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P83900 (RPGF5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rap guanine nucleotide exchange factor 5
Alternative name(s):
M-Ras-regulated Rap GEF
Short name=MR-GEF
Short name=rMR-GEF
Gene names
Name:Rapgef5
Synonyms:Mrgef
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation By similarity. UniProtKB Q92565

Subcellular location

Nucleus By similarity UniProtKB Q92565.

Tissue specificity

In the embryo, expressed in young neurons of the developing telencephalon, diencephalon and hindbrain. Not expressed in progenitor cells in the ventricular zone. Ref.1

Developmental stage

Expression is first detected at embryonic day 13. Ref.1

Induction

Down-regulated in nerve growth factor-treated PC12 cells. Ref.1

Sequence similarities

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Rap guanine nucleotide exchange factor 5
PRO_0000068875

Regions

Domain67 – 200134N-terminal Ras-GEF
Domain344 – 579236Ras-GEF

Sequences

Sequence LengthMass (Da)Tools
P83900 [UniParc].

Last modified May 24, 2004. Version 1.
Checksum: 9B3A0B49944E40FC

FASTA58067,601
        10         20         30         40         50         60 
MGSSRLRVFD PPLERKDSAA LSERQLPLPT FDVPYFKYID EEDEDDEWGS RSQSSTEDDS 

        70         80         90        100        110        120 
VDSLLSDRYV VVSGTPEKIL EHLLNDLHLA EVQHKETETL LDDFLLTYTV FMTTDDLCQA 

       130        140        150        160        170        180 
LLRHYSAKKY QGEEENSDVP CRKRKVLHLV SQWISLYKDW LHEDEHSKMF LKTIYRNVLD 

       190        200        210        220        230        240 
DVYEYPILEK ELKEFQKILG MHRRHTVDEY SPQKKNKALF HQFSLKENWL QHRGTVAETE 

       250        260        270        280        290        300 
EIFCHVYVTE HSYISVKAKV SSTAQEILKV VAEKLQRAEE DLALVAIMFS GEKHEFQPND 

       310        320        330        340        350        360 
LAISKSLEAS GRIYVYRKDL ADTLNPFAEN EESQQRSMRI LGMNTWDLAL ELMSFDWSLF 

       370        380        390        400        410        420 
NSIHEQELIY FTFSRQGSGE HTVNLSLLLQ RCNEVQLWVA TEILLCSQLG KRVQLVKKFI 

       430        440        450        460        470        480 
KIAAHCKAQQ NLNSFFAIVM GLNTASVSRL SQTWEKIPGK FKKLFSELES LTDPSLNHKA 

       490        500        510        520        530        540 
YRDAFKKMKP PKIPFMPLLL KDVTFIHEGN KTFLDNLVNF EKLHMIADTV RTLRHCRTNQ 

       550        560        570        580 
FGSDMSPKEQ QELKSYVNHL YVIDSQQALF ELSHRLEPRA 

« Hide

References

[1]"Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons."
Bithell A., Alberta J., Hornby F., Stiles C.D., Williams B.P.
Brain Res. Dev. Brain Res. 146:107-118(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
Strain: Sprague-Dawley.
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY390379 mRNA. Translation: AAR83745.1.
RefSeqNP_001041380.1. NM_001047915.1.
UniGeneRn.22381.

3D structure databases

ProteinModelPortalP83900.
SMRP83900. Positions 240-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid263730. 1 interaction.
STRING10116.ENSRNOP00000007112.

Proteomic databases

PaxDbP83900.
PRIDEP83900.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID362799.
KEGGrno:362799.
UCSCRGD:1561668. rat.

Organism-specific databases

CTD9771.
RGD1561668. Rapgef5.

Phylogenomic databases

eggNOGNOG236726.
HOVERGENHBG056985.
KOK08019.
PhylomeDBP83900.

Gene expression databases

GenevestigatorP83900.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
InterProIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR008937. Ras_GEF.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PANTHERPTHR23113. PTHR23113. 1 hit.
PfamPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 2 hits.
PROSITEPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio681302.
PROP83900.

Entry information

Entry nameRPGF5_RAT
AccessionPrimary (citable) accession number: P83900
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families