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Protein

Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

Gene

Enpp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity in vitro.1 Publication1 Publication

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Zinc 1; catalyticBy similarity
Active sitei72 – 721NucleophileSequence analysis
Metal bindingi72 – 721Zinc 1; catalyticBy similarity
Metal bindingi191 – 1911Zinc 2; catalyticBy similarity
Metal bindingi195 – 1951Zinc 2; via tele nitrogen; catalyticBy similarity
Metal bindingi238 – 2381Zinc 1; catalyticBy similarity
Metal bindingi239 – 2391Zinc 1; via tele nitrogen; catalyticBy similarity
Metal bindingi339 – 3391Zinc 2; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell communication Source: UniProtKB
  • metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (EC:3.1.-.-)
Short name:
E-NPP 5
Short name:
NPP-5
Gene namesi
Name:Enpp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1359199. Enpp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei432 – 45221HelicalCuratedAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 477453Ectonucleotide pyrophosphatase/phosphodiesterase family member 5PRO_0000188572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication
Glycosylationi158 – 1581N-linked (GlcNAc...)1 Publication
Glycosylationi292 – 2921N-linked (GlcNAc...)1 Publication
Glycosylationi329 – 3291N-linked (GlcNAc...)1 Publication
Glycosylationi362 – 3621N-linked (GlcNAc...)1 Publication
Glycosylationi369 – 3691N-linked (GlcNAc...)1 Publication
Glycosylationi382 – 3821N-linked (GlcNAc...)1 Publication
Glycosylationi389 – 3891N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP84039.
PRIDEiP84039.

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000010232.
GenevisibleiP84039. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013703.

Structurei

3D structure databases

ProteinModelPortaliP84039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2645. Eukaryota.
COG1524. LUCA.
GeneTreeiENSGT00760000119157.
HOGENOMiHOG000231018.
HOVERGENiHBG051485.
InParanoidiP84039.
KOiK18398.
OMAiKHLIHSQ.
OrthoDBiEOG091G06NA.
PhylomeDBiP84039.
TreeFamiTF330032.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024873. E-NPP.
IPR029896. ENPP5.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view]
PANTHERiPTHR10151. PTHR10151. 1 hit.
PTHR10151:SF80. PTHR10151:SF80. 1 hit.
PfamiPF01663. Phosphodiest. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPEFLVVSC TLAALCHSVP LSLQTEQQKV LVVSFDGFRW DYLYKVPTPH
60 70 80 90 100
FHYVMKNGVH VKQVTNVFIT KTYPNHYTLV TGLFAENHGI VANDMFDPVL
110 120 130 140 150
NKSFSLEHMN IYDSKFWEEA TPLWITNQRA GHASGAAMWP GTDVKIHESY
160 170 180 190 200
PTHYLPYNES VSFEDRVAKI IEWFTAKDPI NLGFLYWEEP DDTGHDVGPD
210 220 230 240 250
SPLMGPVISD IDHKLGYLIK MLKKAKLWNN INLIVTSDHG MTQCSKERVI
260 270 280 290 300
ELDQYLDKEH YTLIDHSPVA AILPKEGKFN EVYDALANAH PNLTVYKKEE
310 320 330 340 350
IPERWHYKHS DRVQPIVAVA DEGWYILQNK SDEFLLGNHG YDNALAEMHP
360 370 380 390 400
IFLAHGPAFR KNFTKEAMNS TDLYSLVCHL LNVTALPHNG SFRNVQDLLS
410 420 430 440 450
SAAPKAIPYT QSTTLPLGSA KPGEYEQEES YPYYIGISLG SLIAIVFFVV
460 470
LIKHLIRSQM HTLQYMQVEV AQPLLQA
Length:477
Mass (Da):54,290
Last modified:May 30, 2006 - v2
Checksum:i44DCDDAB98383E1B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411D → G AA sequence (PubMed:12927778).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090331 mRNA. Translation: AAH90331.1.
RefSeqiNP_001012762.1. NM_001012744.1.
XP_006244669.1. XM_006244607.2.
UniGeneiRn.198838.

Genome annotation databases

EnsembliENSRNOT00000013703; ENSRNOP00000013703; ENSRNOG00000010232.
GeneIDi316249.
KEGGirno:316249.
UCSCiRGD:1359199. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090331 mRNA. Translation: AAH90331.1.
RefSeqiNP_001012762.1. NM_001012744.1.
XP_006244669.1. XM_006244607.2.
UniGeneiRn.198838.

3D structure databases

ProteinModelPortaliP84039.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013703.

Proteomic databases

PaxDbiP84039.
PRIDEiP84039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013703; ENSRNOP00000013703; ENSRNOG00000010232.
GeneIDi316249.
KEGGirno:316249.
UCSCiRGD:1359199. rat.

Organism-specific databases

CTDi59084.
RGDi1359199. Enpp5.

Phylogenomic databases

eggNOGiKOG2645. Eukaryota.
COG1524. LUCA.
GeneTreeiENSGT00760000119157.
HOGENOMiHOG000231018.
HOVERGENiHBG051485.
InParanoidiP84039.
KOiK18398.
OMAiKHLIHSQ.
OrthoDBiEOG091G06NA.
PhylomeDBiP84039.
TreeFamiTF330032.

Miscellaneous databases

PROiP84039.

Gene expression databases

BgeeiENSRNOG00000010232.
GenevisibleiP84039. RN.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024873. E-NPP.
IPR029896. ENPP5.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view]
PANTHERiPTHR10151. PTHR10151. 1 hit.
PTHR10151:SF80. PTHR10151:SF80. 1 hit.
PfamiPF01663. Phosphodiest. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiENPP5_RAT
AccessioniPrimary (citable) accession number: P84039
Secondary accession number(s): Q5EAN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.