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Protein

Cytochrome c-2

Gene

Cyt-c-p

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.1 Publication

Miscellaneous

There are two cytochrome C genes in Drosophila: Cyt-c-d (distal) and Cyt-c-p (proximal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19Heme (covalent)1
Binding sitei22Heme (covalent)1
Metal bindingi23Iron (heme axial ligand)1
Metal bindingi85Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-111457 Release of apoptotic factors from the mitochondria
R-DME-3299685 Detoxification of Reactive Oxygen Species
R-DME-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-2
Alternative name(s):
Cytochrome c-proximal
Gene namesi
Name:Cyt-c-p
Synonyms:CYTC2, DC4
ORF Names:CG17903
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0284248 Cyt-c-p

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001082612 – 108Cytochrome c-2Add BLAST107

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiP84029
PRIDEiP84029

Expressioni

Developmental stagei

Expressed at varying, but relatively high levels throughout development.1 Publication

Gene expression databases

BgeeiFBgn0000409
ExpressionAtlasiP84029 differential
GenevisibleiP84029 DM

Interactioni

Protein-protein interaction databases

BioGridi61003, 40 interactors
IntActiP84029, 2 interactors
STRINGi7227.FBpp0080446

Structurei

3D structure databases

ProteinModelPortaliP84029
SMRiP84029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453 Eukaryota
COG3474 LUCA
InParanoidiP84029
KOiK08738
OMAiGLFKTRC
OrthoDBiEOG091G0UQY
PhylomeDBiP84029

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPAGDVEK GKKLFVQRCA QCHTVEAGGK HKVGPNLHGL IGRKTGQAAG
60 70 80 90 100
FAYTDANKAK GITWNEDTLF EYLENPKKYI PGTKMIFAGL KKPNERGDLI

AYLKSATK
Length:108
Mass (Da):11,735
Last modified:January 23, 2007 - v2
Checksum:i535FFBAF282D20D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01760 Genomic DNA Translation: CAA25900.1
M11381 Genomic DNA Translation: AAA28437.1
AE014134 Genomic DNA Translation: AAF53554.1
AY071701 mRNA Translation: AAL49323.1
PIRiA22945 CCFFDM
RefSeqiNP_001285984.1, NM_001299055.1
NP_477176.1, NM_057828.4
UniGeneiDm.4850

Genome annotation databases

EnsemblMetazoaiFBtr0080889; FBpp0080446; FBgn0284248
FBtr0344849; FBpp0311164; FBgn0284248
GeneIDi34996
KEGGidme:Dmel_CG17903

Similar proteinsi

Entry informationi

Entry nameiCYC2_DROME
AccessioniPrimary (citable) accession number: P84029
Secondary accession number(s): P00033, P00034, Q9VJJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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