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P83900

- RPGF5_RAT

UniProt

P83900 - RPGF5_RAT

Protein

Rap guanine nucleotide exchange factor 5

Gene

Rapgef5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (24 May 2004)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation By similarity.By similarity

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 5
    Alternative name(s):
    M-Ras-regulated Rap GEF
    Short name:
    MR-GEF
    Short name:
    rMR-GEF
    Gene namesi
    Name:Rapgef5
    Synonyms:Mrgef
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1561668. Rapgef5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 580580Rap guanine nucleotide exchange factor 5PRO_0000068875Add
    BLAST

    Proteomic databases

    PaxDbiP83900.
    PRIDEiP83900.

    Expressioni

    Tissue specificityi

    In the embryo, expressed in young neurons of the developing telencephalon, diencephalon and hindbrain. Not expressed in progenitor cells in the ventricular zone.1 Publication

    Developmental stagei

    Expression is first detected at embryonic day 13.1 Publication

    Inductioni

    Down-regulated in nerve growth factor-treated PC12 cells.1 Publication

    Gene expression databases

    GenevestigatoriP83900.

    Interactioni

    Protein-protein interaction databases

    BioGridi263730. 1 interaction.
    STRINGi10116.ENSRNOP00000007112.

    Structurei

    3D structure databases

    ProteinModelPortaliP83900.
    SMRiP83900. Positions 240-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 200134N-terminal Ras-GEFCuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini344 – 579236Ras-GEFCuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-terminal Ras-GEF domain.CuratedPROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.CuratedPROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG236726.
    HOVERGENiHBG056985.
    KOiK08019.
    PhylomeDBiP83900.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSRLRVFD PPLERKDSAA LSERQLPLPT FDVPYFKYID EEDEDDEWGS    50
    RSQSSTEDDS VDSLLSDRYV VVSGTPEKIL EHLLNDLHLA EVQHKETETL 100
    LDDFLLTYTV FMTTDDLCQA LLRHYSAKKY QGEEENSDVP CRKRKVLHLV 150
    SQWISLYKDW LHEDEHSKMF LKTIYRNVLD DVYEYPILEK ELKEFQKILG 200
    MHRRHTVDEY SPQKKNKALF HQFSLKENWL QHRGTVAETE EIFCHVYVTE 250
    HSYISVKAKV SSTAQEILKV VAEKLQRAEE DLALVAIMFS GEKHEFQPND 300
    LAISKSLEAS GRIYVYRKDL ADTLNPFAEN EESQQRSMRI LGMNTWDLAL 350
    ELMSFDWSLF NSIHEQELIY FTFSRQGSGE HTVNLSLLLQ RCNEVQLWVA 400
    TEILLCSQLG KRVQLVKKFI KIAAHCKAQQ NLNSFFAIVM GLNTASVSRL 450
    SQTWEKIPGK FKKLFSELES LTDPSLNHKA YRDAFKKMKP PKIPFMPLLL 500
    KDVTFIHEGN KTFLDNLVNF EKLHMIADTV RTLRHCRTNQ FGSDMSPKEQ 550
    QELKSYVNHL YVIDSQQALF ELSHRLEPRA 580
    Length:580
    Mass (Da):67,601
    Last modified:May 24, 2004 - v1
    Checksum:i9B3A0B49944E40FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY390379 mRNA. Translation: AAR83745.1.
    RefSeqiNP_001041380.1. NM_001047915.1.
    UniGeneiRn.22381.

    Genome annotation databases

    GeneIDi362799.
    KEGGirno:362799.
    UCSCiRGD:1561668. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY390379 mRNA. Translation: AAR83745.1 .
    RefSeqi NP_001041380.1. NM_001047915.1.
    UniGenei Rn.22381.

    3D structure databases

    ProteinModelPortali P83900.
    SMRi P83900. Positions 240-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 263730. 1 interaction.
    STRINGi 10116.ENSRNOP00000007112.

    Proteomic databases

    PaxDbi P83900.
    PRIDEi P83900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 362799.
    KEGGi rno:362799.
    UCSCi RGD:1561668. rat.

    Organism-specific databases

    CTDi 9771.
    RGDi 1561668. Rapgef5.

    Phylogenomic databases

    eggNOGi NOG236726.
    HOVERGENi HBG056985.
    KOi K08019.
    PhylomeDBi P83900.

    Miscellaneous databases

    NextBioi 681302.
    PROi P83900.

    Gene expression databases

    Genevestigatori P83900.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons."
      Bithell A., Alberta J., Hornby F., Stiles C.D., Williams B.P.
      Brain Res. Dev. Brain Res. 146:107-118(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
      Strain: Sprague-DawleyImported.
      Tissue: Brain cortexImported.

    Entry informationi

    Entry nameiRPGF5_RAT
    AccessioniPrimary (citable) accession number: P83900
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3