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Protein

60S ribosomal protein L36a

Gene

RPL36A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36a
Alternative name(s):
60S ribosomal protein L44
Cell growth-inhibiting gene 15 protein
Cell migration-inducing gene 6 protein
Large ribosomal subunit protein eL421 Publication
Gene namesi
Name:RPL36A
Synonyms:RPL44
ORF Names:GIG15, MIG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10359. RPL36A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • cytosolic large ribosomal subunit Source: UniProtKB
  • plasma membrane Source: HPA
  • ribosome Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6173.
OpenTargetsiENSG00000241343.
PharmGKBiPA164742367.

Polymorphism and mutation databases

DMDMi47117731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491171 – 10660S ribosomal protein L36aAdd BLAST106

Proteomic databases

EPDiP83881.
MaxQBiP83881.
PaxDbiP83881.
PeptideAtlasiP83881.
PRIDEiP83881.
TopDownProteomicsiP83881.

PTM databases

iPTMnetiP83881.
PhosphoSitePlusiP83881.
SwissPalmiP83881.

Expressioni

Gene expression databases

BgeeiENSG00000241343.
CleanExiHS_RPL36A.
ExpressionAtlasiP83881. baseline and differential.

Organism-specific databases

HPAiHPA077586.

Interactioni

Protein-protein interaction databases

BioGridi112092. 18 interactors.
IntActiP83881. 11 interactors.
MINTiMINT-3023791.
STRINGi9606.ENSP00000404375.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lo1-106[»]
4V6Xelectron microscopy5.00Co1-106[»]
5AJ0electron microscopy3.50Ao1-106[»]
5LKSelectron microscopy3.60Lo1-106[»]
5T2Celectron microscopy3.60i1-106[»]
ProteinModelPortaliP83881.
SMRiP83881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3464. Eukaryota.
COG1631. LUCA.
GeneTreeiENSGT00390000018085.
HOGENOMiHOG000224989.
HOVERGENiHBG056127.
InParanoidiP83881.
KOiK02929.
PhylomeDBiP83881.

Family and domain databases

InterProiView protein in InterPro
IPR000552. Ribosomal_L44e.
IPR011332. Ribosomal_zn-bd.
PANTHERiPTHR10369. PTHR10369. 1 hit.
PfamiView protein in Pfam
PF00935. Ribosomal_L44. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002841. Ribosomal_L44e. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiView protein in PROSITE
PS01172. RIBOSOMAL_L44E. 1 hit.

Sequencei

Sequence statusi: Complete.

P83881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGKRR YDRKQSGYGG
60 70 80 90 100
QTKPIFRKKA KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK

GQVIQF
Length:106
Mass (Da):12,441
Last modified:January 23, 2007 - v2
Checksum:iAE3308265D70BD26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78027 Genomic DNA. Translation: AAB64204.1.
AY305871 mRNA. Translation: AAQ95213.1.
CR542198 mRNA. Translation: CAG46995.1.
AY927233 mRNA. Translation: AAX08138.1.
AL035422 Genomic DNA. No translation available.
CH471115 Genomic DNA. Translation: EAX02860.1.
BC001781 mRNA. Translation: AAH01781.1.
BC031015 mRNA. Translation: AAH31015.1.
BC062219 mRNA. Translation: AAH62219.1.
BC070204 mRNA. Translation: AAH70204.1.
RefSeqiNP_066357.2. NM_021029.5.
UniGeneiHs.432485.
Hs.655348.

Genome annotation databases

EnsembliENST00000553110; ENSP00000446503; ENSG00000241343.
GeneIDi6173.
KEGGihsa:6173.
UCSCiuc065agx.1. human.

Similar proteinsi

Entry informationi

Entry nameiRL36A_HUMAN
AccessioniPrimary (citable) accession number: P83881
Secondary accession number(s): P09896
, P10661, Q08ES5, Q5J9I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families