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P84040 (H4_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone H4
Gene names
Name:His4
Synonyms:H4
AND
Name:His4r
Synonyms:H4r
ORF Names:CG3379
AND
Name:His4:CG31611
ORF Names:CG31611
AND
Name:His4:CG33869
ORF Names:CG33869
AND
Name:His4:CG33871
ORF Names:CG33871
AND
Name:His4:CG33873
ORF Names:CG33873
AND
Name:His4:CG33875
ORF Names:CG33875
AND
Name:His4:CG33877
ORF Names:CG33877
AND
Name:His4:CG33879
ORF Names:CG33879
AND
Name:His4:CG33881
ORF Names:CG33881
AND
Name:His4:CG33883
ORF Names:CG33883
AND
Name:His4:CG33885
ORF Names:CG33885
AND
Name:His4:CG33887
ORF Names:CG33887
AND
Name:His4:CG33889
ORF Names:CG33889
AND
Name:His4:CG33891
ORF Names:CG33891
AND
Name:His4:CG33893
ORF Names:CG33893
AND
Name:His4:CG33895
ORF Names:CG33895
AND
Name:His4:CG33897
ORF Names:CG33897
AND
Name:His4:CG33899
ORF Names:CG33899
AND
Name:His4:CG33901
ORF Names:CG33901
AND
Name:His4:CG33903
ORF Names:CG33903
AND
Name:His4:CG33905
ORF Names:CG33905
AND
Name:His4:CG33907
ORF Names:CG33907
AND
Name:His4:CG33909
ORF Names:CG33909
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit structure

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location

Nucleus. Chromosome.

Post-translational modification

Acetylated on Lys-6 and Lys-13 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H4 Lys-6 acetylation but not for H4 Lys-13 acetylation. Ref.8

Sequence similarities

Belongs to the histone H4 family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KAT2BQ928312EBI-185028,EBI-477430From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 103102Histone H4
PRO_0000158305

Regions

DNA binding17 – 215

Amino acid modifications

Modified residue61N6-acetyllysine Ref.8
Modified residue131N6-acetyllysine Ref.8
Modified residue811Phosphothreonine Ref.9
Modified residue831Phosphothreonine Ref.9

Secondary structure

............... 103
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P84040 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: DF3EB26393BD208C

FASTA10311,381
        10         20         30         40         50         60 
MTGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK 

        70         80         90        100 
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG 

« Hide

References

« Hide 'large scale' references
[1]"tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster."
Matsuo Y., Yamazaki T.
Nucleic Acids Res. 17:225-238(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS4).
Strain: AK-194.
[2]"Identification and characterization of the Drosophila histone H4 replacement gene."
Akhmanova A., Miedema K., Hennig W.
FEBS Lett. 388:219-222(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (HIS4R).
Strain: Canton-S.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS4R; HIS4:CG31611; HIS4:CG33869; HIS4:CG33871; HIS4:CG33873; HIS4:CG33875; HIS4:CG33877; HIS4:CG33879; HIS4:CG33881; HIS4:CG33883; HIS4:CG33885; HIS4:CG33887; HIS4:CG33889; HIS4:CG33891; HIS4:CG33893; HIS4:CG33895; HIS4:CG33897; HIS4:CG33899; HIS4:CG33901; HIS4:CG33903; HIS4:CG33905; HIS4:CG33907 AND HIS4:CG33909).
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[6]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[7]Goldberg M.L.
Thesis (1979), University of Stanford, United States
Cited for: NUCLEOTIDE SEQUENCE OF 1-72 (HIS4).
[8]"A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes."
Ivanovska I., Khandan T., Ito T., Orr-Weaver T.L.
Genes Dev. 19:2571-2582(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION AT LYS-6 AND LYS-13.
[9]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81 AND THR-83, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14215 Genomic DNA. Translation: CAA32435.1.
X97437 Genomic DNA. Translation: CAA66067.1.
X97438 mRNA. Translation: CAA66068.1.
AE014297 Genomic DNA. Translation: AAF55080.1.
AE014134 Genomic DNA. Translation: AAN11126.1.
AE014297 Genomic DNA. Translation: AAN13612.1.
AE014297 Genomic DNA. Translation: AAN13613.1.
AE014134 Genomic DNA. Translation: AAZ66480.1.
AE014134 Genomic DNA. Translation: AAZ66484.1.
AE014134 Genomic DNA. Translation: AAZ66489.1.
AE014134 Genomic DNA. Translation: AAZ66493.1.
AE014134 Genomic DNA. Translation: AAZ66498.1.
AE014134 Genomic DNA. Translation: AAZ66503.1.
AE014134 Genomic DNA. Translation: AAZ66508.1.
AE014134 Genomic DNA. Translation: AAZ66513.1.
AE014134 Genomic DNA. Translation: AAZ66518.1.
AE014134 Genomic DNA. Translation: AAZ66523.1.
AE014134 Genomic DNA. Translation: AAZ66528.1.
AE014134 Genomic DNA. Translation: AAZ66533.1.
AE014134 Genomic DNA. Translation: AAZ66538.1.
AE014134 Genomic DNA. Translation: AAZ66543.1.
AE014134 Genomic DNA. Translation: AAZ66548.1.
AE014134 Genomic DNA. Translation: AAZ66553.1.
AE014134 Genomic DNA. Translation: AAZ66558.1.
AE014134 Genomic DNA. Translation: AAZ66563.1.
AE014134 Genomic DNA. Translation: AAZ66568.1.
AE014134 Genomic DNA. Translation: AAZ66573.1.
AE014134 Genomic DNA. Translation: AAZ66578.1.
BT001842 mRNA. Translation: AAN71603.1.
BT015217 mRNA. Translation: AAT94446.1.
PIRHSFF4. S10098.
RefSeqNP_001027284.1. NM_001032113.1.
NP_001027288.1. NM_001032117.1.
NP_001027293.1. NM_001032122.1.
NP_001027297.1. NM_001032126.1.
NP_001027302.1. NM_001032131.1.
NP_001027307.1. NM_001032136.1.
NP_001027312.1. NM_001032141.1.
NP_001027317.1. NM_001032146.1.
NP_001027322.1. NM_001032151.1.
NP_001027327.1. NM_001032156.1.
NP_001027332.1. NM_001032161.1.
NP_001027337.1. NM_001032166.1.
NP_001027342.1. NM_001032171.1.
NP_001027347.1. NM_001032176.1.
NP_001027352.1. NM_001032181.1.
NP_001027357.1. NM_001032186.1.
NP_001027362.1. NM_001032191.1.
NP_001027367.1. NM_001032196.1.
NP_001027372.1. NM_001032201.1.
NP_001027377.1. NM_001032206.1.
NP_001027382.1. NM_001032211.1.
NP_001262576.1. NM_001275647.1.
NP_524352.1. NM_079628.4.
NP_724344.1. NM_165383.2.
NP_731927.1. NM_169592.3.
NP_731928.1. NM_169593.3.
UniGeneDm.21500.
Dm.29514.
Dm.29527.
Dm.30219.
Dm.30220.
Dm.30221.
Dm.30223.
Dm.30868.
Dm.30869.
Dm.30871.
Dm.30872.
Dm.30873.
Dm.30876.
Dm.33873.
Dm.5747.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30B/F2-102[»]
2PYOX-ray2.43B/F2-103[»]
2XYIX-ray1.75B27-46[»]
3C9CX-ray3.20B16-42[»]
4INMX-ray3.50B/F/L/P25-103[»]
ProteinModelPortalP84040.
SMRP84040. Positions 21-102.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid534263. 1 interaction.
66847. 10 interactions.
77139. 9 interactions.
DIPDIP-29505N.
IntActP84040. 9 interactions.
MINTMINT-836772.
STRING7227.FBpp0091126.

Proteomic databases

PaxDbP84040.
PRIDEP84040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0082962; FBpp0082421; FBgn0013981.
FBtr0082963; FBpp0082422; FBgn0013981.
FBtr0082964; FBpp0082423; FBgn0013981.
FBtr0085926; FBpp0085280; FBgn0051611.
FBtr0091875; FBpp0091116; FBgn0053871.
FBtr0091877; FBpp0091118; FBgn0053873.
FBtr0091879; FBpp0091120; FBgn0053875.
FBtr0091887; FBpp0091128; FBgn0053883.
FBtr0091889; FBpp0091130; FBgn0053885.
FBtr0091891; FBpp0091132; FBgn0053887.
FBtr0091893; FBpp0091134; FBgn0053889.
FBtr0091895; FBpp0091136; FBgn0053891.
FBtr0091897; FBpp0091138; FBgn0053893.
FBtr0091899; FBpp0091140; FBgn0053895.
FBtr0091901; FBpp0091142; FBgn0053897.
FBtr0091903; FBpp0091144; FBgn0053899.
FBtr0091905; FBpp0091146; FBgn0053901.
FBtr0091907; FBpp0091148; FBgn0053903.
FBtr0091909; FBpp0091150; FBgn0053905.
FBtr0091911; FBpp0091152; FBgn0053907.
FBtr0091913; FBpp0091154; FBgn0053909.
FBtr0334029; FBpp0306146; FBgn0013981.
GeneID318846.
3771854.
3771893.
3771908.
3771935.
3771938.
3771941.
3771947.
3772096.
3772113.
3772129.
3772172.
3772211.
3772254.
3772314.
3772317.
3772319.
3772325.
3772509.
3772519.
3772666.
3772708.
41773.
KEGGdme:Dmel_CG31611.
dme:Dmel_CG3379.
dme:Dmel_CG33869.
dme:Dmel_CG33871.
dme:Dmel_CG33873.
dme:Dmel_CG33875.
dme:Dmel_CG33877.
dme:Dmel_CG33879.
dme:Dmel_CG33881.
dme:Dmel_CG33883.
dme:Dmel_CG33885.
dme:Dmel_CG33887.
dme:Dmel_CG33889.
dme:Dmel_CG33891.
dme:Dmel_CG33893.
dme:Dmel_CG33895.
dme:Dmel_CG33897.
dme:Dmel_CG33899.
dme:Dmel_CG33901.
dme:Dmel_CG33903.
dme:Dmel_CG33905.
dme:Dmel_CG33907.
dme:Dmel_CG33909.
UCSCCG31611-RA. d. melanogaster.

Organism-specific databases

CTD318846.
3771854.
3771893.
3771908.
3771935.
3771938.
3771941.
3771947.
3772096.
3772113.
3772129.
3772172.
3772211.
3772254.
3772314.
3772317.
3772319.
3772325.
3772509.
3772519.
3772666.
3772708.
41773.
FlyBaseFBgn0001200. His4.
FBgn0051611. His4:CG31611.
FBgn0053869. His4:CG33869.
FBgn0053871. His4:CG33871.
FBgn0053873. His4:CG33873.
FBgn0053875. His4:CG33875.
FBgn0053877. His4:CG33877.
FBgn0053879. His4:CG33879.
FBgn0053881. His4:CG33881.
FBgn0053883. His4:CG33883.
FBgn0053885. His4:CG33885.
FBgn0053887. His4:CG33887.
FBgn0053889. His4:CG33889.
FBgn0053891. His4:CG33891.
FBgn0053893. His4:CG33893.
FBgn0053895. His4:CG33895.
FBgn0053897. His4:CG33897.
FBgn0053899. His4:CG33899.
FBgn0053901. His4:CG33901.
FBgn0053903. His4:CG33903.
FBgn0053905. His4:CG33905.
FBgn0053907. His4:CG33907.
FBgn0053909. His4:CG33909.
FBgn0013981. His4r.

Phylogenomic databases

eggNOGCOG2036.
GeneTreeENSGT00750000117310.
InParanoidP84040.
KOK11254.
OMAYEEVRVV.
OrthoDBEOG77T174.
PhylomeDBP84040.

Gene expression databases

BgeeP84040.

Family and domain databases

Gene3D1.10.20.10. 1 hit.
InterProIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PfamPF00125. Histone. 1 hit.
[Graphical view]
PRINTSPR00623. HISTONEH4.
SMARTSM00417. H4. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 1 hit.
PROSITEPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHis4r. drosophila.
EvolutionaryTraceP84040.
NextBio846317.

Entry information

Entry nameH4_DROME
AccessionPrimary (citable) accession number: P84040
Secondary accession number(s): A4V2W8 expand/collapse secondary AC list , P02307, Q4AB71, Q4ABE0, Q6AWN1, Q9VFH7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase