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P84040

- H4_DROME

UniProt

P84040 - H4_DROME

Protein

Histone H4

Gene

His4

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi17 – 215

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. centrosome duplication Source: FlyBase
    2. nucleosome assembly Source: UniProtKB

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H4
    Gene namesi
    Name:His4
    Synonyms:H4
    AND
    Name:His4r
    Synonyms:H4r
    ORF Names:CG3379
    AND
    Name:His4:CG31611
    ORF Names:CG31611
    AND
    Name:His4:CG33869
    ORF Names:CG33869
    AND
    Name:His4:CG33871
    ORF Names:CG33871
    AND
    Name:His4:CG33873
    ORF Names:CG33873
    AND
    Name:His4:CG33875
    ORF Names:CG33875
    AND
    Name:His4:CG33877
    ORF Names:CG33877
    AND
    Name:His4:CG33879
    ORF Names:CG33879
    AND
    Name:His4:CG33881
    ORF Names:CG33881
    AND
    Name:His4:CG33883
    ORF Names:CG33883
    AND
    Name:His4:CG33885
    ORF Names:CG33885
    AND
    Name:His4:CG33887
    ORF Names:CG33887
    AND
    Name:His4:CG33889
    ORF Names:CG33889
    AND
    Name:His4:CG33891
    ORF Names:CG33891
    AND
    Name:His4:CG33893
    ORF Names:CG33893
    AND
    Name:His4:CG33895
    ORF Names:CG33895
    AND
    Name:His4:CG33897
    ORF Names:CG33897
    AND
    Name:His4:CG33899
    ORF Names:CG33899
    AND
    Name:His4:CG33901
    ORF Names:CG33901
    AND
    Name:His4:CG33903
    ORF Names:CG33903
    AND
    Name:His4:CG33905
    ORF Names:CG33905
    AND
    Name:His4:CG33907
    ORF Names:CG33907
    AND
    Name:His4:CG33909
    ORF Names:CG33909
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L, UP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0001200. His4.
    FBgn0051611. His4:CG31611.
    FBgn0053869. His4:CG33869.
    FBgn0053871. His4:CG33871.
    FBgn0053873. His4:CG33873.
    FBgn0053875. His4:CG33875.
    FBgn0053877. His4:CG33877.
    FBgn0053879. His4:CG33879.
    FBgn0053881. His4:CG33881.
    FBgn0053883. His4:CG33883.
    FBgn0053885. His4:CG33885.
    FBgn0053887. His4:CG33887.
    FBgn0053889. His4:CG33889.
    FBgn0053891. His4:CG33891.
    FBgn0053893. His4:CG33893.
    FBgn0053895. His4:CG33895.
    FBgn0053897. His4:CG33897.
    FBgn0053899. His4:CG33899.
    FBgn0053901. His4:CG33901.
    FBgn0053903. His4:CG33903.
    FBgn0053905. His4:CG33905.
    FBgn0053907. His4:CG33907.
    FBgn0053909. His4:CG33909.
    FBgn0013981. His4r.

    Subcellular locationi

    GO - Cellular componenti

    1. lipid particle Source: FlyBase
    2. nucleosome Source: UniProtKB
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 103102Histone H4PRO_0000158305Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei6 – 61N6-acetyllysine1 Publication
    Modified residuei13 – 131N6-acetyllysine1 Publication
    Modified residuei81 – 811Phosphothreonine1 Publication
    Modified residuei83 – 831Phosphothreonine1 Publication

    Post-translational modificationi

    Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation.2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP84040.
    PRIDEiP84040.

    Expressioni

    Gene expression databases

    BgeeiP84040.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KAT2BQ928312EBI-185028,EBI-477430From a different organism.

    Protein-protein interaction databases

    BioGridi534263. 1 interaction.
    66847. 10 interactions.
    77139. 9 interactions.
    DIPiDIP-29505N.
    IntActiP84040. 9 interactions.
    MINTiMINT-836772.
    STRINGi7227.FBpp0091126.

    Structurei

    Secondary structure

    1
    103
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi26 – 294
    Helixi32 – 409
    Beta strandi45 – 473
    Helixi51 – 7626
    Beta strandi80 – 823
    Helixi84 – 9310
    Beta strandi98 – 1014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NQBX-ray2.30B/F2-103[»]
    2PYOX-ray2.43B/F2-103[»]
    2XYIX-ray1.75B27-46[»]
    3C9CX-ray3.20B16-42[»]
    4INMX-ray3.50B/F/L/P25-103[»]
    ProteinModelPortaliP84040.
    SMRiP84040. Positions 21-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP84040.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H4 family.Curated

    Phylogenomic databases

    eggNOGiCOG2036.
    GeneTreeiENSGT00750000117310.
    InParanoidiP84040.
    KOiK11254.
    OMAiYEEVRVV.
    OrthoDBiEOG77T174.
    PhylomeDBiP84040.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001951. Histone_H4.
    IPR019809. Histone_H4_CS.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00623. HISTONEH4.
    SMARTiSM00417. H4. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00047. HISTONE_H4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84040-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL    50
    IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG 100
    FGG 103
    Length:103
    Mass (Da):11,381
    Last modified:January 23, 2007 - v2
    Checksum:iDF3EB26393BD208C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14215 Genomic DNA. Translation: CAA32435.1.
    X97437 Genomic DNA. Translation: CAA66067.1.
    X97438 mRNA. Translation: CAA66068.1.
    AE014297 Genomic DNA. Translation: AAF55080.1.
    AE014134 Genomic DNA. Translation: AAN11126.1.
    AE014297 Genomic DNA. Translation: AAN13612.1.
    AE014297 Genomic DNA. Translation: AAN13613.1.
    AE014134 Genomic DNA. Translation: AAZ66480.1.
    AE014134 Genomic DNA. Translation: AAZ66484.1.
    AE014134 Genomic DNA. Translation: AAZ66489.1.
    AE014134 Genomic DNA. Translation: AAZ66493.1.
    AE014134 Genomic DNA. Translation: AAZ66498.1.
    AE014134 Genomic DNA. Translation: AAZ66503.1.
    AE014134 Genomic DNA. Translation: AAZ66508.1.
    AE014134 Genomic DNA. Translation: AAZ66513.1.
    AE014134 Genomic DNA. Translation: AAZ66518.1.
    AE014134 Genomic DNA. Translation: AAZ66523.1.
    AE014134 Genomic DNA. Translation: AAZ66528.1.
    AE014134 Genomic DNA. Translation: AAZ66533.1.
    AE014134 Genomic DNA. Translation: AAZ66538.1.
    AE014134 Genomic DNA. Translation: AAZ66543.1.
    AE014134 Genomic DNA. Translation: AAZ66548.1.
    AE014134 Genomic DNA. Translation: AAZ66553.1.
    AE014134 Genomic DNA. Translation: AAZ66558.1.
    AE014134 Genomic DNA. Translation: AAZ66563.1.
    AE014134 Genomic DNA. Translation: AAZ66568.1.
    AE014134 Genomic DNA. Translation: AAZ66573.1.
    AE014134 Genomic DNA. Translation: AAZ66578.1.
    BT001842 mRNA. Translation: AAN71603.1.
    BT015217 mRNA. Translation: AAT94446.1.
    PIRiS10098. HSFF4.
    RefSeqiNP_001027284.1. NM_001032113.1.
    NP_001027288.1. NM_001032117.1.
    NP_001027293.1. NM_001032122.1.
    NP_001027297.1. NM_001032126.1.
    NP_001027302.1. NM_001032131.1.
    NP_001027307.1. NM_001032136.1.
    NP_001027312.1. NM_001032141.1.
    NP_001027317.1. NM_001032146.1.
    NP_001027322.1. NM_001032151.1.
    NP_001027327.1. NM_001032156.1.
    NP_001027332.1. NM_001032161.1.
    NP_001027337.1. NM_001032166.1.
    NP_001027342.1. NM_001032171.1.
    NP_001027347.1. NM_001032176.1.
    NP_001027352.1. NM_001032181.1.
    NP_001027357.1. NM_001032186.1.
    NP_001027362.1. NM_001032191.1.
    NP_001027367.1. NM_001032196.1.
    NP_001027372.1. NM_001032201.1.
    NP_001027377.1. NM_001032206.1.
    NP_001027382.1. NM_001032211.1.
    NP_001262576.1. NM_001275647.1.
    NP_524352.1. NM_079628.4.
    NP_724344.1. NM_165383.2.
    NP_731927.1. NM_169592.3.
    NP_731928.1. NM_169593.3.
    UniGeneiDm.21500.
    Dm.29514.
    Dm.29527.
    Dm.30219.
    Dm.30220.
    Dm.30221.
    Dm.30223.
    Dm.30868.
    Dm.30869.
    Dm.30871.
    Dm.30872.
    Dm.30873.
    Dm.30876.
    Dm.33873.
    Dm.5747.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082962; FBpp0082421; FBgn0013981.
    FBtr0082963; FBpp0082422; FBgn0013981.
    FBtr0082964; FBpp0082423; FBgn0013981.
    FBtr0085926; FBpp0085280; FBgn0051611.
    FBtr0091875; FBpp0091116; FBgn0053871.
    FBtr0091877; FBpp0091118; FBgn0053873.
    FBtr0091879; FBpp0091120; FBgn0053875.
    FBtr0091887; FBpp0091128; FBgn0053883.
    FBtr0091889; FBpp0091130; FBgn0053885.
    FBtr0091891; FBpp0091132; FBgn0053887.
    FBtr0091893; FBpp0091134; FBgn0053889.
    FBtr0091895; FBpp0091136; FBgn0053891.
    FBtr0091897; FBpp0091138; FBgn0053893.
    FBtr0091899; FBpp0091140; FBgn0053895.
    FBtr0091901; FBpp0091142; FBgn0053897.
    FBtr0091903; FBpp0091144; FBgn0053899.
    FBtr0091905; FBpp0091146; FBgn0053901.
    FBtr0091907; FBpp0091148; FBgn0053903.
    FBtr0091909; FBpp0091150; FBgn0053905.
    FBtr0091911; FBpp0091152; FBgn0053907.
    FBtr0091913; FBpp0091154; FBgn0053909.
    FBtr0334029; FBpp0306146; FBgn0013981.
    GeneIDi318846.
    3771854.
    3771893.
    3771908.
    3771935.
    3771938.
    3771941.
    3771947.
    3772096.
    3772113.
    3772129.
    3772172.
    3772211.
    3772254.
    3772314.
    3772317.
    3772319.
    3772325.
    3772509.
    3772519.
    3772666.
    3772708.
    41773.
    KEGGidme:Dmel_CG31611.
    dme:Dmel_CG3379.
    dme:Dmel_CG33869.
    dme:Dmel_CG33871.
    dme:Dmel_CG33873.
    dme:Dmel_CG33875.
    dme:Dmel_CG33877.
    dme:Dmel_CG33879.
    dme:Dmel_CG33881.
    dme:Dmel_CG33883.
    dme:Dmel_CG33885.
    dme:Dmel_CG33887.
    dme:Dmel_CG33889.
    dme:Dmel_CG33891.
    dme:Dmel_CG33893.
    dme:Dmel_CG33895.
    dme:Dmel_CG33897.
    dme:Dmel_CG33899.
    dme:Dmel_CG33901.
    dme:Dmel_CG33903.
    dme:Dmel_CG33905.
    dme:Dmel_CG33907.
    dme:Dmel_CG33909.
    UCSCiCG31611-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14215 Genomic DNA. Translation: CAA32435.1 .
    X97437 Genomic DNA. Translation: CAA66067.1 .
    X97438 mRNA. Translation: CAA66068.1 .
    AE014297 Genomic DNA. Translation: AAF55080.1 .
    AE014134 Genomic DNA. Translation: AAN11126.1 .
    AE014297 Genomic DNA. Translation: AAN13612.1 .
    AE014297 Genomic DNA. Translation: AAN13613.1 .
    AE014134 Genomic DNA. Translation: AAZ66480.1 .
    AE014134 Genomic DNA. Translation: AAZ66484.1 .
    AE014134 Genomic DNA. Translation: AAZ66489.1 .
    AE014134 Genomic DNA. Translation: AAZ66493.1 .
    AE014134 Genomic DNA. Translation: AAZ66498.1 .
    AE014134 Genomic DNA. Translation: AAZ66503.1 .
    AE014134 Genomic DNA. Translation: AAZ66508.1 .
    AE014134 Genomic DNA. Translation: AAZ66513.1 .
    AE014134 Genomic DNA. Translation: AAZ66518.1 .
    AE014134 Genomic DNA. Translation: AAZ66523.1 .
    AE014134 Genomic DNA. Translation: AAZ66528.1 .
    AE014134 Genomic DNA. Translation: AAZ66533.1 .
    AE014134 Genomic DNA. Translation: AAZ66538.1 .
    AE014134 Genomic DNA. Translation: AAZ66543.1 .
    AE014134 Genomic DNA. Translation: AAZ66548.1 .
    AE014134 Genomic DNA. Translation: AAZ66553.1 .
    AE014134 Genomic DNA. Translation: AAZ66558.1 .
    AE014134 Genomic DNA. Translation: AAZ66563.1 .
    AE014134 Genomic DNA. Translation: AAZ66568.1 .
    AE014134 Genomic DNA. Translation: AAZ66573.1 .
    AE014134 Genomic DNA. Translation: AAZ66578.1 .
    BT001842 mRNA. Translation: AAN71603.1 .
    BT015217 mRNA. Translation: AAT94446.1 .
    PIRi S10098. HSFF4.
    RefSeqi NP_001027284.1. NM_001032113.1.
    NP_001027288.1. NM_001032117.1.
    NP_001027293.1. NM_001032122.1.
    NP_001027297.1. NM_001032126.1.
    NP_001027302.1. NM_001032131.1.
    NP_001027307.1. NM_001032136.1.
    NP_001027312.1. NM_001032141.1.
    NP_001027317.1. NM_001032146.1.
    NP_001027322.1. NM_001032151.1.
    NP_001027327.1. NM_001032156.1.
    NP_001027332.1. NM_001032161.1.
    NP_001027337.1. NM_001032166.1.
    NP_001027342.1. NM_001032171.1.
    NP_001027347.1. NM_001032176.1.
    NP_001027352.1. NM_001032181.1.
    NP_001027357.1. NM_001032186.1.
    NP_001027362.1. NM_001032191.1.
    NP_001027367.1. NM_001032196.1.
    NP_001027372.1. NM_001032201.1.
    NP_001027377.1. NM_001032206.1.
    NP_001027382.1. NM_001032211.1.
    NP_001262576.1. NM_001275647.1.
    NP_524352.1. NM_079628.4.
    NP_724344.1. NM_165383.2.
    NP_731927.1. NM_169592.3.
    NP_731928.1. NM_169593.3.
    UniGenei Dm.21500.
    Dm.29514.
    Dm.29527.
    Dm.30219.
    Dm.30220.
    Dm.30221.
    Dm.30223.
    Dm.30868.
    Dm.30869.
    Dm.30871.
    Dm.30872.
    Dm.30873.
    Dm.30876.
    Dm.33873.
    Dm.5747.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NQB X-ray 2.30 B/F 2-103 [» ]
    2PYO X-ray 2.43 B/F 2-103 [» ]
    2XYI X-ray 1.75 B 27-46 [» ]
    3C9C X-ray 3.20 B 16-42 [» ]
    4INM X-ray 3.50 B/F/L/P 25-103 [» ]
    ProteinModelPortali P84040.
    SMRi P84040. Positions 21-102.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 534263. 1 interaction.
    66847. 10 interactions.
    77139. 9 interactions.
    DIPi DIP-29505N.
    IntActi P84040. 9 interactions.
    MINTi MINT-836772.
    STRINGi 7227.FBpp0091126.

    Proteomic databases

    PaxDbi P84040.
    PRIDEi P84040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082962 ; FBpp0082421 ; FBgn0013981 .
    FBtr0082963 ; FBpp0082422 ; FBgn0013981 .
    FBtr0082964 ; FBpp0082423 ; FBgn0013981 .
    FBtr0085926 ; FBpp0085280 ; FBgn0051611 .
    FBtr0091875 ; FBpp0091116 ; FBgn0053871 .
    FBtr0091877 ; FBpp0091118 ; FBgn0053873 .
    FBtr0091879 ; FBpp0091120 ; FBgn0053875 .
    FBtr0091887 ; FBpp0091128 ; FBgn0053883 .
    FBtr0091889 ; FBpp0091130 ; FBgn0053885 .
    FBtr0091891 ; FBpp0091132 ; FBgn0053887 .
    FBtr0091893 ; FBpp0091134 ; FBgn0053889 .
    FBtr0091895 ; FBpp0091136 ; FBgn0053891 .
    FBtr0091897 ; FBpp0091138 ; FBgn0053893 .
    FBtr0091899 ; FBpp0091140 ; FBgn0053895 .
    FBtr0091901 ; FBpp0091142 ; FBgn0053897 .
    FBtr0091903 ; FBpp0091144 ; FBgn0053899 .
    FBtr0091905 ; FBpp0091146 ; FBgn0053901 .
    FBtr0091907 ; FBpp0091148 ; FBgn0053903 .
    FBtr0091909 ; FBpp0091150 ; FBgn0053905 .
    FBtr0091911 ; FBpp0091152 ; FBgn0053907 .
    FBtr0091913 ; FBpp0091154 ; FBgn0053909 .
    FBtr0334029 ; FBpp0306146 ; FBgn0013981 .
    GeneIDi 318846.
    3771854.
    3771893.
    3771908.
    3771935.
    3771938.
    3771941.
    3771947.
    3772096.
    3772113.
    3772129.
    3772172.
    3772211.
    3772254.
    3772314.
    3772317.
    3772319.
    3772325.
    3772509.
    3772519.
    3772666.
    3772708.
    41773.
    KEGGi dme:Dmel_CG31611.
    dme:Dmel_CG3379.
    dme:Dmel_CG33869.
    dme:Dmel_CG33871.
    dme:Dmel_CG33873.
    dme:Dmel_CG33875.
    dme:Dmel_CG33877.
    dme:Dmel_CG33879.
    dme:Dmel_CG33881.
    dme:Dmel_CG33883.
    dme:Dmel_CG33885.
    dme:Dmel_CG33887.
    dme:Dmel_CG33889.
    dme:Dmel_CG33891.
    dme:Dmel_CG33893.
    dme:Dmel_CG33895.
    dme:Dmel_CG33897.
    dme:Dmel_CG33899.
    dme:Dmel_CG33901.
    dme:Dmel_CG33903.
    dme:Dmel_CG33905.
    dme:Dmel_CG33907.
    dme:Dmel_CG33909.
    UCSCi CG31611-RA. d. melanogaster.

    Organism-specific databases

    CTDi 318846.
    3771854.
    3771893.
    3771908.
    3771935.
    3771938.
    3771941.
    3771947.
    3772096.
    3772113.
    3772129.
    3772172.
    3772211.
    3772254.
    3772314.
    3772317.
    3772319.
    3772325.
    3772509.
    3772519.
    3772666.
    3772708.
    41773.
    FlyBasei FBgn0001200. His4.
    FBgn0051611. His4:CG31611.
    FBgn0053869. His4:CG33869.
    FBgn0053871. His4:CG33871.
    FBgn0053873. His4:CG33873.
    FBgn0053875. His4:CG33875.
    FBgn0053877. His4:CG33877.
    FBgn0053879. His4:CG33879.
    FBgn0053881. His4:CG33881.
    FBgn0053883. His4:CG33883.
    FBgn0053885. His4:CG33885.
    FBgn0053887. His4:CG33887.
    FBgn0053889. His4:CG33889.
    FBgn0053891. His4:CG33891.
    FBgn0053893. His4:CG33893.
    FBgn0053895. His4:CG33895.
    FBgn0053897. His4:CG33897.
    FBgn0053899. His4:CG33899.
    FBgn0053901. His4:CG33901.
    FBgn0053903. His4:CG33903.
    FBgn0053905. His4:CG33905.
    FBgn0053907. His4:CG33907.
    FBgn0053909. His4:CG33909.
    FBgn0013981. His4r.

    Phylogenomic databases

    eggNOGi COG2036.
    GeneTreei ENSGT00750000117310.
    InParanoidi P84040.
    KOi K11254.
    OMAi YEEVRVV.
    OrthoDBi EOG77T174.
    PhylomeDBi P84040.

    Miscellaneous databases

    ChiTaRSi His4r. drosophila.
    EvolutionaryTracei P84040.
    NextBioi 846317.

    Gene expression databases

    Bgeei P84040.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001951. Histone_H4.
    IPR019809. Histone_H4_CS.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00623. HISTONEH4.
    SMARTi SM00417. H4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00047. HISTONE_H4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster."
      Matsuo Y., Yamazaki T.
      Nucleic Acids Res. 17:225-238(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS4).
      Strain: AK-194.
    2. "Identification and characterization of the Drosophila histone H4 replacement gene."
      Akhmanova A., Miedema K., Hennig W.
      FEBS Lett. 388:219-222(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (HIS4R).
      Strain: Canton-S.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS4R; HIS4:CG31611; HIS4:CG33869; HIS4:CG33871; HIS4:CG33873; HIS4:CG33875; HIS4:CG33877; HIS4:CG33879; HIS4:CG33881; HIS4:CG33883; HIS4:CG33885; HIS4:CG33887; HIS4:CG33889; HIS4:CG33891; HIS4:CG33893; HIS4:CG33895; HIS4:CG33897; HIS4:CG33899; HIS4:CG33901; HIS4:CG33903; HIS4:CG33905; HIS4:CG33907 AND HIS4:CG33909).
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.
    6. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    7. Goldberg M.L.
      Thesis (1979), University of Stanford, United States
      Cited for: NUCLEOTIDE SEQUENCE OF 1-72 (HIS4).
    8. "A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes."
      Ivanovska I., Khandan T., Ito T., Orr-Weaver T.L.
      Genes Dev. 19:2571-2582(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION AT LYS-6 AND LYS-13.
    9. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81 AND THR-83, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiH4_DROME
    AccessioniPrimary (citable) accession number: P84040
    Secondary accession number(s): A4V2W8
    , P02307, Q4AB71, Q4ABE0, Q6AWN1, Q9VFH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3