Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P84029

- CYC2_DROME

UniProt

P84029 - CYC2_DROME

Protein

Cytochrome c-2

Gene

Cyt-c-p

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191Heme (covalent)
    Binding sitei22 – 221Heme (covalent)
    Metal bindingi23 – 231Iron (heme axial ligand)
    Metal bindingi85 – 851Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: FlyBase
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB
    2. oxidative phosphorylation Source: FlyBase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_204218. Release of apoptotic factors from the mitochondria.
    REACT_207898. Respiratory electron transport.
    REACT_209269. Detoxification of Reactive Oxygen Species.
    REACT_226175. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c-2
    Alternative name(s):
    Cytochrome c-proximal
    Gene namesi
    Name:Cyt-c-p
    Synonyms:CYTC2, DC4
    ORF Names:CG17903
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0000409. Cyt-c-p.

    Subcellular locationi

    Mitochondrion intermembrane space 1 Publication
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: FlyBase
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. mitochondrion Source: FlyBase
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 108107Cytochrome c-2PRO_0000108261Add
    BLAST

    Post-translational modificationi

    Binds 1 heme group per subunit.

    Proteomic databases

    PaxDbiP84029.
    PRIDEiP84029.

    Expressioni

    Developmental stagei

    Expressed at varying, but relatively high levels throughout development.1 Publication

    Gene expression databases

    BgeeiP84029.

    Interactioni

    Protein-protein interaction databases

    BioGridi61003. 37 interactions.
    IntActiP84029. 2 interactions.
    MINTiMINT-305906.

    Structurei

    3D structure databases

    ProteinModelPortaliP84029.
    SMRiP84029. Positions 6-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    GeneTreeiENSGT00390000009405.
    InParanoidiP84029.
    KOiK08738.
    OMAiDDQEITD.
    OrthoDBiEOG761BWX.
    PhylomeDBiP84029.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84029-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVPAGDVEK GKKLFVQRCA QCHTVEAGGK HKVGPNLHGL IGRKTGQAAG    50
    FAYTDANKAK GITWNEDTLF EYLENPKKYI PGTKMIFAGL KKPNERGDLI 100
    AYLKSATK 108
    Length:108
    Mass (Da):11,735
    Last modified:January 23, 2007 - v2
    Checksum:i535FFBAF282D20D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01760 Genomic DNA. Translation: CAA25900.1.
    M11381 Genomic DNA. Translation: AAA28437.1.
    AE014134 Genomic DNA. Translation: AAF53554.1.
    AY071701 mRNA. Translation: AAL49323.1.
    PIRiA22945. CCFFDM.
    RefSeqiNP_477176.1. NM_057828.4.
    UniGeneiDm.4850.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080889; FBpp0080446; FBgn0000409.
    GeneIDi34996.
    KEGGidme:Dmel_CG17903.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01760 Genomic DNA. Translation: CAA25900.1 .
    M11381 Genomic DNA. Translation: AAA28437.1 .
    AE014134 Genomic DNA. Translation: AAF53554.1 .
    AY071701 mRNA. Translation: AAL49323.1 .
    PIRi A22945. CCFFDM.
    RefSeqi NP_477176.1. NM_057828.4.
    UniGenei Dm.4850.

    3D structure databases

    ProteinModelPortali P84029.
    SMRi P84029. Positions 6-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61003. 37 interactions.
    IntActi P84029. 2 interactions.
    MINTi MINT-305906.

    Proteomic databases

    PaxDbi P84029.
    PRIDEi P84029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080889 ; FBpp0080446 ; FBgn0000409 .
    GeneIDi 34996.
    KEGGi dme:Dmel_CG17903.

    Organism-specific databases

    CTDi 34996.
    FlyBasei FBgn0000409. Cyt-c-p.

    Phylogenomic databases

    eggNOGi COG3474.
    GeneTreei ENSGT00390000009405.
    InParanoidi P84029.
    KOi K08738.
    OMAi DDQEITD.
    OrthoDBi EOG761BWX.
    PhylomeDBi P84029.

    Enzyme and pathway databases

    Reactomei REACT_204218. Release of apoptotic factors from the mitochondria.
    REACT_207898. Respiratory electron transport.
    REACT_209269. Detoxification of Reactive Oxygen Species.
    REACT_226175. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    GenomeRNAii 34996.
    NextBioi 791302.
    PROi P84029.

    Gene expression databases

    Bgeei P84029.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two Drosophila melanogaster cytochrome c genes and their transcripts."
      Limbach K.J., Wu R.
      Nucleic Acids Res. 13:631-644(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE.
    2. "Developmental expression of nuclear genes that encode mitochondrial proteins: insect cytochromes c."
      Swanson M.S., Zieminn S.M., Miller D.D., Garber E.A.E., Margoliash E.
      Proc. Natl. Acad. Sci. U.S.A. 82:1964-1968(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.
    6. "Developmental variation and amino acid sequences of cytochromes c of the fruit fly Drosophila melanogaster and the flesh fly Boettcherisca peregrina."
      Inoue S., Inoue H., Hiroyoshi T., Matsubara H., Yamanaka T.
      J. Biochem. 100:955-965(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-108.

    Entry informationi

    Entry nameiCYC2_DROME
    AccessioniPrimary (citable) accession number: P84029
    Secondary accession number(s): P00033, P00034, Q9VJJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Miscellaneous

    There are two cytochrome C genes in Drosophila: Cyt-c-d (distal) and Cyt-c-p (proximal).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3