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Protein

Histone H4

Gene

His4

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. centrosome duplication Source: FlyBase
  2. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:His4
Synonyms:H4
AND
Name:His4r
Synonyms:H4r
ORF Names:CG3379
AND
Name:His4:CG31611
ORF Names:CG31611
AND
Name:His4:CG33869
ORF Names:CG33869
AND
Name:His4:CG33871
ORF Names:CG33871
AND
Name:His4:CG33873
ORF Names:CG33873
AND
Name:His4:CG33875
ORF Names:CG33875
AND
Name:His4:CG33877
ORF Names:CG33877
AND
Name:His4:CG33879
ORF Names:CG33879
AND
Name:His4:CG33881
ORF Names:CG33881
AND
Name:His4:CG33883
ORF Names:CG33883
AND
Name:His4:CG33885
ORF Names:CG33885
AND
Name:His4:CG33887
ORF Names:CG33887
AND
Name:His4:CG33889
ORF Names:CG33889
AND
Name:His4:CG33891
ORF Names:CG33891
AND
Name:His4:CG33893
ORF Names:CG33893
AND
Name:His4:CG33895
ORF Names:CG33895
AND
Name:His4:CG33897
ORF Names:CG33897
AND
Name:His4:CG33899
ORF Names:CG33899
AND
Name:His4:CG33901
ORF Names:CG33901
AND
Name:His4:CG33903
ORF Names:CG33903
AND
Name:His4:CG33905
ORF Names:CG33905
AND
Name:His4:CG33907
ORF Names:CG33907
AND
Name:His4:CG33909
ORF Names:CG33909
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componentsi: Chromosome 2L, Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001200. His4.
FBgn0051611. His4:CG31611.
FBgn0053869. His4:CG33869.
FBgn0053871. His4:CG33871.
FBgn0053873. His4:CG33873.
FBgn0053875. His4:CG33875.
FBgn0053877. His4:CG33877.
FBgn0053879. His4:CG33879.
FBgn0053881. His4:CG33881.
FBgn0053883. His4:CG33883.
FBgn0053885. His4:CG33885.
FBgn0053887. His4:CG33887.
FBgn0053889. His4:CG33889.
FBgn0053891. His4:CG33891.
FBgn0053893. His4:CG33893.
FBgn0053895. His4:CG33895.
FBgn0053897. His4:CG33897.
FBgn0053899. His4:CG33899.
FBgn0053901. His4:CG33901.
FBgn0053903. His4:CG33903.
FBgn0053905. His4:CG33905.
FBgn0053907. His4:CG33907.
FBgn0053909. His4:CG33909.
FBgn0013981. His4r.

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: FlyBase
  2. nucleosome Source: UniProtKB
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 103102Histone H4PRO_0000158305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61N6-acetyllysine1 Publication
Modified residuei13 – 131N6-acetyllysine1 Publication
Modified residuei81 – 811Phosphothreonine1 Publication
Modified residuei83 – 831Phosphothreonine1 Publication

Post-translational modificationi

Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP84040.
PRIDEiP84040.

Expressioni

Gene expression databases

BgeeiP84040.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
KAT2BQ928312EBI-185028,EBI-477430From a different organism.

Protein-protein interaction databases

BioGridi534263. 1 interaction.
66847. 10 interactions.
77139. 9 interactions.
DIPiDIP-29505N.
IntActiP84040. 27 interactions.
MINTiMINT-836772.
STRINGi7227.FBpp0091126.

Structurei

Secondary structure

1
103
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 294Combined sources
Helixi32 – 409Combined sources
Beta strandi45 – 473Combined sources
Helixi51 – 7626Combined sources
Beta strandi80 – 823Combined sources
Helixi84 – 9310Combined sources
Beta strandi98 – 1014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30B/F2-103[»]
2PYOX-ray2.43B/F2-103[»]
2XYIX-ray1.75B27-46[»]
3C9CX-ray3.20B16-42[»]
4UUZX-ray2.90B1-103[»]
4X23X-ray3.50B/F/L/P25-103[»]
ProteinModelPortaliP84040.
SMRiP84040. Positions 21-102.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84040.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiCOG2036.
GeneTreeiENSGT00760000119019.
InParanoidiP84040.
KOiK11254.
OMAiFAMSGRG.
OrthoDBiEOG77T174.
PhylomeDBiP84040.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,381
Last modified:January 23, 2007 - v2
Checksum:iDF3EB26393BD208C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32435.1.
X97437 Genomic DNA. Translation: CAA66067.1.
X97438 mRNA. Translation: CAA66068.1.
AE014297 Genomic DNA. Translation: AAF55080.1.
AE014134 Genomic DNA. Translation: AAN11126.1.
AE014297 Genomic DNA. Translation: AAN13612.1.
AE014297 Genomic DNA. Translation: AAN13613.1.
AE014134 Genomic DNA. Translation: AAZ66480.1.
AE014134 Genomic DNA. Translation: AAZ66484.1.
AE014134 Genomic DNA. Translation: AAZ66489.1.
AE014134 Genomic DNA. Translation: AAZ66493.1.
AE014134 Genomic DNA. Translation: AAZ66498.1.
AE014134 Genomic DNA. Translation: AAZ66503.1.
AE014134 Genomic DNA. Translation: AAZ66508.1.
AE014134 Genomic DNA. Translation: AAZ66513.1.
AE014134 Genomic DNA. Translation: AAZ66518.1.
AE014134 Genomic DNA. Translation: AAZ66523.1.
AE014134 Genomic DNA. Translation: AAZ66528.1.
AE014134 Genomic DNA. Translation: AAZ66533.1.
AE014134 Genomic DNA. Translation: AAZ66538.1.
AE014134 Genomic DNA. Translation: AAZ66543.1.
AE014134 Genomic DNA. Translation: AAZ66548.1.
AE014134 Genomic DNA. Translation: AAZ66553.1.
AE014134 Genomic DNA. Translation: AAZ66558.1.
AE014134 Genomic DNA. Translation: AAZ66563.1.
AE014134 Genomic DNA. Translation: AAZ66568.1.
AE014134 Genomic DNA. Translation: AAZ66573.1.
AE014134 Genomic DNA. Translation: AAZ66578.1.
BT001842 mRNA. Translation: AAN71603.1.
BT015217 mRNA. Translation: AAT94446.1.
PIRiS10098. HSFF4.
RefSeqiNP_001027284.1. NM_001032113.2.
NP_001027288.1. NM_001032117.2.
NP_001027293.1. NM_001032122.2.
NP_001027297.1. NM_001032126.2.
NP_001027302.1. NM_001032131.2.
NP_001027307.1. NM_001032136.2.
NP_001027312.1. NM_001032141.2.
NP_001027317.1. NM_001032146.2.
NP_001027322.1. NM_001032151.2.
NP_001027327.1. NM_001032156.2.
NP_001027332.1. NM_001032161.2.
NP_001027337.1. NM_001032166.2.
NP_001027342.1. NM_001032171.2.
NP_001027347.1. NM_001032176.2.
NP_001027352.1. NM_001032181.2.
NP_001027357.1. NM_001032186.2.
NP_001027362.1. NM_001032191.2.
NP_001027367.1. NM_001032196.1.
NP_001027372.1. NM_001032201.1.
NP_001027377.1. NM_001032206.1.
NP_001027382.1. NM_001032211.1.
NP_001262576.1. NM_001275647.1.
NP_524352.1. NM_079628.4.
NP_724344.1. NM_165383.3.
NP_731927.1. NM_169592.3.
NP_731928.1. NM_169593.3.
UniGeneiDm.29514.
Dm.30223.
Dm.30876.
Dm.5747.

Genome annotation databases

EnsemblMetazoaiFBtr0082962; FBpp0082421; FBgn0013981.
FBtr0082963; FBpp0082422; FBgn0013981.
FBtr0082964; FBpp0082423; FBgn0013981.
FBtr0085926; FBpp0085280; FBgn0051611.
FBtr0091875; FBpp0091116; FBgn0053871.
FBtr0091877; FBpp0091118; FBgn0053873.
FBtr0091879; FBpp0091120; FBgn0053875.
FBtr0091887; FBpp0091128; FBgn0053883.
FBtr0091889; FBpp0091130; FBgn0053885.
FBtr0091891; FBpp0091132; FBgn0053887.
FBtr0091893; FBpp0091134; FBgn0053889.
FBtr0091895; FBpp0091136; FBgn0053891.
FBtr0091897; FBpp0091138; FBgn0053893.
FBtr0091899; FBpp0091140; FBgn0053895.
FBtr0091901; FBpp0091142; FBgn0053897.
FBtr0091903; FBpp0091144; FBgn0053899.
FBtr0091905; FBpp0091146; FBgn0053901.
FBtr0091907; FBpp0091148; FBgn0053903.
FBtr0091909; FBpp0091150; FBgn0053905.
FBtr0091911; FBpp0091152; FBgn0053907.
FBtr0091913; FBpp0091154; FBgn0053909.
FBtr0334029; FBpp0306146; FBgn0013981.
GeneIDi318846.
3771854.
3771893.
3771908.
3771935.
3771938.
3771941.
3771947.
3772096.
3772113.
3772129.
3772172.
3772211.
3772254.
3772314.
3772317.
3772319.
3772325.
3772509.
3772519.
3772666.
3772708.
41773.
KEGGidme:Dmel_CG31611.
dme:Dmel_CG3379.
dme:Dmel_CG33869.
dme:Dmel_CG33871.
dme:Dmel_CG33873.
dme:Dmel_CG33875.
dme:Dmel_CG33877.
dme:Dmel_CG33879.
dme:Dmel_CG33881.
dme:Dmel_CG33883.
dme:Dmel_CG33885.
dme:Dmel_CG33887.
dme:Dmel_CG33889.
dme:Dmel_CG33891.
dme:Dmel_CG33893.
dme:Dmel_CG33895.
dme:Dmel_CG33897.
dme:Dmel_CG33899.
dme:Dmel_CG33901.
dme:Dmel_CG33903.
dme:Dmel_CG33905.
dme:Dmel_CG33907.
dme:Dmel_CG33909.
UCSCiCG31611-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32435.1.
X97437 Genomic DNA. Translation: CAA66067.1.
X97438 mRNA. Translation: CAA66068.1.
AE014297 Genomic DNA. Translation: AAF55080.1.
AE014134 Genomic DNA. Translation: AAN11126.1.
AE014297 Genomic DNA. Translation: AAN13612.1.
AE014297 Genomic DNA. Translation: AAN13613.1.
AE014134 Genomic DNA. Translation: AAZ66480.1.
AE014134 Genomic DNA. Translation: AAZ66484.1.
AE014134 Genomic DNA. Translation: AAZ66489.1.
AE014134 Genomic DNA. Translation: AAZ66493.1.
AE014134 Genomic DNA. Translation: AAZ66498.1.
AE014134 Genomic DNA. Translation: AAZ66503.1.
AE014134 Genomic DNA. Translation: AAZ66508.1.
AE014134 Genomic DNA. Translation: AAZ66513.1.
AE014134 Genomic DNA. Translation: AAZ66518.1.
AE014134 Genomic DNA. Translation: AAZ66523.1.
AE014134 Genomic DNA. Translation: AAZ66528.1.
AE014134 Genomic DNA. Translation: AAZ66533.1.
AE014134 Genomic DNA. Translation: AAZ66538.1.
AE014134 Genomic DNA. Translation: AAZ66543.1.
AE014134 Genomic DNA. Translation: AAZ66548.1.
AE014134 Genomic DNA. Translation: AAZ66553.1.
AE014134 Genomic DNA. Translation: AAZ66558.1.
AE014134 Genomic DNA. Translation: AAZ66563.1.
AE014134 Genomic DNA. Translation: AAZ66568.1.
AE014134 Genomic DNA. Translation: AAZ66573.1.
AE014134 Genomic DNA. Translation: AAZ66578.1.
BT001842 mRNA. Translation: AAN71603.1.
BT015217 mRNA. Translation: AAT94446.1.
PIRiS10098. HSFF4.
RefSeqiNP_001027284.1. NM_001032113.2.
NP_001027288.1. NM_001032117.2.
NP_001027293.1. NM_001032122.2.
NP_001027297.1. NM_001032126.2.
NP_001027302.1. NM_001032131.2.
NP_001027307.1. NM_001032136.2.
NP_001027312.1. NM_001032141.2.
NP_001027317.1. NM_001032146.2.
NP_001027322.1. NM_001032151.2.
NP_001027327.1. NM_001032156.2.
NP_001027332.1. NM_001032161.2.
NP_001027337.1. NM_001032166.2.
NP_001027342.1. NM_001032171.2.
NP_001027347.1. NM_001032176.2.
NP_001027352.1. NM_001032181.2.
NP_001027357.1. NM_001032186.2.
NP_001027362.1. NM_001032191.2.
NP_001027367.1. NM_001032196.1.
NP_001027372.1. NM_001032201.1.
NP_001027377.1. NM_001032206.1.
NP_001027382.1. NM_001032211.1.
NP_001262576.1. NM_001275647.1.
NP_524352.1. NM_079628.4.
NP_724344.1. NM_165383.3.
NP_731927.1. NM_169592.3.
NP_731928.1. NM_169593.3.
UniGeneiDm.29514.
Dm.30223.
Dm.30876.
Dm.5747.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30B/F2-103[»]
2PYOX-ray2.43B/F2-103[»]
2XYIX-ray1.75B27-46[»]
3C9CX-ray3.20B16-42[»]
4UUZX-ray2.90B1-103[»]
4X23X-ray3.50B/F/L/P25-103[»]
ProteinModelPortaliP84040.
SMRiP84040. Positions 21-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi534263. 1 interaction.
66847. 10 interactions.
77139. 9 interactions.
DIPiDIP-29505N.
IntActiP84040. 27 interactions.
MINTiMINT-836772.
STRINGi7227.FBpp0091126.

Proteomic databases

PaxDbiP84040.
PRIDEiP84040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082962; FBpp0082421; FBgn0013981.
FBtr0082963; FBpp0082422; FBgn0013981.
FBtr0082964; FBpp0082423; FBgn0013981.
FBtr0085926; FBpp0085280; FBgn0051611.
FBtr0091875; FBpp0091116; FBgn0053871.
FBtr0091877; FBpp0091118; FBgn0053873.
FBtr0091879; FBpp0091120; FBgn0053875.
FBtr0091887; FBpp0091128; FBgn0053883.
FBtr0091889; FBpp0091130; FBgn0053885.
FBtr0091891; FBpp0091132; FBgn0053887.
FBtr0091893; FBpp0091134; FBgn0053889.
FBtr0091895; FBpp0091136; FBgn0053891.
FBtr0091897; FBpp0091138; FBgn0053893.
FBtr0091899; FBpp0091140; FBgn0053895.
FBtr0091901; FBpp0091142; FBgn0053897.
FBtr0091903; FBpp0091144; FBgn0053899.
FBtr0091905; FBpp0091146; FBgn0053901.
FBtr0091907; FBpp0091148; FBgn0053903.
FBtr0091909; FBpp0091150; FBgn0053905.
FBtr0091911; FBpp0091152; FBgn0053907.
FBtr0091913; FBpp0091154; FBgn0053909.
FBtr0334029; FBpp0306146; FBgn0013981.
GeneIDi318846.
3771854.
3771893.
3771908.
3771935.
3771938.
3771941.
3771947.
3772096.
3772113.
3772129.
3772172.
3772211.
3772254.
3772314.
3772317.
3772319.
3772325.
3772509.
3772519.
3772666.
3772708.
41773.
KEGGidme:Dmel_CG31611.
dme:Dmel_CG3379.
dme:Dmel_CG33869.
dme:Dmel_CG33871.
dme:Dmel_CG33873.
dme:Dmel_CG33875.
dme:Dmel_CG33877.
dme:Dmel_CG33879.
dme:Dmel_CG33881.
dme:Dmel_CG33883.
dme:Dmel_CG33885.
dme:Dmel_CG33887.
dme:Dmel_CG33889.
dme:Dmel_CG33891.
dme:Dmel_CG33893.
dme:Dmel_CG33895.
dme:Dmel_CG33897.
dme:Dmel_CG33899.
dme:Dmel_CG33901.
dme:Dmel_CG33903.
dme:Dmel_CG33905.
dme:Dmel_CG33907.
dme:Dmel_CG33909.
UCSCiCG31611-RA. d. melanogaster.

Organism-specific databases

CTDi318846.
3771854.
3771893.
3771908.
3771935.
3771938.
3771941.
3771947.
3772096.
3772113.
3772129.
3772172.
3772211.
3772254.
3772314.
3772317.
3772319.
3772325.
3772509.
3772519.
3772666.
3772708.
41773.
FlyBaseiFBgn0001200. His4.
FBgn0051611. His4:CG31611.
FBgn0053869. His4:CG33869.
FBgn0053871. His4:CG33871.
FBgn0053873. His4:CG33873.
FBgn0053875. His4:CG33875.
FBgn0053877. His4:CG33877.
FBgn0053879. His4:CG33879.
FBgn0053881. His4:CG33881.
FBgn0053883. His4:CG33883.
FBgn0053885. His4:CG33885.
FBgn0053887. His4:CG33887.
FBgn0053889. His4:CG33889.
FBgn0053891. His4:CG33891.
FBgn0053893. His4:CG33893.
FBgn0053895. His4:CG33895.
FBgn0053897. His4:CG33897.
FBgn0053899. His4:CG33899.
FBgn0053901. His4:CG33901.
FBgn0053903. His4:CG33903.
FBgn0053905. His4:CG33905.
FBgn0053907. His4:CG33907.
FBgn0053909. His4:CG33909.
FBgn0013981. His4r.

Phylogenomic databases

eggNOGiCOG2036.
GeneTreeiENSGT00760000119019.
InParanoidiP84040.
KOiK11254.
OMAiFAMSGRG.
OrthoDBiEOG77T174.
PhylomeDBiP84040.

Miscellaneous databases

ChiTaRSiHis4r. fly.
EvolutionaryTraceiP84040.
NextBioi846317.
PROiP84040.

Gene expression databases

BgeeiP84040.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster."
    Matsuo Y., Yamazaki T.
    Nucleic Acids Res. 17:225-238(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS4).
    Strain: AK-194.
  2. "Identification and characterization of the Drosophila histone H4 replacement gene."
    Akhmanova A., Miedema K., Hennig W.
    FEBS Lett. 388:219-222(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (HIS4R).
    Strain: Canton-S.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS4R; HIS4:CG31611; HIS4:CG33869; HIS4:CG33871; HIS4:CG33873; HIS4:CG33875; HIS4:CG33877; HIS4:CG33879; HIS4:CG33881; HIS4:CG33883; HIS4:CG33885; HIS4:CG33887; HIS4:CG33889; HIS4:CG33891; HIS4:CG33893; HIS4:CG33895; HIS4:CG33897; HIS4:CG33899; HIS4:CG33901; HIS4:CG33903; HIS4:CG33905; HIS4:CG33907 AND HIS4:CG33909).
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  6. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  7. Goldberg M.L.
    Thesis (1979), University of Stanford, United States
    Cited for: NUCLEOTIDE SEQUENCE OF 1-72 (HIS4).
  8. "A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes."
    Ivanovska I., Khandan T., Ito T., Orr-Weaver T.L.
    Genes Dev. 19:2571-2582(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT LYS-6 AND LYS-13.
  9. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81 AND THR-83, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiH4_DROME
AccessioniPrimary (citable) accession number: P84040
Secondary accession number(s): A4V2W8
, P02307, Q4AB71, Q4ABE0, Q6AWN1, Q9VFH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.