P84066 (DTD_LEIMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable D-tyrosyl-tRNA(Tyr) deacylase EC=3.1.-.-
Organism	Leishmania major
Taxonomic identifier	5664 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine By similarity. UniProtKB P32147
Subunit structure	Homodimer. Ref.1
Subcellular location	Cytoplasm By similarity UniProtKB P32147.
Sequence similarities	Belongs to the DTD family. Highly divergent.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	D-amino acid catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 181

181

Probable D-tyrosyl-tRNA(Tyr) deacylase

PRO_0000164628

Secondary structure

1

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181

Helix Strand Turn

Details...

Beta strand

1 – 11

11

Beta strand

13 – 16

4

Beta strand

18 – 21

4

Beta strand

23 – 32

10

Helix

42 – 54

13

Beta strand

80 – 85

6

Helix

87 – 90

4

Beta strand

92 – 94

3

Beta strand

97 – 99

3

Helix

106 – 123

18

Beta strand

135 – 139

5

Helix

140 – 142

3

Beta strand

146 – 148

3

Beta strand

156 – 158

3

Beta strand

167 – 172

6

Sequences

	Sequence		Length	Mass (Da)
	P84066 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: 406E11C5B03123A1	FASTA	181	20,114
	10 20 30 40 50 60 MLQAMDQGHL LVNNVDKYVR AGRGVMVYIA FLSDRDSAPI TDEALRHAVG VLLHTKIFTH 70 80 90 100 110 120 FSPEKMINQP QSLEECPEMD ILIVPQASLG GKVKGRSVQF HQLVAKDVGA ALYDRFCHFV 130 140 150 160 170 180 RVARGVDESR VDANGAPRSE GDAPKAEGWI KYNSRVISGT FGNRQGLRFE SEGPFTHMFD I

References

[1]	"Structural analysis of a probable eukaryotic D-amino acid tRNA deacylase." Robein M.A., Hol W.G.J. Submitted (JUN-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS), SUBUNIT.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TC5	X-ray	1.93	A/B/C/D	1-181	[»]

ProteinModelPortal

P84066.

SMR

P84066. Positions 1-181.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR023509. DTD-like_dom.
IPR003732. DTyrtRNA_deacyls.
[Graphical view]

Gene3D

G3DSA:3.50.80.10. DTyrtRNA_deacyls. 1 hit.

PANTHER

PTHR10472. DTyrtRNA_deacyls. 1 hit.

Pfam

PF02580. Tyr_Deacylase. 1 hit.
[Graphical view]

SUPFAM

SSF69500. DTyrtRNA_deacyls. 1 hit.

ProtoNet

Search...

Entry information

Entry name

DTD_LEIMA

Accession

Primary (citable) accession number: P84066

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	March 8, 2011
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)