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P83900

- RPGF5_RAT

UniProt

P83900 - RPGF5_RAT

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Protein

Rap guanine nucleotide exchange factor 5

Gene

Rapgef5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity).By similarity

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 5
Alternative name(s):
M-Ras-regulated Rap GEF
Short name:
MR-GEF
Short name:
rMR-GEF
Gene namesi
Name:Rapgef5
Synonyms:Mrgef
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1561668. Rapgef5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Rap guanine nucleotide exchange factor 5PRO_0000068875Add
BLAST

Proteomic databases

PaxDbiP83900.
PRIDEiP83900.

Expressioni

Tissue specificityi

In the embryo, expressed in young neurons of the developing telencephalon, diencephalon and hindbrain. Not expressed in progenitor cells in the ventricular zone.1 Publication

Developmental stagei

Expression is first detected at embryonic day 13.1 Publication

Inductioni

Down-regulated in nerve growth factor-treated PC12 cells.1 Publication

Gene expression databases

GenevestigatoriP83900.

Interactioni

Protein-protein interaction databases

BioGridi263730. 1 interaction.
STRINGi10116.ENSRNOP00000007112.

Structurei

3D structure databases

ProteinModelPortaliP83900.
SMRiP83900. Positions 240-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 200134N-terminal Ras-GEFCuratedPROSITE-ProRule annotationAdd
BLAST
Domaini344 – 579236Ras-GEFCuratedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.CuratedPROSITE-ProRule annotation
Contains 1 Ras-GEF domain.CuratedPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG236726.
HOVERGENiHBG056985.
InParanoidiP83900.
KOiK08019.
PhylomeDBiP83900.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83900-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSSRLRVFD PPLERKDSAA LSERQLPLPT FDVPYFKYID EEDEDDEWGS
60 70 80 90 100
RSQSSTEDDS VDSLLSDRYV VVSGTPEKIL EHLLNDLHLA EVQHKETETL
110 120 130 140 150
LDDFLLTYTV FMTTDDLCQA LLRHYSAKKY QGEEENSDVP CRKRKVLHLV
160 170 180 190 200
SQWISLYKDW LHEDEHSKMF LKTIYRNVLD DVYEYPILEK ELKEFQKILG
210 220 230 240 250
MHRRHTVDEY SPQKKNKALF HQFSLKENWL QHRGTVAETE EIFCHVYVTE
260 270 280 290 300
HSYISVKAKV SSTAQEILKV VAEKLQRAEE DLALVAIMFS GEKHEFQPND
310 320 330 340 350
LAISKSLEAS GRIYVYRKDL ADTLNPFAEN EESQQRSMRI LGMNTWDLAL
360 370 380 390 400
ELMSFDWSLF NSIHEQELIY FTFSRQGSGE HTVNLSLLLQ RCNEVQLWVA
410 420 430 440 450
TEILLCSQLG KRVQLVKKFI KIAAHCKAQQ NLNSFFAIVM GLNTASVSRL
460 470 480 490 500
SQTWEKIPGK FKKLFSELES LTDPSLNHKA YRDAFKKMKP PKIPFMPLLL
510 520 530 540 550
KDVTFIHEGN KTFLDNLVNF EKLHMIADTV RTLRHCRTNQ FGSDMSPKEQ
560 570 580
QELKSYVNHL YVIDSQQALF ELSHRLEPRA
Length:580
Mass (Da):67,601
Last modified:May 24, 2004 - v1
Checksum:i9B3A0B49944E40FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY390379 mRNA. Translation: AAR83745.1.
RefSeqiNP_001041380.1. NM_001047915.1.
UniGeneiRn.22381.

Genome annotation databases

GeneIDi362799.
KEGGirno:362799.
UCSCiRGD:1561668. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY390379 mRNA. Translation: AAR83745.1 .
RefSeqi NP_001041380.1. NM_001047915.1.
UniGenei Rn.22381.

3D structure databases

ProteinModelPortali P83900.
SMRi P83900. Positions 240-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 263730. 1 interaction.
STRINGi 10116.ENSRNOP00000007112.

Proteomic databases

PaxDbi P83900.
PRIDEi P83900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 362799.
KEGGi rno:362799.
UCSCi RGD:1561668. rat.

Organism-specific databases

CTDi 9771.
RGDi 1561668. Rapgef5.

Phylogenomic databases

eggNOGi NOG236726.
HOVERGENi HBG056985.
InParanoidi P83900.
KOi K08019.
PhylomeDBi P83900.

Miscellaneous databases

NextBioi 681302.
PROi P83900.

Gene expression databases

Genevestigatori P83900.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons."
    Bithell A., Alberta J., Hornby F., Stiles C.D., Williams B.P.
    Brain Res. Dev. Brain Res. 146:107-118(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: Sprague-DawleyImported.
    Tissue: Brain cortexImported.

Entry informationi

Entry nameiRPGF5_RAT
AccessioniPrimary (citable) accession number: P83900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3