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Protein

PHD finger-like domain-containing protein 5A

Gene

Phf5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha. Also involved in pre-mRNA splicing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger-like domain-containing protein 5A
Short name:
PHD finger-like domain protein 5A
Alternative name(s):
Splicing factor 3B-associated 14 kDa protein
Short name:
SF3b14b
Gene namesi
Name:Phf5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2156864. Phf5a.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • nuclear matrix Source: MGI
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: MGI
  • precatalytic spliceosome Source: GO_Central
  • U12-type spliceosomal complex Source: MGI
  • U2 snRNP Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002187172 – 110PHD finger-like domain-containing protein 5AAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3N6-acetyllysineCombined sources1
Modified residuei94PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP83870.
MaxQBiP83870.
PaxDbiP83870.
PeptideAtlasiP83870.
PRIDEiP83870.

PTM databases

iPTMnetiP83870.
PhosphoSitePlusiP83870.

Expressioni

Tissue specificityi

Expressed in primary spermatocytes (at protein level). Ubiquitously expressed in pre- and postnatal tissues.2 Publications

Gene expression databases

BgeeiENSMUSG00000061360.
CleanExiMM_PHF5A.
GenevisibleiP83870. MM.

Interactioni

Subunit structurei

Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Interacts (via N-terminus) with U2AF1 and SRSF5; acts to bridge the two. Interacts (via C-terminus) with EP400 and DDX1; acts to bridge the two.By similarity1 Publication

Protein-protein interaction databases

BioGridi212875. 1 interactor.
IntActiP83870. 2 interactors.
MINTiMINT-4107454.
STRINGi10090.ENSMUSP00000023117.

Structurei

3D structure databases

ProteinModelPortaliP83870.
SMRiP83870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PHF5 family.Curated

Phylogenomic databases

eggNOGiKOG1705. Eukaryota.
ENOG4111JIM. LUCA.
GeneTreeiENSGT00390000018518.
HOGENOMiHOG000168285.
HOVERGENiHBG053587.
InParanoidiP83870.
KOiK12834.
OMAiYCKECTV.
OrthoDBiEOG091G0W8V.
PhylomeDBiP83870.
TreeFamiTF105627.

Family and domain databases

InterProiIPR005345. PHF5.
[Graphical view]
PANTHERiPTHR13120. PTHR13120. 1 hit.
PfamiPF03660. PHF5. 1 hit.
[Graphical view]
PIRSFiPIRSF016468. PHF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHHPDLIF CRKQAGVAIG RLCEKCDGKC VICDSYVRPC TLVRICDECN
60 70 80 90 100
YGSYQGRCVI CGGPGVSDAY YCKECTIQEK DRDGCPKIVN LGSSKTDLFY
110
ERKKYGFKKR
Length:110
Mass (Da):12,405
Last modified:April 26, 2004 - v1
Checksum:i90F7469DE7292BF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479286 Genomic DNA. Translation: AAM49735.1.
AF479288 mRNA. Translation: AAM49736.1.
AK003520 mRNA. Translation: BAB22833.1.
AK143590 mRNA. Translation: BAE25453.1.
AK163247 mRNA. Translation: BAE37255.1.
AK167932 mRNA. Translation: BAE39936.1.
AK167955 mRNA. Translation: BAE39955.1.
BC025161 mRNA. Translation: AAH25161.1.
CCDSiCCDS27674.1.
PIRiJC7851.
RefSeqiNP_081013.1. NM_026737.3.
UniGeneiMm.271715.

Genome annotation databases

EnsembliENSMUST00000023117; ENSMUSP00000023117; ENSMUSG00000061360.
GeneIDi68479.
KEGGimmu:68479.
UCSCiuc007wxo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479286 Genomic DNA. Translation: AAM49735.1.
AF479288 mRNA. Translation: AAM49736.1.
AK003520 mRNA. Translation: BAB22833.1.
AK143590 mRNA. Translation: BAE25453.1.
AK163247 mRNA. Translation: BAE37255.1.
AK167932 mRNA. Translation: BAE39936.1.
AK167955 mRNA. Translation: BAE39955.1.
BC025161 mRNA. Translation: AAH25161.1.
CCDSiCCDS27674.1.
PIRiJC7851.
RefSeqiNP_081013.1. NM_026737.3.
UniGeneiMm.271715.

3D structure databases

ProteinModelPortaliP83870.
SMRiP83870.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212875. 1 interactor.
IntActiP83870. 2 interactors.
MINTiMINT-4107454.
STRINGi10090.ENSMUSP00000023117.

PTM databases

iPTMnetiP83870.
PhosphoSitePlusiP83870.

Proteomic databases

EPDiP83870.
MaxQBiP83870.
PaxDbiP83870.
PeptideAtlasiP83870.
PRIDEiP83870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023117; ENSMUSP00000023117; ENSMUSG00000061360.
GeneIDi68479.
KEGGimmu:68479.
UCSCiuc007wxo.1. mouse.

Organism-specific databases

CTDi84844.
MGIiMGI:2156864. Phf5a.

Phylogenomic databases

eggNOGiKOG1705. Eukaryota.
ENOG4111JIM. LUCA.
GeneTreeiENSGT00390000018518.
HOGENOMiHOG000168285.
HOVERGENiHBG053587.
InParanoidiP83870.
KOiK12834.
OMAiYCKECTV.
OrthoDBiEOG091G0W8V.
PhylomeDBiP83870.
TreeFamiTF105627.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiP83870.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061360.
CleanExiMM_PHF5A.
GenevisibleiP83870. MM.

Family and domain databases

InterProiIPR005345. PHF5.
[Graphical view]
PANTHERiPTHR13120. PTHR13120. 1 hit.
PfamiPF03660. PHF5. 1 hit.
[Graphical view]
PIRSFiPIRSF016468. PHF5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHF5A_MOUSE
AccessioniPrimary (citable) accession number: P83870
Secondary accession number(s): Q3TQX7, Q9UH06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.