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Protein

Histone H2A

Gene

His2A

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

  • chromatin organization Source: FlyBase
  • chromatin silencing Source: GO_Central
  • larval somatic muscle development Source: FlyBase
  • nucleosome assembly Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-212300 PRC2 methylates histones and DNA
R-DME-2299718 Condensation of Prophase Chromosomes
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-3214815 HDACs deacetylate histones
R-DME-3214847 HATs acetylate histones
R-DME-3214858 RMTs methylate histone arginines
R-DME-427359 SIRT1 negatively regulates rRNA expression
R-DME-427413 NoRC negatively regulates rRNA expression
R-DME-5578749 Transcriptional regulation by small RNAs
R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-5689901 Metalloprotease DUBs
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-5693571 Nonhomologous End-Joining (NHEJ)
R-DME-73777 RNA Polymerase I Chain Elongation
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A
Gene namesi
Name:His2A
Synonyms:H2a
AND
ORF Names:CG31618
AND
ORF Names:CG33808
AND
ORF Names:CG33814
AND
ORF Names:CG33817
AND
ORF Names:CG33820
AND
ORF Names:CG33823
AND
ORF Names:CG33826
AND
ORF Names:CG33829
AND
ORF Names:CG33832
AND
ORF Names:CG33835
AND
ORF Names:CG33838
AND
ORF Names:CG33841
AND
ORF Names:CG33844
AND
ORF Names:CG33847
AND
ORF Names:CG33850
AND
ORF Names:CG33862
AND
ORF Names:CG33865
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001196 His2A
FBgn0051618 His2A:CG31618
FBgn0053808 His2A:CG33808
FBgn0053814 His2A:CG33814
FBgn0053817 His2A:CG33817
FBgn0053820 His2A:CG33820
FBgn0053823 His2A:CG33823
FBgn0053826 His2A:CG33826
FBgn0053829 His2A:CG33829
FBgn0053832 His2A:CG33832
FBgn0053835 His2A:CG33835
FBgn0053838 His2A:CG33838
FBgn0053841 His2A:CG33841
FBgn0053844 His2A:CG33844
FBgn0053847 His2A:CG33847
FBgn0053850 His2A:CG33850
FBgn0053862 His2A:CG33862
FBgn0053865 His2A:CG33865

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000552222 – 124Histone H2AAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine1 Publication1
Modified residuei36N6-succinyllysine1 Publication1
Modified residuei104N5-methylglutamineBy similarity1
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei120Phosphothreonine2 Publications1

Post-translational modificationi

The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.3 Publications
Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP84051
PRIDEiP84051

PTM databases

iPTMnetiP84051

Expressioni

Gene expression databases

BgeeiFBgn0051618
GenevisibleiP84051 DM

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
cidQ9V6Q22EBI-182580,EBI-129287

GO - Molecular functioni

Protein-protein interaction databases

BioGridi534102, 1 interactor
77146, 21 interactors
DIPiDIP-29504N
IntActiP84051, 9 interactors
MINTiP84051
STRINGi7227.FBpp0091111

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 21Combined sources5
Helixi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Helixi46 – 72Combined sources27
Beta strandi76 – 78Combined sources3
Helixi80 – 88Combined sources9
Helixi91 – 96Combined sources6
Turni97 – 99Combined sources3
Beta strandi100 – 102Combined sources3
Helixi113 – 115Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30C/G2-124[»]
2PYOX-ray2.43C/G2-121[»]
4QLCX-ray3.50C/G2-124[»]
4X23X-ray3.50C/G/M/Q16-117[»]
ProteinModelPortaliP84051
SMRiP84051
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84051

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981
InParanoidiP84051
KOiK11251
OMAiHAYLYSA
OrthoDBiEOG091G0XGD
PhylomeDBiP84051

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKV KGKAKSRSNR AGLQFPVGRI HRLLRKGNYA ERVGAGAPVY
60 70 80 90 100
LAAVMEYLAA EVLELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLSGV
110 120
TIAQGGVLPN IQAVLLPKKT EKKA
Length:124
Mass (Da):13,363
Last modified:January 23, 2007 - v2
Checksum:i725BA63C393155F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA Translation: CAA32431.1
X14215 Genomic DNA Translation: CAA32436.1
AE014134 Genomic DNA Translation: AAN11125.1
AE014134 Genomic DNA Translation: AAZ66488.1
AE014134 Genomic DNA Translation: AAZ66497.1
AE014134 Genomic DNA Translation: AAZ66502.1
AE014134 Genomic DNA Translation: AAZ66507.1
AE014134 Genomic DNA Translation: AAZ66512.1
AE014134 Genomic DNA Translation: AAZ66517.1
AE014134 Genomic DNA Translation: AAZ66522.1
AE014134 Genomic DNA Translation: AAZ66527.1
AE014134 Genomic DNA Translation: AAZ66532.1
AE014134 Genomic DNA Translation: AAZ66537.1
AE014134 Genomic DNA Translation: AAZ66542.1
AE014134 Genomic DNA Translation: AAZ66547.1
AE014134 Genomic DNA Translation: AAZ66552.1
AE014134 Genomic DNA Translation: AAZ66557.1
AE014134 Genomic DNA Translation: AAZ66577.1
AE014134 Genomic DNA Translation: AAZ66582.1
PIRiS10094 HSFF2
RefSeqiNP_001027292.1, NM_001032121.2
NP_001027301.1, NM_001032130.2
NP_001027306.1, NM_001032135.2
NP_001027311.1, NM_001032140.2
NP_001027316.1, NM_001032145.2
NP_001027321.1, NM_001032150.2
NP_001027326.1, NM_001032155.2
NP_001027331.1, NM_001032160.2
NP_001027336.1, NM_001032165.2
NP_001027341.1, NM_001032170.2
NP_001027346.1, NM_001032175.2
NP_001027351.1, NM_001032180.2
NP_001027356.1, NM_001032185.2
NP_001027361.1, NM_001032190.2
NP_001027381.1, NM_001032210.2
NP_001027386.1, NM_001032215.2
NP_724343.1, NM_165382.3

Genome annotation databases

EnsemblMetazoaiFBtr0085893; FBpp0085249; FBgn0051618
FBtr0091812; FBpp0091055; FBgn0053808
FBtr0091818; FBpp0091060; FBgn0053814
FBtr0091821; FBpp0091063; FBgn0053817
FBtr0091824; FBpp0091066; FBgn0053820
FBtr0091827; FBpp0091069; FBgn0053823
FBtr0091830; FBpp0091072; FBgn0053826
FBtr0091833; FBpp0091075; FBgn0053829
FBtr0091836; FBpp0091078; FBgn0053832
FBtr0091839; FBpp0091081; FBgn0053835
FBtr0091842; FBpp0091084; FBgn0053838
FBtr0091845; FBpp0091087; FBgn0053841
FBtr0091848; FBpp0091090; FBgn0053844
FBtr0091851; FBpp0091093; FBgn0053847
FBtr0091854; FBpp0091096; FBgn0053850
FBtr0091866; FBpp0091108; FBgn0053862
FBtr0091869; FBpp0091111; FBgn0053865
GeneIDi318855
3771774
3771783
3771785
3772148
3772278
3772282
3772345
3772351
3772360
3772447
3772448
3772505
3772541
3772565
3772618
3772632
KEGGidme:Dmel_CG31618
dme:Dmel_CG33808
dme:Dmel_CG33814
dme:Dmel_CG33817
dme:Dmel_CG33820
dme:Dmel_CG33823
dme:Dmel_CG33826
dme:Dmel_CG33829
dme:Dmel_CG33832
dme:Dmel_CG33835
dme:Dmel_CG33838
dme:Dmel_CG33841
dme:Dmel_CG33844
dme:Dmel_CG33847
dme:Dmel_CG33850
dme:Dmel_CG33862
dme:Dmel_CG33865
UCSCiCG31618-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiH2A_DROME
AccessioniPrimary (citable) accession number: P84051
Secondary accession number(s): P02267, Q4ABC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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