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Protein

Homeotic protein ultrabithorax

Gene

Ubx

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi295 – 354HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • anterior/posterior pattern specification Source: UniProtKB
  • anterior Malpighian tubule development Source: FlyBase
  • cell fate determination Source: FlyBase
  • dorsal vessel aortic cell fate commitment Source: FlyBase
  • endoderm formation Source: FlyBase
  • haltere development Source: FlyBase
  • heart development Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • mesodermal cell fate specification Source: FlyBase
  • midgut development Source: FlyBase
  • muscle cell fate specification Source: FlyBase
  • negative regulation of gene silencing Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • open tracheal system development Source: FlyBase
  • positive regulation of muscle organ development Source: FlyBase
  • regulation of cell fate specification Source: FlyBase
  • regulation of imaginal disc growth Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB
  • somatic muscle development Source: FlyBase
  • specification of animal organ identity Source: FlyBase
  • specification of segmental identity, thorax Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP83949.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein ultrabithorax
Gene namesi
Name:Ubx
ORF Names:CG10388
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003944. Ubx.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002681 – 389Homeotic protein ultrabithoraxAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170Phosphothreonine1 Publication1
Modified residuei174Phosphoserine1 Publication1
Modified residuei177Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP83949.
PRIDEiP83949.

PTM databases

iPTMnetiP83949.

Expressioni

Tissue specificityi

In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system.1 Publication

Gene expression databases

BgeeiFBgn0003944.
ExpressionAtlasiP83949. baseline.
GenevisibleiP83949. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
alQ064533EBI-202590,EBI-188244
Cbp80Q7K4N33EBI-202590,EBI-137965
DIP1Q9TW277EBI-202571,EBI-443968
hP140033EBI-202590,EBI-123011

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi67078. 65 interactors.
DIPiDIP-33048N.
IntActiP83949. 27 interactors.
MINTiMINT-86744.
STRINGi7227.FBpp0082793.

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi241 – 243Combined sources3
Helixi304 – 316Combined sources13
Helixi322 – 332Combined sources11
Helixi336 – 355Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8IX-ray2.40A233-356[»]
4CYCX-ray2.36A233-367[»]
4UUSX-ray2.55A/E292-367[»]
4UUTX-ray2.80A233-367[»]
DisProtiDP00623.
ProteinModelPortaliP83949.
SMRiP83949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83949.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 244Antp-type hexapeptide6
Motifi368 – 383QAAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 39Poly-Ala7
Compositional biasi111 – 129Poly-GlyAdd BLAST19
Compositional biasi322 – 325Poly-Arg4

Domaini

The QA motif is able to mediate transcriptional repression.By similarity

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
InParanoidiP83949.
KOiK09311.
OMAiDWLGTNG.
OrthoDBiEOG091G0P0U.
PhylomeDBiP83949.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IB (identifier: P83949-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS
60 70 80 90 100
PYANHHLQRT TQDSPYDASI TAACNKIYGD GAGAYKQDCL NIKADAVNGY
110 120 130 140 150
KDIWNTGGSN GGGGGGGGGG GGGAGGTGGA GNANGGNAAN ANGQNNPAGG
160 170 180 190 200
MPVRPSACTP DSRVGGYLDT SGGSPVSHRG GSAGGNVSVS GGNGNAGGVQ
210 220 230 240 250
SGVGVAGAGT AWNANCTISG AAAQTAAASS LHQASNHTFY PWMAIAGECP
260 270 280 290 300
EDPTKSKIRS DLTQYGGIST DMGKRYSESL AGSLLPDWLG TNGLRRRGRQ
310 320 330 340 350
TYTRYQTLEL EKEFHTNHYL TRRRRIEMAH ALCLTERQIK IWFQNRRMKL
360 370 380
KKEIQAIKEL NEQEKQAQAQ KAAAAAAAAA AVQGGHLDQ
Length:389
Mass (Da):40,040
Last modified:June 7, 2004 - v1
Checksum:iD452E8FFE55D8F53
GO
Isoform IA (identifier: P83949-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     248-256: Missing.

Show »
Length:380
Mass (Da):39,053
Checksum:iB8A8FE2B19724E28
GO
Isoform IIA (identifier: P83949-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     248-273: Missing.

Show »
Length:363
Mass (Da):37,229
Checksum:i55DD2D46391F1FC6
GO
Isoform IIB (identifier: P83949-4) [UniParc] [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     258-274: Missing.

Show »
Length:372
Mass (Da):38,216
Checksum:iA58E24FA4415FD4C
GO
Isoform IVA (identifier: P83949-5) [UniParc] [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     248-290: Missing.

Show »
Length:346
Mass (Da):35,355
Checksum:i4D4610EC2BA13E05
GO
Isoform IVB (identifier: P83949-6) [UniParc] [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     257-290: Missing.

Show »
Length:355
Mass (Da):36,342
Checksum:i9C764B4C095711D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75N → Y in AAA84412 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84411 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84410 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84409 (PubMed:7667301).Curated1
Sequence conflicti75N → Y in AAA84408 (PubMed:7667301).Curated1
Sequence conflicti330H → Y in AAA28615 (PubMed:6327065).Curated1
Sequence conflicti340K → E in AAA28615 (PubMed:6327065).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002407248 – 290Missing in isoform IVA. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_002406248 – 273Missing in isoform IIA. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_002405248 – 256Missing in isoform IA. 2 Publications9
Alternative sequenceiVSP_002409257 – 290Missing in isoform IVB. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_002408258 – 274Missing in isoform IIB. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05723
, X05724, X05725, X05727 Genomic DNA. Translation: CAA29194.1.
X76210 mRNA. Translation: CAA53803.1.
U31961 Genomic DNA. Translation: AAA84412.1.
U31961 Genomic DNA. Translation: AAA84411.1.
U31961 Genomic DNA. Translation: AAA84410.1.
U31961 Genomic DNA. Translation: AAA84409.1.
U31961 Genomic DNA. Translation: AAA84408.1.
AE014297 Genomic DNA. Translation: AAF55355.2.
AE014297 Genomic DNA. Translation: AAF55356.1.
AE014297 Genomic DNA. Translation: AAN13717.1.
AE014297 Genomic DNA. Translation: AAN13718.1.
AE014297 Genomic DNA. Translation: AAN13719.1.
AE014297 Genomic DNA. Translation: AAS65158.1.
BT010241 mRNA. Translation: AAQ23559.1.
K01963 Genomic DNA. Translation: AAA29008.1. Sequence problems.
K01959 Genomic DNA. Translation: AAA28615.1. Sequence problems.
X05427 Genomic DNA. Translation: CAA29009.1.
PIRiB27867.
D26995.
RefSeqiNP_536748.1. NM_080500.4. [P83949-5]
NP_536752.1. NM_080504.4. [P83949-1]
NP_732171.1. NM_169728.3. [P83949-3]
NP_732172.1. NM_169729.3. [P83949-2]
NP_732173.1. NM_169730.3. [P83949-4]
NP_996219.1. NM_206497.3. [P83949-6]
UniGeneiDm.21668.

Genome annotation databases

EnsemblMetazoaiFBtr0083347; FBpp0082793; FBgn0003944. [P83949-1]
GeneIDi42034.
KEGGidme:Dmel_CG10388.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05723
, X05724, X05725, X05727 Genomic DNA. Translation: CAA29194.1.
X76210 mRNA. Translation: CAA53803.1.
U31961 Genomic DNA. Translation: AAA84412.1.
U31961 Genomic DNA. Translation: AAA84411.1.
U31961 Genomic DNA. Translation: AAA84410.1.
U31961 Genomic DNA. Translation: AAA84409.1.
U31961 Genomic DNA. Translation: AAA84408.1.
AE014297 Genomic DNA. Translation: AAF55355.2.
AE014297 Genomic DNA. Translation: AAF55356.1.
AE014297 Genomic DNA. Translation: AAN13717.1.
AE014297 Genomic DNA. Translation: AAN13718.1.
AE014297 Genomic DNA. Translation: AAN13719.1.
AE014297 Genomic DNA. Translation: AAS65158.1.
BT010241 mRNA. Translation: AAQ23559.1.
K01963 Genomic DNA. Translation: AAA29008.1. Sequence problems.
K01959 Genomic DNA. Translation: AAA28615.1. Sequence problems.
X05427 Genomic DNA. Translation: CAA29009.1.
PIRiB27867.
D26995.
RefSeqiNP_536748.1. NM_080500.4. [P83949-5]
NP_536752.1. NM_080504.4. [P83949-1]
NP_732171.1. NM_169728.3. [P83949-3]
NP_732172.1. NM_169729.3. [P83949-2]
NP_732173.1. NM_169730.3. [P83949-4]
NP_996219.1. NM_206497.3. [P83949-6]
UniGeneiDm.21668.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8IX-ray2.40A233-356[»]
4CYCX-ray2.36A233-367[»]
4UUSX-ray2.55A/E292-367[»]
4UUTX-ray2.80A233-367[»]
DisProtiDP00623.
ProteinModelPortaliP83949.
SMRiP83949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67078. 65 interactors.
DIPiDIP-33048N.
IntActiP83949. 27 interactors.
MINTiMINT-86744.
STRINGi7227.FBpp0082793.

PTM databases

iPTMnetiP83949.

Proteomic databases

PaxDbiP83949.
PRIDEiP83949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083347; FBpp0082793; FBgn0003944. [P83949-1]
GeneIDi42034.
KEGGidme:Dmel_CG10388.

Organism-specific databases

CTDi42034.
FlyBaseiFBgn0003944. Ubx.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
InParanoidiP83949.
KOiK09311.
OMAiDWLGTNG.
OrthoDBiEOG091G0P0U.
PhylomeDBiP83949.

Enzyme and pathway databases

SignaLinkiP83949.

Miscellaneous databases

ChiTaRSiUbx. fly.
EvolutionaryTraceiP83949.
GenomeRNAii42034.
PROiP83949.

Gene expression databases

BgeeiFBgn0003944.
ExpressionAtlasiP83949. baseline.
GenevisibleiP83949. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBX_DROME
AccessioniPrimary (citable) accession number: P83949
Secondary accession number(s): P02834
, Q9TX83, Q9VER4, Q9VER5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.