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Protein

Elongin-C

Gene

Eloc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226).By similarity2 Publications
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongin-C
Short name:
EloC
Alternative name(s):
Elongin 15 kDa subunit
RNA polymerase II transcription factor SIII subunit C
SIII p15
Stromal membrane-associated protein SMAP1B homolog
Transcription elongation factor B polypeptide 1
Gene namesi
Name:ElocImported
Synonyms:Tceb1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915173 Eloc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872591 – 112Elongin-CAdd BLAST112

Proteomic databases

EPDiP83940
MaxQBiP83940
PaxDbiP83940
PeptideAtlasiP83940
PRIDEiP83940

PTM databases

iPTMnetiP83940
PhosphoSitePlusiP83940

Expressioni

Gene expression databases

BgeeiENSMUSG00000079658
ExpressionAtlasiP83940 baseline and differential
GenevisibleiP83940 MM

Interactioni

Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (PubMed:27863225, PubMed:27863226). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1. The elongin BC complex is part of a complex with hydroxylated HIF1A. Interacts with VHL. Interacts with TMF1. Interacts with SPSB1. posed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.6 Publications

Protein-protein interaction databases

BioGridi212537, 24 interactors
CORUMiP83940
DIPiDIP-42814N
IntActiP83940, 19 interactors
MINTiP83940
STRINGi10090.ENSMUSP00000111009

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 22Combined sources5
Beta strandi28 – 32Combined sources5
Helixi33 – 36Combined sources4
Helixi37 – 39Combined sources3
Helixi40 – 47Combined sources8
Helixi48 – 50Combined sources3
Beta strandi54 – 56Combined sources3
Beta strandi59 – 61Combined sources3
Helixi67 – 84Combined sources18
Beta strandi85 – 89Combined sources5
Turni97 – 99Combined sources3
Helixi100 – 110Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FNJX-ray1.80C17-112[»]
2JZ3NMR-C17-112[»]
4JGHX-ray3.00C17-112[»]
ProteinModelPortaliP83940
SMRiP83940
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83940

Family & Domainsi

Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGiKOG3473 Eukaryota
ENOG41123WR LUCA
GeneTreeiENSGT00390000011717
HOGENOMiHOG000216525
HOVERGENiHBG007440
InParanoidiP83940
KOiK03872
PhylomeDBiP83940
TreeFamiTF300233

Family and domain databases

InterProiView protein in InterPro
IPR001232 SKP1-like
IPR011333 SKP1/BTB/POZ_sf
IPR016073 Skp1_comp_POZ
PfamiView protein in Pfam
PF03931 Skp1_POZ, 1 hit
SMARTiView protein in SMART
SM00512 Skp1, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

P83940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG
60 70 80 90 100
QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA
110
LELLMAANFL DC
Length:112
Mass (Da):12,473
Last modified:June 7, 2004 - v1
Checksum:i98D88696E883538B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013089 mRNA Translation: BAB28641.1
AK011757 mRNA Translation: BAB27825.1
AK011958 mRNA Translation: BAB27939.1
AK012909 mRNA Translation: BAB28546.1
AK039746 mRNA Translation: BAC30437.1
BC009104 mRNA Translation: AAH09104.1
BC028545 mRNA Translation: AAH28545.1
CCDSiCCDS35517.1
RefSeqiNP_001297399.1, NM_001310470.1
NP_080732.1, NM_026456.4
XP_006495624.1, XM_006495561.2
XP_006495625.1, XM_006495562.1
XP_006495626.1, XM_006495563.3
XP_006495627.1, XM_006495564.1
UniGeneiMm.289248

Genome annotation databases

EnsembliENSMUST00000115352; ENSMUSP00000111009; ENSMUSG00000079658
ENSMUST00000185771; ENSMUSP00000139675; ENSMUSG00000079658
ENSMUST00000186948; ENSMUSP00000140962; ENSMUSG00000079658
ENSMUST00000188641; ENSMUSP00000140422; ENSMUSG00000079658
GeneIDi67923
KEGGimmu:67923
UCSCiuc007ajv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELOC_MOUSE
AccessioniPrimary (citable) accession number: P83940
Secondary accession number(s): Q63182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health