29417.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    InParanoidi P84074.
    OMAi QANYKMV.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi P84074.
    TreeFami TF300009.

    Miscellaneous databases

    GeneWikii Hippocalcin.
    GenomeRNAii 3208.
    NextBioi 12766.
    PROi P84074.
    SOURCEi Search...

    Gene expression databases

    Bgeei P84074.
    CleanExi HS_HPCA.
    Genevestigatori P84074.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    Pfami PF00036. EF-hand_1. 3 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene."
      Takamatsu K., Kobayashi M., Saitoh S., Fujishiro M., Noguchi T.
      Biochem. Biophys. Res. Commun. 200:606-611(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hippocampus.
    2. "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes."
      Masaki T., Sakai E., Furuta Y., Kobayashi M., Takamatsu K.
      Gene 225:117-124(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiHPCA_HUMAN
    AccessioniPrimary (citable) accession number: P84074
    Secondary accession number(s): B2R9T3
    , D3DPQ7, P32076, P41211, P70510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3