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Protein

Cytochrome c-2

Gene

Cyt-c-p

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19Heme (covalent)1
Binding sitei22Heme (covalent)1
Metal bindingi23Iron (heme axial ligand)1
Metal bindingi85Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-2
Alternative name(s):
Cytochrome c-proximal
Gene namesi
Name:Cyt-c-p
Synonyms:CYTC2, DC4
ORF Names:CG17903
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000409. Cyt-c-p.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001082612 – 108Cytochrome c-2Add BLAST107

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

PaxDbiP84029.
PRIDEiP84029.

Expressioni

Developmental stagei

Expressed at varying, but relatively high levels throughout development.1 Publication

Gene expression databases

BgeeiFBgn0000409.
GenevisibleiP84029. DM.

Interactioni

Protein-protein interaction databases

BioGridi61003. 37 interactors.
IntActiP84029. 2 interactors.
MINTiMINT-305906.
STRINGi7227.FBpp0080446.

Structurei

3D structure databases

ProteinModelPortaliP84029.
SMRiP84029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
InParanoidiP84029.
KOiK08738.
OMAiNANKNMA.
OrthoDBiEOG091G0UQY.
PhylomeDBiP84029.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiView protein in PROSITE
PS51007. CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPAGDVEK GKKLFVQRCA QCHTVEAGGK HKVGPNLHGL IGRKTGQAAG
60 70 80 90 100
FAYTDANKAK GITWNEDTLF EYLENPKKYI PGTKMIFAGL KKPNERGDLI

AYLKSATK
Length:108
Mass (Da):11,735
Last modified:January 23, 2007 - v2
Checksum:i535FFBAF282D20D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01760 Genomic DNA. Translation: CAA25900.1.
M11381 Genomic DNA. Translation: AAA28437.1.
AE014134 Genomic DNA. Translation: AAF53554.1.
AY071701 mRNA. Translation: AAL49323.1.
PIRiA22945. CCFFDM.
RefSeqiNP_001285984.1. NM_001299055.1.
NP_477176.1. NM_057828.4.
UniGeneiDm.4850.

Genome annotation databases

EnsemblMetazoaiFBtr0080889; FBpp0080446; FBgn0000409.
FBtr0344849; FBpp0311164; FBgn0000409.
GeneIDi34996.
KEGGidme:Dmel_CG17903.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01760 Genomic DNA. Translation: CAA25900.1.
M11381 Genomic DNA. Translation: AAA28437.1.
AE014134 Genomic DNA. Translation: AAF53554.1.
AY071701 mRNA. Translation: AAL49323.1.
PIRiA22945. CCFFDM.
RefSeqiNP_001285984.1. NM_001299055.1.
NP_477176.1. NM_057828.4.
UniGeneiDm.4850.

3D structure databases

ProteinModelPortaliP84029.
SMRiP84029.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61003. 37 interactors.
IntActiP84029. 2 interactors.
MINTiMINT-305906.
STRINGi7227.FBpp0080446.

Proteomic databases

PaxDbiP84029.
PRIDEiP84029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080889; FBpp0080446; FBgn0000409.
FBtr0344849; FBpp0311164; FBgn0000409.
GeneIDi34996.
KEGGidme:Dmel_CG17903.

Organism-specific databases

CTDi34996.
FlyBaseiFBgn0000409. Cyt-c-p.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
InParanoidiP84029.
KOiK08738.
OMAiNANKNMA.
OrthoDBiEOG091G0UQY.
PhylomeDBiP84029.

Miscellaneous databases

GenomeRNAii34996.
PROiP84029.

Gene expression databases

BgeeiFBgn0000409.
GenevisibleiP84029. DM.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiView protein in PROSITE
PS51007. CYTC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYC2_DROME
AccessioniPrimary (citable) accession number: P84029
Secondary accession number(s): P00033, P00034, Q9VJJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

There are two cytochrome C genes in Drosophila: Cyt-c-d (distal) and Cyt-c-p (proximal).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.