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Protein

Transcription elongation factor B polypeptide 1

Gene

Tceb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

GO - Molecular functioni

  • protein complex binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor B polypeptide 1
Alternative name(s):
Elongin 15 kDa subunit
Elongin-C
Short name:
EloC
RNA polymerase II transcription factor SIII subunit C
SIII p15
Stromal membrane-associated protein SMAP1B homolog
Gene namesi
Name:Tceb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620658. Tceb1.

Subcellular locationi

GO - Cellular componenti

  • elongin complex Source: GO_Central
  • VCB complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 112112Transcription elongation factor B polypeptide 1PRO_0000187260Add
BLAST

Proteomic databases

PaxDbiP83941.
PRIDEiP83941.

PTM databases

PhosphoSiteiP83941.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031730.
GenevisibleiP83941. RN.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. Interacts with SPSB1. posed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi249109. 8 interactions.
IntActiP83941. 4 interactions.
MINTiMINT-4094320.
STRINGi10116.ENSRNOP00000067410.

Structurei

3D structure databases

ProteinModelPortaliP83941.
SMRiP83941. Positions 17-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGiKOG3473. Eukaryota.
ENOG41123WR. LUCA.
GeneTreeiENSGT00390000011717.
HOGENOMiHOG000216525.
HOVERGENiHBG007440.
InParanoidiP83941.
KOiK03872.
OMAiDMDIPVE.
PhylomeDBiP83941.
TreeFamiTF300233.

Family and domain databases

InterProiIPR001232. SKP1-like.
IPR011333. SKP1/BTB/POZ.
IPR016073. Skp1_comp_POZ.
[Graphical view]
PfamiPF03931. Skp1_POZ. 1 hit.
[Graphical view]
SMARTiSM00512. Skp1. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P83941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG
60 70 80 90 100
QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA
110
LELLMAANFL DC
Length:112
Mass (Da):12,473
Last modified:June 7, 2004 - v1
Checksum:i98D88696E883538B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29259 mRNA. Translation: AAA41109.1.
BC060566 mRNA. Translation: AAH60566.1.
RefSeqiNP_001257490.1. NM_001270561.1.
NP_001257491.1. NM_001270562.1.
NP_001257492.1. NM_001270563.1.
NP_072115.1. NM_022593.4.
XP_006237786.1. XM_006237724.2.
UniGeneiRn.38378.
Rn.5996.

Genome annotation databases

EnsembliENSRNOT00000050236; ENSRNOP00000067410; ENSRNOG00000031730.
ENSRNOT00000082813; ENSRNOP00000071456; ENSRNOG00000031730.
ENSRNOT00000090313; ENSRNOP00000069739; ENSRNOG00000031730.
GeneIDi64525.
KEGGirno:64525.
UCSCiRGD:620658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29259 mRNA. Translation: AAA41109.1.
BC060566 mRNA. Translation: AAH60566.1.
RefSeqiNP_001257490.1. NM_001270561.1.
NP_001257491.1. NM_001270562.1.
NP_001257492.1. NM_001270563.1.
NP_072115.1. NM_022593.4.
XP_006237786.1. XM_006237724.2.
UniGeneiRn.38378.
Rn.5996.

3D structure databases

ProteinModelPortaliP83941.
SMRiP83941. Positions 17-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249109. 8 interactions.
IntActiP83941. 4 interactions.
MINTiMINT-4094320.
STRINGi10116.ENSRNOP00000067410.

PTM databases

PhosphoSiteiP83941.

Proteomic databases

PaxDbiP83941.
PRIDEiP83941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050236; ENSRNOP00000067410; ENSRNOG00000031730.
ENSRNOT00000082813; ENSRNOP00000071456; ENSRNOG00000031730.
ENSRNOT00000090313; ENSRNOP00000069739; ENSRNOG00000031730.
GeneIDi64525.
KEGGirno:64525.
UCSCiRGD:620658. rat.

Organism-specific databases

CTDi6921.
RGDi620658. Tceb1.

Phylogenomic databases

eggNOGiKOG3473. Eukaryota.
ENOG41123WR. LUCA.
GeneTreeiENSGT00390000011717.
HOGENOMiHOG000216525.
HOVERGENiHBG007440.
InParanoidiP83941.
KOiK03872.
OMAiDMDIPVE.
PhylomeDBiP83941.
TreeFamiTF300233.

Miscellaneous databases

PROiP83941.

Gene expression databases

BgeeiENSRNOG00000031730.
GenevisibleiP83941. RN.

Family and domain databases

InterProiIPR001232. SKP1-like.
IPR011333. SKP1/BTB/POZ.
IPR016073. Skp1_comp_POZ.
[Graphical view]
PfamiPF03931. Skp1_POZ. 1 hit.
[Graphical view]
SMARTiSM00512. Skp1. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiELOC_RAT
AccessioniPrimary (citable) accession number: P83941
Secondary accession number(s): Q63182
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.