Reviewed, UniProtKB/Swiss-Prot P83958 (TLP_ACTCH)

Names and origin

Protein names

Recommended name:
    Thaumatin-like protein
Alternative name(s):
    Allergen=Act c 2

Gene names

Name:

tlp

Organism

Actinidia chinensis (Kiwi) (Yangtao)

Taxonomic identifier

3625 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › Ericales › Actinidiaceae › Actinidia

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has antifungal activity against B.cinerea, C.comatus, M.arachidicola, P.piricola, C.albicans and S.carlsbergensis. Inhibits HIV-1 reverse transcriptase. Ref.1 Ref.2
Subcellular location	Secreted.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE from the serum of kiwi-allergic patients. Ref.2
Sequence similarities	Belongs to the thaumatin family.

Ontologies

Keywords
Biological process	Plant defense
Cellular component	Secreted
Disease	Allergen
Molecular function	Antimicrobial Fungicide Pathogenesis-related protein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW killing of cells of another organism Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Thaumatin-like protein		PRO_0000096222
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P83958-1 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: 1DBB22DEC9076F19	FASTA	20	2,140
	10 20 ATFNFINNCP FTVWAAAVPG

References

[1]	"Isolation of an antifungal thaumatin-like protein from kiwi fruits." Wang H., Ng T.B. Phytochemistry 61:1-6(2002) [PubMed: 12165295] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION.
[2]	"Isolation and biochemical characterization of a thaumatin-like kiwi allergen." Gavrovic-Jankulovic M., Cirkovic T., Vuckovic O., Atanaskovic-Markovic M., Petersen A., Gojgic G., Burazer L., Jankov R.M. J. Allergy Clin. Immunol. 110:805-810(2002) [PubMed: 12417892] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-13, FUNCTION, ALLERGENICITY.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001938. Thaumatin. [Graphical view]
Pfam	PF00314. Thaumatin. 1 hit. [Graphical view]
PROSITE	PS00316. THAUMATIN_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TLP_ACTCH

Accession

Primary (citable) accession number: P83958

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	June 7, 2004
Last modified:	November 24, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)