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P84029

- CYC2_DROME

UniProt

P84029 - CYC2_DROME

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Protein

Cytochrome c-2

Gene

Cyt-c-p

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191Heme (covalent)
Binding sitei22 – 221Heme (covalent)
Metal bindingi23 – 231Iron (heme axial ligand)
Metal bindingi85 – 851Iron (heme axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: FlyBase
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB
  2. oxidative phosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_204218. Release of apoptotic factors from the mitochondria.
REACT_207898. Respiratory electron transport.
REACT_209269. Detoxification of Reactive Oxygen Species.
REACT_226175. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-2
Alternative name(s):
Cytochrome c-proximal
Gene namesi
Name:Cyt-c-p
Synonyms:CYTC2, DC4
ORF Names:CG17903
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000409. Cyt-c-p.

Subcellular locationi

Mitochondrion intermembrane space 1 Publication
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. mitochondrial inner membrane Source: FlyBase
  2. mitochondrion Source: FlyBase
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 108107Cytochrome c-2PRO_0000108261Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiP84029.
PRIDEiP84029.

Expressioni

Developmental stagei

Expressed at varying, but relatively high levels throughout development.1 Publication

Gene expression databases

BgeeiP84029.

Interactioni

Protein-protein interaction databases

BioGridi61003. 37 interactions.
IntActiP84029. 2 interactions.
MINTiMINT-305906.

Structurei

3D structure databases

ProteinModelPortaliP84029.
SMRiP84029. Positions 6-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
GeneTreeiENSGT00390000009405.
InParanoidiP84029.
KOiK08738.
OMAiDDQEITD.
OrthoDBiEOG761BWX.
PhylomeDBiP84029.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84029-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVPAGDVEK GKKLFVQRCA QCHTVEAGGK HKVGPNLHGL IGRKTGQAAG
60 70 80 90 100
FAYTDANKAK GITWNEDTLF EYLENPKKYI PGTKMIFAGL KKPNERGDLI

AYLKSATK
Length:108
Mass (Da):11,735
Last modified:January 23, 2007 - v2
Checksum:i535FFBAF282D20D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01760 Genomic DNA. Translation: CAA25900.1.
M11381 Genomic DNA. Translation: AAA28437.1.
AE014134 Genomic DNA. Translation: AAF53554.1.
AY071701 mRNA. Translation: AAL49323.1.
PIRiA22945. CCFFDM.
RefSeqiNP_477176.1. NM_057828.4.
UniGeneiDm.4850.

Genome annotation databases

EnsemblMetazoaiFBtr0080889; FBpp0080446; FBgn0000409.
GeneIDi34996.
KEGGidme:Dmel_CG17903.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01760 Genomic DNA. Translation: CAA25900.1 .
M11381 Genomic DNA. Translation: AAA28437.1 .
AE014134 Genomic DNA. Translation: AAF53554.1 .
AY071701 mRNA. Translation: AAL49323.1 .
PIRi A22945. CCFFDM.
RefSeqi NP_477176.1. NM_057828.4.
UniGenei Dm.4850.

3D structure databases

ProteinModelPortali P84029.
SMRi P84029. Positions 6-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61003. 37 interactions.
IntActi P84029. 2 interactions.
MINTi MINT-305906.

Proteomic databases

PaxDbi P84029.
PRIDEi P84029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080889 ; FBpp0080446 ; FBgn0000409 .
GeneIDi 34996.
KEGGi dme:Dmel_CG17903.

Organism-specific databases

CTDi 34996.
FlyBasei FBgn0000409. Cyt-c-p.

Phylogenomic databases

eggNOGi COG3474.
GeneTreei ENSGT00390000009405.
InParanoidi P84029.
KOi K08738.
OMAi DDQEITD.
OrthoDBi EOG761BWX.
PhylomeDBi P84029.

Enzyme and pathway databases

Reactomei REACT_204218. Release of apoptotic factors from the mitochondria.
REACT_207898. Respiratory electron transport.
REACT_209269. Detoxification of Reactive Oxygen Species.
REACT_226175. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

GenomeRNAii 34996.
NextBioi 791302.
PROi P84029.

Gene expression databases

Bgeei P84029.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two Drosophila melanogaster cytochrome c genes and their transcripts."
    Limbach K.J., Wu R.
    Nucleic Acids Res. 13:631-644(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "Developmental expression of nuclear genes that encode mitochondrial proteins: insect cytochromes c."
    Swanson M.S., Zieminn S.M., Miller D.D., Garber E.A.E., Margoliash E.
    Proc. Natl. Acad. Sci. U.S.A. 82:1964-1968(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  6. "Developmental variation and amino acid sequences of cytochromes c of the fruit fly Drosophila melanogaster and the flesh fly Boettcherisca peregrina."
    Inoue S., Inoue H., Hiroyoshi T., Matsubara H., Yamanaka T.
    J. Biochem. 100:955-965(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-108.

Entry informationi

Entry nameiCYC2_DROME
AccessioniPrimary (citable) accession number: P84029
Secondary accession number(s): P00033, P00034, Q9VJJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

There are two cytochrome C genes in Drosophila: Cyt-c-d (distal) and Cyt-c-p (proximal).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3