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Protein

Histone H2A

Gene

His2A

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • centrosome duplication Source: FlyBase
  • chromatin organization Source: FlyBase
  • chromatin silencing Source: GO_Central
  • larval somatic muscle development Source: FlyBase
  • nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A
Gene namesi
Name:His2A
Synonyms:H2a
AND
ORF Names:CG31618
AND
ORF Names:CG33808
AND
ORF Names:CG33814
AND
ORF Names:CG33817
AND
ORF Names:CG33820
AND
ORF Names:CG33823
AND
ORF Names:CG33826
AND
ORF Names:CG33829
AND
ORF Names:CG33832
AND
ORF Names:CG33835
AND
ORF Names:CG33838
AND
ORF Names:CG33841
AND
ORF Names:CG33844
AND
ORF Names:CG33847
AND
ORF Names:CG33850
AND
ORF Names:CG33862
AND
ORF Names:CG33865
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001196. His2A.
FBgn0051618. His2A:CG31618.
FBgn0053808. His2A:CG33808.
FBgn0053814. His2A:CG33814.
FBgn0053817. His2A:CG33817.
FBgn0053820. His2A:CG33820.
FBgn0053823. His2A:CG33823.
FBgn0053826. His2A:CG33826.
FBgn0053829. His2A:CG33829.
FBgn0053832. His2A:CG33832.
FBgn0053835. His2A:CG33835.
FBgn0053838. His2A:CG33838.
FBgn0053841. His2A:CG33841.
FBgn0053844. His2A:CG33844.
FBgn0053847. His2A:CG33847.
FBgn0053850. His2A:CG33850.
FBgn0053862. His2A:CG33862.
FBgn0053865. His2A:CG33865.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: FlyBase
  • lipid particle Source: FlyBase
  • nuclear chromatin Source: GO_Central
  • nuclear nucleosome Source: FlyBase
  • nucleosome Source: UniProtKB
  • nucleus Source: FlyBase
  • polytene chromosome Source: FlyBase
  • polytene chromosome band Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000552222 – 124Histone H2AAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine1 Publication1
Modified residuei104N5-methylglutamineBy similarity1
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei120Phosphothreonine2 Publications1

Post-translational modificationi

The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.3 Publications
Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP84051.
PRIDEiP84051.

PTM databases

iPTMnetiP84051.

Expressioni

Gene expression databases

BgeeiFBgn0051618.
GenevisibleiP84051. DM.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi534102. 1 interactor.
77146. 9 interactors.
DIPiDIP-17375N.
DIP-29504N.
IntActiP84051. 8 interactors.
MINTiMINT-742075.
STRINGi7227.FBpp0091111.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 21Combined sources5
Helixi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Helixi46 – 72Combined sources27
Beta strandi76 – 78Combined sources3
Helixi80 – 88Combined sources9
Helixi91 – 96Combined sources6
Turni97 – 99Combined sources3
Beta strandi100 – 102Combined sources3
Helixi113 – 115Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30C/G2-124[»]
2PYOX-ray2.43C/G2-121[»]
4QLCX-ray3.50C/G2-124[»]
4X23X-ray3.50C/G/M/Q16-117[»]
ProteinModelPortaliP84051.
SMRiP84051.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84051.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00760000118934.
ENSGT00860000133717.
InParanoidiP84051.
KOiK11251.
OMAiKANSQEY.
OrthoDBiEOG091G0XGD.
PhylomeDBiP84051.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKV KGKAKSRSNR AGLQFPVGRI HRLLRKGNYA ERVGAGAPVY
60 70 80 90 100
LAAVMEYLAA EVLELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLSGV
110 120
TIAQGGVLPN IQAVLLPKKT EKKA
Length:124
Mass (Da):13,363
Last modified:January 23, 2007 - v2
Checksum:i725BA63C393155F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32431.1.
X14215 Genomic DNA. Translation: CAA32436.1.
AE014134 Genomic DNA. Translation: AAN11125.1.
AE014134 Genomic DNA. Translation: AAZ66488.1.
AE014134 Genomic DNA. Translation: AAZ66497.1.
AE014134 Genomic DNA. Translation: AAZ66502.1.
AE014134 Genomic DNA. Translation: AAZ66507.1.
AE014134 Genomic DNA. Translation: AAZ66512.1.
AE014134 Genomic DNA. Translation: AAZ66517.1.
AE014134 Genomic DNA. Translation: AAZ66522.1.
AE014134 Genomic DNA. Translation: AAZ66527.1.
AE014134 Genomic DNA. Translation: AAZ66532.1.
AE014134 Genomic DNA. Translation: AAZ66537.1.
AE014134 Genomic DNA. Translation: AAZ66542.1.
AE014134 Genomic DNA. Translation: AAZ66547.1.
AE014134 Genomic DNA. Translation: AAZ66552.1.
AE014134 Genomic DNA. Translation: AAZ66557.1.
AE014134 Genomic DNA. Translation: AAZ66577.1.
AE014134 Genomic DNA. Translation: AAZ66582.1.
PIRiS10094. HSFF2.
RefSeqiNP_001027292.1. NM_001032121.2.
NP_001027301.1. NM_001032130.2.
NP_001027306.1. NM_001032135.2.
NP_001027311.1. NM_001032140.2.
NP_001027316.1. NM_001032145.2.
NP_001027321.1. NM_001032150.2.
NP_001027326.1. NM_001032155.2.
NP_001027331.1. NM_001032160.2.
NP_001027336.1. NM_001032165.2.
NP_001027341.1. NM_001032170.2.
NP_001027346.1. NM_001032175.2.
NP_001027351.1. NM_001032180.2.
NP_001027356.1. NM_001032185.2.
NP_001027361.1. NM_001032190.2.
NP_001027381.1. NM_001032210.2.
NP_001027386.1. NM_001032215.2.
NP_724343.1. NM_165382.3.

Genome annotation databases

EnsemblMetazoaiFBtr0085893; FBpp0085249; FBgn0051618.
FBtr0091812; FBpp0091055; FBgn0053808.
FBtr0091818; FBpp0091060; FBgn0053814.
FBtr0091821; FBpp0091063; FBgn0053817.
FBtr0091824; FBpp0091066; FBgn0053820.
FBtr0091827; FBpp0091069; FBgn0053823.
FBtr0091830; FBpp0091072; FBgn0053826.
FBtr0091833; FBpp0091075; FBgn0053829.
FBtr0091836; FBpp0091078; FBgn0053832.
FBtr0091839; FBpp0091081; FBgn0053835.
FBtr0091842; FBpp0091084; FBgn0053838.
FBtr0091845; FBpp0091087; FBgn0053841.
FBtr0091848; FBpp0091090; FBgn0053844.
FBtr0091851; FBpp0091093; FBgn0053847.
FBtr0091854; FBpp0091096; FBgn0053850.
FBtr0091866; FBpp0091108; FBgn0053862.
FBtr0091869; FBpp0091111; FBgn0053865.
GeneIDi318855.
3771774.
3771783.
3771785.
3772148.
3772278.
3772282.
3772345.
3772351.
3772360.
3772447.
3772448.
3772505.
3772541.
3772565.
3772618.
3772632.
KEGGidme:Dmel_CG31618.
dme:Dmel_CG33808.
dme:Dmel_CG33814.
dme:Dmel_CG33817.
dme:Dmel_CG33820.
dme:Dmel_CG33823.
dme:Dmel_CG33826.
dme:Dmel_CG33829.
dme:Dmel_CG33832.
dme:Dmel_CG33835.
dme:Dmel_CG33838.
dme:Dmel_CG33841.
dme:Dmel_CG33844.
dme:Dmel_CG33847.
dme:Dmel_CG33850.
dme:Dmel_CG33862.
dme:Dmel_CG33865.
UCSCiCG31618-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32431.1.
X14215 Genomic DNA. Translation: CAA32436.1.
AE014134 Genomic DNA. Translation: AAN11125.1.
AE014134 Genomic DNA. Translation: AAZ66488.1.
AE014134 Genomic DNA. Translation: AAZ66497.1.
AE014134 Genomic DNA. Translation: AAZ66502.1.
AE014134 Genomic DNA. Translation: AAZ66507.1.
AE014134 Genomic DNA. Translation: AAZ66512.1.
AE014134 Genomic DNA. Translation: AAZ66517.1.
AE014134 Genomic DNA. Translation: AAZ66522.1.
AE014134 Genomic DNA. Translation: AAZ66527.1.
AE014134 Genomic DNA. Translation: AAZ66532.1.
AE014134 Genomic DNA. Translation: AAZ66537.1.
AE014134 Genomic DNA. Translation: AAZ66542.1.
AE014134 Genomic DNA. Translation: AAZ66547.1.
AE014134 Genomic DNA. Translation: AAZ66552.1.
AE014134 Genomic DNA. Translation: AAZ66557.1.
AE014134 Genomic DNA. Translation: AAZ66577.1.
AE014134 Genomic DNA. Translation: AAZ66582.1.
PIRiS10094. HSFF2.
RefSeqiNP_001027292.1. NM_001032121.2.
NP_001027301.1. NM_001032130.2.
NP_001027306.1. NM_001032135.2.
NP_001027311.1. NM_001032140.2.
NP_001027316.1. NM_001032145.2.
NP_001027321.1. NM_001032150.2.
NP_001027326.1. NM_001032155.2.
NP_001027331.1. NM_001032160.2.
NP_001027336.1. NM_001032165.2.
NP_001027341.1. NM_001032170.2.
NP_001027346.1. NM_001032175.2.
NP_001027351.1. NM_001032180.2.
NP_001027356.1. NM_001032185.2.
NP_001027361.1. NM_001032190.2.
NP_001027381.1. NM_001032210.2.
NP_001027386.1. NM_001032215.2.
NP_724343.1. NM_165382.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30C/G2-124[»]
2PYOX-ray2.43C/G2-121[»]
4QLCX-ray3.50C/G2-124[»]
4X23X-ray3.50C/G/M/Q16-117[»]
ProteinModelPortaliP84051.
SMRiP84051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi534102. 1 interactor.
77146. 9 interactors.
DIPiDIP-17375N.
DIP-29504N.
IntActiP84051. 8 interactors.
MINTiMINT-742075.
STRINGi7227.FBpp0091111.

PTM databases

iPTMnetiP84051.

Proteomic databases

PaxDbiP84051.
PRIDEiP84051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085893; FBpp0085249; FBgn0051618.
FBtr0091812; FBpp0091055; FBgn0053808.
FBtr0091818; FBpp0091060; FBgn0053814.
FBtr0091821; FBpp0091063; FBgn0053817.
FBtr0091824; FBpp0091066; FBgn0053820.
FBtr0091827; FBpp0091069; FBgn0053823.
FBtr0091830; FBpp0091072; FBgn0053826.
FBtr0091833; FBpp0091075; FBgn0053829.
FBtr0091836; FBpp0091078; FBgn0053832.
FBtr0091839; FBpp0091081; FBgn0053835.
FBtr0091842; FBpp0091084; FBgn0053838.
FBtr0091845; FBpp0091087; FBgn0053841.
FBtr0091848; FBpp0091090; FBgn0053844.
FBtr0091851; FBpp0091093; FBgn0053847.
FBtr0091854; FBpp0091096; FBgn0053850.
FBtr0091866; FBpp0091108; FBgn0053862.
FBtr0091869; FBpp0091111; FBgn0053865.
GeneIDi318855.
3771774.
3771783.
3771785.
3772148.
3772278.
3772282.
3772345.
3772351.
3772360.
3772447.
3772448.
3772505.
3772541.
3772565.
3772618.
3772632.
KEGGidme:Dmel_CG31618.
dme:Dmel_CG33808.
dme:Dmel_CG33814.
dme:Dmel_CG33817.
dme:Dmel_CG33820.
dme:Dmel_CG33823.
dme:Dmel_CG33826.
dme:Dmel_CG33829.
dme:Dmel_CG33832.
dme:Dmel_CG33835.
dme:Dmel_CG33838.
dme:Dmel_CG33841.
dme:Dmel_CG33844.
dme:Dmel_CG33847.
dme:Dmel_CG33850.
dme:Dmel_CG33862.
dme:Dmel_CG33865.
UCSCiCG31618-RA. d. melanogaster.

Organism-specific databases

CTDi318855.
3771774.
3771783.
3771785.
3772148.
3772278.
3772282.
3772345.
3772351.
3772360.
3772447.
3772448.
3772505.
3772541.
3772565.
3772618.
3772632.
FlyBaseiFBgn0001196. His2A.
FBgn0051618. His2A:CG31618.
FBgn0053808. His2A:CG33808.
FBgn0053814. His2A:CG33814.
FBgn0053817. His2A:CG33817.
FBgn0053820. His2A:CG33820.
FBgn0053823. His2A:CG33823.
FBgn0053826. His2A:CG33826.
FBgn0053829. His2A:CG33829.
FBgn0053832. His2A:CG33832.
FBgn0053835. His2A:CG33835.
FBgn0053838. His2A:CG33838.
FBgn0053841. His2A:CG33841.
FBgn0053844. His2A:CG33844.
FBgn0053847. His2A:CG33847.
FBgn0053850. His2A:CG33850.
FBgn0053862. His2A:CG33862.
FBgn0053865. His2A:CG33865.

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
GeneTreeiENSGT00760000118934.
ENSGT00860000133717.
InParanoidiP84051.
KOiK11251.
OMAiKANSQEY.
OrthoDBiEOG091G0XGD.
PhylomeDBiP84051.

Miscellaneous databases

ChiTaRSiHis2Av. fly.
EvolutionaryTraceiP84051.
PROiP84051.

Gene expression databases

BgeeiFBgn0051618.
GenevisibleiP84051. DM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2A_DROME
AccessioniPrimary (citable) accession number: P84051
Secondary accession number(s): P02267, Q4ABC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.