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Protein

Dystrobrevin beta

Gene

Dtnb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin beta
Short name:
DTN-B
Alternative name(s):
Beta-dystrobrevin
Gene namesi
Name:DtnbBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1309579. Dtnb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Dystrobrevin betaPRO_0000086880Add
BLAST

Proteomic databases

PaxDbiP84060.
PRIDEiP84060.

PTM databases

iPTMnetiP84060.

Expressioni

Gene expression databases

ExpressionAtlasiP84060. baseline and differential.
GenevisibleiP84060. RN.

Interactioni

Subunit structurei

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2. Binds dystrobrevin binding protein 1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi263662. 4 interactions.
IntActiP84060. 1 interaction.
STRINGi10116.ENSRNOP00000057536.

Structurei

3D structure databases

ProteinModelPortaliP84060.
SMRiP84060. Positions 237-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni399 – 44850Syntrophin-binding regionBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili429 – 51991Sequence analysisAdd
BLAST

Domaini

The coiled coil domain may mediate the interaction with dystrophin.By similarity

Sequence similaritiesi

Belongs to the dystrophin family. Dystrobrevin subfamily.By similarity
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4301. Eukaryota.
ENOG410XP3C. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000230684.
HOVERGENiHBG005539.
InParanoidiP84060.
OMAiPQQRKIM.
OrthoDBiEOG7N8ZV0.
PhylomeDBiP84060.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEEGGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHATEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QINVEQSISL LLNFMIAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
IFSQMSDSNG LMMFGKLDQF LKEALKLPTA VFEGPSFGYT EHAVRTCFPQ
210 220 230 240 250
QKKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCHCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKELS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PSREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM
360 370 380 390 400
SSGVPTPTKR LQYGQDMPNL LADEHALIAS YVARLQHCTR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNMT RPPTDASFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPTLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EGLMKLLKAQ ATGSPHTSPT HGGGRSMPMP VRSTSAGSTP
560 570 580 590 600
THGPQDSLSG VGGDVQEAFA QGTRRNLRND LLVAADSITN TMSSLVKELH
610 620 630 640 650
SGETQRFPLV SSSPSCPLPC PTIPTHSPSF HATFPSRNTR DLHPVPPSHM

VSLY
Length:654
Mass (Da):73,878
Last modified:December 6, 2005 - v2
Checksum:iAC0A98AE9E0A7234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081889 mRNA. Translation: AAH81889.1.
AA899479 mRNA. No translation available.
RefSeqiNP_001012191.1. NM_001012191.1.
XP_006239878.1. XM_006239816.2.
UniGeneiRn.61275.

Genome annotation databases

EnsembliENSRNOT00000060810; ENSRNOP00000057536; ENSRNOG00000011914.
GeneIDi362715.
KEGGirno:362715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081889 mRNA. Translation: AAH81889.1.
AA899479 mRNA. No translation available.
RefSeqiNP_001012191.1. NM_001012191.1.
XP_006239878.1. XM_006239816.2.
UniGeneiRn.61275.

3D structure databases

ProteinModelPortaliP84060.
SMRiP84060. Positions 237-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263662. 4 interactions.
IntActiP84060. 1 interaction.
STRINGi10116.ENSRNOP00000057536.

PTM databases

iPTMnetiP84060.

Proteomic databases

PaxDbiP84060.
PRIDEiP84060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000060810; ENSRNOP00000057536; ENSRNOG00000011914.
GeneIDi362715.
KEGGirno:362715.

Organism-specific databases

CTDi1838.
RGDi1309579. Dtnb.

Phylogenomic databases

eggNOGiKOG4301. Eukaryota.
ENOG410XP3C. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000230684.
HOVERGENiHBG005539.
InParanoidiP84060.
OMAiPQQRKIM.
OrthoDBiEOG7N8ZV0.
PhylomeDBiP84060.

Miscellaneous databases

PROiP84060.

Gene expression databases

ExpressionAtlasiP84060. baseline and differential.
GenevisibleiP84060. RN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Normalization and subtraction: two approaches to facilitate gene discovery."
    Bonaldo M.F., Lennon G., Soares M.B.
    Genome Res. 6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 350-451.
    Strain: Sprague-Dawley1 Publication.
    Tissue: Embryo1 Publication.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDTNB_RAT
AccessioniPrimary (citable) accession number: P84060
Secondary accession number(s): Q66HF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.