Reviewed, UniProtKB/Swiss-Prot P83918 (PEM_IRPLA)

Names and origin

Protein names	Recommended name:     Peroxidase manganese-dependent     EC=1.11.1.13
Organism	Irpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae)
Taxonomic identifier	5319 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Aphyllophorales › Polyporales incertae sedis › Irpex

Protein attributes

Sequence length	35 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has manganese peroxidase activity. Ref.1
Catalytic activity	2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity. Binds 2 calcium ions per subunit By similarity.
Induction	By incubation with textile industry wastewater. Ref.1
Sequence similarities	Belongs to the peroxidase family.
Caution	The order of the peptides shown is unknown.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Manganese Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›35	›35	Peroxidase manganese-dependent		PRO_0000055615
Experimental info
	Non-adjacent residues	9 – 10	2
	Non-adjacent residues	24 – 25	2
	Non-terminal residue	1	1
	Non-terminal residue	35	1

Sequences

	Sequence		Length	Mass (Da)
	P83918-1 [UniParc]. Last modified May 24, 2004. Version 1. Checksum: A50241B69A6A805D	FASTA	35	3,819
	10 20 30 LSLLGHDERV TPEPFDSVTA QNARGNQADV QSLPR

References

[1]	"Purification and characterization of manganese peroxidase of the white-rot fungus Irpex lacteus." Shin K.-S., Kim Y.H., Lim J.-S. J. Microbiol. 43:503-509(2005) [PubMed: 16410766] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, INDUCTION.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.11.1.13. 96336.
Family and domain databases
InterPro	IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
PROSITE	PS00435. PEROXIDASE_1. Partial match. PS00436. PEROXIDASE_2. Partial match. PS50873. PEROXIDASE_4. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PEM_IRPLA

Accession

Primary (citable) accession number: P83918

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	May 24, 2004
Last modified:	May 5, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)