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Protein

Ventricular natriuretic peptide

Gene

vnp

Organism
Acipenser transmontanus (White sturgeon)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits natriuretic and vasodepressor activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Protein family/group databases

TCDBi1.C.46.2.2. the c-type natriuretic peptide (cnp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ventricular natriuretic peptide
Gene namesi
Name:vnp
OrganismiAcipenser transmontanus (White sturgeon)
Taxonomic identifieri7904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiChondrosteiAcipenseriformesAcipenseridaeAcipenser

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – ?PRO_0000001611
Peptidei112 – 14534Ventricular natriuretic peptidePRO_0000001612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 133By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Heart atrium and ventricle, and to a very low extent in brain.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG097921.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMGKIAVGY GFLLLLVFQL GVRASTLFNK YNVQELSSLK DLLERLEEKL
60 70 80 90 100
SPGEESDVYA GSEDLVNDPE EDADLILDNV RKQAEKEFYK PAGFRDENLQ
110 120 130 140
RGRLRSIATS ARSMNGCFGN RIERIGSWSS LGCNNSRFGS KKRIF
Length:145
Mass (Da):16,390
Last modified:July 5, 2004 - v1
Checksum:i9877CAD6CEBCD62B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB087730 mRNA. Translation: BAD02837.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB087730 mRNA. Translation: BAD02837.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.46.2.2. the c-type natriuretic peptide (cnp) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG097921.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANFV_ACITR
AccessioniPrimary (citable) accession number: P83962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.