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Protein

PHD finger-like domain-containing protein 5A

Gene

Phf5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha. Also involved in pre-mRNA splicing.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger-like domain-containing protein 5A
Short name:
PHD finger-like domain protein 5A
Alternative name(s):
Splicing factor 3B-associated 14 kDa protein
Short name:
SF3b14b
Gene namesi
Name:Phf5a
Synonyms:Ini
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621555. Phf5a.

Subcellular locationi

  • Nucleus 1 Publication
  • Nucleus speckle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 110109PHD finger-like domain-containing protein 5APRO_0000218718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei3 – 31N6-acetyllysineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP83871.
PRIDEiP83871.

PTM databases

iPTMnetiP83871.
PhosphoSiteiP83871.

Expressioni

Tissue specificityi

Expressed in all tissues tested including brain, heart, ovary, uterus, skeletal muscle and testis.1 Publication

Inductioni

By estrogen.1 Publication

Gene expression databases

BgeeiENSRNOG00000024170.
ExpressionAtlasiP83871. baseline and differential.
GenevisibleiP83871. RN.

Interactioni

Subunit structurei

Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Interacts (via N-terminus) with U2AF1 and SRSF5; acts to bridge the two. Interacts (via C-terminus) with EP400 and DDX1; acts to bridge the two (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005837.

Structurei

3D structure databases

ProteinModelPortaliP83871.
SMRiP83871. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PHF5 family.Curated

Phylogenomic databases

eggNOGiKOG1705. Eukaryota.
ENOG4111JIM. LUCA.
GeneTreeiENSGT00390000018518.
HOGENOMiHOG000168285.
HOVERGENiHBG053587.
InParanoidiP83871.
KOiK12834.
OMAiYCKECTV.
OrthoDBiEOG091G0W8V.
PhylomeDBiP83871.
TreeFamiTF105627.

Family and domain databases

InterProiIPR005345. PHF5.
[Graphical view]
PANTHERiPTHR13120. PTHR13120. 1 hit.
PfamiPF03660. PHF5. 1 hit.
[Graphical view]
PIRSFiPIRSF016468. PHF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHHPDLIF CRKQAGVAIG RLCEKCDGKC VICDSYVRPC TLVRICDECN
60 70 80 90 100
YGSYQGRCVI CGGPGVSDAY YCKECTIQEK DRDGCPKIVN LGSSKTDLFY
110
ERKKYGFKKR
Length:110
Mass (Da):12,405
Last modified:April 26, 2004 - v1
Checksum:i90F7469DE7292BF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495522 mRNA. Translation: AAM14623.1.
RefSeqiNP_620243.1. NM_138888.1.
UniGeneiRn.9116.

Genome annotation databases

EnsembliENSRNOT00000005837; ENSRNOP00000005837; ENSRNOG00000024170.
GeneIDi192246.
KEGGirno:192246.
UCSCiRGD:621555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495522 mRNA. Translation: AAM14623.1.
RefSeqiNP_620243.1. NM_138888.1.
UniGeneiRn.9116.

3D structure databases

ProteinModelPortaliP83871.
SMRiP83871. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005837.

PTM databases

iPTMnetiP83871.
PhosphoSiteiP83871.

Proteomic databases

PaxDbiP83871.
PRIDEiP83871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005837; ENSRNOP00000005837; ENSRNOG00000024170.
GeneIDi192246.
KEGGirno:192246.
UCSCiRGD:621555. rat.

Organism-specific databases

CTDi84844.
RGDi621555. Phf5a.

Phylogenomic databases

eggNOGiKOG1705. Eukaryota.
ENOG4111JIM. LUCA.
GeneTreeiENSGT00390000018518.
HOGENOMiHOG000168285.
HOVERGENiHBG053587.
InParanoidiP83871.
KOiK12834.
OMAiYCKECTV.
OrthoDBiEOG091G0W8V.
PhylomeDBiP83871.
TreeFamiTF105627.

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiP83871.

Gene expression databases

BgeeiENSRNOG00000024170.
ExpressionAtlasiP83871. baseline and differential.
GenevisibleiP83871. RN.

Family and domain databases

InterProiIPR005345. PHF5.
[Graphical view]
PANTHERiPTHR13120. PTHR13120. 1 hit.
PfamiPF03660. PHF5. 1 hit.
[Graphical view]
PIRSFiPIRSF016468. PHF5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHF5A_RAT
AccessioniPrimary (citable) accession number: P83871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.