Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Omwaprin-a

Gene
N/A
Organism
Oxyuranus microlepidotus (Inland taipan)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Damages membranes of susceptible bacteria. Has antibacterial activity against the Gram-positive bacteria B.megaterium and S.warneri. Has no antibacterial activity against the Gram-positive bacteria B.thuringiensis, S.aureus and S.clavuligerus, or the Gram-negative bacteria E.coli and A.tumefaciens. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Omwaprin-a
Alternative name(s):
Oxywaprin
Oxywaprin-a
OrganismiOxyuranus microlepidotus (Inland taipan)
Taxonomic identifieri111177 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeAcanthophiinaeOxyuranus

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5050Omwaprin-aPRO_0000188989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi10 ↔ 35PROSITE-ProRule annotation1 Publication
Disulfide bondi18 ↔ 39PROSITE-ProRule annotation1 Publication
Disulfide bondi22 ↔ 34PROSITE-ProRule annotation1 Publication
Disulfide bondi28 ↔ 43PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

1
50
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93Combined sources
Helixi25 – 273Combined sources
Beta strandi33 – 364Combined sources
Beta strandi41 – 444Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGGX-ray1.33A/B1-50[»]
ProteinModelPortaliP83952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 4745WAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the snake waprin family.Curated
Contains 1 WAP domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KDRPKKPGLC PPRPQKPCVK ECKNDDSCPG QQKCCNYGCK DECRDPIFVG
Length:50
Mass (Da):5,611
Last modified:June 7, 2004 - v1
Checksum:i18654615BAE58FC6
GO

Mass spectrometryi

Molecular mass is 5602 Da from positions 1 - 50. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGGX-ray1.33A/B1-50[»]
ProteinModelPortaliP83952.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins."
    Nair D.G., Fry B.G., Alewood P.F., Kumar P.P., Kini R.M.
    Biochem. J. 402:93-104(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, DISULFIDE BONDS.
    Tissue: Venom1 Publication.

Entry informationi

Entry nameiWAPA_OXYMI
AccessioniPrimary (citable) accession number: P83952
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 7, 2004
Last modified: December 9, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.