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P83881

- RL36A_HUMAN

UniProt

P83881 - RL36A_HUMAN

Protein

60S ribosomal protein L36a

Gene

RPL36A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L36a
    Alternative name(s):
    60S ribosomal protein L44
    Cell growth-inhibiting gene 15 protein
    Cell migration-inducing gene 6 protein
    Gene namesi
    Name:RPL36A
    Synonyms:RPL44
    ORF Names:GIG15, MIG6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:10359. RPL36A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB
    3. ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164742367.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10610660S ribosomal protein L36aPRO_0000149117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiP83881.
    PaxDbiP83881.
    PRIDEiP83881.

    PTM databases

    PhosphoSiteiP83881.

    Expressioni

    Gene expression databases

    BgeeiP83881.
    CleanExiHS_RPL36A.
    GenevestigatoriP83881.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAGEB2O154791EBI-1054835,EBI-1057615
    PSTPIP1O435861EBI-1054835,EBI-1050964

    Protein-protein interaction databases

    BioGridi112092. 8 interactions.
    IntActiP83881. 5 interactions.
    MINTiMINT-3023791.
    STRINGi9606.ENSP00000404375.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00o1-106[»]
    ProteinModelPortaliP83881.
    SMRiP83881. Positions 2-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L44e family.Curated

    Phylogenomic databases

    eggNOGiCOG1631.
    HOGENOMiHOG000224989.
    HOVERGENiHBG056127.
    KOiK02929.
    PhylomeDBiP83881.

    Family and domain databases

    Gene3Di3.10.450.80. 1 hit.
    InterProiIPR000552. Ribosomal_L44e.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PANTHERiPTHR10369. PTHR10369. 1 hit.
    PfamiPF00935. Ribosomal_L44. 1 hit.
    [Graphical view]
    ProDomiPD002841. Ribosomal_L44e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    PROSITEiPS01172. RIBOSOMAL_L44E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P83881-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGKRR YDRKQSGYGG    50
    QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK 100
    GQVIQF 106
    Length:106
    Mass (Da):12,441
    Last modified:January 23, 2007 - v2
    Checksum:iAE3308265D70BD26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78027 Genomic DNA. Translation: AAB64204.1.
    AY305871 mRNA. Translation: AAQ95213.1.
    CR542198 mRNA. Translation: CAG46995.1.
    AY927233 mRNA. Translation: AAX08138.1.
    AL035422 Genomic DNA. Translation: CAI42360.1.
    CH471115 Genomic DNA. Translation: EAX02860.1.
    BC001781 mRNA. Translation: AAH01781.1.
    BC031015 mRNA. Translation: AAH31015.1.
    BC062219 mRNA. Translation: AAH62219.1.
    BC070204 mRNA. Translation: AAH70204.1.
    RefSeqiNP_066357.2. NM_021029.5.
    UniGeneiHs.432485.
    Hs.655348.

    Genome annotation databases

    EnsembliENST00000553110; ENSP00000446503; ENSG00000241343.
    GeneIDi6173.
    KEGGihsa:6173.

    Polymorphism databases

    DMDMi47117731.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78027 Genomic DNA. Translation: AAB64204.1 .
    AY305871 mRNA. Translation: AAQ95213.1 .
    CR542198 mRNA. Translation: CAG46995.1 .
    AY927233 mRNA. Translation: AAX08138.1 .
    AL035422 Genomic DNA. Translation: CAI42360.1 .
    CH471115 Genomic DNA. Translation: EAX02860.1 .
    BC001781 mRNA. Translation: AAH01781.1 .
    BC031015 mRNA. Translation: AAH31015.1 .
    BC062219 mRNA. Translation: AAH62219.1 .
    BC070204 mRNA. Translation: AAH70204.1 .
    RefSeqi NP_066357.2. NM_021029.5.
    UniGenei Hs.432485.
    Hs.655348.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 o 1-106 [» ]
    ProteinModelPortali P83881.
    SMRi P83881. Positions 2-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112092. 8 interactions.
    IntActi P83881. 5 interactions.
    MINTi MINT-3023791.
    STRINGi 9606.ENSP00000404375.

    PTM databases

    PhosphoSitei P83881.

    Polymorphism databases

    DMDMi 47117731.

    Proteomic databases

    MaxQBi P83881.
    PaxDbi P83881.
    PRIDEi P83881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000553110 ; ENSP00000446503 ; ENSG00000241343 .
    GeneIDi 6173.
    KEGGi hsa:6173.

    Organism-specific databases

    CTDi 6173.
    GeneCardsi GC0XP100645.
    H-InvDB HIX0016927.
    HIX0056232.
    HGNCi HGNC:10359. RPL36A.
    MIMi 300902. gene.
    neXtProti NX_P83881.
    PharmGKBi PA164742367.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1631.
    HOGENOMi HOG000224989.
    HOVERGENi HBG056127.
    KOi K02929.
    PhylomeDBi P83881.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL36A. human.
    GeneWikii RPL36A.
    GenomeRNAii 6173.
    NextBioi 23983.
    PROi P83881.
    SOURCEi Search...

    Gene expression databases

    Bgeei P83881.
    CleanExi HS_RPL36A.
    Genevestigatori P83881.

    Family and domain databases

    Gene3Di 3.10.450.80. 1 hit.
    InterProi IPR000552. Ribosomal_L44e.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    PANTHERi PTHR10369. PTHR10369. 1 hit.
    Pfami PF00935. Ribosomal_L44. 1 hit.
    [Graphical view ]
    ProDomi PD002841. Ribosomal_L44e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    PROSITEi PS01172. RIBOSOMAL_L44E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains."
      Oeltjen J.C., Malley T.M., Muzny D.M., Miller W., Gibbs R.A., Belmont J.W.
      Genome Res. 7:315-329(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of a migration-inducing gene."
      Kim J.W.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Identification of cell growth-inhibiting gene."
      Kim J.W., Kim H.K.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye, Lung and Testis.
    8. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL36A_HUMAN
    AccessioniPrimary (citable) accession number: P83881
    Secondary accession number(s): P09896
    , P10661, Q08ES5, Q5J9I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3