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Protein

Chromobox protein homolog 1

Gene

CBX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21Histone H3K9me2By similarity1
Binding sitei23Histone H3A7By similarity1
Binding sitei40Histone H3A7By similarity1
Binding sitei42Histone H3A7By similarity1
Binding sitei42Histone H3K9me2By similarity1
Binding sitei45Histone H3K9me2By similarity1
Binding sitei58Histone H3A7By similarity1
Binding sitei60Histone H3A7By similarity1
Binding sitei125PxVxL motifBy similarity1
Binding sitei126PxVxL motifBy similarity1
Binding sitei135PxVxL motifBy similarity1
Binding sitei146PxVxL motifBy similarity1
Binding sitei163PxVxL motifBy similarity1
Binding sitei167PxVxL motifBy similarity1
Binding sitei168PxVxL motifBy similarity1
Binding sitei170PxVxL motifBy similarity1

GO - Molecular functioni

  • chromatin binding Source: ProtInc
  • enzyme binding Source: UniProtKB
  • histone methyltransferase binding Source: BHF-UCL
  • protein homodimerization activity Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

SIGNORiP83916

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 1
Alternative name(s):
HP1Hsbeta
Heterochromatin protein 1 homolog beta
Short name:
HP1 beta
Heterochromatin protein p25
M31
Modifier 1 protein
p25beta
Gene namesi
Name:CBX1
Synonyms:CBX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108468.14
HGNCiHGNC:1551 CBX1
MIMi604511 gene
neXtProtiNX_P83916

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161I → E: Abolishes homodimer formation and binding to EMSY. 1 Publication1

Organism-specific databases

DisGeNETi10951
OpenTargetsiENSG00000108468
PharmGKBiPA26126

Chemistry databases

ChEMBLiCHEMBL1741193

Polymorphism and mutation databases

BioMutaiCBX1
DMDMi48428808

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801991 – 185Chromobox protein homolog 1Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei89PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei175PhosphoserineCombined sources1

Post-translational modificationi

Not phosphorylated.
Ubiquitinated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP83916
PaxDbiP83916
PeptideAtlasiP83916
PRIDEiP83916
TopDownProteomicsiP83916

PTM databases

iPTMnetiP83916
PhosphoSitePlusiP83916
SwissPalmiP83916

Expressioni

Tissue specificityi

Expressed in all adult and embryonic tissues.

Gene expression databases

BgeeiENSG00000108468
CleanExiHS_CBX1
ExpressionAtlasiP83916 baseline and differential
GenevisibleiP83916 HS

Organism-specific databases

HPAiCAB012265

Interactioni

Subunit structurei

Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, KMT5B and KMT5C. Interacts with PRDM6. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. Interacts with INCENP. Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1.8 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone methyltransferase binding Source: BHF-UCL
  • protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

BioGridi116151, 78 interactors
DIPiDIP-28135N
IntActiP83916, 108 interactors
MINTiP83916
STRINGi9606.ENSP00000225603

Chemistry databases

BindingDBiP83916

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 32Combined sources10
Beta strandi35 – 42Combined sources8
Helixi47 – 49Combined sources3
Beta strandi51 – 54Combined sources4
Helixi55 – 57Combined sources3
Helixi61 – 68Combined sources8
Helixi112 – 115Combined sources4
Beta strandi119 – 128Combined sources10
Beta strandi131 – 138Combined sources8
Beta strandi145 – 148Combined sources4
Helixi149 – 155Combined sources7
Helixi157 – 165Combined sources9
Beta strandi168 – 172Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FMMX-ray1.80A/B/C/D104-175[»]
3F2UX-ray1.80A20-73[»]
3Q6SX-ray1.93A/B/C/D108-185[»]
5T1GX-ray1.90A108-185[»]
ProteinModelPortaliP83916
SMRiP83916
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP83916

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 79Chromo 1PROSITE-ProRule annotationAdd BLAST59
Domaini117 – 175Chromo 2; shadow subtypePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KDV3 Eukaryota
ENOG4111H4A LUCA
GeneTreeiENSGT00510000046310
HOGENOMiHOG000220852
HOVERGENiHBG000400
InParanoidiP83916
KOiK11585
OMAiQTWEPED
OrthoDBiEOG091G0RBS
PhylomeDBiP83916
TreeFamiTF350503

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR008251 Chromo_shadow_dom
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF01393 Chromo_shadow, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00300 ChSh, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 2 hits

Sequencei

Sequence statusi: Complete.

P83916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN
60 70 80 90 100
TWEPEENLDC PDLIAEFLQS QKTAHETDKS EGGKRKADSD SEDKGEESKP
110 120 130 140 150
KKKKEESEKP RGFARGLEPE RIIGATDSSG ELMFLMKWKN SDEADLVPAK
160 170 180
EANVKCPQVV ISFYEERLTW HSYPSEDDDK KDDKN
Length:185
Mass (Da):21,418
Last modified:June 7, 2004 - v1
Checksum:iBE687AF9C66E48E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35451 mRNA Translation: AAB81548.1
BC002609 mRNA Translation: AAH02609.1
BC021302 mRNA Translation: AAH21302.1
CCDSiCCDS11525.1
PIRiG02080
RefSeqiNP_001120700.1, NM_001127228.1
NP_006798.1, NM_006807.4
UniGeneiHs.77254

Genome annotation databases

EnsembliENST00000225603; ENSP00000225603; ENSG00000108468
ENST00000393408; ENSP00000377060; ENSG00000108468
GeneIDi10951
KEGGihsa:10951

Similar proteinsi

Entry informationi

Entry nameiCBX1_HUMAN
AccessioniPrimary (citable) accession number: P83916
Secondary accession number(s): P23197
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 25, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health